Entire duration of active psychosis and neurocognitive performance in first-episode non-affective psychosis
Aim: To explore if the entire duration of active psychosis (DAP) is related to neurocognitive performance at baseline and at 3-year follow-up in patients with first episode psychosis (FEP). Methods: DAP was estimated for 481 FEP patients. A neuropsychological battery was administered to measure neur...
| Authors: | ; ; ; ; ; ; |
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| Format: | Article |
| Publication date: | 2021 |
| Country: | España |
| Institution: | Universidad de Cantabria (UC) |
| Repository: | UCrea Repositorio Abierto de la Universidad de Cantabria |
| Language: | English |
| OAI Identifier: | oai:repositorio.unican.es:10902/37216 |
| Online Access: | https://hdl.handle.net/10902/37216 |
| Access Level: | Open access |
| Keyword: | Cognition Cognitive impairment Neuropsychology Psychosis Psychotic disorders |
| _version_ | 1878734792359411712 |
|---|---|
| author | Murillo García, Nancy |
| author2 | Setién Suero, María Esther Pardo-de-Santayana, Guillermo Murillo-García, Marisol Pelayo Terán, José María Crespo Facorro, Benedicto|||0000-0001-9709-1276 Ayesa Arriola, Rosa |
| author2_role | author author author author author author |
| author_browse | Ayesa Arriola, Rosa Crespo Facorro, Benedicto|||0000-0001-9709-1276 Murillo García, Nancy Murillo-García, Marisol Pardo-de-Santayana, Guillermo Pelayo Terán, José María Setién Suero, María Esther |
| author_facet | Murillo García, Nancy Setién Suero, María Esther Pardo-de-Santayana, Guillermo Murillo-García, Marisol Pelayo Terán, José María Crespo Facorro, Benedicto|||0000-0001-9709-1276 Ayesa Arriola, Rosa |
| author_role | author |
| collection | UCrea Repositorio Abierto de la Universidad de Cantabria |
| description | Aim: To explore if the entire duration of active psychosis (DAP) is related to neurocognitive performance at baseline and at 3-year follow-up in patients with first episode psychosis (FEP). Methods: DAP was estimated for 481 FEP patients. A neuropsychological battery was administered to measure neurocognitive specific domains, and a global indicator of neurocognitive impairment (global deficits score, GDS) was calculated. According to the DAP quartiles, four subgroups were formed, and these were compared. In addition, a logistic regression analysis was carried out to predict neurocognitive impairment at 3-year follow-up. Results: FEP patients with the longest DAP (more than 18.36 months) presented a more severe global neurocognitive impairment evidenced in their GDS, both at baseline (F = 5.53; p< .01) and at 3-year follow-up (F = 4.16; p< .01). Moreover, a subgroup of participants with DAP between 7.40 and 18.36 months showed a specific attentional decline over the 3-year follow-up (F = 3.089; p< .05).The logistic regression model showed that sex (Wald = 7.29, p<.010), premorbid adjustment (Wald = 7.24, p<.010), attention (Wald = 12.10, p<.001), verbal memory (Wald = 16.29, p<.001) and visual memory (Wald = 9.41, p<.010) were significant predictors of neurocognitive impairment 3 years after the FEP. The variables composing the DAP were not significant predictors in this model. Conclusions: DAP seems to be related to global neurocognitive impairment in FEP patients. These findings contribute in several ways to our understanding of the effects of active psychosis on the brain, and provide the basis for future research. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_6ff8e484b0335e7c8fa3cf66b7e4eab2 |
| institution | Universidad de Cantabria (UC) |
| instname_str | Universidad de Cantabria (UC) |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:repositorio.unican.es:10902/37216 |
| publishDate | 2021 |
| publishDateSort | 2021 |
| publisher | Wiley |
| publisherStr | Wiley |
| reponame_str | UCrea Repositorio Abierto de la Universidad de Cantabria |
| spelling | Entire duration of active psychosis and neurocognitive performance in first-episode non-affective psychosis Murillo García, Nancy Setién Suero, María Esther Pardo-de-Santayana, Guillermo Murillo-García, Marisol Pelayo Terán, José María Crespo Facorro, Benedicto|||0000-0001-9709-1276 Ayesa Arriola, Rosa Cognition Cognitive impairment Neuropsychology Psychosis Psychotic disorders Aim: To explore if the entire duration of active psychosis (DAP) is related to neurocognitive performance at baseline and at 3-year follow-up in patients with first episode psychosis (FEP). Methods: DAP was estimated for 481 FEP patients. A neuropsychological battery was administered to measure neurocognitive specific domains, and a global indicator of neurocognitive impairment (global deficits score, GDS) was calculated. According to the DAP quartiles, four subgroups were formed, and these were compared. In addition, a logistic regression analysis was carried out to predict neurocognitive impairment at 3-year follow-up. Results: FEP patients with the longest DAP (more than 18.36 months) presented a more severe global neurocognitive impairment evidenced in their GDS, both at baseline (F = 5.53; p< .01) and at 3-year follow-up (F = 4.16; p< .01). Moreover, a subgroup of participants with DAP between 7.40 and 18.36 months showed a specific attentional decline over the 3-year follow-up (F = 3.089; p< .05).The logistic regression model showed that sex (Wald = 7.29, p<.010), premorbid adjustment (Wald = 7.24, p<.010), attention (Wald = 12.10, p<.001), verbal memory (Wald = 16.29, p<.001) and visual memory (Wald = 9.41, p<.010) were significant predictors of neurocognitive impairment 3 years after the FEP. The variables composing the DAP were not significant predictors in this model. Conclusions: DAP seems to be related to global neurocognitive impairment in FEP patients. These findings contribute in several ways to our understanding of the effects of active psychosis on the brain, and provide the basis for future research. Instituto de Investigación Sanitaria Valdecilla y Universidad de Cantabria, Grant/Award Number: Predoctoral contract BOC49; REF. IDI-13; Nancy Mur; Instituto de Salud Carlos III, Grant/Award Number: Miguel Servet contract CP18/00003; Dr. Rosa Ayesa-Arriola Wiley https://hdl.handle.net/10902/37216 |
| spellingShingle | Entire duration of active psychosis and neurocognitive performance in first-episode non-affective psychosis Murillo García, Nancy Cognition Cognitive impairment Neuropsychology Psychosis Psychotic disorders |
| title | Entire duration of active psychosis and neurocognitive performance in first-episode non-affective psychosis |
| title_full | Entire duration of active psychosis and neurocognitive performance in first-episode non-affective psychosis |
| title_fullStr | Entire duration of active psychosis and neurocognitive performance in first-episode non-affective psychosis |
| title_full_unstemmed | Entire duration of active psychosis and neurocognitive performance in first-episode non-affective psychosis |
| title_short | Entire duration of active psychosis and neurocognitive performance in first-episode non-affective psychosis |
| title_sort | Entire duration of active psychosis and neurocognitive performance in first-episode non-affective psychosis |
| topic | Cognition Cognitive impairment Neuropsychology Psychosis Psychotic disorders |
| topic_facet | Cognition Cognitive impairment Neuropsychology Psychosis Psychotic disorders |
| url | https://hdl.handle.net/10902/37216 |