Brain IGF-I regulates LTP, spatial memory, and sexual dimorphic behavior
Insulin-like growth factor-I (IGF-I) exerts multiple actions, yet the role of IGF-I from different sources is poorly understood. Here, we explored the functional and behavioral consequences of the conditional deletion of Igf-I in the nervous system (Igf-I¿/¿), and demonstrated that long-term potenti...
| Authors: | ; ; ; ; ; ; ; ; ; ; ; ; |
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| Format: | Article |
| Status: | Published version |
| Publication date: | 2023 |
| Country: | España |
| Institution: | Universidad Pública de Navarra |
| Repository: | Academica-e. Repositorio Institucional de la Universidad Pública de Navarra |
| OAI Identifier: | oai:academica-e.unavarra.es:2454/46547 |
| Online Access: | https://hdl.handle.net/2454/46547 |
| Access Level: | Open access |
| Keyword: | Insulin-like growth factor-I (IGF-I) Igf-I deletion |
| _version_ | 1878734305554857984 |
|---|---|
| author | Herrero-Labrador, Raquel |
| author2 | Fernández Irigoyen, Joaquín Vecino, Rebeca González-Arias, Canela Ausín, Karina Crespo, Inmaculada Fernández Acosta, Francisco J. Nieto-Estévez, Vanesa Román, M. José Perea, Gertrudis Torres-Alemán, Ignacio Santamaría Martínez, Enrique Vicario, Carlos |
| author2_role | author author author author author author author author author author author author |
| author_browse | Ausín, Karina Crespo, Inmaculada Fernández Acosta, Francisco J. Fernández Irigoyen, Joaquín González-Arias, Canela Herrero-Labrador, Raquel Nieto-Estévez, Vanesa Perea, Gertrudis Román, M. José Santamaría Martínez, Enrique Torres-Alemán, Ignacio Vecino, Rebeca Vicario, Carlos |
| author_facet | Herrero-Labrador, Raquel Fernández Irigoyen, Joaquín Vecino, Rebeca González-Arias, Canela Ausín, Karina Crespo, Inmaculada Fernández Acosta, Francisco J. Nieto-Estévez, Vanesa Román, M. José Perea, Gertrudis Torres-Alemán, Ignacio Santamaría Martínez, Enrique Vicario, Carlos |
| author_role | author |
| collection | Academica-e. Repositorio Institucional de la Universidad Pública de Navarra |
| description | Insulin-like growth factor-I (IGF-I) exerts multiple actions, yet the role of IGF-I from different sources is poorly understood. Here, we explored the functional and behavioral consequences of the conditional deletion of Igf-I in the nervous system (Igf-I¿/¿), and demonstrated that long-term potentiation was impaired in hippocampal slices. Moreover, Igf-I¿/¿ mice showed spatial memory deficits in the Morris water maze, and the significant sex-dependent differences displayed by Igf-ICtrl/Ctrl mice disappeared in Igf-I¿/¿ mice in the open field and rota-rod tests. Brain Igf-I deletion disorganized the granule cell layer of the dentate gyrus (DG), and it modified the relative expressions of GAD and VGLUT1, which are preferentially localized to inhibitory and excitatory presynaptic terminals. Furthermore, Igf-I deletion altered protein modules involved in receptor trafficking, synaptic proteins, and proteins that functionally interact with estrogen and androgen metabolism. Our findings indicate that brain IGF-I is crucial for long-term potentiation, and that it is involved in the regulation of spatial memory and sexual dimorphic behaviors, possibly by maintaining the granule cell layer structure and the stability of synaptic-related protein modules. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_6767bfb39dfcf3adf16d6f0178985eef |
| institution | Universidad Pública de Navarra |
| instname_str | Universidad Pública de Navarra |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:academica-e.unavarra.es:2454/46547 |
| publishDate | 2023 |
| publishDateSort | 2023 |
| publisher | Life Science Alliance |
| publisherStr | Life Science Alliance |
| reponame_str | Academica-e. Repositorio Institucional de la Universidad Pública de Navarra |
| spelling | Brain IGF-I regulates LTP, spatial memory, and sexual dimorphic behavior Herrero-Labrador, Raquel Fernández Irigoyen, Joaquín Vecino, Rebeca González-Arias, Canela Ausín, Karina Crespo, Inmaculada Fernández Acosta, Francisco J. Nieto-Estévez, Vanesa Román, M. José Perea, Gertrudis Torres-Alemán, Ignacio Santamaría Martínez, Enrique Vicario, Carlos Insulin-like growth factor-I (IGF-I) Igf-I deletion Insulin-like growth factor-I (IGF-I) exerts multiple actions, yet the role of IGF-I from different sources is poorly understood. Here, we explored the functional and behavioral consequences of the conditional deletion of Igf-I in the nervous system (Igf-I¿/¿), and demonstrated that long-term potentiation was impaired in hippocampal slices. Moreover, Igf-I¿/¿ mice showed spatial memory deficits in the Morris water maze, and the significant sex-dependent differences displayed by Igf-ICtrl/Ctrl mice disappeared in Igf-I¿/¿ mice in the open field and rota-rod tests. Brain Igf-I deletion disorganized the granule cell layer of the dentate gyrus (DG), and it modified the relative expressions of GAD and VGLUT1, which are preferentially localized to inhibitory and excitatory presynaptic terminals. Furthermore, Igf-I deletion altered protein modules involved in receptor trafficking, synaptic proteins, and proteins that functionally interact with estrogen and androgen metabolism. Our findings indicate that brain IGF-I is crucial for long-term potentiation, and that it is involved in the regulation of spatial memory and sexual dimorphic behaviors, possibly by maintaining the granule cell layer structure and the stability of synaptic-related protein modules. This work was funded by grants from the Spanish “Ministerio Ciencia, Innovación y Universidades, and the Ministerio de Ciencia e Innovación/Agencia Estatal de Investigación” (MICIU and MICINN/AEI SAF2016-80419-R, PID2019-109059RB-100, and CIBERNED CB06/05/0065 to C Vicario; PID2019-110356RB-I00/AEI/10.13039/501100011033 to J Fernández-Irigoyen and E Santamaría; PID2019-104376RB-I00 to I Torres-Alemán; and PID2019-106579RB-I00 funded by MCIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe to G Perea, and BES-2017-080303 to C González-Arias. Life Science Alliance https://hdl.handle.net/2454/46547 |
| spellingShingle | Brain IGF-I regulates LTP, spatial memory, and sexual dimorphic behavior Herrero-Labrador, Raquel Insulin-like growth factor-I (IGF-I) Igf-I deletion |
| status_str | publishedVersion |
| title | Brain IGF-I regulates LTP, spatial memory, and sexual dimorphic behavior |
| title_full | Brain IGF-I regulates LTP, spatial memory, and sexual dimorphic behavior |
| title_fullStr | Brain IGF-I regulates LTP, spatial memory, and sexual dimorphic behavior |
| title_full_unstemmed | Brain IGF-I regulates LTP, spatial memory, and sexual dimorphic behavior |
| title_short | Brain IGF-I regulates LTP, spatial memory, and sexual dimorphic behavior |
| title_sort | Brain IGF-I regulates LTP, spatial memory, and sexual dimorphic behavior |
| topic | Insulin-like growth factor-I (IGF-I) Igf-I deletion |
| topic_facet | Insulin-like growth factor-I (IGF-I) Igf-I deletion |
| url | https://hdl.handle.net/2454/46547 |