Effect of Alirocumab on Mortality After Acute Coronary Syndromes An Analysis of the ODYSSEY OUTCOMES Randomized Clinical Trial
Background: Previous trials of PCSK9 (proprotein convertase subtilisin-kexin type 9) inhibitors demonstrated reductions in major adverse cardiovascular events, but not death. We assessed the effects of alirocumab on death after index acute coronary syndrome. Methods: ODYSSEY OUTCOMES (Evaluation of...
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| Format: | Article |
| Status: | Published version |
| Publication date: | 2019 |
| Country: | España |
| Institution: | Institut d'Investigació i Innovació Parc Taulí (I3PT) |
| Repository: | r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí |
| OAI Identifier: | oai:i3pt.fundanetsuite.com:p2950 |
| Online Access: | https://i3pt.portalinvestigacion.com/publicaciones/2950 |
| Access Level: | Open access |
| Keyword: | acute coronary syndrome alirocumab cholesterol mortality PCSK9 protein |
| _version_ | 1878734893166362624 |
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| author | Steg, PG |
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DJ Marcus, J Mathews, R Mehta, RH Mentz, RJ Moreira, HG Patel, CB Pereira, SB Perkins, L Povsic, TJ Puymirat, E Jones, WS Shah, BR Sherwood, MW Stringfellow, K Sujjavanich, D Toma, M Van Diepen, SFP Wilson, MD Yan, ATK Lopes, RD Trotter, C Schiavi, LB Garrido, M Alvarisqueta, AF Sassone, SA Bordonava, AP De Lima, AEA Schmidberg, JM Duronto, EA Caruso, OC Novaretto, LP Hominal, MA Montana, OR Caccavo, A Vilamajo, OAG Lorenzatti, AJ Cartasegna, LR Paterlini, GA Mackinnon, IJ Caime, GD Amuchastegui, M Salomone, R Codutti, OR Jure, HO Bono, JOE Hrabar, AD Vallejos, JA Guerrero, RAA Novoa, F Patocchi, CA Zaidman, CJ Giuliano, ME Dran, RD Vico, ML Carnero, GS Guzman, PN Allende, JCM Brasca, DFG Labarta, MHB Nani, S Blumberg, EDS Colombo, HR Liberman, A Luciardi, HL Waisman, GD Berli, MA Duran, ROG Cestari, HG Luquez, HA Giordano, JA Saavedra, SS Zapata, G Costamagna, O Llois, S Waites, JH Collins, N Soward, A Aylward, PE Hii, CLS Shaw, J Arstall, MA Horowitz, J Rogers, JF Colquhoun, D 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Akyea-Djamson, A Labroo, A Marais, HJ Claxton, E Berk, M Rossi, P Joshi, P Khaira, AS Kumkumian, G Lupovitch, S Purow, J Welka, S Hoffman, D Fischer, S Soroka, E Eagerton, D Pancholy, S Ray, M Farrar, M Pollock, S French, WJ Diamantis, S Gimple, L Neustel, M Schwartz, S Pereira, E Spriggs, D Strain, J Vo, A Chane, M Hall, J Vijay, N Lotun, K Lester, FM Nahhas, A Pope, T Nager, P Vohra, R Bashir, R Ahmed, H Berlowitz, M Fishberg, R Barrucco, R Yang, E Radin, M Sporn, D Eisenberg, S Landzberg, J Mcgough, M Turk, S Schwartz, M Sundram, PS Jain, D Zainea, M Bayron, C Karlsberg, R Lui, H Keen, W Westerhausen, D Khurana, S Agarwal, H Birchem, J Penny, W Chang, M Murphy, S Schifferdecker, B Gilbert, JM Chalavarya, G Eaton, C Schmedtje, JF Christenson, S Denham, D Macdonell, A Gibson, P Rahman, A Al Joundi, T Conrad, G Kotha, P Love, M Giesler, G Rubenstein, H Akright, L Krawczyk, J Wells, T Welker, J Foster, R Gilmore, R Anderson, J Jacoby, D Gardner, G Dandillaya, R Vora, K Kostis, J Hunter, J Laxson, D Ball, E Camp, A Lopes, R Egydio, F Kawakami, A Oliveira, J Wozniak, J Matthews, A Ratky, C Valiris, J Berdan, L Hepditch, A Quintero, K Rorick, T Westbrook, M Pascual, A Rovito, C Bezault, M Drouet, E Simon, T Alsweiler, C Luyten, A Aylward, P Butters, J Griffith, L Shaw, M Hagstrom, E Grunberg, L Islam, S Bregeault, MF Bougon, N Faustino, D Fontecave, S Murphy, J Tamby, JF Verrier, M Agnetti, V Andersen, D Badreddine, E Bekkouche, M Bouancheau, C Brigui, I Brocklehurst, M Cianciarulo, J Devaul, D Domokos, S Gache, C Gobillot, C Guillou, S Healy, J Heath, M Jaiwal, G Javierre, C Labeirie, J Monier, M Morales, U Mrabti, A Mthombeni, B Okan, B Smith, L Sheller, J Sopena, S Pellan, V Benbernou, F Bengrait, N Lamoureux, M Kralova, K Scemama, M Bejuit, R Coulange, A Berthou, C Repincay, J Lorenzato, C Etienne, A Gouet, V Loizeau, V Normand, M Ourliac, A Rondel, C Adamo, A Beltran, P Barraud, P Dubois-Gache, H Halle, B Metwally, L Mourgues, M Sotty, M Vincendet, M Cotruta, R Zhu, CY Fournie-Lloret, D Morrello, C Perthuis, A Picault, P Zobouyan, I |
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| author_browse | Abbas, J Abbate, A Abdullakutty, J Abdullkutty, J Abhyanakar, AD Aboyans, V Abrantes, JAM Abu-Fadel, M Acevedo, M Ackar, AN Adamkova, V Adamo, A Adhyapak, S Agarwal, H Aggarwal, R Aggarwal, RK Agnetti, V Aguirre, A Ahmed, H Ahremark, U Airaksinen, JK Aitken, D Akatova, E Akhter, F Ako, J Akright, L Akyea-Djamson, A Al Joundi, T Al-Windy, NYY Alan, D Alexander, JH Alexander, K Alexandru, TM Alexopoulos, D Alings, M Allende, JCM Alsweiler, C Alvarisqueta, AF Amarasekera, S Amarasena, N Amir, O Amlani, M Amosova, E Amuchastegui, M Andersen, D Andersen, K Andersen, R Anderson, J Ando, K Annam, S Anscombe, R Apostolovic, SR Appel, KF Arandjelovic, A Araneda, G Arbel, Y Arif, I Armaganijan, L Aroney, C Arroyo, JAC Arstall, MA Asanin, MR Atar, S Athyros, V Auguadro, C Ayala, CAC Aylward, P Aylward, PE Ayoub, JCA Azizad, MM Badreddine, E Bagai, A Bagriy, A Bahit, MC Bai, F Baldari, D Balinovac, J Ball, E Bang, LE Banuru, S Barakovic, F Baranov, E Baranova, E Barbarash, OL Barbato, E Barna, OM Barone-Rochette, G Barr, C Barraud, P Barrucco, R Bartels, GL Bashir, R Basson, MMD Bastos, JM Bata, I Batushkin, V Bayat, J Bayron, C Beauloye, C Bednarski, J Behrens, S Bejuit, R Bekkouche, M Belhassane, A Beltran, P Benbernou, F Bencic, ML Benecke, JLA Benedicto, A Bengrait, N Bengus, CM Benov, HO Berdan, L Berger, R Berglund, S Berk, M Berland, J Berli, MA Berlowitz, M Berman, B Bernan, A Berthou, C Berti, S Bezault, M Bhagwat, A Bhagwat, R Bhansali, P Bhatt, DL Binder, R Birchem, J Bittner, VA Blicharski, T Blok, T Blumberg, EDS Boccara, F Bocker, D Bodanese, LC Bojovski, S Bokarev, I Bokern, MJJA Bonfanti, AJC Bono, JOE Bordonava, AP Borse, R Bortnick, A Bos, RJ Botelho, A Botelho, RV Botia, DCL Bottcher, M Bouancheau, C Bougon, N Bourgeois, R Brabham, D Braganza, D Brasca, DFG Braun-Dullaeus, R Breedveld, RW Bregeault, MF Brennan, JM Brigui, I Brocklehurst, M Brodison, A Bronzwaer, PNA Brueren, BR Budaj, A Bugan, V Busmane, A Busz-Papiez, B Butler, R Butters, J Bystryk, L Caccavo, A Caime, GD Calabro, P Calvillo, JC Camp, A Campos, PF Camsari, A Car, S Caraco, Y Carey, C Carlson, E Carnero, GS Carroll, PA Cartasegna, LR Carter, L Caruso, OC Cassimjee, S Castadot, M Castillo, AG Cavallini, C Cerqueira, MJAG Cestari, HG Cevc, M Cha, J Chae, IH Chaitman, B Chalavarya, G Chaleff, F Chambilla, JMC Chandna, H Chane, M Chang, M Chaudhary, S Chavez, VER Chen, D Chen, JY Chen, YD Cheng, SC Cheng, XS Chiang, CE Chizhov, P Chopda, M Chopra, VK Chotnoparatpat, P Christenson, S Chu, A Chua, T Chumakova, G Chumburidze, V Cianciarulo, J Cioranu, RS Citron, B Claeys, M Claxton, E Clemmensen, P Clerc, J Cleveland, D Clifford, P Clifton, S Coching, RM Codutti, OR Cohen, S Collins, N Colombo, HR Colquhoun, D Coman, I Commerford, PJ Concha, YMR Conrad, G Constantine, G Constantinescu, MCA Convens, C Cools, F Corbett, C Cornel, JH Cortada, JB Cosavalente, LAC Costa, F Costamagna, O Coste, P Cotruta, R Cottin, Y Coufal, Z Coulange, A Coverdale, SGM Cristian, G Cuccia, C Cui, L Cyster, HP Czerski, T D'Urso, M Daboul, N Dagher, G Dahl, C Dai, K Dalby, AJ Danchin, N Dandillaya, R Daniels, C Das, S Davidovic, G Davidsen, F Davidson, L Davies, R Davis, W De Cesare, NB De La Tassa, CM De Leo, A De Leon, ERR De Leon, MG De Lima, AEA De Luca, G De Pellegrin, A De Salazar, DIM De Silva, HA De Wolf, L DeVore, AD Delarche, N Deloatch, S Demirtas, M Denham, D Devarapalli, SK Devaul, D Diamantis, S Diaz, A Diaz, BG Diaz, R Dick, R Dickey, S Dilic, M Dimkovic, S Dimov, BI Dimulescu, D Dincic, DV Ding, CH Dion, D Diz, FW Dodds, G Dodic, S Dombrowski, K Domokos, S Doncovska, S Dong, SH Dong, YG Dorobantu, M Dorsel, T Dran, RD Drexel, H Drouet, E Drzewiecka, A Dubois-Gache, H Ducas, J Ducrocq, G Duda, N Dujardin, K Dukat, A Dulak, E Dupuis, R Durak-Nalbantic, A Duran, ROG Duronto, EA Dzupina, A Dzyak, G Eagerton, D Eapen, Z East, C Eaton, C Ebrahim, IO Edelberg, JM Edes, I Egorova, L Egydio, F Eisenberg, S Ekanayaka, R El Shahawy, M El-Ahdab, F Elias, M Elias, N Eliaschewitz, FG Elliott, J Endsley, P Eppinger, A Erglis, A Ersanli, M Escudier, JM Esperon, GAL Etienne, A Fadlallah, H Faes, D Faggiano, P Fairlamb, J Falukozy, J Fan, ZC Fang, CY Fang, WY Farhat, N Farrar, M Faustino, D Fazekas, F Fazlibegovic, E Feitosa, GS Fell, D Feng, Y Fernandez, JFD Fernandez, JMC Fernandez, JRD Fernandez, JT Fernandez, M Fernando, N Ferrari, E Ferratini, M Ferrolino, A Filardi, PP Fillat, ARC Fischer, S Fishberg, R Fisher, D Fisher, N Fisher, R Florenzano, F Flores, E Flores, REO Flores, RMC Fong, P Fontecave, S Forgosh, L Foster, M Foster, R Fournie-Lloret, D Fragoso, JCN Francis, A Franek, E Fras, Z French, WJ Friedman, D Frost, L Fu, GS Fuchs, S Fujii, K Fujimoto, K Fujinaga, H Fulop, P Fulwani, MC Furukawa, Y Gache, C Galski, T Galvani, M Gamba, MAA Gapon, L Garcia-Dorado, D Gardner, G Garrahy, PJ Garrido, M Gavish, D Ge, JB Gelormini, J Gerber, J Gerber, R Ghitis, A Ghlonti, R Gibson, P Gielen, S Giesler, G Gil-Extremera, B Gilbert, JM Gillespie, E Gilmore, R Gimple, L Giordano, JA Giorgeto, FE Gislason, G Giuliano, ME Gniot, J Gobillot, C Goch, A Goloborodko, B Gonsorcik, J Gonzales, RJV Gonzalez-Juanatey, C Gonzalez-Juanatey, JR Goodman, SG Gordeev, I Gordienko, A Gorny, J Goronja, B Gosselin, G Gosselink, ATM Gotcheva, NN Gouet, V Govinda, RA Goyal, NK Gremmler, U Grewal, JS Griffith, L Griffiths, H Gring, C Groenemeijer, BE Groutars, RGEJ Grunberg, L Guardigli, G Guerrero, RAA Guha, S Guillou, S Gullestad, L Guneri, S Guo, Y Gurevich, V Guzman, PN Haddad, T Hagstrom, E Hahalis, G Halabi, M Halcox, J Hald, F Haldis, T Hall, J Halle, B Halvorsen, S Hameed, A Haniffa, R Hanotin, C Hansen, O Haraguchi, T Harding, S Harkut, P Harrington, RA Harris, B Harrison, RW Hart, H Hata, Y Hattler, B Hatzitolios, A Healy, J Heath, M Hedman, A Heidenreich, L Heinc, P Heitzer, T Hemetsberger, R Henderson, D Henkin, Y Hepditch, A Herath, JI Herazo, AS Hermans, K Hermans, WRM Hernandez, HAA Herrman, JPR Hersbach, FMRJ Herzog, W Hess, CN Higashikata, T Higuera, JD Hii, CLS Hirayama, A Hirooka, K Hlatky, MA Hoag, G Hodes, Z Hoffer, E Hoffman, D Hominal, MA Hong, T Hoogslag, PAM Hoppe, U Horak, D Horowitz, J Horvath, I Horwitz, P Hove, JD Hrabar, AD Hranai, M Hsieh, IC Huang, L Huang, SA Huang, TY Huang, WJ Huber, K Huidobro, L Huikuri, H Hunter, J Hurtig, U Hussein, O Huynh, T Hwang, JJ Ilic, S Ilieva-Pandeva, KA Ince, C Iniguez, A Iqbal, SM Irimpen, A Islam, S Istratoaie, O Ito, K Ivanov, IG Ivanova, R Ivanovic, N Iyengar, SS Izzo, M Jacoby, D Jafar, Z Jaffrani, N Jain, D Jaiwal, G Janik, M Janosik, D Jaramillo, N Jatin, FGM Javierre, C Jaworska, K Jayawardena, J Jensen, SA Jeong, MH Jeppesen, J Jeserich, M Jiang, WH Jimenez, FF Jintapakorn, W Johansen, PB Jonas, M Jones, WS Jordan, JD Jorge, JCM Jortveit, J Joshi, AB Joshi, P Jovin, I Jujjuru, S Jukema, JW Juonala, M Jure, HO Jurgaitiene, R Kadr, H Kaewsuwanna, P Kahali, D Kaikkonen, K Kaiser, S Kalashetti, S Kalil, R Kamensky, G Kamiya, H Kandasamy, B Kanorsky, S Kapin, T Kaplan, R Kapp, IE Karalis, I Karlsberg, R Karna, S Karpenko, O Karpenko, Y Karpov, Y Kartalis, A Kasim, S Katona, A Katsuda, Y Katz, A Kaucak, V Kavaliauskiene, R Kawakami, A Kawasaki, T Ke, YN Keating, F Kedev, S Keen, W Kehasukcharoen, W Kelsey, SF Kerkar, P Khabeishvili, G Khaira, AS Khaisheva, L Khan, A Khan, M Khasanov, N Khintibidze, I Khurana, S Kibarskis, A Kichukov, KN Killat, H Kim, C Kim, HS Kim, MH Kim, SH Kim, Y Kimmelstiel, C Kimura, K Kimura, T King, M Kinzfogl, G Kirma, C Kishi, K Kiss, RG Kiviniemi, T Kjovkaroski, A Klancke, K Klantsa, A Klausen, IC Kline, G Klutstein, M Knickelbine, T Knowles, JW Knutson, T Koba, S Kobalava, Z Kobayashi, J Koike, A Koldas, L Kolls, BJ Kondo, NI Kong, DF Kopytsya, M Koren, M Kormann, A Kornder, J Kornowski, R Korol, M Kosinski, E Kosmachova, E Kostarska-Srokosz, E Kostis, J Kotha, P Kouz, S Kovalskyi, I Kozuma, K Kralova, K Krasowski, W Krawczyk, J Krichmar, P Kristensen, KS Kristjan, A Krstulovic, SM Kubica, J Kubilius, R Kuchar, J Kuhlman, P Kultursay, H Kumar, A Kumar, P Kumbla, M Kumkumian, G Kuo, JY Kurian, J Kushnir, M Kutniy, O Kyiak, Y Labarta, MHB Labeirie, J Labroo, A Lai, C Lai, WT Lambert, C Lamoureux, M Landeo, JH Landzberg, J Larry, J Larsen, J Laucevicius, A Laufs, U Laxson, D Lazov, PV Leaes, PE Leclercq, F Lecorps, G Lee, K Lefevre, T Leggewie, S Lehman, SJ Leimbach, W Lekakis, J Leon, RPC Leonardi, S Leone, A Lepage, S Lepor, N Leshchuk, O Lester, FM Leung, R Levy, T Li, HM Li, JP Li, TC Li, X Li, XD Li, Y Lianopoulos, E Liberman, A Liberopoulos, E Libov, I Licciardello, G Lieber, I Liem, AAH Liew, HB Lillis, L Lin, JX Lin, WH Lin, XF Lindsey, J Linhart, A Link, C Lip, GYH Lipko, JA Lishner, M Liu, ME Liu, SW Llamas, EAB Lledo, JAG Llois, S Loizeau, V Lomakin, NV Lomholdt, JD Lominadze, Z Lopes, R Lopes, RD Lopez, GAR Lopez, R Lopez, RB Lopez-Jaramillo, P Lorenzato, C Lorenzatti, AJ Lotan, C Lottering, H Lotun, K Loussararian, A Love, M Lozada, HJG Lozance, N Lu, QH Lubinski, A Luciardi, HL Lui, H Luo, ZR Lupkovics, G Lupovitch, S Luquez, HA Luyten, A Lyamina, N Lysek, R MacDonald, P Macdonell, A Mach, F Machado, L Machova, V Mackinnon, IJ Madrigal, JC Mahaffey, KW Mahajan, A Mahal, S Maia, LN Majercak, I Makotoko, EM Malhotra, V Malik, A Malozzi, C Malynovsky, Y Manakshe, GV Manenti, ERFF Mannucci, JEB Mano, T Manolis, A Mansourati, J Marais, HJ Marcus, J Marin, F Marin, JA Markov, DT Markov, V Maron, DJ Martin, JJA Martin, MD Martins, D Martsin, K Marusincova, I Marx, N Marx, R Maskon, O Masutani, M Matei, AV Mathews, R Mathur, A Mathur, R Matiga, G Matthews, A Matuska, J May, O May, W Mayurathan, G Mazur, J Mcclure, S Mcgarvey, J Mcgough, M Mclaurin, B Mehta, RH Mehta, S Meloni, C Mendis, S Mendonca, C Mendoza, JLA Mentz, RJ Merkely, B Metwally, L Michalaros, YL Michaud, N Michishita, I Micko, K Midzic, Z Miguel, SAN Miklaszewicz, B Mileta, D Milicic, D Militaru, C Mincheva, VM Minescu, B Mintale, I Mirek-Bryniarska, E Misonis, N Moccetti, T Mody, F Mohamed, WMIW Mohart, AE Molchanova, O Mollov, MN Monier, M Montalescot, G Montana, OR Montecinos, H Monteiro, MR Monteiro, P Moodley, R Morais, J Morales, DD Morales, U Moran, J Moreira, HG Morel, O Moriarty, A Moriarty, PM Morino, Y Morisset, A Morrello, C Moryusef, A Mosseri, M Mostovoy, Y Motovska, Z Mourgues, M Mourtzinis, G Mrabti, A Mthombeni, B Mudawi, T Muenzel, T Mulkay, A Muller, C Muller, G Munk, PS Munusamy, V Murillo, FC Murin, J Murphy, J Murphy, S Muslibegovic, A Musumeci, G Muthusamy, R Mutlu, B Mynhardt, JH Myshanych, H Nager, P Nagy, L Nahhas, A Nahuelpan, L Nani, S Naplava, R Natour, M Navarro, NCL Nelson, W Neuenschwander, F Neustel, M Nicol, P Nicolau, JC Nielsen, PK Nielsen, T Nieminen, MS Nigro, F Nijmeijer, R Nikolaev, K Nikolov, FP Nikolsky, E Nishibe, A Nociar, J Nogareda, G Norkiene, S Normand, M Novaretto, LP Novo, S Novoa, F Novotny, V Nowins, R Nunez, CAZ Nygard, O O'Donnell, PJ Okan, B Olexa, P Olivares, C Oliveira, J Oliver, R Olsson, AG Omran, H Ong, HY Ong, TK Ono, Y Oomen, A Oomman, A Orcajo, NA Orlikova, O Osokina, N Ostadal, P Otero, RS Ourliac, A Ovando, SRF Paganelli, F Pagava, Z Palimkar, P Palka, J Palmer, B Palvarini, M Panchal, V Pancholy, S Pandey, A Pandurangi, U Parada, JC Parepa, IR Park, H Park, HS Parkhomenko, A Parthenakis, F Pascual, A Pasquini, J Patange, A Patel, CB Paterlini, GA Patil, SN Patki, N Patocchi, CA Patsilinakos, S Pawlowicz, L Payeras, AC Pearce, S Pecin, I Pella, D Pellan, V Peng, DQ Penny, W Pepine, C Pereira, E Pereira, HH Pereira, SB Perez, ESS Perez, IP Perez, L Pericas, LM Peris, VB Perkins, L Perlmutter, N Persic, V Perthuis, A Pesant, Y Petranov, SL Petrulioniene, Z Piatti, P Picault, P Picone, M Piepiorka, M Pillay, T Pimentel, P Pincetti, C Pintaric, H Piovaccari, G Pirenne, B Piyayotai, D Podoleanu, CGC Podpera, I Poh, KK Pojskic, B Poklukar, J Pollock, S Ponce, G Pontaga, N Pope, T Pordy, R Portales, JF Porthan, K Porwal, S Posio, P Potau, MC Pothineni, RB Potthoff, S Poulsen, SH 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SS Sabatino, K Sabbah, E Sader, M Sakagami, S Sakalyte, G Sakamoto, T Salas, LGG Sales, JC Salmon, GF Salomone, R Salvioni, A Saminsk, K Sanchez, CRM Sandhu, M Sansanayudh, N Santharaj, W Saporito, W Sarkar, D Sarvan, M Sasiela, WJ Sassone, SA Sastravaha, K Sathe, S Savard, D Sawhney, J Scemama, M Schaeufele, T Schellenberg, D Schiavi, LB Schiele, F Schifferdecker, B Schmalfuss, C Schmedtje, JF Schmidberg, JM Schmidt, E Schmitt, S Schuchard, T Schwartz, GG Schwartz, M Schwartz, S Sciborski, R Scott, D Sebastian, PJ Seferovic, P Seixo, F Selecky, J Senaratne, M Senaratne, V Sethi, S Shaburishvili, T Shah, AV Shah, BR Shah, V Shalaev, S Sharman, D Shaw, J Shaw, M Shechter, M Shehova-Yankova, NS Sheldon, W Sheller, J Sherwood, MW Shetty, S Shi, XB Shimizu, M Shinde, R Shinke, T Shogenov, Z Shou, XL Shoukfeh, M Shustov, S Shvarts, Y Sijbrands, EJG Sikic, J Silva, PGMD Silva, RP Silva, SIB Silveira, JA Silver, K Simaitis, A Sime, I Simic, D Simon, T Simonis, G Simoons, ML Singal, D Singh, N Singsaas, EG Sinha, D Sinnaeve, P Sionis, D Sirisena, T Siu, DCW Skonieczny, G Skorski, M Skoumas, I Slapikas, R Smik, R Smith, L Soggia, AP Soonfuang, W Soopold, U Soots, M Sopena, S Soran, H Soroka, E Sotnikova, T Sotty, M Sousa, L Souza, WKSB Soward, A Sparby, JA Speirs, S Spinar, J Sporn, D Spriggs, D Sritara, P Stambuk, K Staneta, P Stanislavchuk, M Stankovic, A Starcevic, B Starmer, G Stasek, J Stasiewski, A Steg, PG Steiner, S Stellbrink, C Stewart, R Stojic, S Stone, J Storey, R Strader, J Strain, J Stratmann, M Strbova, J Strelnieks, A Striekwold, H Stringfellow, K Strozzi, M Stryuk, R Su, GH Su, X Subkovas, E Sudnik, W Sugino, H Suh, D Sujjavanich, D Sukonthasarn, A Suligoj, NC Sulit, DJ Sumner, A Sun, YM Sun, YX Sundelin, T Sundram, PS Suryapranata, H Sussex, B Svab, P Sy, RAG Sy, RG Sydow, K Szarek, M Szpajer, M Szwed, H Taguchi, S Tahk, SJ Takahashi, T Takata, T Takeda, Y Tamby, JF Tan, E Tashchuk, V Tasic, N Taskinen, MR Taurio, J Ternouth, I Terzic, I Tesloianu, DN Tespili, M Teufel, E Thakkar, M Thew, S Ticona, JRC Tirador, L Tissera, N Todorov, GV Toma, M Tomala, T Tomulic, V Tonnessen, G Torstensson, I Toursarkissian, N Tov, N Tragant, GG Treasure, C Tretyakova, TV Trevelyan, J Triana, MAU Tricoci, P Troquay, RPT Trotter, C Tsai, WC Tse, HF Tseluyko, V Tumbev, HS Tunon, J Turgeman, Y Turi, T Turk, S Tyrenko, VV Tzekova, ML Ueda, Y Uehara, H Ueng, KC Ungi, I Ural, E Ushakov, O Utsu, N Vahula, V Vakaluyk, I Valdivielso, P Valdovinos, PCM Valgimigli, M Valiris, J Vallejo, GS Vallejos, JA Van Der Wal, RMA Van Der Zwaan, CC Van Diepen, SFP Van Huysduynen-Monraats, PSH Van Zyl, LJ Vardas, P Vardi, G Varleta, P Vatutin, M Vazquez, ES Vedere, A Vejar, M Velasquez, JRD Velcheva, ES Verdel, GJE Vered, Z Verrier, M Vervoort, G Vico, ML Vida, M Videbaek, L Vidotti, MH Vidovich, M Viergever, EP Viigimaa, M Vijay, N Vijayaraghavan, R Vikman, S Viktorova, I Vilamajo, OAG Vincendet, M Violini, R Vishnevsky, AY Vizel, S Vo, A Voevoda, MI Vogel, R Vohra, R Voller, H Vora, K Voyce, S Vrolix, MCM Vulic, D Vuurmans, T Wada, A Waider, W Waisman, GD Waites, JH Wali, A Walichiewicz, PM Waltenberger, J Waltman, J Wang, JA Wang, JF Wang, JZ Wattanakit, K Wei, M Weidinger, F Weil, J Weintraub, H Weissbrodt, M Welka, S Welker, J Wells, T Werner, N Westbrook, M Westerhausen, D Whitaker, J White, HD White, L White, M Wiersma, JJ Wilkins, G Wilkinson, P Willems, FF Wilson, MD Winkelmann, B Wiseman, A Witt, N Wlodarczak, A Wojewod, P Wollaert, B Wong, YK Wongpraparut, N Wozniak, J Wright, S Wu, C Xavier, D Xenakis, M Xu, BA Xu, DL Xu, XP Xu, YZ Yagensky, A Yakushin, S Yan, ATK Yan, BPY Yanez, M Yang, E Yang, XC Yang, XJ Yao, ZH Yazdani, S Yerra, SK Yin, WH Yong, H Yoon, JH Younis, L Yu, YH Yuan, ZY Yusoff, K Zahger, D Zaidman, CJ Zainea, M Zaman, A Zamorano, JL Zapata, G Zdravko, B Zeiher, AM Zhang, RY Zhang, WW Zhang, XL Zhang, Z Zhao, XS Zheleznyy, V Zheng, Y Zheng, ZQ Zhou, YJ Zhu, CY Zhu, H Zhu, JH Zirlik, A Zizka, J Zobouyan, I Zong, WX Zrazhevsky, K Zuniga, JDH Zurakowski, A Zuran, I Zweiker, R de Santos, MON de Souza, JA |
| author_facet | Steg, PG Szarek, M Bhatt, DL Bittner, VA Diaz, R Edelberg, JM Hanotin, C Harrington, RA Jukema, JW Lecorps, G Mahaffey, KW Moryusef, A Pordy, R Tricoci, P Vogel, R White, HD Zeiher, AM Schwartz, GG Sasiela, WJ Drexel, H Sinnaeve, P Dilic, M Gotcheva, NN Goodman, SG Prieto, JC Yong, H Lopez-Jaramillo, P Pecin, I Reiner, Z Poulsen, SH Viigimaa, M Nieminen, MS Danchin, N Chumburidze, V Tse, HF Xavier, D Zahger, D Valgimigli, M Kim, HS Erglis, A Laucevicius, A Lopez, R Lopez, GAR Alings, M Chua, T Murin, J Fras, Z Dalby, AJ Tunon, J De Silva, HA Chiang, CE Sritara, P Guneri, S Parkhomenko, A Ray, KK Moriarty, PM Roe, MT Chaitman, B Kelsey, SF Olsson, AG Rouleau, JL Simoons, ML Alexander, K Meloni, C Rosenson, R Sijbrands, EJG Alexander, JH Armaganijan, L Bagai, A Bahit, MC Brennan, JM Clifton, S DeVore, AD Deloatch, S Dickey, S Dombrowski, K Ducrocq, G Eapen, Z Endsley, P Eppinger, A Harrison, RW Hess, CN Hlatky, MA Jordan, JD Knowles, JW Kolls, BJ Kong, DF Leonardi, S Lillis, L Maron, DJ Marcus, J Mathews, R Mehta, RH Mentz, RJ Moreira, HG Patel, CB Pereira, SB Perkins, L Povsic, TJ Puymirat, E Jones, WS Shah, BR Sherwood, MW Stringfellow, K Sujjavanich, D Toma, M Van Diepen, SFP Wilson, MD Yan, ATK Lopes, RD Trotter, C Schiavi, LB Garrido, M Alvarisqueta, AF Sassone, SA Bordonava, AP De Lima, AEA Schmidberg, JM Duronto, EA Caruso, OC Novaretto, LP Hominal, MA Montana, OR Caccavo, A Vilamajo, OAG Lorenzatti, AJ Cartasegna, LR Paterlini, GA Mackinnon, IJ Caime, GD Amuchastegui, M Salomone, R Codutti, OR Jure, HO Bono, JOE Hrabar, AD Vallejos, JA Guerrero, RAA Novoa, F Patocchi, CA Zaidman, CJ Giuliano, ME Dran, RD Vico, ML Carnero, GS Guzman, PN Allende, JCM Brasca, DFG Labarta, MHB Nani, S Blumberg, EDS Colombo, HR Liberman, A Luciardi, HL Waisman, GD Berli, MA Duran, ROG Cestari, HG Luquez, HA Giordano, JA Saavedra, SS Zapata, G Costamagna, O Llois, S Waites, JH Collins, N Soward, A Aylward, PE Hii, CLS Shaw, J Arstall, MA Horowitz, J Rogers, JF Colquhoun, D Flores, REO Roberts-Thomson, P Raffel, O Lehman, SJ Aroney, C Coverdale, SGM Garrahy, PJ Starmer, G Sader, M Carroll, PA Dick, R Zweiker, R Hoppe, U Huber, K Berger, R Weidinger, F Faes, D Hermans, K Pirenne, B Leone, A Hoffer, E Vrolix, MCM De Wolf, L Wollaert, B Castadot, M Dujardin, K Beauloye, C Vervoort, G Striekwold, H Convens, C Roosen, J Barbato, E Claeys, M Cools, F Terzic, I Barakovic, F Midzic, Z Pojskic, B Fazlibegovic, E Durak-Nalbantic, A Vulic, D Muslibegovic, A Goronja, B Reis, G Sousa, L Nicolau, JC Giorgeto, FE Silva, RP Maia, LN Rech, R Rossi, PRF Cerqueira, MJAG Duda, N Kalil, R Kormann, A Abrantes, JAM Pimentel, P Soggia, AP de Santos, MON Neuenschwander, F Bodanese, LC Michalaros, YL Eliaschewitz, FG Vidotti, MH Leaes, PE Botelho, RV Kaiser, S Manenti, ERFF Precoma, DB Jorge, JCM Silva, PGMD Silveira, JA Saporito, W Marin, JA Feitosa, GS Ritt, LEF de Souza, JA Costa, F Souza, WKSB Reis, HJL Machado, L Ayoub, JCA Todorov, GV Nikolov, FP Velcheva, ES Tzekova, ML Benov, HO Petranov, SL Tumbev, HS Shehova-Yankova, NS Markov, DT Raev, DH Mollov, MN Kichukov, KN Ilieva-Pandeva, KA Ivanova, R Mincheva, VM Lazov, PV Dimov, BI Senaratne, M Stone, J Kornder, J Pearce, S Dion, D Savard, D Pesant, Y Pandey, A Robinson, S Gosselin, G Vizel, S Hoag, G Bourgeois, R Morisset, A Sabbah, E Sussex, B Kouz, S MacDonald, P Diaz, A Michaud, N Fell, D Leung, R Vuurmans, T Lai, C Nigro, F Davies, R Nogareda, G Vijayaraghavan, R Ducas, J Lepage, S Mehta, S Cha, J Dupuis, R Fong, P Rodes-Cabau, J Fadlallah, H Cleveland, D Huynh, T Bata, I Hameed, A Pincetti, C Potthoff, S Acevedo, M Aguirre, A Vejar, M Yanez, M Araneda, G Fernandez, M Perez, L Varleta, P Florenzano, F Huidobro, L Raffo, CA Olivares, C Nahuelpan, L Montecinos, H Chen, JY Dong, YG Huang, WJ Wang, JZ Huang, SA Yao, ZH Li, X Cui, L Lin, WH Sun, YM Wang, JF Li, JP Zhang, XL Zhu, H Chen, D Huang, L Dong, SH Su, GH Xu, BA Su, X Cheng, XS Lin, JX Zong, WX Li, HM Feng, Y Xu, DL Yang, XC Ke, YN Lin, XF Zhang, Z Zheng, ZQ Luo, ZR Chen, YD Ding, CH Zheng, Y Li, XD Peng, DQ Li, Y Wei, M Liu, SW Yu, YH Qu, BM Jiang, WH Zhou, YJ Zhao, XS Yuan, ZY Guo, Y Xu, XP Shi, XB Ge, JB Fu, GS Bai, F Fang, WY Shou, XL Yang, XJ Wang, JA Sun, YX Lu, QH Zhang, RY Zhu, JH Xu, YZ Fan, ZC Li, TC Wu, C Jaramillo, N Vallejo, GS Botia, DCL Lopez, RB De Salazar, DIM Bonfanti, AJC Higuera, JD Silva, SIB Lozada, HJG Arroyo, JAC Mendoza, JLA Ruiz, RLF Jatin, FGM Herazo, AS Parada, JC Triana, MAU Strozzi, M Car, S Milicic, D Bencic, ML Pintaric, H Prvulovic, D Sikic, J Persic, V Mileta, D Stambuk, K Zdravko, B Tomulic, V Krstulovic, SM Starcevic, B Spinar, J Horak, D Stasek, J Alan, D Machova, V Linhart, A Novotny, V Kaucak, V Rokyta, R Naplava, R Coufal, Z Adamkova, V Podpera, I Zizka, J Motovska, Z Marusincova, I Svab, P Ostadal, P Heinc, P Kuchar, J Povolny, P Matuska, J Raungaard, B Clemmensen, P Bang, LE May, O Bottcher, M Hove, JD Frost, L Gislason, G Larsen, J Johansen, PB Hald, F Jeppesen, J Nielsen, T Kristensen, KS Walichiewicz, PM Lomholdt, JD Klausen, IC Nielsen, PK Davidsen, F Videbaek, L Soots, M Vahula, V Hedman, A Soopold, U Martsin, K Kristjan, A Taskinen, MR Porthan, K Airaksinen, JK Juonala, M Kiviniemi, T Vikman, S Posio, P Taurio, J Huikuri, H Kaikkonen, K Coste, P Ferrari, E Morel, O Montalescot, G Barone-Rochette, G Mansourati, J Cottin, Y Leclercq, F Belhassane, A Delarche, N Boccara, F Paganelli, F Clerc, J Schiele, F Aboyans, V Probst, V Berland, J Lefevre, T Citron, B Khintibidze, I Shaburishvili, T Pagava, Z Ghlonti, R Lominadze, Z Khabeishvili, G Hemetsberger, R Rauch-Krohnert, U Stratmann, M Appel, KF Schmidt, E Omran, H Stellbrink, C Dorsel, T Lianopoulos, E Marx, R Zirlik, A Schellenberg, D Heitzer, T Laufs, U Marx, N Gielen, S Winkelmann, B Behrens, S Sydow, K Simonis, G Muenzel, T Werner, N Leggewie, S Bocker, D Braun-Dullaeus, R Toursarkissian, N Jeserich, M Weissbrodt, M Schaeufele, T Weil, J Voller, H Waltenberger, J Natour, M Schmitt, S Steiner, S Heidenreich, L Gremmler, U Killat, H Rieker, W Patsilinakos, S Kartalis, A Manolis, A Sionis, D Liberopoulos, E Skoumas, I Athyros, V Vardas, P Parthenakis, F Alexopoulos, D Hahalis, G Lekakis, J Hatzitolios, A Ovando, SRF Valdovinos, PCM Benecke, JLA De Leon, ERR Yan, BPY Siu, DCW Turi, T Merkely, B Kiss, RG Ungi, I Lupkovics, G Nagy, L Katona, A Edes, I Muller, G Horvath, I Kapin, T Falukozy, J Kumbla, M Sandhu, M Annam, S Proddutur, NR Premchand, RK Mahajan, A Abhyanakar, AD Kerkar, P Govinda, RA Oomman, A Sinha, D Patil, SN Kahali, D Sawhney, J Joshi, AB Chaudhary, S Harkut, P Guha, S Porwal, S Jujjuru, S Pothineni, RB Monteiro, MR Khan, A Iyengar, SS Grewal, JS Chopda, M Fulwani, MC Patange, A Chopra, VK Goyal, NK Shinde, R Manakshe, GV Patki, N Sethi, S Munusamy, V Karna, S Adhyapak, S Pandurangi, U Mathur, R Kalashetti, S Bhagwat, A Raghuraman, B Yerra, SK Bhansali, P Borse, R Das, S Abdullakutty, J Saathe, S Abdullkutty, J Sathe, S Palimkar, P Atar, S Shechter, M Mosseri, M Arbel, Y Lotan, C Rosenschein, U Katz, A Henkin, Y Francis, A Klutstein, M Nikolsky, E Turgeman, Y Halabi, M Kornowski, R Jonas, M Amir, O Rozenman, Y Fuchs, S Hussein, O Gavish, D Vered, Z Caraco, Y Elias, M Tov, N Lishner, M Elias, N Piovaccari, G De Pellegrin, A Guardigli, G Licciardello, G Auguadro, C Cuccia, C Salvioni, A Musumeci, G Calabro, P Novo, S Faggiano, P De Cesare, NB Berti, S Cavallini, C Puccioni, E Galvani, M Tespili, M Piatti, P Palvarini, M De Luca, G Violini, R De Leo, A Filardi, PP Ferratini, M Ricca, V Dai, K Kamiya, H Ando, K Takeda, Y Morino, Y Hata, Y Kimura, K Kishi, K Michishita, I Uehara, H Higashikata, T Hirayama, A Hirooka, K Sakagami, S Taguchi, S Koike, A Fujinaga, H Koba, S Kozuma, K Kawasaki, T Ono, Y Shimizu, M Katsuda, Y Wada, A Shinke, T Kimura, T Ako, J Fujii, K Takahashi, T Sakamoto, T Furukawa, Y Sugino, H Mano, T Utsu, N Ito, K Haraguchi, T Ueda, Y Nishibe, A Masutani, M Fujimoto, K Yoon, JH Kim, SH Park, HS Chae, IH Kim, MH Jeong, MH Rha, S Kim, C Hong, T Tahk, SJ Kim, Y Busmane, A Pontaga, N Strelnieks, A Mintale, I Sime, I Petrulioniene, Z Kavaliauskiene, R Jurgaitiene, R Sakalyte, G Slapikas, R Norkiene, S Misonis, N Kibarskis, A Kubilius, R Bojovski, S Kedev, S Lozance, N Kjovkaroski, A Doncovska, S Ong, TK Kasim, S Maskon, O Kandasamy, B Yusoff, K Liew, HB Mohamed, WMIW Castillo, AG Calvillo, JC Campos, PF Fragoso, JCN Llamas, EAB Gamba, MAA Madrigal, JC Salas, LGG Rosas, EL Diaz, BG Vazquez, ES Ackar, AN Esperon, GAL Sanchez, CRM De Leon, MG Otero, RS Salmon, GF Rios, JA Ruiz, JAG Breedveld, RW Hoogslag, PAM Suryapranata, H Oomen, A Wiersma, JJ Van Der Wal, RMA Van Huysduynen-Monraats, PSH Karalis, I Verdel, GJE Brueren, BR Troquay, RPT Viergever, EP Al-Windy, NYY Bartels, GL Cornel, JH Hermans, WRM Herrman, JPR Bos, RJ Groutars, RGEJ Van Der Zwaan, CC Kaplan, R Ronner, E Groenemeijer, BE Bronzwaer, PNA Liem, AAH Rensing, BJWM Bokern, MJJA Nijmeijer, R Hersbach, FMRJ Willems, FF Gosselink, ATM Elliott, J Wilkins, G Fisher, R Scott, D Hart, H Stewart, R Harding, S Ternouth, I Fisher, N Aitken, D Anscombe, R Davidson, L Tomala, T Nygard, O Sparby, JA Andersen, K Gullestad, L Jortveit, J Munk, PS Singsaas, EG Halvorsen, S Hurtig, U Flores, RMC Ticona, JRC Velasquez, JRD Miguel, SAN Perez, ESS Chambilla, JMC Ayala, CAC Leon, RPC Gonzales, RJV Zuniga, JDH Cosavalente, LAC Mannucci, JEB Landeo, JH Navarro, NCL Concha, YMR Chavez, VER Hernandez, HAA Nunez, CAZ Ramos, WM Ferrolino, A Sy, RAG Tirador, L Sy, RG Matiga, G Coching, RM Bernan, A Rogelio, G Morales, DD Tan, E Sulit, DJ Wlodarczak, A Jaworska, K Skonieczny, G Pawlowicz, L Wojewod, P Busz-Papiez, B Bednarski, J Goch, A Staneta, P Dulak, E Budaj, A Saminsk, K Krasowski, W Sudnik, W Zurakowski, A Skorski, M Lysek, R Miklaszewicz, B Kubica, J Lipko, JA Kostarska-Srokosz, E Piepiorka, M Drzewiecka, A Sciborski, R Stasiewski, A Blicharski, T Bystryk, L Szpajer, M Korol, M Czerski, T Mirek-Bryniarska, E Gniot, J Lubinski, A Gorny, J Franek, E Raczak, G Szwed, H Monteiro, P Bastos, JM Pereira, HH Martins, D Morais, J Seixo, F Mendonca, C Botelho, A Minescu, B Istratoaie, O Tesloianu, DN Dorobantu, M Cristian, G Podoleanu, CGC Constantinescu, MCA Bengus, CM Militaru, C Rosu, D Parepa, IR Matei, AV Alexandru, TM Coman, I Cioranu, RS Dimulescu, D Shvarts, Y Orlikova, O Kobalava, Z Barbarash, OL Markov, V Lyamina, N Gordienko, A Zrazhevsky, K Vishnevsky, AY Gurevich, V Stryuk, R Lomakin, NV Bokarev, I Shalaev, S Khaisheva, L Chizhov, P Viktorova, I Osokina, N Akatova, E Chumakova, G Libov, I Voevoda, MI Tretyakova, TV Baranov, E Shustov, S Yakushin, S Gordeev, I Khasanov, N Reshetko, O Sotnikova, T Molchanova, O Nikolaev, K Gapon, L Baranova, E Shogenov, Z Kosmachova, E Karpov, Y Povzun, A Egorova, L Tyrenko, VV Ivanov, IG Kanorsky, S Simic, D Ivanovic, N Davidovic, G Tasic, N Asanin, MR Stojic, S Apostolovic, SR Ilic, S Putnikovic, B Stankovic, A Arandjelovic, A Radovanovic, S Ristic, AD Balinovac, J Dincic, DV Seferovic, P 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Fernando, N Jayawardena, J Santharaj, W Ekanayaka, R Mendis, S Senaratne, V Mayurathan, G Sirisena, T Rajapaksha, A Herath, JI Amarasena, N Berglund, S Rasmanis, G Witt, N Mourtzinis, G Nicol, P Hansen, O Romeo, S Jensen, SA Torstensson, I Ahremark, U Sundelin, T Moccetti, T Muller, C Mach, F Binder, R Tsai, WC Ueng, KC Lai, WT Liu, ME Hwang, JJ Yin, WH Hsieh, IC Kuo, JY Huang, TY Fang, CY Kaewsuwanna, P Soonfuang, W Jintapakorn, W Sukonthasarn, A Wongpraparut, N Sastravaha, K Sansanayudh, N Kehasukcharoen, W Piyayotai, D Chotnoparatpat, P Camsari, A Kultursay, H Mutlu, B Ersanli, M Demirtas, M Kirma, C Ural, E Koldas, L Karpenko, O Prokhorov, A Vakaluyk, I Myshanych, H Reshotko, D Batushkin, V Rudenko, L Kovalskyi, I Kushnir, M Tseluyko, V Mostovoy, Y Stanislavchuk, M Kyiak, Y Karpenko, Y Malynovsky, Y Klantsa, A Kutniy, O Amosova, E Tashchuk, V Leshchuk, O Rishko, M Kopytsya, M Yagensky, A Vatutin, M Bagriy, A Barna, OM Ushakov, O Dzyak, G Goloborodko, B Rudenko, A Zheleznyy, V Trevelyan, J Zaman, A Lee, K Moriarty, A Aggarwal, RK Clifford, P Wong, YK Iqbal, SM Subkovas, E Braganza, D Sarkar, D Storey, R Griffiths, H Mcclure, S Muthusamy, R Kurian, J Levy, T Barr, C Kadr, H Gerber, R Simaitis, A Soran, H Mathur, A Brodison, A Oliver, R Mudawi, T Reynolds, T Sharman, D Butler, R Wilkinson, P Lip, GYH Halcox, J Vardi, G Baldari, D Brabham, D Treasure, C Dahl, C Palmer, B Wiseman, A Puri, S Mohart, AE Ince, C Flores, E Wright, S Cheng, SC Rosenberg, M Rogers, W Kosinski, E Forgosh, L Waltman, J Khan, M Shoukfeh, M Dagher, G Lieber, I Kumar, P East, C Krichmar, P White, L Knickelbine, T Haldis, T Gillespie, E Suh, D Arif, I Akhter, F Carlson, E D'Urso, M El-Ahdab, F Nelson, W Harris, B Cohen, S Carter, L Sabatino, K Haddad, T Malik, A Rao, S Mulkay, A Jovin, I Klancke, K Malhotra, V Devarapalli, SK Koren, M Chandna, H Dodds, G Janik, M Moran, J Sumner, A Kobayashi, J Davis, W Yazdani, S Pasquini, J Thakkar, M Vedere, A Leimbach, W Rider, J Singh, N Shah, AV Janosik, D Pepine, C Berman, B Gelormini, J Daniels, C Keating, F Kondo, NI Shetty, S Waider, W Takata, T Abu-Fadel, M Shah, V Aggarwal, R Izzo, M Kumar, A Hattler, B Link, C Bortnick, A Kinzfogl, G Ghitis, A Larry, J Teufel, E Kuhlman, P Mclaurin, B Zhang, WW Thew, S Abbas, J White, M Ranadive, N Gring, C Henderson, D Schuchard, T Farhat, N Kline, G Mahal, S Whitaker, J Speirs, S Andersen, R Daboul, N Horwitz, P Ponce, G Jafar, Z Mcgarvey, J Panchal, V Voyce, S Blok, T Sheldon, W Azizad, MM Schmalfuss, C Picone, M Herzog, W Lindsey, J Nowins, R Lepor, N El Shahawy, M Weintraub, H Irimpen, A May, W Galski, T Chu, A Mody, F Hodes, Z Rose, G Fairlamb, J Lambert, C Raisinghani, A Abbate, A King, M Carey, C Gerber, J Younis, L Park, H Vidovich, M Knutson, T Friedman, D Chaleff, F Loussararian, A Rozeman, P Kimmelstiel, C Silver, K Foster, M Tonnessen, G Amlani, M Wali, A Malozzi, C Wattanakit, K O'Donnell, PJ Singal, D Jaffrani, N Banuru, S Fisher, D Xenakis, M Perlmutter, N Bhagwat, R Strader, J Akyea-Djamson, A Labroo, A Marais, HJ Claxton, E Berk, M Rossi, P Joshi, P Khaira, AS Kumkumian, G Lupovitch, S Purow, J Welka, S Hoffman, D Fischer, S Soroka, E Eagerton, D Pancholy, S Ray, M Farrar, M Pollock, S French, WJ Diamantis, S Gimple, L Neustel, M Schwartz, S Pereira, E Spriggs, D Strain, J Vo, A Chane, M Hall, J Vijay, N Lotun, K Lester, FM Nahhas, A Pope, T Nager, P Vohra, R Bashir, R Ahmed, H Berlowitz, M Fishberg, R Barrucco, R Yang, E Radin, M Sporn, D Eisenberg, S Landzberg, J Mcgough, M Turk, S Schwartz, M Sundram, PS Jain, D Zainea, M Bayron, C Karlsberg, R Lui, H Keen, W Westerhausen, D Khurana, S Agarwal, H Birchem, J Penny, W Chang, M Murphy, S Schifferdecker, B Gilbert, JM Chalavarya, G Eaton, C Schmedtje, JF Christenson, S Denham, D Macdonell, A Gibson, P Rahman, A Al Joundi, T Conrad, G Kotha, P Love, M Giesler, G Rubenstein, H Akright, L Krawczyk, J Wells, T Welker, J Foster, R Gilmore, R Anderson, J Jacoby, D Gardner, G Dandillaya, R Vora, K Kostis, J Hunter, J Laxson, D Ball, E Camp, A Lopes, R Egydio, F Kawakami, A Oliveira, J Wozniak, J Matthews, A Ratky, C Valiris, J Berdan, L Hepditch, A Quintero, K Rorick, T Westbrook, M Pascual, A Rovito, C Bezault, M Drouet, E Simon, T Alsweiler, C Luyten, A Aylward, P Butters, J Griffith, L Shaw, M Hagstrom, E Grunberg, L Islam, S Bregeault, MF Bougon, N Faustino, D Fontecave, S Murphy, J Tamby, JF Verrier, M Agnetti, V Andersen, D Badreddine, E Bekkouche, M Bouancheau, C Brigui, I Brocklehurst, M Cianciarulo, J Devaul, D Domokos, S Gache, C Gobillot, C Guillou, S Healy, J Heath, M Jaiwal, G Javierre, C Labeirie, J Monier, M Morales, U Mrabti, A Mthombeni, B Okan, B Smith, L Sheller, J Sopena, S Pellan, V Benbernou, F Bengrait, N Lamoureux, M Kralova, K Scemama, M Bejuit, R Coulange, A Berthou, C Repincay, J Lorenzato, C Etienne, A Gouet, V Loizeau, V Normand, M Ourliac, A Rondel, C Adamo, A Beltran, P Barraud, P Dubois-Gache, H Halle, B Metwally, L Mourgues, M Sotty, M Vincendet, M Cotruta, R Zhu, CY Fournie-Lloret, D Morrello, C Perthuis, A Picault, P Zobouyan, I |
| author_role | author |
| collection | r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí |
| description | Background: Previous trials of PCSK9 (proprotein convertase subtilisin-kexin type 9) inhibitors demonstrated reductions in major adverse cardiovascular events, but not death. We assessed the effects of alirocumab on death after index acute coronary syndrome. Methods: ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) was a double-blind, randomized comparison of alirocumab or placebo in 18 924 patients who had an ACS 1 to 12 months previously and elevated atherogenic lipoproteins despite intensive statin therapy. Alirocumab dose was blindly titrated to target achieved low-density lipoprotein cholesterol (LDL-C) between 25 and 50 mg/dL. We examined the effects of treatment on all-cause death and its components, cardiovascular and noncardiovascular death, with log-rank testing. Joint semiparametric models tested associations between nonfatal cardiovascular events and cardiovascular or noncardiovascular death. Results: Median follow-up was 2.8 years. Death occurred in 334 (3.5%) and 392 (4.1%) patients, respectively, in the alirocumab and placebo groups (hazard ratio [HR], 0.85; 95% CI, 0.73 to 0.98; P=0.03, nominal P value). This resulted from nonsignificantly fewer cardiovascular (240 [2.5%] vs 271 [2.9%]; HR, 0.88; 95% CI, 0.74 to 1.05; P=0.15) and noncardiovascular (94 [1.0%] vs 121 [1.3%]; HR, 0.77; 95% CI, 0.59 to 1.01; P=0.06) deaths with alirocumab. In a prespecified analysis of 8242 patients eligible for >= 3 years follow-up, alirocumab reduced death (HR, 0.78; 95% CI, 0.65 to 0.94; P=0.01). Patients with nonfatal cardiovascular events were at increased risk for cardiovascular and noncardiovascular deaths (P<0.0001 for the associations). Alirocumab reduced total nonfatal cardiovascular events (P<0.001) and thereby may have attenuated the number of cardiovascular and noncardiovascular deaths. A post hoc analysis found that, compared to patients with lower LDL-C, patients with baseline LDL-C >= 100 mg/dL (2.59 mmol/L) had a greater absolute risk of death and a larger mortality benefit from alirocumab (HR, 0.71; 95% CI, 0.56 to 0.90; P-interaction=0.007). In the alirocumab group, all-cause death declined with achieved LDL-C at 4 months of treatment, to a level of approximately 30 mg/dL (adjusted P=0.017 for linear trend). Conclusions: Alirocumab added to intensive statin therapy has the potential to reduce death after acute coronary syndrome, particularly if treatment is maintained for >= 3 years, if baseline LDL-C is >= 100 mg/dL, or if achieved LDL-C is low. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_71e902f3dcb053110709e042f6d6d883 |
| institution | Institut d'Investigació i Innovació Parc Taulí (I3PT) |
| instname_str | Institut d'Investigació i Innovació Parc Taulí (I3PT) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:i3pt.fundanetsuite.com:p2950 |
| publishDate | 2019 |
| publishDateSort | 2019 |
| publisher | LIPPINCOTT WILLIAMS & WILKINS |
| publisherStr | LIPPINCOTT WILLIAMS & WILKINS |
| reponame_str | r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí |
| spelling | Effect of Alirocumab on Mortality After Acute Coronary Syndromes An Analysis of the ODYSSEY OUTCOMES Randomized Clinical Trial Steg, PG Szarek, M Bhatt, DL Bittner, VA Diaz, R Edelberg, JM Hanotin, C Harrington, RA Jukema, JW Lecorps, G Mahaffey, KW Moryusef, A Pordy, R Tricoci, P Vogel, R White, HD Zeiher, AM Schwartz, GG Sasiela, WJ Drexel, H Sinnaeve, P Dilic, M Gotcheva, NN Goodman, SG Prieto, JC Yong, H Lopez-Jaramillo, P Pecin, I Reiner, Z Poulsen, SH Viigimaa, M Nieminen, MS Danchin, N Chumburidze, V Tse, HF Xavier, D Zahger, D Valgimigli, M Kim, HS Erglis, A Laucevicius, A Lopez, R Lopez, GAR Alings, M Chua, T Murin, J Fras, Z Dalby, AJ Tunon, J De Silva, HA Chiang, CE Sritara, P Guneri, S Parkhomenko, A Ray, KK Moriarty, PM Roe, MT Chaitman, B Kelsey, SF Olsson, AG Rouleau, JL Simoons, ML Alexander, K Meloni, C Rosenson, R Sijbrands, EJG Alexander, JH Armaganijan, L Bagai, A Bahit, MC Brennan, JM Clifton, S DeVore, AD Deloatch, S Dickey, S Dombrowski, K Ducrocq, G Eapen, Z Endsley, P Eppinger, A Harrison, RW Hess, CN Hlatky, MA Jordan, JD Knowles, JW Kolls, BJ Kong, DF Leonardi, S Lillis, L Maron, DJ Marcus, J Mathews, R Mehta, RH Mentz, RJ Moreira, HG Patel, CB Pereira, SB Perkins, L Povsic, TJ Puymirat, E Jones, WS Shah, BR Sherwood, MW Stringfellow, K Sujjavanich, D Toma, M Van Diepen, SFP Wilson, MD Yan, ATK Lopes, RD Trotter, C Schiavi, LB Garrido, M Alvarisqueta, AF Sassone, SA Bordonava, AP De Lima, AEA Schmidberg, JM Duronto, EA Caruso, OC Novaretto, LP Hominal, MA Montana, OR Caccavo, A Vilamajo, OAG Lorenzatti, AJ Cartasegna, LR Paterlini, GA Mackinnon, IJ Caime, GD Amuchastegui, M Salomone, R Codutti, OR Jure, HO Bono, JOE Hrabar, AD Vallejos, JA Guerrero, RAA Novoa, F Patocchi, CA Zaidman, CJ Giuliano, ME Dran, RD Vico, ML Carnero, GS Guzman, PN Allende, JCM Brasca, DFG Labarta, MHB Nani, S Blumberg, EDS Colombo, HR Liberman, A Luciardi, HL Waisman, GD Berli, MA Duran, ROG Cestari, HG Luquez, HA Giordano, JA Saavedra, SS Zapata, G 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GS Ritt, LEF de Souza, JA Costa, F Souza, WKSB Reis, HJL Machado, L Ayoub, JCA Todorov, GV Nikolov, FP Velcheva, ES Tzekova, ML Benov, HO Petranov, SL Tumbev, HS Shehova-Yankova, NS Markov, DT Raev, DH Mollov, MN Kichukov, KN Ilieva-Pandeva, KA Ivanova, R Mincheva, VM Lazov, PV Dimov, BI Senaratne, M Stone, J Kornder, J Pearce, S Dion, D Savard, D Pesant, Y Pandey, A Robinson, S Gosselin, G Vizel, S Hoag, G Bourgeois, R Morisset, A Sabbah, E Sussex, B Kouz, S MacDonald, P Diaz, A Michaud, N Fell, D Leung, R Vuurmans, T Lai, C Nigro, F Davies, R Nogareda, G Vijayaraghavan, R Ducas, J Lepage, S Mehta, S Cha, J Dupuis, R Fong, P Rodes-Cabau, J Fadlallah, H Cleveland, D Huynh, T Bata, I Hameed, A Pincetti, C Potthoff, S Acevedo, M Aguirre, A Vejar, M Yanez, M Araneda, G Fernandez, M Perez, L Varleta, P Florenzano, F Huidobro, L Raffo, CA Olivares, C Nahuelpan, L Montecinos, H Chen, JY Dong, YG Huang, WJ Wang, JZ Huang, SA Yao, ZH Li, X Cui, L Lin, WH Sun, YM Wang, JF Li, JP Zhang, XL Zhu, H Chen, D Huang, L Dong, SH Su, GH Xu, BA Su, X Cheng, XS Lin, JX Zong, WX Li, HM Feng, Y Xu, DL Yang, XC Ke, YN Lin, XF Zhang, Z Zheng, ZQ Luo, ZR Chen, YD Ding, CH Zheng, Y Li, XD Peng, DQ Li, Y Wei, M Liu, SW Yu, YH Qu, BM Jiang, WH Zhou, YJ Zhao, XS Yuan, ZY Guo, Y Xu, XP Shi, XB Ge, JB Fu, GS Bai, F Fang, WY Shou, XL Yang, XJ Wang, JA Sun, YX Lu, QH Zhang, RY Zhu, JH Xu, YZ Fan, ZC Li, TC Wu, C Jaramillo, N Vallejo, GS Botia, DCL Lopez, RB De Salazar, DIM Bonfanti, AJC Higuera, JD Silva, SIB Lozada, HJG Arroyo, JAC Mendoza, JLA Ruiz, RLF Jatin, FGM Herazo, AS Parada, JC Triana, MAU Strozzi, M Car, S Milicic, D Bencic, ML Pintaric, H Prvulovic, D Sikic, J Persic, V Mileta, D Stambuk, K Zdravko, B Tomulic, V Krstulovic, SM Starcevic, B Spinar, J Horak, D Stasek, J Alan, D Machova, V Linhart, A Novotny, V Kaucak, V Rokyta, R Naplava, R Coufal, Z Adamkova, V Podpera, I Zizka, J Motovska, Z Marusincova, I Svab, P Ostadal, P Heinc, P Kuchar, J Povolny, P Matuska, J Raungaard, B 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PNA Liem, AAH Rensing, BJWM Bokern, MJJA Nijmeijer, R Hersbach, FMRJ Willems, FF Gosselink, ATM Elliott, J Wilkins, G Fisher, R Scott, D Hart, H Stewart, R Harding, S Ternouth, I Fisher, N Aitken, D Anscombe, R Davidson, L Tomala, T Nygard, O Sparby, JA Andersen, K Gullestad, L Jortveit, J Munk, PS Singsaas, EG Halvorsen, S Hurtig, U Flores, RMC Ticona, JRC Velasquez, JRD Miguel, SAN Perez, ESS Chambilla, JMC Ayala, CAC Leon, RPC Gonzales, RJV Zuniga, JDH Cosavalente, LAC Mannucci, JEB Landeo, JH Navarro, NCL Concha, YMR Chavez, VER Hernandez, HAA Nunez, CAZ Ramos, WM Ferrolino, A Sy, RAG Tirador, L Sy, RG Matiga, G Coching, RM Bernan, A Rogelio, G Morales, DD Tan, E Sulit, DJ Wlodarczak, A Jaworska, K Skonieczny, G Pawlowicz, L Wojewod, P Busz-Papiez, B Bednarski, J Goch, A Staneta, P Dulak, E Budaj, A Saminsk, K Krasowski, W Sudnik, W Zurakowski, A Skorski, M Lysek, R Miklaszewicz, B Kubica, J Lipko, JA Kostarska-Srokosz, E Piepiorka, M Drzewiecka, A Sciborski, R Stasiewski, A Blicharski, T Bystryk, L Szpajer, M Korol, M Czerski, T Mirek-Bryniarska, E Gniot, J Lubinski, A Gorny, J Franek, E Raczak, G Szwed, H Monteiro, P Bastos, JM Pereira, HH Martins, D Morais, J Seixo, F Mendonca, C Botelho, A Minescu, B Istratoaie, O Tesloianu, DN Dorobantu, M Cristian, G Podoleanu, CGC Constantinescu, MCA Bengus, CM Militaru, C Rosu, D Parepa, IR Matei, AV Alexandru, TM Coman, I Cioranu, RS Dimulescu, D Shvarts, Y Orlikova, O Kobalava, Z Barbarash, OL Markov, V Lyamina, N Gordienko, A Zrazhevsky, K Vishnevsky, AY Gurevich, V Stryuk, R Lomakin, NV Bokarev, I Shalaev, S Khaisheva, L Chizhov, P Viktorova, I Osokina, N Akatova, E Chumakova, G Libov, I Voevoda, MI Tretyakova, TV Baranov, E Shustov, S Yakushin, S Gordeev, I Khasanov, N Reshetko, O Sotnikova, T Molchanova, O Nikolaev, K Gapon, L Baranova, E Shogenov, Z Kosmachova, E Karpov, Y Povzun, A Egorova, L Tyrenko, VV Ivanov, IG Kanorsky, S Simic, D Ivanovic, N Davidovic, G Tasic, N Asanin, MR Stojic, S Apostolovic, SR Ilic, S Putnikovic, B Stankovic, A Arandjelovic, A Radovanovic, S Ristic, AD Balinovac, J Dincic, DV Seferovic, P Dodic, S Dimkovic, S Poh, KK Ong, HY Micko, K Nociar, J Pella, D Fulop, P Hranai, M Palka, J Mazur, J Majercak, I Dzupina, A Fazekas, F Gonsorcik, J Bugan, V Selecky, J Kamensky, G Strbova, J Smik, R Dukat, A Olexa, P Zuran, I Poklukar, J Suligoj, NC Cevc, M Cyster, HP Ranjith, N Corbett, C Bayat, J Makotoko, EM Kapp, IE Basson, MMD Lottering, H Van Zyl, LJ Sebastian, PJ Pillay, T Saaiman, JA Commerford, PJ Cassimjee, S Ebrahim, IO Sarvan, M Mynhardt, JH Reuter, H Moodley, R Vida, M Fillat, ARC Peris, VB Jimenez, FF Marin, F Fernandez, JMC Gil-Extremera, B Diz, FW Garcia-Dorado, D Iniguez, A Fernandez, JT Gonzalez-Juanatey, JR Portales, JF Murillo, FC Pericas, LM Zamorano, JL Martin, MD Cortada, JB Martin, JJA Fernandez, JRD Fernandez, JFD Lledo, JAG Sales, JC Rodriguez, JB Tragant, GG Benedicto, A Gonzalez-Juanatey, C Potau, MC Perez, IP De La Tassa, CM Rincon, PLO Recena, JB Escudier, JM Payeras, AC Orcajo, NA Valdivielso, P Constantine, G Haniffa, R Tissera, N Amarasekera, S Fernando, N Jayawardena, J Santharaj, W Ekanayaka, R Mendis, S Senaratne, V Mayurathan, G Sirisena, T Rajapaksha, A Herath, JI Amarasena, N Berglund, S Rasmanis, G Witt, N Mourtzinis, G Nicol, P Hansen, O Romeo, S Jensen, SA Torstensson, I Ahremark, U Sundelin, T Moccetti, T Muller, C Mach, F Binder, R Tsai, WC Ueng, KC Lai, WT Liu, ME Hwang, JJ Yin, WH Hsieh, IC Kuo, JY Huang, TY Fang, CY Kaewsuwanna, P Soonfuang, W Jintapakorn, W Sukonthasarn, A Wongpraparut, N Sastravaha, K Sansanayudh, N Kehasukcharoen, W Piyayotai, D Chotnoparatpat, P Camsari, A Kultursay, H Mutlu, B Ersanli, M Demirtas, M Kirma, C Ural, E Koldas, L Karpenko, O Prokhorov, A Vakaluyk, I Myshanych, H Reshotko, D Batushkin, V Rudenko, L Kovalskyi, I Kushnir, M Tseluyko, V Mostovoy, Y Stanislavchuk, M Kyiak, Y Karpenko, Y Malynovsky, Y Klantsa, A Kutniy, O Amosova, E Tashchuk, V Leshchuk, O Rishko, M Kopytsya, M Yagensky, A Vatutin, M Bagriy, A Barna, OM Ushakov, O Dzyak, G Goloborodko, B Rudenko, A Zheleznyy, V Trevelyan, J Zaman, A Lee, K Moriarty, A Aggarwal, RK Clifford, P Wong, YK Iqbal, SM Subkovas, E Braganza, D Sarkar, D Storey, R Griffiths, H Mcclure, S Muthusamy, R Kurian, J Levy, T Barr, C Kadr, H Gerber, R Simaitis, A Soran, H Mathur, A Brodison, A Oliver, R Mudawi, T Reynolds, T Sharman, D Butler, R Wilkinson, P Lip, GYH Halcox, J Vardi, G Baldari, D Brabham, D Treasure, C Dahl, C Palmer, B Wiseman, A Puri, S Mohart, AE Ince, C Flores, E Wright, S Cheng, SC Rosenberg, M Rogers, W Kosinski, E Forgosh, L Waltman, J Khan, M Shoukfeh, M Dagher, G Lieber, I Kumar, P East, C Krichmar, P White, L Knickelbine, T Haldis, T Gillespie, E Suh, D Arif, I Akhter, F Carlson, E D'Urso, M El-Ahdab, F Nelson, W Harris, B Cohen, S Carter, L Sabatino, K Haddad, T Malik, A Rao, S Mulkay, A Jovin, I Klancke, K Malhotra, V Devarapalli, SK Koren, M Chandna, H Dodds, G Janik, M Moran, J Sumner, A Kobayashi, J Davis, W Yazdani, S Pasquini, J Thakkar, M Vedere, A Leimbach, W Rider, J Singh, N Shah, AV Janosik, D Pepine, C Berman, B Gelormini, J Daniels, C Keating, F Kondo, NI Shetty, S Waider, W Takata, T Abu-Fadel, M Shah, V Aggarwal, R Izzo, M Kumar, A Hattler, B Link, C Bortnick, A Kinzfogl, G Ghitis, A Larry, J Teufel, E Kuhlman, P Mclaurin, B Zhang, WW Thew, S Abbas, J White, M Ranadive, N Gring, C Henderson, D Schuchard, T Farhat, N Kline, G Mahal, S Whitaker, J Speirs, S Andersen, R Daboul, N Horwitz, P Ponce, G Jafar, Z Mcgarvey, J Panchal, V Voyce, S Blok, T Sheldon, W Azizad, MM Schmalfuss, C Picone, M Herzog, W Lindsey, J Nowins, R Lepor, N El Shahawy, M Weintraub, H Irimpen, A May, W Galski, T Chu, A Mody, F Hodes, Z Rose, G Fairlamb, J Lambert, C Raisinghani, A Abbate, A King, M Carey, C Gerber, J Younis, L Park, H Vidovich, M Knutson, T Friedman, D Chaleff, F Loussararian, A Rozeman, P Kimmelstiel, C Silver, K Foster, M Tonnessen, G Amlani, M Wali, A Malozzi, C Wattanakit, K O'Donnell, PJ Singal, D Jaffrani, N Banuru, S Fisher, D Xenakis, M Perlmutter, N Bhagwat, R Strader, J Akyea-Djamson, A Labroo, A Marais, HJ Claxton, E Berk, M Rossi, P Joshi, P Khaira, AS Kumkumian, G Lupovitch, S Purow, J Welka, S Hoffman, D Fischer, S Soroka, E Eagerton, D Pancholy, S Ray, M Farrar, M Pollock, S French, WJ Diamantis, S Gimple, L Neustel, M Schwartz, S Pereira, E Spriggs, D Strain, J Vo, A Chane, M Hall, J Vijay, N Lotun, K Lester, FM Nahhas, A Pope, T Nager, P Vohra, R Bashir, R Ahmed, H Berlowitz, M Fishberg, R Barrucco, R Yang, E Radin, M Sporn, D Eisenberg, S Landzberg, J Mcgough, M Turk, S Schwartz, M Sundram, PS Jain, D Zainea, M Bayron, C Karlsberg, R Lui, H Keen, W Westerhausen, D Khurana, S Agarwal, H Birchem, J Penny, W Chang, M Murphy, S Schifferdecker, B Gilbert, JM Chalavarya, G Eaton, C Schmedtje, JF Christenson, S Denham, D Macdonell, A Gibson, P Rahman, A Al Joundi, T Conrad, G Kotha, P Love, M Giesler, G Rubenstein, H Akright, L Krawczyk, J Wells, T Welker, J Foster, R Gilmore, R Anderson, J Jacoby, D Gardner, G Dandillaya, R Vora, K Kostis, J Hunter, J Laxson, D Ball, E Camp, A Lopes, R Egydio, F Kawakami, A Oliveira, J Wozniak, J Matthews, A Ratky, C Valiris, J Berdan, L Hepditch, A Quintero, K Rorick, T Westbrook, M Pascual, A Rovito, C Bezault, M Drouet, E Simon, T Alsweiler, C Luyten, A Aylward, P Butters, J Griffith, L Shaw, M Hagstrom, E Grunberg, L Islam, S Bregeault, MF Bougon, N Faustino, D Fontecave, S Murphy, J Tamby, JF Verrier, M Agnetti, V Andersen, D Badreddine, E Bekkouche, M Bouancheau, C Brigui, I Brocklehurst, M Cianciarulo, J Devaul, D Domokos, S Gache, C Gobillot, C Guillou, S Healy, J Heath, M Jaiwal, G Javierre, C Labeirie, J Monier, M Morales, U Mrabti, A Mthombeni, B Okan, B Smith, L Sheller, J Sopena, S Pellan, V Benbernou, F Bengrait, N Lamoureux, M Kralova, K Scemama, M Bejuit, R Coulange, A Berthou, C Repincay, J Lorenzato, C Etienne, A Gouet, V Loizeau, V Normand, M Ourliac, A Rondel, C Adamo, A Beltran, P Barraud, P Dubois-Gache, H Halle, B Metwally, L Mourgues, M Sotty, M Vincendet, M Cotruta, R Zhu, CY Fournie-Lloret, D Morrello, C Perthuis, A Picault, P Zobouyan, I acute coronary syndrome alirocumab cholesterol mortality PCSK9 protein Background: Previous trials of PCSK9 (proprotein convertase subtilisin-kexin type 9) inhibitors demonstrated reductions in major adverse cardiovascular events, but not death. We assessed the effects of alirocumab on death after index acute coronary syndrome. Methods: ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) was a double-blind, randomized comparison of alirocumab or placebo in 18 924 patients who had an ACS 1 to 12 months previously and elevated atherogenic lipoproteins despite intensive statin therapy. Alirocumab dose was blindly titrated to target achieved low-density lipoprotein cholesterol (LDL-C) between 25 and 50 mg/dL. We examined the effects of treatment on all-cause death and its components, cardiovascular and noncardiovascular death, with log-rank testing. Joint semiparametric models tested associations between nonfatal cardiovascular events and cardiovascular or noncardiovascular death. Results: Median follow-up was 2.8 years. Death occurred in 334 (3.5%) and 392 (4.1%) patients, respectively, in the alirocumab and placebo groups (hazard ratio [HR], 0.85; 95% CI, 0.73 to 0.98; P=0.03, nominal P value). This resulted from nonsignificantly fewer cardiovascular (240 [2.5%] vs 271 [2.9%]; HR, 0.88; 95% CI, 0.74 to 1.05; P=0.15) and noncardiovascular (94 [1.0%] vs 121 [1.3%]; HR, 0.77; 95% CI, 0.59 to 1.01; P=0.06) deaths with alirocumab. In a prespecified analysis of 8242 patients eligible for >= 3 years follow-up, alirocumab reduced death (HR, 0.78; 95% CI, 0.65 to 0.94; P=0.01). Patients with nonfatal cardiovascular events were at increased risk for cardiovascular and noncardiovascular deaths (P<0.0001 for the associations). Alirocumab reduced total nonfatal cardiovascular events (P<0.001) and thereby may have attenuated the number of cardiovascular and noncardiovascular deaths. A post hoc analysis found that, compared to patients with lower LDL-C, patients with baseline LDL-C >= 100 mg/dL (2.59 mmol/L) had a greater absolute risk of death and a larger mortality benefit from alirocumab (HR, 0.71; 95% CI, 0.56 to 0.90; P-interaction=0.007). In the alirocumab group, all-cause death declined with achieved LDL-C at 4 months of treatment, to a level of approximately 30 mg/dL (adjusted P=0.017 for linear trend). Conclusions: Alirocumab added to intensive statin therapy has the potential to reduce death after acute coronary syndrome, particularly if treatment is maintained for >= 3 years, if baseline LDL-C is >= 100 mg/dL, or if achieved LDL-C is low. LIPPINCOTT WILLIAMS & WILKINS https://i3pt.portalinvestigacion.com/publicaciones/2950 |
| spellingShingle | Effect of Alirocumab on Mortality After Acute Coronary Syndromes An Analysis of the ODYSSEY OUTCOMES Randomized Clinical Trial Steg, PG acute coronary syndrome alirocumab cholesterol mortality PCSK9 protein |
| status_str | publishedVersion |
| title | Effect of Alirocumab on Mortality After Acute Coronary Syndromes An Analysis of the ODYSSEY OUTCOMES Randomized Clinical Trial |
| title_full | Effect of Alirocumab on Mortality After Acute Coronary Syndromes An Analysis of the ODYSSEY OUTCOMES Randomized Clinical Trial |
| title_fullStr | Effect of Alirocumab on Mortality After Acute Coronary Syndromes An Analysis of the ODYSSEY OUTCOMES Randomized Clinical Trial |
| title_full_unstemmed | Effect of Alirocumab on Mortality After Acute Coronary Syndromes An Analysis of the ODYSSEY OUTCOMES Randomized Clinical Trial |
| title_short | Effect of Alirocumab on Mortality After Acute Coronary Syndromes An Analysis of the ODYSSEY OUTCOMES Randomized Clinical Trial |
| title_sort | Effect of Alirocumab on Mortality After Acute Coronary Syndromes An Analysis of the ODYSSEY OUTCOMES Randomized Clinical Trial |
| topic | acute coronary syndrome alirocumab cholesterol mortality PCSK9 protein |
| topic_facet | acute coronary syndrome alirocumab cholesterol mortality PCSK9 protein |
| url | https://i3pt.portalinvestigacion.com/publicaciones/2950 |