A network analysis to identify mediators of germline-driven differences in breast cancer prognosis.
Identifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the potential function of germline variants in breast cancer prognosis. This network-based...
| Autores: | ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; |
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| Tipo de documento: | Artículo |
| Fecha de publicación: | 2020 |
| País: | España |
| Institución: | Instituto de Salud Carlos III (ISCIII) |
| Repositorio: | Repisalud |
| Lenguaje: | Inglés |
| OAI Identifier: | oai:repisalud.isciii.es:20.500.12105/12181 |
| Acceso en línea: | http://hdl.handle.net/20.500.12105/12181 |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | Genetic Variation Genome-Wide Association Study Germ Cells Apoptosis Breast Neoplasms Circadian Clocks Computational Biology Female GTP-Binding Protein alpha Subunits GTP-Binding Protein alpha Subunits, Gq-G11 Gene Regulatory Networks Genotype Humans Prognosis Receptors, Estrogen Signal Transduction |
| _version_ | 1878733025281310720 |
|---|---|
| author | Escala-Garcia, Maria |
| author2 | Abraham, Jean Andrulis, Irene L Anton-Culver, Hoda Arndt, Volker Ashworth, Alan Auer, Paul L Auvinen, Päivi Beckmann, Matthias W Beesley, Jonathan Behrens, Sabine Benitez, Javier Bermisheva, Marina Blomqvist, Carl Blot, William Bogdanova, Natalia V Bojesen, Stig E Bolla, Manjeet K Børresen-Dale, Anne-Lise Brauch, Hiltrud Brenner, Hermann Brucker, Sara Y Burwinkel, Barbara Caldas, Carlos Canzian, Federico Chang-Claude, Jenny Chanock, Stephen J Chin, Suet-Feung Clarke, Christine L Couch, Fergus J Cox, Angela Cross, Simon S Czene, Kamila Daly, Mary B Dennis, Joe Devilee, Peter Dunn, Janet A Dunning, Alison M Dwek, Miriam Earl, Helena M Eccles, Diana M Eliassen, A Heather Ellberg, Carolina Evans, D Gareth Fasching, Peter A Figueroa, Jonine Flyger, Henrik Gago-Dominguez, Manuela Gapstur, Susan M García-Closas, Montserrat García-Sáenz, José A Gaudet, Mia M George, Angela Giles, Graham G Goldgar, David E González-Neira, Anna Grip, Mervi Guénel, Pascal Guo, Qi Haiman, Christopher A Håkansson, Niclas Hamann, Ute Harrington, Patricia A Hiller, Louise Hooning, Maartje J Hopper, John L Howell, Anthony Huang, Chiun-Sheng Huang, Guanmengqian Hunter, David J Jakubowska, Anna John, Esther M Kaaks, Rudolf Kapoor, Pooja Middha Keeman, Renske Kitahara, Cari M Kraft, Peter Lambrechts, Diether Le Marchand, Loic Lejbkowicz, Flavio Lindblom, Annika Lubiński, Jan Mannermaa, Arto Manoochehri, Mehdi Manoukian, Siranoush Margolin, Sara Martinez, Maria Elena Maurer, Tabea Mavroudis, Dimitrios Meindl, Alfons Milne, Roger L Mulligan, Anna Marie Neuhausen, Susan L Nevanlinna, Heli Newman, William G Olshan, Andrew F Olson, Janet E Olsson, Håkan Orr, Nick Peterlongo, Paolo Petridis, Christos Prentice, Ross L Presneau, Nadege Punie, Kevin Ramachandran, Dhanya Rennert, Gad Romero, Atocha Sachchithananthan, Mythily Saloustros, Emmanouil Sawyer, Elinor J Schmutzler, Rita K Schwentner, Lukas Scott, Christopher Simard, Jacques Sohn, Christof Southey, Melissa C Swerdlow, Anthony J Tamimi, Rulla M Tapper, William J Teixeira, Manuel R Terry, Mary Beth Thorne, Heather Tollenaar, Rob A E M Tomlinson, Ian Troester, Melissa A Truong, Thérèse Turnbull, Clare Vachon, Celine M van der Kolk, Lizet E Wang, Qin Winqvist, Robert Wolk, Alicja Yang, Xiaohong R Ziogas, Argyrios Pharoah, Paul D P Hall, Per Wessels, Lodewyk F A Chenevix-Trench, Georgia Bader, Gary D Dörk, Thilo Easton, Douglas F Canisius, Sander Schmidt, Marjanka K Gonzalez Neira, Anna Andrulis, Irene L. Auer, Paul L. Beckmann, Matthias W. Bogdanova, Natalia V. Bojesen, Stig E. Bolla, Manjeet K. Brucker, Sara Y. Chanock, Stephen J. Clarke, Christine L. Couch, Fergus J. Cross, Simon S. Daly, Mary B. Dunn, Janet A. Dunning, Alison M. Earl, Helena M. Eccles, Diana M. Eliassen, A. Heather Evans, D. Gareth Fasching, Peter A. Gapstur, Susan M. García-Sáenz, José A. Gaudet, Mia M. Giles, Graham G. Goldgar, David E. Haiman, Christopher A. Harrington, Patricia A. Hooning, Maartje J. Hopper, John L. Hunter, David J. John, Esther M. Kitahara, Cari M. Koppert, Linetta B Kristensen, Vessela N Milne, Roger L. Neuhausen, Susan L. Newman, William G. Olshan, Andrew F. Olson, Janet E. Prentice, Ross L. Sawyer, Elinor J. Schmutzler, Rita K. Southey, Melissa C. Swerdlow, Anthony J. Tamimi, Rulla M. Tapper, William J. Tollenaar, Rob A. E. M. Troester, Melissa A. Vachon, Celine M. van der Kolk, Lizet E. Yang, Xiaohong R. Pharoah, Paul D. P. Wessels, Lodewyk F. A. Bader, Gary D. Easton, Douglas F. Schmidt, Marjanka K. |
| author2_role | author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| author_browse | Abraham, Jean Andrulis, Irene L Andrulis, Irene L. Anton-Culver, Hoda Arndt, Volker Ashworth, Alan Auer, Paul L Auer, Paul L. Auvinen, Päivi Bader, Gary D Bader, Gary D. Beckmann, Matthias W Beckmann, Matthias W. Beesley, Jonathan Behrens, Sabine Benitez, Javier Bermisheva, Marina Blomqvist, Carl Blot, William Bogdanova, Natalia V Bogdanova, Natalia V. Bojesen, Stig E Bojesen, Stig E. Bolla, Manjeet K Bolla, Manjeet K. Brauch, Hiltrud Brenner, Hermann Brucker, Sara Y Brucker, Sara Y. Burwinkel, Barbara Børresen-Dale, Anne-Lise Caldas, Carlos Canisius, Sander Canzian, Federico Chang-Claude, Jenny Chanock, Stephen J Chanock, Stephen J. Chenevix-Trench, Georgia Chin, Suet-Feung Clarke, Christine L Clarke, Christine L. Couch, Fergus J Couch, Fergus J. Cox, Angela Cross, Simon S Cross, Simon S. Czene, Kamila Daly, Mary B Daly, Mary B. Dennis, Joe Devilee, Peter Dunn, Janet A Dunn, Janet A. Dunning, Alison M Dunning, Alison M. Dwek, Miriam Dörk, Thilo Earl, Helena M Earl, Helena M. Easton, Douglas F Easton, Douglas F. Eccles, Diana M Eccles, Diana M. Eliassen, A Heather Eliassen, A. Heather Ellberg, Carolina Escala-Garcia, Maria Evans, D Gareth Evans, D. Gareth Fasching, Peter A Fasching, Peter A. Figueroa, Jonine Flyger, Henrik Gago-Dominguez, Manuela Gapstur, Susan M Gapstur, Susan M. García-Closas, Montserrat García-Sáenz, José A García-Sáenz, José A. Gaudet, Mia M Gaudet, Mia M. George, Angela Giles, Graham G Giles, Graham G. Goldgar, David E Goldgar, David E. Gonzalez Neira, Anna González-Neira, Anna Grip, Mervi Guo, Qi Guénel, Pascal Haiman, Christopher A Haiman, Christopher A. Hall, Per Hamann, Ute Harrington, Patricia A Harrington, Patricia A. Hiller, Louise Hooning, Maartje J Hooning, Maartje J. Hopper, John L Hopper, John L. Howell, Anthony Huang, Chiun-Sheng Huang, Guanmengqian Hunter, David J Hunter, David J. Håkansson, Niclas Jakubowska, Anna John, Esther M John, Esther M. Kaaks, Rudolf Kapoor, Pooja Middha Keeman, Renske Kitahara, Cari M Kitahara, Cari M. Koppert, Linetta B Kraft, Peter Kristensen, Vessela N Lambrechts, Diether Le Marchand, Loic Lejbkowicz, Flavio Lindblom, Annika Lubiński, Jan Mannermaa, Arto Manoochehri, Mehdi Manoukian, Siranoush Margolin, Sara Martinez, Maria Elena Maurer, Tabea Mavroudis, Dimitrios Meindl, Alfons Milne, Roger L Milne, Roger L. Mulligan, Anna Marie Neuhausen, Susan L Neuhausen, Susan L. Nevanlinna, Heli Newman, William G Newman, William G. Olshan, Andrew F Olshan, Andrew F. Olson, Janet E Olson, Janet E. Olsson, Håkan Orr, Nick Peterlongo, Paolo Petridis, Christos Pharoah, Paul D P Pharoah, Paul D. P. Prentice, Ross L Prentice, Ross L. Presneau, Nadege Punie, Kevin Ramachandran, Dhanya Rennert, Gad Romero, Atocha Sachchithananthan, Mythily Saloustros, Emmanouil Sawyer, Elinor J Sawyer, Elinor J. Schmidt, Marjanka K Schmidt, Marjanka K. Schmutzler, Rita K Schmutzler, Rita K. Schwentner, Lukas Scott, Christopher Simard, Jacques Sohn, Christof Southey, Melissa C Southey, Melissa C. Swerdlow, Anthony J Swerdlow, Anthony J. Tamimi, Rulla M Tamimi, Rulla M. Tapper, William J Tapper, William J. Teixeira, Manuel R Terry, Mary Beth Thorne, Heather Tollenaar, Rob A E M Tollenaar, Rob A. E. M. Tomlinson, Ian Troester, Melissa A Troester, Melissa A. Truong, Thérèse Turnbull, Clare Vachon, Celine M Vachon, Celine M. Wang, Qin Wessels, Lodewyk F A Wessels, Lodewyk F. A. Winqvist, Robert Wolk, Alicja Yang, Xiaohong R Yang, Xiaohong R. Ziogas, Argyrios van der Kolk, Lizet E van der Kolk, Lizet E. |
| author_facet | Escala-Garcia, Maria Abraham, Jean Andrulis, Irene L Anton-Culver, Hoda Arndt, Volker Ashworth, Alan Auer, Paul L Auvinen, Päivi Beckmann, Matthias W Beesley, Jonathan Behrens, Sabine Benitez, Javier Bermisheva, Marina Blomqvist, Carl Blot, William Bogdanova, Natalia V Bojesen, Stig E Bolla, Manjeet K Børresen-Dale, Anne-Lise Brauch, Hiltrud Brenner, Hermann Brucker, Sara Y Burwinkel, Barbara Caldas, Carlos Canzian, Federico Chang-Claude, Jenny Chanock, Stephen J Chin, Suet-Feung Clarke, Christine L Couch, Fergus J Cox, Angela Cross, Simon S Czene, Kamila Daly, Mary B Dennis, Joe Devilee, Peter Dunn, Janet A Dunning, Alison M Dwek, Miriam Earl, Helena M Eccles, Diana M Eliassen, A Heather Ellberg, Carolina Evans, D Gareth Fasching, Peter A Figueroa, Jonine Flyger, Henrik Gago-Dominguez, Manuela Gapstur, Susan M García-Closas, Montserrat García-Sáenz, José A Gaudet, Mia M George, Angela Giles, Graham G Goldgar, David E González-Neira, Anna Grip, Mervi Guénel, Pascal Guo, Qi Haiman, Christopher A Håkansson, Niclas Hamann, Ute Harrington, Patricia A Hiller, Louise Hooning, Maartje J Hopper, John L Howell, Anthony Huang, Chiun-Sheng Huang, Guanmengqian Hunter, David J Jakubowska, Anna John, Esther M Kaaks, Rudolf Kapoor, Pooja Middha Keeman, Renske Kitahara, Cari M Kraft, Peter Lambrechts, Diether Le Marchand, Loic Lejbkowicz, Flavio Lindblom, Annika Lubiński, Jan Mannermaa, Arto Manoochehri, Mehdi Manoukian, Siranoush Margolin, Sara Martinez, Maria Elena Maurer, Tabea Mavroudis, Dimitrios Meindl, Alfons Milne, Roger L Mulligan, Anna Marie Neuhausen, Susan L Nevanlinna, Heli Newman, William G Olshan, Andrew F Olson, Janet E Olsson, Håkan Orr, Nick Peterlongo, Paolo Petridis, Christos Prentice, Ross L Presneau, Nadege Punie, Kevin Ramachandran, Dhanya Rennert, Gad Romero, Atocha Sachchithananthan, Mythily Saloustros, Emmanouil Sawyer, Elinor J Schmutzler, Rita K Schwentner, Lukas Scott, Christopher Simard, Jacques Sohn, Christof Southey, Melissa C Swerdlow, Anthony J Tamimi, Rulla M Tapper, William J Teixeira, Manuel R Terry, Mary Beth Thorne, Heather Tollenaar, Rob A E M Tomlinson, Ian Troester, Melissa A Truong, Thérèse Turnbull, Clare Vachon, Celine M van der Kolk, Lizet E Wang, Qin Winqvist, Robert Wolk, Alicja Yang, Xiaohong R Ziogas, Argyrios Pharoah, Paul D P Hall, Per Wessels, Lodewyk F A Chenevix-Trench, Georgia Bader, Gary D Dörk, Thilo Easton, Douglas F Canisius, Sander Schmidt, Marjanka K Gonzalez Neira, Anna Andrulis, Irene L. Auer, Paul L. Beckmann, Matthias W. Bogdanova, Natalia V. Bojesen, Stig E. Bolla, Manjeet K. Brucker, Sara Y. Chanock, Stephen J. Clarke, Christine L. Couch, Fergus J. Cross, Simon S. Daly, Mary B. Dunn, Janet A. Dunning, Alison M. Earl, Helena M. Eccles, Diana M. Eliassen, A. Heather Evans, D. Gareth Fasching, Peter A. Gapstur, Susan M. García-Sáenz, José A. Gaudet, Mia M. Giles, Graham G. Goldgar, David E. Haiman, Christopher A. Harrington, Patricia A. Hooning, Maartje J. Hopper, John L. Hunter, David J. John, Esther M. Kitahara, Cari M. Koppert, Linetta B Kristensen, Vessela N Milne, Roger L. Neuhausen, Susan L. Newman, William G. Olshan, Andrew F. Olson, Janet E. Prentice, Ross L. Sawyer, Elinor J. Schmutzler, Rita K. Southey, Melissa C. Swerdlow, Anthony J. Tamimi, Rulla M. Tapper, William J. Tollenaar, Rob A. E. M. Troester, Melissa A. Vachon, Celine M. van der Kolk, Lizet E. Yang, Xiaohong R. Pharoah, Paul D. P. Wessels, Lodewyk F. A. Bader, Gary D. Easton, Douglas F. Schmidt, Marjanka K. |
| author_role | author |
| collection | Repisalud |
| description | Identifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the potential function of germline variants in breast cancer prognosis. This network-based analysis studies ~7.3 million variants in 84,457 breast cancer patients in relation to breast cancer survival and confirms the results on 12,381 independent patients. Aggregating the prognostic effects of genetic variants across multiple genes, we identify four gene modules associated with survival in estrogen receptor (ER)-negative and one in ER-positive disease. The modules show biological enrichment for cancer-related processes such as G-alpha signaling, circadian clock, angiogenesis, and Rho-GTPases in apoptosis. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_4e90fa852f8244b157b13a8ffbbcf0ae |
| institution | Instituto de Salud Carlos III (ISCIII) |
| instname_str | Instituto de Salud Carlos III (ISCIII) |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:repisalud.isciii.es:20.500.12105/12181 |
| publishDate | 2020 |
| publishDateSort | 2020 |
| publisher | Nature Publishing Group |
| publisherStr | Nature Publishing Group |
| reponame_str | Repisalud |
| spelling | A network analysis to identify mediators of germline-driven differences in breast cancer prognosis. Escala-Garcia, Maria Abraham, Jean Andrulis, Irene L Anton-Culver, Hoda Arndt, Volker Ashworth, Alan Auer, Paul L Auvinen, Päivi Beckmann, Matthias W Beesley, Jonathan Behrens, Sabine Benitez, Javier Bermisheva, Marina Blomqvist, Carl Blot, William Bogdanova, Natalia V Bojesen, Stig E Bolla, Manjeet K Børresen-Dale, Anne-Lise Brauch, Hiltrud Brenner, Hermann Brucker, Sara Y Burwinkel, Barbara Caldas, Carlos Canzian, Federico Chang-Claude, Jenny Chanock, Stephen J Chin, Suet-Feung Clarke, Christine L Couch, Fergus J Cox, Angela Cross, Simon S Czene, Kamila Daly, Mary B Dennis, Joe Devilee, Peter Dunn, Janet A Dunning, Alison M Dwek, Miriam Earl, Helena M Eccles, Diana M Eliassen, A Heather Ellberg, Carolina Evans, D Gareth Fasching, Peter A Figueroa, Jonine Flyger, Henrik Gago-Dominguez, Manuela Gapstur, Susan M García-Closas, Montserrat García-Sáenz, José A Gaudet, Mia M George, Angela Giles, Graham G Goldgar, David E González-Neira, Anna Grip, Mervi Guénel, Pascal Guo, Qi Haiman, Christopher A Håkansson, Niclas Hamann, Ute Harrington, Patricia A Hiller, Louise Hooning, Maartje J Hopper, John L Howell, Anthony Huang, Chiun-Sheng Huang, Guanmengqian Hunter, David J Jakubowska, Anna John, Esther M Kaaks, Rudolf Kapoor, Pooja Middha Keeman, Renske Kitahara, Cari M Kraft, Peter Lambrechts, Diether Le Marchand, Loic Lejbkowicz, Flavio Lindblom, Annika Lubiński, Jan Mannermaa, Arto Manoochehri, Mehdi Manoukian, Siranoush Margolin, Sara Martinez, Maria Elena Maurer, Tabea Mavroudis, Dimitrios Meindl, Alfons Milne, Roger L Mulligan, Anna Marie Neuhausen, Susan L Nevanlinna, Heli Newman, William G Olshan, Andrew F Olson, Janet E Olsson, Håkan Orr, Nick Peterlongo, Paolo Petridis, Christos Prentice, Ross L Presneau, Nadege Punie, Kevin Ramachandran, Dhanya Rennert, Gad Romero, Atocha Sachchithananthan, Mythily Saloustros, Emmanouil Sawyer, Elinor J Schmutzler, Rita K Schwentner, Lukas Scott, Christopher Simard, Jacques Sohn, Christof Southey, Melissa C Swerdlow, Anthony J Tamimi, Rulla M Tapper, William J Teixeira, Manuel R Terry, Mary Beth Thorne, Heather Tollenaar, Rob A E M Tomlinson, Ian Troester, Melissa A Truong, Thérèse Turnbull, Clare Vachon, Celine M van der Kolk, Lizet E Wang, Qin Winqvist, Robert Wolk, Alicja Yang, Xiaohong R Ziogas, Argyrios Pharoah, Paul D P Hall, Per Wessels, Lodewyk F A Chenevix-Trench, Georgia Bader, Gary D Dörk, Thilo Easton, Douglas F Canisius, Sander Schmidt, Marjanka K Gonzalez Neira, Anna Andrulis, Irene L. Auer, Paul L. Beckmann, Matthias W. Bogdanova, Natalia V. Bojesen, Stig E. Bolla, Manjeet K. Brucker, Sara Y. Chanock, Stephen J. Clarke, Christine L. Couch, Fergus J. Cross, Simon S. Daly, Mary B. Dunn, Janet A. Dunning, Alison M. Earl, Helena M. Eccles, Diana M. Eliassen, A. Heather Evans, D. Gareth Fasching, Peter A. Gapstur, Susan M. García-Sáenz, José A. Gaudet, Mia M. Giles, Graham G. Goldgar, David E. Haiman, Christopher A. Harrington, Patricia A. Hooning, Maartje J. Hopper, John L. Hunter, David J. John, Esther M. Kitahara, Cari M. Koppert, Linetta B Kristensen, Vessela N Milne, Roger L. Neuhausen, Susan L. Newman, William G. Olshan, Andrew F. Olson, Janet E. Prentice, Ross L. Sawyer, Elinor J. Schmutzler, Rita K. Southey, Melissa C. Swerdlow, Anthony J. Tamimi, Rulla M. Tapper, William J. Tollenaar, Rob A. E. M. Troester, Melissa A. Vachon, Celine M. van der Kolk, Lizet E. Yang, Xiaohong R. Pharoah, Paul D. P. Wessels, Lodewyk F. A. Bader, Gary D. Easton, Douglas F. Schmidt, Marjanka K. Genetic Variation Genome-Wide Association Study Germ Cells Apoptosis Breast Neoplasms Circadian Clocks Computational Biology Female GTP-Binding Protein alpha Subunits GTP-Binding Protein alpha Subunits, Gq-G11 Gene Regulatory Networks Genotype Humans Prognosis Receptors, Estrogen Signal Transduction Identifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the potential function of germline variants in breast cancer prognosis. This network-based analysis studies ~7.3 million variants in 84,457 breast cancer patients in relation to breast cancer survival and confirms the results on 12,381 independent patients. Aggregating the prognostic effects of genetic variants across multiple genes, we identify four gene modules associated with survival in estrogen receptor (ER)-negative and one in ER-positive disease. The modules show biological enrichment for cancer-related processes such as G-alpha signaling, circadian clock, angiogenesis, and Rho-GTPases in apoptosis. Nature Publishing Group http://hdl.handle.net/20.500.12105/12181 |
| spellingShingle | A network analysis to identify mediators of germline-driven differences in breast cancer prognosis. Escala-Garcia, Maria Genetic Variation Genome-Wide Association Study Germ Cells Apoptosis Breast Neoplasms Circadian Clocks Computational Biology Female GTP-Binding Protein alpha Subunits GTP-Binding Protein alpha Subunits, Gq-G11 Gene Regulatory Networks Genotype Humans Prognosis Receptors, Estrogen Signal Transduction |
| title | A network analysis to identify mediators of germline-driven differences in breast cancer prognosis. |
| title_full | A network analysis to identify mediators of germline-driven differences in breast cancer prognosis. |
| title_fullStr | A network analysis to identify mediators of germline-driven differences in breast cancer prognosis. |
| title_full_unstemmed | A network analysis to identify mediators of germline-driven differences in breast cancer prognosis. |
| title_short | A network analysis to identify mediators of germline-driven differences in breast cancer prognosis. |
| title_sort | A network analysis to identify mediators of germline-driven differences in breast cancer prognosis. |
| topic | Genetic Variation Genome-Wide Association Study Germ Cells Apoptosis Breast Neoplasms Circadian Clocks Computational Biology Female GTP-Binding Protein alpha Subunits GTP-Binding Protein alpha Subunits, Gq-G11 Gene Regulatory Networks Genotype Humans Prognosis Receptors, Estrogen Signal Transduction |
| topic_facet | Genetic Variation Genome-Wide Association Study Germ Cells Apoptosis Breast Neoplasms Circadian Clocks Computational Biology Female GTP-Binding Protein alpha Subunits GTP-Binding Protein alpha Subunits, Gq-G11 Gene Regulatory Networks Genotype Humans Prognosis Receptors, Estrogen Signal Transduction |
| url | http://hdl.handle.net/20.500.12105/12181 |