Functional renal failure and haemorrhagic gastritis associated with endotoxaemia in cirrhosis
Forty-three patients with cirrhosis and ascites, 21 with normal renal function, 10 with a progressive functional renal failure (FRF), and 12 with a steady FRF, were investigated for the presence of endotoxaemia by the Limulus lysate test. Endotoxaemia was found in nine patients with FRF and in none...
| Authors: | ; ; ; ; ; |
|---|---|
| Format: | Article |
| Status: | Published version |
| Publication date: | 1977 |
| Country: | España |
| Institution: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repository: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/18642 |
| Online Access: | https://hdl.handle.net/2445/18642 |
| Access Level: | Open access |
| Keyword: | Insuficiència renal aguda Cirrosi hepàtica Hemorràgia gastrointestinal Endotoxines Gastritis Hepatic cirrhosis Acute renal failure Gastrointestinal hemorrhage Endotoxins |
| _version_ | 1878733553306435584 |
|---|---|
| author | Clemente, C. |
| author2 | Bosch i Genover, Jaume Rodés, J. Arroyo, Vicente Mas Comas, Ana M. Maragall, S. |
| author2_role | author author author author author |
| author_browse | Arroyo, Vicente Bosch i Genover, Jaume Clemente, C. Maragall, S. Mas Comas, Ana M. Rodés, J. |
| author_facet | Clemente, C. Bosch i Genover, Jaume Rodés, J. Arroyo, Vicente Mas Comas, Ana M. Maragall, S. |
| author_role | author |
| collection | Recercat. Dipósit de la Recerca de Catalunya |
| description | Forty-three patients with cirrhosis and ascites, 21 with normal renal function, 10 with a progressive functional renal failure (FRF), and 12 with a steady FRF, were investigated for the presence of endotoxaemia by the Limulus lysate test. Endotoxaemia was found in nine patients with FRF and in none of the 21 with normal renal function (P less than 0-01). A positive Limulus test was almost exclusively associated with a progressive FRF (eight of 10 patients) and all but one of them died. Renal function improved as endotoxaemia disappeared in the survivor. Endotoxaemia was also associated with haemorrhage due to acute erosions of the gastric mucosa, being present in six of the seven patients who had this complication. Intravascular coagulation was not found in any patient. The Limulus test was positive in the ascitic fluid in 18 of 21 patients tested, although only two of them had peritonitis. These results suggest that endotoxaemia may play a critical role in the development of progressive renal failure and haemorrhagic gastritis in cirrhosis, and emphasise the potential risk of procedures involving reinfusion of ascitic fluid. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_586cabdce7a1a685040a8b21f4fa2432 |
| institution | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:recercat.cat:2445/18642 |
| publishDate | 1977 |
| publishDateSort | 1977 |
| publisher | BMJ Group |
| publisherStr | BMJ Group |
| reponame_str | Recercat. Dipósit de la Recerca de Catalunya |
| spelling | Functional renal failure and haemorrhagic gastritis associated with endotoxaemia in cirrhosis Clemente, C. Bosch i Genover, Jaume Rodés, J. Arroyo, Vicente Mas Comas, Ana M. Maragall, S. Insuficiència renal aguda Cirrosi hepàtica Hemorràgia gastrointestinal Endotoxines Gastritis Hepatic cirrhosis Acute renal failure Gastrointestinal hemorrhage Endotoxins Forty-three patients with cirrhosis and ascites, 21 with normal renal function, 10 with a progressive functional renal failure (FRF), and 12 with a steady FRF, were investigated for the presence of endotoxaemia by the Limulus lysate test. Endotoxaemia was found in nine patients with FRF and in none of the 21 with normal renal function (P less than 0-01). A positive Limulus test was almost exclusively associated with a progressive FRF (eight of 10 patients) and all but one of them died. Renal function improved as endotoxaemia disappeared in the survivor. Endotoxaemia was also associated with haemorrhage due to acute erosions of the gastric mucosa, being present in six of the seven patients who had this complication. Intravascular coagulation was not found in any patient. The Limulus test was positive in the ascitic fluid in 18 of 21 patients tested, although only two of them had peritonitis. These results suggest that endotoxaemia may play a critical role in the development of progressive renal failure and haemorrhagic gastritis in cirrhosis, and emphasise the potential risk of procedures involving reinfusion of ascitic fluid. BMJ Group https://hdl.handle.net/2445/18642 |
| spellingShingle | Functional renal failure and haemorrhagic gastritis associated with endotoxaemia in cirrhosis Clemente, C. Insuficiència renal aguda Cirrosi hepàtica Hemorràgia gastrointestinal Endotoxines Gastritis Hepatic cirrhosis Acute renal failure Gastrointestinal hemorrhage Endotoxins |
| status_str | publishedVersion |
| title | Functional renal failure and haemorrhagic gastritis associated with endotoxaemia in cirrhosis |
| title_full | Functional renal failure and haemorrhagic gastritis associated with endotoxaemia in cirrhosis |
| title_fullStr | Functional renal failure and haemorrhagic gastritis associated with endotoxaemia in cirrhosis |
| title_full_unstemmed | Functional renal failure and haemorrhagic gastritis associated with endotoxaemia in cirrhosis |
| title_short | Functional renal failure and haemorrhagic gastritis associated with endotoxaemia in cirrhosis |
| title_sort | Functional renal failure and haemorrhagic gastritis associated with endotoxaemia in cirrhosis |
| topic | Insuficiència renal aguda Cirrosi hepàtica Hemorràgia gastrointestinal Endotoxines Gastritis Hepatic cirrhosis Acute renal failure Gastrointestinal hemorrhage Endotoxins |
| topic_facet | Insuficiència renal aguda Cirrosi hepàtica Hemorràgia gastrointestinal Endotoxines Gastritis Hepatic cirrhosis Acute renal failure Gastrointestinal hemorrhage Endotoxins |
| url | https://hdl.handle.net/2445/18642 |