EQD2 Analyses of Vaginal Complications in Exclusive Brachytherapy for Postoperative Endometrial Carcinoma
Background: To evaluate whether EQD2(α/β = 3Gy) at 2 cm3 of the most exposed area of the vagina is related to late vaginal toxicity in postoperative endometrial cancer (PEC) patients (p) treated with exclusive brachytherapy (BT). Methods: From 2014 to 2017, 43p were included in this study. BT was ad...
| Autores: | ; ; ; ; ; ; ; ; ; ; ; ; ; |
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| Tipo de documento: | Artículo |
| Estado: | Published version |
| Fecha de publicación: | 2020 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/179352 |
| Acceso en línea: | https://hdl.handle.net/2445/179352 |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | Càncer d'endometri Radioteràpia Endometrial cancer Radiotherapy |
| _version_ | 1878733009741414400 |
|---|---|
| author | Zhang, Yaowen |
| author2 | Fornes, Balbino Gómez, Gabriela Bentoldrà, Irene Carmona, Clara Herreros, Antonio Sabater, Sebastià Nicolás, Inmaculada Li, Yan Sánchez, Joan Biete Solà, Albert Torné Bladé, Aureli Ascaso Terrén, Carlos Rovirosa Casino, Angeles |
| author2_role | author author author author author author author author author author author author author |
| author_browse | Ascaso Terrén, Carlos Bentoldrà, Irene Biete Solà, Albert Carmona, Clara Fornes, Balbino Gómez, Gabriela Herreros, Antonio Li, Yan Nicolás, Inmaculada Rovirosa Casino, Angeles Sabater, Sebastià Sánchez, Joan Torné Bladé, Aureli Zhang, Yaowen |
| author_facet | Zhang, Yaowen Fornes, Balbino Gómez, Gabriela Bentoldrà, Irene Carmona, Clara Herreros, Antonio Sabater, Sebastià Nicolás, Inmaculada Li, Yan Sánchez, Joan Biete Solà, Albert Torné Bladé, Aureli Ascaso Terrén, Carlos Rovirosa Casino, Angeles |
| author_role | author |
| collection | Recercat. Dipósit de la Recerca de Catalunya |
| description | Background: To evaluate whether EQD2(α/β = 3Gy) at 2 cm3 of the most exposed area of the vagina is related to late vaginal toxicity in postoperative endometrial cancer (PEC) patients (p) treated with exclusive brachytherapy (BT). Methods: From 2014 to 2017, 43p were included in this study. BT was administered: 3-fractions of 6Gy in 37p and 2-fractions of 7.5Gy in 6p. The dose was prescribed at a depth of 5 mm from the applicator surface with dose-point optimization based on distance. The active treatment length was 2.5 cm. CTV-D90 and the dose to the most exposed 2 cm3 of the vagina was calculated for each patient. Late toxicity of the bladder and rectum was assessed using Radiation Therapy Oncology Group (RTOG) criteria, and vaginal toxicity by objective Late Effects Normal Tissue Task Force (LENT)-Subjective, Objective, Management, Analytic (SOMA) (LENT-SOMA) criteria. Statistics: frequency tables, mean, median, range, standard deviation, and box plot. Results: The median follow-up was 51 months (12-68). 20 p (46.5%) and 2 p (4.7%) developed G1 and G2 vaginal complications, respectively. Only 1/2 p-G2 receiving EQD2(α/β = 3Gy) at 2 cm3 >68Gy presented vaginal shortening and 18/20 p-G1 received doses < 68Gy. Conclusions: PECp receiving exclusive brachytherapy with doses < 68Gy EQD2(α/β = 3Gy) at 2 cm2 of the vagina presented only G0-G1 vaginal toxicity, except for one with bleeding telangiectasias. Larger prospective studies are necessary to confirm the present results. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_4e51197360bb8df715a0cc4e9c272c2d |
| institution | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:recercat.cat:2445/179352 |
| publishDate | 2020 |
| publishDateSort | 2020 |
| publisher | MDPI |
| publisherStr | MDPI |
| reponame_str | Recercat. Dipósit de la Recerca de Catalunya |
| spelling | EQD2 Analyses of Vaginal Complications in Exclusive Brachytherapy for Postoperative Endometrial Carcinoma Zhang, Yaowen Fornes, Balbino Gómez, Gabriela Bentoldrà, Irene Carmona, Clara Herreros, Antonio Sabater, Sebastià Nicolás, Inmaculada Li, Yan Sánchez, Joan Biete Solà, Albert Torné Bladé, Aureli Ascaso Terrén, Carlos Rovirosa Casino, Angeles Càncer d'endometri Radioteràpia Endometrial cancer Radiotherapy Background: To evaluate whether EQD2(α/β = 3Gy) at 2 cm3 of the most exposed area of the vagina is related to late vaginal toxicity in postoperative endometrial cancer (PEC) patients (p) treated with exclusive brachytherapy (BT). Methods: From 2014 to 2017, 43p were included in this study. BT was administered: 3-fractions of 6Gy in 37p and 2-fractions of 7.5Gy in 6p. The dose was prescribed at a depth of 5 mm from the applicator surface with dose-point optimization based on distance. The active treatment length was 2.5 cm. CTV-D90 and the dose to the most exposed 2 cm3 of the vagina was calculated for each patient. Late toxicity of the bladder and rectum was assessed using Radiation Therapy Oncology Group (RTOG) criteria, and vaginal toxicity by objective Late Effects Normal Tissue Task Force (LENT)-Subjective, Objective, Management, Analytic (SOMA) (LENT-SOMA) criteria. Statistics: frequency tables, mean, median, range, standard deviation, and box plot. Results: The median follow-up was 51 months (12-68). 20 p (46.5%) and 2 p (4.7%) developed G1 and G2 vaginal complications, respectively. Only 1/2 p-G2 receiving EQD2(α/β = 3Gy) at 2 cm3 >68Gy presented vaginal shortening and 18/20 p-G1 received doses < 68Gy. Conclusions: PECp receiving exclusive brachytherapy with doses < 68Gy EQD2(α/β = 3Gy) at 2 cm2 of the vagina presented only G0-G1 vaginal toxicity, except for one with bleeding telangiectasias. Larger prospective studies are necessary to confirm the present results. MDPI https://hdl.handle.net/2445/179352 |
| spellingShingle | EQD2 Analyses of Vaginal Complications in Exclusive Brachytherapy for Postoperative Endometrial Carcinoma Zhang, Yaowen Càncer d'endometri Radioteràpia Endometrial cancer Radiotherapy |
| status_str | publishedVersion |
| title | EQD2 Analyses of Vaginal Complications in Exclusive Brachytherapy for Postoperative Endometrial Carcinoma |
| title_full | EQD2 Analyses of Vaginal Complications in Exclusive Brachytherapy for Postoperative Endometrial Carcinoma |
| title_fullStr | EQD2 Analyses of Vaginal Complications in Exclusive Brachytherapy for Postoperative Endometrial Carcinoma |
| title_full_unstemmed | EQD2 Analyses of Vaginal Complications in Exclusive Brachytherapy for Postoperative Endometrial Carcinoma |
| title_short | EQD2 Analyses of Vaginal Complications in Exclusive Brachytherapy for Postoperative Endometrial Carcinoma |
| title_sort | EQD2 Analyses of Vaginal Complications in Exclusive Brachytherapy for Postoperative Endometrial Carcinoma |
| topic | Càncer d'endometri Radioteràpia Endometrial cancer Radiotherapy |
| topic_facet | Càncer d'endometri Radioteràpia Endometrial cancer Radiotherapy |
| url | https://hdl.handle.net/2445/179352 |