Functional impairment and painful physical symptoms in patients with major depressive disorder treated with antidepressants: real-world evidence from the Middle East
BACKGROUND: The Global Burden of Disease 2010 study reported the relative size of major depressive disorder (MDD) burden to be greater in the Middle East and North Africa than anywhere else. However, little research has been carried out to examine the comparative effectiveness of antidepressants in...
| Authors: | ; ; ; ; ; |
|---|---|
| Format: | Article |
| Status: | Published version |
| Publication date: | 2017 |
| Country: | España |
| Institution: | Universidad de Barcelona |
| Repository: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/124247 |
| Online Access: | https://hdl.handle.net/2445/124247 |
| Access Level: | Open access |
| Keyword: | Depressió psíquica Antidepressius Farmacologia Assistència psiquiàtrica Orient Mitjà Àfrica del Nord Mental depression Antidepressants Pharmacology Mental health services Middle East Africa, North |
| _version_ | 1878733154383036416 |
|---|---|
| author | Hong, Jihyung |
| author2 | Novick, Diego Moneta, Maria Victoria El-Shafei, Ahmed Dueñas, Héctor Haro Abad, Josep Maria |
| author2_role | author author author author author |
| author_browse | Dueñas, Héctor El-Shafei, Ahmed Haro Abad, Josep Maria Hong, Jihyung Moneta, Maria Victoria Novick, Diego |
| author_facet | Hong, Jihyung Novick, Diego Moneta, Maria Victoria El-Shafei, Ahmed Dueñas, Héctor Haro Abad, Josep Maria |
| author_role | author |
| collection | Dipòsit Digital de la UB |
| description | BACKGROUND: The Global Burden of Disease 2010 study reported the relative size of major depressive disorder (MDD) burden to be greater in the Middle East and North Africa than anywhere else. However, little research has been carried out to examine the comparative effectiveness of antidepressants in this region. OBJECTIVE: To assess and compare functioning levels in Middle Eastern patients with MDD treated with either duloxetine or a selective serotonin reuptake inhibitor (SSRI), and to examine the impacts of depression-related pain on functioning by the type of treatment. METHOD: This post-hoc analysis, which focused on Middle Eastern patients, used data from a 6-month prospective observational study that included 1,549 MDD patients without sexual dysfunction. Levels of functional impairment and depression-related pain were assessed using the Sheehan Disability Scale (SDS) and the modified Somatic Symptom Inventory, respectively. A mixed model with repeated measures (MMRM) was employed. RESULTS: The mean age of the patients was 37.3 (SD=8.4) years, and 34.6% were female. Patient functioning was, on average, moderately impaired at baseline, but improved substantially during follow-up in both the duloxetine (n=152) and the SSRI (n=123) cohorts. The MMRM results showed a lower level of functional impairment at 24 weeks in the duloxetine cohort than in the SSRI cohort (p<0.001). Pain severity at baseline was positively associated with functional impairment during follow-up only in the SSRI cohort (p=0.003). CONCLUSION: Duloxetine-treated MDD patients achieved better functioning than SSRI-treated patients. This treatment difference was partly driven by depression-related pain. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_51150ef55feb7e5dae2be58b96da609e |
| institution | Universidad de Barcelona |
| instname_str | Universidad de Barcelona |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:diposit.ub.edu:2445/124247 |
| publishDate | 2017 |
| publishDateSort | 2017 |
| publisher | BioMed Central |
| publisherStr | BioMed Central |
| reponame_str | Dipòsit Digital de la UB |
| spelling | Functional impairment and painful physical symptoms in patients with major depressive disorder treated with antidepressants: real-world evidence from the Middle East Hong, Jihyung Novick, Diego Moneta, Maria Victoria El-Shafei, Ahmed Dueñas, Héctor Haro Abad, Josep Maria Depressió psíquica Antidepressius Farmacologia Assistència psiquiàtrica Orient Mitjà Àfrica del Nord Mental depression Antidepressants Pharmacology Mental health services Middle East Africa, North BACKGROUND: The Global Burden of Disease 2010 study reported the relative size of major depressive disorder (MDD) burden to be greater in the Middle East and North Africa than anywhere else. However, little research has been carried out to examine the comparative effectiveness of antidepressants in this region. OBJECTIVE: To assess and compare functioning levels in Middle Eastern patients with MDD treated with either duloxetine or a selective serotonin reuptake inhibitor (SSRI), and to examine the impacts of depression-related pain on functioning by the type of treatment. METHOD: This post-hoc analysis, which focused on Middle Eastern patients, used data from a 6-month prospective observational study that included 1,549 MDD patients without sexual dysfunction. Levels of functional impairment and depression-related pain were assessed using the Sheehan Disability Scale (SDS) and the modified Somatic Symptom Inventory, respectively. A mixed model with repeated measures (MMRM) was employed. RESULTS: The mean age of the patients was 37.3 (SD=8.4) years, and 34.6% were female. Patient functioning was, on average, moderately impaired at baseline, but improved substantially during follow-up in both the duloxetine (n=152) and the SSRI (n=123) cohorts. The MMRM results showed a lower level of functional impairment at 24 weeks in the duloxetine cohort than in the SSRI cohort (p<0.001). Pain severity at baseline was positively associated with functional impairment during follow-up only in the SSRI cohort (p=0.003). CONCLUSION: Duloxetine-treated MDD patients achieved better functioning than SSRI-treated patients. This treatment difference was partly driven by depression-related pain. BioMed Central https://hdl.handle.net/2445/124247 |
| spellingShingle | Functional impairment and painful physical symptoms in patients with major depressive disorder treated with antidepressants: real-world evidence from the Middle East Hong, Jihyung Depressió psíquica Antidepressius Farmacologia Assistència psiquiàtrica Orient Mitjà Àfrica del Nord Mental depression Antidepressants Pharmacology Mental health services Middle East Africa, North |
| status_str | publishedVersion |
| title | Functional impairment and painful physical symptoms in patients with major depressive disorder treated with antidepressants: real-world evidence from the Middle East |
| title_full | Functional impairment and painful physical symptoms in patients with major depressive disorder treated with antidepressants: real-world evidence from the Middle East |
| title_fullStr | Functional impairment and painful physical symptoms in patients with major depressive disorder treated with antidepressants: real-world evidence from the Middle East |
| title_full_unstemmed | Functional impairment and painful physical symptoms in patients with major depressive disorder treated with antidepressants: real-world evidence from the Middle East |
| title_short | Functional impairment and painful physical symptoms in patients with major depressive disorder treated with antidepressants: real-world evidence from the Middle East |
| title_sort | Functional impairment and painful physical symptoms in patients with major depressive disorder treated with antidepressants: real-world evidence from the Middle East |
| topic | Depressió psíquica Antidepressius Farmacologia Assistència psiquiàtrica Orient Mitjà Àfrica del Nord Mental depression Antidepressants Pharmacology Mental health services Middle East Africa, North |
| topic_facet | Depressió psíquica Antidepressius Farmacologia Assistència psiquiàtrica Orient Mitjà Àfrica del Nord Mental depression Antidepressants Pharmacology Mental health services Middle East Africa, North |
| url | https://hdl.handle.net/2445/124247 |