Perceived illness-related uncertainty among patients with mid-stage relapsing-remitting multiple sclerosis
Background: Patients with multiple sclerosis (MS) have to deal with a variable disease trajectory often associated with disability and productivity loss. Objective: This study aimed to assess illness-related uncertainty and associated correlates in patients with relapsing-remitting multiple sclerosi...
| Autores: | ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; |
|---|---|
| Tipo de documento: | Artículo |
| Estado: | Published version |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
| Repositorio: | r-FISABIO. Repositorio Institucional de Producción Científica |
| OAI Identifier: | oai:fisabio.fundanetsuite.com:p17804 |
| Acceso en línea: | https://fisabio.portalinvestigacion.com/publicaciones/17804 |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | Disease progression Patient-reported outcome measures Relapsing-remitting multiple sclerosis Uncertainty |
| _version_ | 1878733143332093952 |
|---|---|
| author | Sabin, J |
| author2 | Salas, E Martín-Martínez, J Candeliere-Merlicco, A Barrero, FJ Alonso, A Sánchez-Menoyo, JL Borrega, L Rodríguez-Rodríguez, M Gómez-Gutiérrez, M Eichau, S Hernández-Pérez, MA Calles, C Fernández-Díaz, E Carmona, O Orviz, A López-Real, A López-Muñoz, P Mendonza, A Agüera, E Maurino, J |
| author2_role | author author author author author author author author author author author author author author author author author author author author |
| author_browse | Agüera, E Alonso, A Barrero, FJ Borrega, L Calles, C Candeliere-Merlicco, A Carmona, O Eichau, S Fernández-Díaz, E Gómez-Gutiérrez, M Hernández-Pérez, MA López-Muñoz, P López-Real, A Martín-Martínez, J Maurino, J Mendonza, A Orviz, A Rodríguez-Rodríguez, M Sabin, J Salas, E Sánchez-Menoyo, JL |
| author_facet | Sabin, J Salas, E Martín-Martínez, J Candeliere-Merlicco, A Barrero, FJ Alonso, A Sánchez-Menoyo, JL Borrega, L Rodríguez-Rodríguez, M Gómez-Gutiérrez, M Eichau, S Hernández-Pérez, MA Calles, C Fernández-Díaz, E Carmona, O Orviz, A López-Real, A López-Muñoz, P Mendonza, A Agüera, E Maurino, J |
| author_role | author |
| collection | r-FISABIO. Repositorio Institucional de Producción Científica |
| description | Background: Patients with multiple sclerosis (MS) have to deal with a variable disease trajectory often associated with disability and productivity loss. Objective: This study aimed to assess illness-related uncertainty and associated correlates in patients with relapsing-remitting multiple sclerosis (RRMS) beyond the near diagnosis phase. Methods: We conducted a multicenter, non-interventional study including patients diagnosed with RRMS (2017 revised McDonald criteria) and a disease duration of 3 to 8 years. Perceived uncertainty was measured using the Mishel Uncertainty of Illness Scale (MUIS). Associations between the MUIS and different patient-based outcome measures were analyzed using Spearman's rank correlation. Results: A total of 201 patients were studied (mean age (standard deviation): 38.7 (8.4) years, 71.4 % female). The median disease duration (interquartile range) was 6.0 (4.0-7.0) years and the median EDSS score was 1.0 (0.0-2.0). The mean MUIS score was 38.2 (10.8). Perceived uncertainty was positively correlated with fatigue (p < 0.001), symptom severity (p < 0.001), anxiety (p < 0.001), depressive symptoms (p < 0.001), and a threatening illness perception (p < 0.001), and negatively correlated with self-management (p < 0.001), self-efficacy (p < 0.001), processing speed (p < 0.001), knowledge of MS (p = 0.006), and quality of life (p < 0.001). Conclusion: Illness-related uncertainty was common in a population of mid-stage RRMS. Identifying uncertainty and its associated factors may be useful for implementing preventive strategies to help patients cope with the disease throughout life. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_50e37fdbf4666579f28e81db46e2273e |
| institution | Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
| instname_str | Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:fisabio.fundanetsuite.com:p17804 |
| publishDate | 2024 |
| publishDateSort | 2024 |
| publisher | ELSEVIER SCI LTD |
| publisherStr | ELSEVIER SCI LTD |
| reponame_str | r-FISABIO. Repositorio Institucional de Producción Científica |
| spelling | Perceived illness-related uncertainty among patients with mid-stage relapsing-remitting multiple sclerosis Sabin, J Salas, E Martín-Martínez, J Candeliere-Merlicco, A Barrero, FJ Alonso, A Sánchez-Menoyo, JL Borrega, L Rodríguez-Rodríguez, M Gómez-Gutiérrez, M Eichau, S Hernández-Pérez, MA Calles, C Fernández-Díaz, E Carmona, O Orviz, A López-Real, A López-Muñoz, P Mendonza, A Agüera, E Maurino, J Disease progression Patient-reported outcome measures Relapsing-remitting multiple sclerosis Uncertainty Background: Patients with multiple sclerosis (MS) have to deal with a variable disease trajectory often associated with disability and productivity loss. Objective: This study aimed to assess illness-related uncertainty and associated correlates in patients with relapsing-remitting multiple sclerosis (RRMS) beyond the near diagnosis phase. Methods: We conducted a multicenter, non-interventional study including patients diagnosed with RRMS (2017 revised McDonald criteria) and a disease duration of 3 to 8 years. Perceived uncertainty was measured using the Mishel Uncertainty of Illness Scale (MUIS). Associations between the MUIS and different patient-based outcome measures were analyzed using Spearman's rank correlation. Results: A total of 201 patients were studied (mean age (standard deviation): 38.7 (8.4) years, 71.4 % female). The median disease duration (interquartile range) was 6.0 (4.0-7.0) years and the median EDSS score was 1.0 (0.0-2.0). The mean MUIS score was 38.2 (10.8). Perceived uncertainty was positively correlated with fatigue (p < 0.001), symptom severity (p < 0.001), anxiety (p < 0.001), depressive symptoms (p < 0.001), and a threatening illness perception (p < 0.001), and negatively correlated with self-management (p < 0.001), self-efficacy (p < 0.001), processing speed (p < 0.001), knowledge of MS (p = 0.006), and quality of life (p < 0.001). Conclusion: Illness-related uncertainty was common in a population of mid-stage RRMS. Identifying uncertainty and its associated factors may be useful for implementing preventive strategies to help patients cope with the disease throughout life. ELSEVIER SCI LTD https://fisabio.portalinvestigacion.com/publicaciones/17804 |
| spellingShingle | Perceived illness-related uncertainty among patients with mid-stage relapsing-remitting multiple sclerosis Sabin, J Disease progression Patient-reported outcome measures Relapsing-remitting multiple sclerosis Uncertainty |
| status_str | publishedVersion |
| title | Perceived illness-related uncertainty among patients with mid-stage relapsing-remitting multiple sclerosis |
| title_full | Perceived illness-related uncertainty among patients with mid-stage relapsing-remitting multiple sclerosis |
| title_fullStr | Perceived illness-related uncertainty among patients with mid-stage relapsing-remitting multiple sclerosis |
| title_full_unstemmed | Perceived illness-related uncertainty among patients with mid-stage relapsing-remitting multiple sclerosis |
| title_short | Perceived illness-related uncertainty among patients with mid-stage relapsing-remitting multiple sclerosis |
| title_sort | Perceived illness-related uncertainty among patients with mid-stage relapsing-remitting multiple sclerosis |
| topic | Disease progression Patient-reported outcome measures Relapsing-remitting multiple sclerosis Uncertainty |
| topic_facet | Disease progression Patient-reported outcome measures Relapsing-remitting multiple sclerosis Uncertainty |
| url | https://fisabio.portalinvestigacion.com/publicaciones/17804 |