MicroRNA-185-5p: a marker of brain-sparing in foetuses with late-onset growth restriction.
To compare the expression of microRNA-185-5p (miR-185-5p) in normal foetuses and in foetuses with late-onset growth restriction (FGR) and to determine the factors influencing this expression. In a prospective study, 40 foetuses (22 of them with late-onset FGR and 18 with normal growth) were scanned...
| Authors: | ; ; ; ; ; ; |
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| Format: | Article |
| Status: | Published version |
| Publication date: | 2022 |
| Country: | España |
| Institution: | INCLIVA |
| Repository: | r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA |
| OAI Identifier: | oai:incliva.fundanetsuite.com:p16378 |
| Online Access: | https://incliva.portalinvestigacion.com/publicaciones/16378 |
| Access Level: | Open access |
| Keyword: | MicroRNA-185-5p foetal Doppler foetal growth late-onset foetal growth restriction |
| _version_ | 1878733889616216064 |
|---|---|
| author | Morales-Rosello, J |
| author2 | Loscalzo, G Garcia-Lopez, EM Cabellos, JSI Garcia-Gimenez, JL Martinez, AJC Marin, AP |
| author2_role | author author author author author author |
| author_browse | Cabellos, JSI Garcia-Gimenez, JL Garcia-Lopez, EM Loscalzo, G Marin, AP Martinez, AJC Morales-Rosello, J |
| author_facet | Morales-Rosello, J Loscalzo, G Garcia-Lopez, EM Cabellos, JSI Garcia-Gimenez, JL Martinez, AJC Marin, AP |
| author_role | author |
| collection | r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA |
| description | To compare the expression of microRNA-185-5p (miR-185-5p) in normal foetuses and in foetuses with late-onset growth restriction (FGR) and to determine the factors influencing this expression. In a prospective study, 40 foetuses (22 of them with late-onset FGR and 18 with normal growth) were scanned with Doppler ultrasound after week 35 and followed until birth. Subsequently, blood samples from umbilical cords were collected after delivery to evaluate the expression of miR-185-5p using real-time qPCR. Finally, multivariable regression analysis was applied to determine the clinical and ultrasonographic factors influencing miR-185-5p expression in both normal and late-onset FGR foetuses. In comparison with normal foetuses, late-onset FGR foetuses expressed upregulation of miR-185-5p (2.26 ± 1.30 versus 1.27 ± 1.03 2^-ddCt, P = 0.011). Multivariable regression analysis confirmed that cerebroplacental ratio (P < 0.05) was the only determinant of this overexpression. FGR foetuses overexpress miR-185-5p in relation to brain-sparing. Future studies will be needed to investigate the role of miR-185 in the management of late-onset FGR. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_5ef7bb55b5bcdbca0b4de7e3fbaf2b8e |
| institution | INCLIVA |
| instname_str | INCLIVA |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:incliva.fundanetsuite.com:p16378 |
| publishDate | 2022 |
| publishDateSort | 2022 |
| publisher | TAYLOR & FRANCIS INC |
| publisherStr | TAYLOR & FRANCIS INC |
| reponame_str | r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA |
| spelling | MicroRNA-185-5p: a marker of brain-sparing in foetuses with late-onset growth restriction. Morales-Rosello, J Loscalzo, G Garcia-Lopez, EM Cabellos, JSI Garcia-Gimenez, JL Martinez, AJC Marin, AP MicroRNA-185-5p foetal Doppler foetal growth late-onset foetal growth restriction To compare the expression of microRNA-185-5p (miR-185-5p) in normal foetuses and in foetuses with late-onset growth restriction (FGR) and to determine the factors influencing this expression. In a prospective study, 40 foetuses (22 of them with late-onset FGR and 18 with normal growth) were scanned with Doppler ultrasound after week 35 and followed until birth. Subsequently, blood samples from umbilical cords were collected after delivery to evaluate the expression of miR-185-5p using real-time qPCR. Finally, multivariable regression analysis was applied to determine the clinical and ultrasonographic factors influencing miR-185-5p expression in both normal and late-onset FGR foetuses. In comparison with normal foetuses, late-onset FGR foetuses expressed upregulation of miR-185-5p (2.26 ± 1.30 versus 1.27 ± 1.03 2^-ddCt, P = 0.011). Multivariable regression analysis confirmed that cerebroplacental ratio (P < 0.05) was the only determinant of this overexpression. FGR foetuses overexpress miR-185-5p in relation to brain-sparing. Future studies will be needed to investigate the role of miR-185 in the management of late-onset FGR. TAYLOR & FRANCIS INC https://incliva.portalinvestigacion.com/publicaciones/16378 |
| spellingShingle | MicroRNA-185-5p: a marker of brain-sparing in foetuses with late-onset growth restriction. Morales-Rosello, J MicroRNA-185-5p foetal Doppler foetal growth late-onset foetal growth restriction |
| status_str | publishedVersion |
| title | MicroRNA-185-5p: a marker of brain-sparing in foetuses with late-onset growth restriction. |
| title_full | MicroRNA-185-5p: a marker of brain-sparing in foetuses with late-onset growth restriction. |
| title_fullStr | MicroRNA-185-5p: a marker of brain-sparing in foetuses with late-onset growth restriction. |
| title_full_unstemmed | MicroRNA-185-5p: a marker of brain-sparing in foetuses with late-onset growth restriction. |
| title_short | MicroRNA-185-5p: a marker of brain-sparing in foetuses with late-onset growth restriction. |
| title_sort | MicroRNA-185-5p: a marker of brain-sparing in foetuses with late-onset growth restriction. |
| topic | MicroRNA-185-5p foetal Doppler foetal growth late-onset foetal growth restriction |
| topic_facet | MicroRNA-185-5p foetal Doppler foetal growth late-onset foetal growth restriction |
| url | https://incliva.portalinvestigacion.com/publicaciones/16378 |