Reliable Characterization of Organic & Pharmaceutical Compounds with High Resolution Monochromated EEL Spectroscopy
Organic and biological compounds (especially those related to the pharmaceutical industry) have always been of great interest for researchers due to their importance for the development of new drugs to diagnose, cure, treat or prevent disease. As many new API (active pharmaceutical ingredients) and...
| Autores: | ; ; ; ; ; ; ; ; ; |
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| Tipo de documento: | Artículo |
| Estado: | Published version |
| Fecha de publicación: | 2020 |
| País: | España |
| Institución: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/176302 |
| Acceso en línea: | https://hdl.handle.net/2445/176302 |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | Indústria farmacèutica Daltonisme Pharmaceutical industry Color blindness |
| _version_ | 1878733035071864832 |
|---|---|
| author | Das, Partha Pratim |
| author2 | Guzzinati, Giulio Coll, Cristina Gómez Pérez, Alejandro Nicolopoulos, Stavros Estradé Albiol, Sònia Peiró Martínez, Francisca Verbeeck, Johan Zompra, Aikaterini A. Galanis, Athanassios S. |
| author2_role | author author author author author author author author author |
| author_browse | Coll, Cristina Das, Partha Pratim Estradé Albiol, Sònia Galanis, Athanassios S. Guzzinati, Giulio Gómez Pérez, Alejandro Nicolopoulos, Stavros Peiró Martínez, Francisca Verbeeck, Johan Zompra, Aikaterini A. |
| author_facet | Das, Partha Pratim Guzzinati, Giulio Coll, Cristina Gómez Pérez, Alejandro Nicolopoulos, Stavros Estradé Albiol, Sònia Peiró Martínez, Francisca Verbeeck, Johan Zompra, Aikaterini A. Galanis, Athanassios S. |
| author_role | author |
| collection | Dipòsit Digital de la UB |
| description | Organic and biological compounds (especially those related to the pharmaceutical industry) have always been of great interest for researchers due to their importance for the development of new drugs to diagnose, cure, treat or prevent disease. As many new API (active pharmaceutical ingredients) and their polymorphs are in nanocrystalline or in amorphous form blended with amorphous polymeric matrix (known as amorphous solid dispersion-ASD), their structural identification and characterization at nm scale with conventional X-Ray/Raman/IR techniques becomes difficult. During any API synthesis/production or in the formulated drug product, impurities must be identified and characterized. Electron energy loss spectroscopy (EELS) at high energy resolution by transmission electron microscope (TEM) is expected to be a promising technique to screen and identify the different (organic) compounds used in a typical pharmaceutical or biological system and to detect any impurities present, if any, during the synthesis or formulation process. In this work, we propose the use of monochromated TEM-EELS, to analyze selected peptides and organic compounds and their polymorphs. In order to validate EELS for fingerprinting (in low loss/optical region) and by further correlation with advanced DFT, simulations were utilized. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_4eceeedf3c9e036cc2f98627eaa07fcd |
| institution | Universidad de Barcelona |
| instname_str | Universidad de Barcelona |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:diposit.ub.edu:2445/176302 |
| publishDate | 2020 |
| publishDateSort | 2020 |
| publisher | MDPI |
| publisherStr | MDPI |
| reponame_str | Dipòsit Digital de la UB |
| spelling | Reliable Characterization of Organic & Pharmaceutical Compounds with High Resolution Monochromated EEL Spectroscopy Das, Partha Pratim Guzzinati, Giulio Coll, Cristina Gómez Pérez, Alejandro Nicolopoulos, Stavros Estradé Albiol, Sònia Peiró Martínez, Francisca Verbeeck, Johan Zompra, Aikaterini A. Galanis, Athanassios S. Indústria farmacèutica Daltonisme Pharmaceutical industry Color blindness Organic and biological compounds (especially those related to the pharmaceutical industry) have always been of great interest for researchers due to their importance for the development of new drugs to diagnose, cure, treat or prevent disease. As many new API (active pharmaceutical ingredients) and their polymorphs are in nanocrystalline or in amorphous form blended with amorphous polymeric matrix (known as amorphous solid dispersion-ASD), their structural identification and characterization at nm scale with conventional X-Ray/Raman/IR techniques becomes difficult. During any API synthesis/production or in the formulated drug product, impurities must be identified and characterized. Electron energy loss spectroscopy (EELS) at high energy resolution by transmission electron microscope (TEM) is expected to be a promising technique to screen and identify the different (organic) compounds used in a typical pharmaceutical or biological system and to detect any impurities present, if any, during the synthesis or formulation process. In this work, we propose the use of monochromated TEM-EELS, to analyze selected peptides and organic compounds and their polymorphs. In order to validate EELS for fingerprinting (in low loss/optical region) and by further correlation with advanced DFT, simulations were utilized. MDPI https://hdl.handle.net/2445/176302 |
| spellingShingle | Reliable Characterization of Organic & Pharmaceutical Compounds with High Resolution Monochromated EEL Spectroscopy Das, Partha Pratim Indústria farmacèutica Daltonisme Pharmaceutical industry Color blindness |
| status_str | publishedVersion |
| title | Reliable Characterization of Organic & Pharmaceutical Compounds with High Resolution Monochromated EEL Spectroscopy |
| title_full | Reliable Characterization of Organic & Pharmaceutical Compounds with High Resolution Monochromated EEL Spectroscopy |
| title_fullStr | Reliable Characterization of Organic & Pharmaceutical Compounds with High Resolution Monochromated EEL Spectroscopy |
| title_full_unstemmed | Reliable Characterization of Organic & Pharmaceutical Compounds with High Resolution Monochromated EEL Spectroscopy |
| title_short | Reliable Characterization of Organic & Pharmaceutical Compounds with High Resolution Monochromated EEL Spectroscopy |
| title_sort | Reliable Characterization of Organic & Pharmaceutical Compounds with High Resolution Monochromated EEL Spectroscopy |
| topic | Indústria farmacèutica Daltonisme Pharmaceutical industry Color blindness |
| topic_facet | Indústria farmacèutica Daltonisme Pharmaceutical industry Color blindness |
| url | https://hdl.handle.net/2445/176302 |