Characteristics of subjective cognitive decline associated with amyloid positivity

Introduction The evidence for characteristics of persons with subjective cognitive decline (SCD) associated with amyloid positivity is limited. Methods In 1640 persons with SCD from 20 Amyloid Biomarker Study cohort, we investigated the associations of SCD-specific characteristics (informant confirm...

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Authors: Janssen, O; Jansen, WJ; Vos, SJB; Boada, M; Parnetti, L; Gabryelewicz, T; Fladby, T; Molinuevo, JL; Villeneuve, S; Hort, J; Epelbaum, S; Lleo, A; Engelborghs, S; van der Flier, WM; Landau, S; Popp, J; Wallin, A; Scheltens, P; Rikkert, MO; Snyder, PJ; Rowe, C; Chetelat, G; Ruiz, A; Marquie, M; Chipi, E; Wolfsgruber, S; Heneka, M; Boecker, H; Peters, O; Jarholm, J; Rami, L; Tort-Merino, A; Binette, AP; Poirier, J; Rosa-Neto, P; Cerman, J; Dubois, B; Teichmann, M; Alcolea, D; Fortea, J; Sanchez-Saudinos, MB; Ebenau, J; Pocnet, C; Eckerstrom, M; Thompson, L; Villemagne, V; Buckley, R; Burnham, S; Delarue, M; Freund-Levi, Y; Wallin, AK; Ramakers, I; Tsolaki, M; Soininen, H; Hampel, H; Spiru, L; Tijms, B; Ossenkoppele, R; Verhey, FRJ; Jessen, F; Visser, PJ
Format: Article
Status:Published version
Publication date:2022
Country:España
Institution:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repository:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p5851
Online Access:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=5851
https://ddd.uab.cat/record/282309
Access Level:Open access
Keyword:Alzheimer's disease
amyloid
cerebrospinal fluid
positron emission tomography
subjective cognitive decline
Summary:Introduction The evidence for characteristics of persons with subjective cognitive decline (SCD) associated with amyloid positivity is limited. Methods In 1640 persons with SCD from 20 Amyloid Biomarker Study cohort, we investigated the associations of SCD-specific characteristics (informant confirmation, domain-specific complaints, concerns, feelings of worse performance) demographics, setting, apolipoprotein E gene (APOE) epsilon 4 carriership, and neuropsychiatric symptoms with amyloid positivity. Results Between cohorts, amyloid positivity in 70-year-olds varied from 10% to 76%. Only older age, clinical setting, and APOE epsilon 4 carriership showed univariate associations with increased amyloid positivity. After adjusting for these, lower education was also associated with increased amyloid positivity. Only within a research setting, informant-confirmed complaints, memory complaints, attention/concentration complaints, and no depressive symptoms were associated with increased amyloid positivity. Feelings of worse performance were associated with less amyloid positivity at younger ages and more at older ages. Discussion Next to age, setting, and APOE epsilon 4 carriership, SCD-specific characteristics may facilitate the identification of amyloid-positive individuals.

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