Sexually dimorphic tibia shape is linked to natural osteoarthritis in STR/Ort mice
Objectives:Human osteoarthritis (OA) is detected only at late stages. Male STR/Ort mice develop knee OAspontaneously with known longitudinal trajectory, offering scope to identify OA predisposing factors. Weexploit the lack of overt OA in female STR/Ort and in both sexes of parental, control CBA mic...
| Autores: | ; ; ; ; ; ; ; ; |
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| Tipo de documento: | Artículo |
| Fecha de publicación: | 2018 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:20.500.12327/384 |
| Acceso en línea: | http://hdl.handle.net/20.500.12327/384 https://doi.org/10.1016/j.joca.2018.03.008 |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | 619 |
| Sumario: | Objectives:Human osteoarthritis (OA) is detected only at late stages. Male STR/Ort mice develop knee OAspontaneously with known longitudinal trajectory, offering scope to identify OA predisposing factors. Weexploit the lack of overt OA in female STR/Ort and in both sexes of parental, control CBA mice to explorewhether early divergence in tibial bone mass or shape are linked to emergent OA.Method:We undertook detailed micro-CT comparisons of trabecular and cortical bone, multiple struc-tural/architectural parameters andfinite element modelling (FEM) of the tibia from male and female STR/Ort and CBA mice at 8e10 (pre-OA), 18e20 (OA onset) and 40þweeks (advanced OA) of age.Results:We found higher trabecular bone mass in female STR/Ort than in either OA-prone male STR/Ortor non-prone CBA mice. Cortical bone, as expected, showed greater cross-sectional area in male thanfemale CBA, which surprisingly was reversed in STR/Ort mice. STR/Ort also exhibited higher cortical bonemass than CBA mice. Our analyses revealed similar tibial ellipticity, yet greater predicted resistance totorsion in male than female CBA mice. In contrast, male STR/Ort exhibited greater ellipticity than bothfemale STR/Ort and CBA mice at specific cortical sites. Longitudinal analysis revealed greater tibia cur-vature and shape deviations in male STR/Ort mice that coincided with onset and were more pronouncedin late OA.Conclusion:Generalised higher bone mass in STR/Ort mice is more marked in non OA-prone females, butpre-OA divergence in bone shape is restricted to male STR/Ort mice in which OA develops spontaneously. |
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