Modeling practice effects in healthy middle‐aged participants of the Alzheimer and Families parent cohort
Introduction. Repetitive administration of neuropsychological tests can lead to performance improvement merely due to previous exposure. The magnitude of such practice effects (PEs) may be used as a marker of subtle cognitive impairment because they are diminished in healthy individuals subsequently...
| Authors: | ; ; ; ; |
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| Format: | Article |
| Status: | Published version |
| Publication date: | 2016 |
| Country: | España |
| Institution: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repository: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:10230/69054 |
| Online Access: | http://hdl.handle.net/10230/69054 http://dx.doi.org/10.1016/j.dadm.2016.07.001 |
| Access Level: | Open access |
| Keyword: | Alzheimer&apos s disease Preclinical Cognition Practice effects APOE Family history |
| _version_ | 1878733965879148544 |
|---|---|
| author | Sánchez Benavides, Gonzalo |
| author2 | Gispert, Juan Domingo Fauria, Karine Molinuevo, José Luis Gramunt Fombuena, Nina |
| author2_role | author author author author |
| author_browse | Fauria, Karine Gispert, Juan Domingo Gramunt Fombuena, Nina Molinuevo, José Luis Sánchez Benavides, Gonzalo |
| author_facet | Sánchez Benavides, Gonzalo Gispert, Juan Domingo Fauria, Karine Molinuevo, José Luis Gramunt Fombuena, Nina |
| author_role | author |
| collection | Recercat. Dipósit de la Recerca de Catalunya |
| description | Introduction. Repetitive administration of neuropsychological tests can lead to performance improvement merely due to previous exposure. The magnitude of such practice effects (PEs) may be used as a marker of subtle cognitive impairment because they are diminished in healthy individuals subsequently developing Alzheimer's disease (AD). Methods. To explore the relationship between sociodemographic factors, AD family history (FH), and APOE ε4 status, and the magnitude of PE, four subtests of the Wechsler Adult Intelligence Scale-IV were administered twice to 400 middle-aged healthy individuals, most of them first-degree descendants of AD patients. Results. PEs were observed in all measures. Sociodemographic variables did not show a uniform effect on PE. Baseline score was the strongest predictor of change, being inversely related to PE magnitude. Significant effects of the interaction term APOE ε4∗Age in processing speed and working memory were observed. Discussion. PEs exert a relevant effect in cognitive outcomes at retest and, accordingly, they must be taken into consideration in clinical trials. The magnitude of PE in processing speed and working memory could be of special interest for the development of cognitive markers of preclinical AD. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_608a2041b0746bbe00c42e254cfc19b2 |
| institution | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:recercat.cat:10230/69054 |
| publishDate | 2016 |
| publishDateSort | 2016 |
| publisher | Wiley |
| publisherStr | Wiley |
| reponame_str | Recercat. Dipósit de la Recerca de Catalunya |
| spelling | Modeling practice effects in healthy middle‐aged participants of the Alzheimer and Families parent cohort Sánchez Benavides, Gonzalo Gispert, Juan Domingo Fauria, Karine Molinuevo, José Luis Gramunt Fombuena, Nina Alzheimer&apos s disease Preclinical Cognition Practice effects APOE Family history Introduction. Repetitive administration of neuropsychological tests can lead to performance improvement merely due to previous exposure. The magnitude of such practice effects (PEs) may be used as a marker of subtle cognitive impairment because they are diminished in healthy individuals subsequently developing Alzheimer's disease (AD). Methods. To explore the relationship between sociodemographic factors, AD family history (FH), and APOE ε4 status, and the magnitude of PE, four subtests of the Wechsler Adult Intelligence Scale-IV were administered twice to 400 middle-aged healthy individuals, most of them first-degree descendants of AD patients. Results. PEs were observed in all measures. Sociodemographic variables did not show a uniform effect on PE. Baseline score was the strongest predictor of change, being inversely related to PE magnitude. Significant effects of the interaction term APOE ε4∗Age in processing speed and working memory were observed. Discussion. PEs exert a relevant effect in cognitive outcomes at retest and, accordingly, they must be taken into consideration in clinical trials. The magnitude of PE in processing speed and working memory could be of special interest for the development of cognitive markers of preclinical AD. Wiley http://hdl.handle.net/10230/69054 http://dx.doi.org/10.1016/j.dadm.2016.07.001 |
| spellingShingle | Modeling practice effects in healthy middle‐aged participants of the Alzheimer and Families parent cohort Sánchez Benavides, Gonzalo Alzheimer&apos s disease Preclinical Cognition Practice effects APOE Family history |
| status_str | publishedVersion |
| title | Modeling practice effects in healthy middle‐aged participants of the Alzheimer and Families parent cohort |
| title_full | Modeling practice effects in healthy middle‐aged participants of the Alzheimer and Families parent cohort |
| title_fullStr | Modeling practice effects in healthy middle‐aged participants of the Alzheimer and Families parent cohort |
| title_full_unstemmed | Modeling practice effects in healthy middle‐aged participants of the Alzheimer and Families parent cohort |
| title_short | Modeling practice effects in healthy middle‐aged participants of the Alzheimer and Families parent cohort |
| title_sort | Modeling practice effects in healthy middle‐aged participants of the Alzheimer and Families parent cohort |
| topic | Alzheimer&apos s disease Preclinical Cognition Practice effects APOE Family history |
| topic_facet | Alzheimer&apos s disease Preclinical Cognition Practice effects APOE Family history |
| url | http://hdl.handle.net/10230/69054 http://dx.doi.org/10.1016/j.dadm.2016.07.001 |