Gut IgA functionally interacts with systemic IgG to enhance antipneumococcal vaccine responses
The gut microbiota enhances systemic immunoglobulin G (IgG) responses to vaccines, but it is unknown whether this effect involves IgA, which coats intestinal microbes. That IgA may amplify postimmune IgG production is suggested by the impaired IgG response to pneumococcal vaccines in some IgA-defici...
| Autores: | ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; |
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| Tipo de documento: | Artículo |
| Estado: | Published version |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/219500 |
| Acceso en línea: | https://hdl.handle.net/2445/219500 |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | Immunoglobulina G Microbiota intestinal Immunoglobulina A Vacuna antipneumocòccica Immunoglobulin G Gastrointestinal microbiome Immunoglobulin A Pneumococcal vaccine |
| _version_ | 1878732920558977025 |
|---|---|
| author | Gutzeit, Cindy |
| author2 | Grasset, Emilie K. Matthews, Dean B. Maglione, Paul J. Britton, Graham J. Miller, Halley Magri, Giuliana Tomalin, Lewis Stapylton, Matthew Canales Herrerias, Pablo Sominskaia, Musia Guzman, Mauricio Pybus, Marc Tejedor Vaquero, Sonia Radigan, Lin Tachó Piñot, Roser Martín Nalda, Andrea García Prat, Marina Martínez Gallo, Mónica Dieli Crimi, Romina Clemente, José C. Mehandru, Saurabh Suárez Farinas, Mayte Faith, Jeremiah J. Cunningham-Rundles, Charlotte Cerutti, Andrea |
| author2_role | author author author author author author author author author author author author author author author author author author author author author author author author author |
| author_browse | Britton, Graham J. Canales Herrerias, Pablo Cerutti, Andrea Clemente, José C. Cunningham-Rundles, Charlotte Dieli Crimi, Romina Faith, Jeremiah J. García Prat, Marina Grasset, Emilie K. Gutzeit, Cindy Guzman, Mauricio Maglione, Paul J. Magri, Giuliana Martín Nalda, Andrea Martínez Gallo, Mónica Matthews, Dean B. Mehandru, Saurabh Miller, Halley Pybus, Marc Radigan, Lin Sominskaia, Musia Stapylton, Matthew Suárez Farinas, Mayte Tachó Piñot, Roser Tejedor Vaquero, Sonia Tomalin, Lewis |
| author_facet | Gutzeit, Cindy Grasset, Emilie K. Matthews, Dean B. Maglione, Paul J. Britton, Graham J. Miller, Halley Magri, Giuliana Tomalin, Lewis Stapylton, Matthew Canales Herrerias, Pablo Sominskaia, Musia Guzman, Mauricio Pybus, Marc Tejedor Vaquero, Sonia Radigan, Lin Tachó Piñot, Roser Martín Nalda, Andrea García Prat, Marina Martínez Gallo, Mónica Dieli Crimi, Romina Clemente, José C. Mehandru, Saurabh Suárez Farinas, Mayte Faith, Jeremiah J. Cunningham-Rundles, Charlotte Cerutti, Andrea |
| author_role | author |
| collection | Recercat. Dipósit de la Recerca de Catalunya |
| description | The gut microbiota enhances systemic immunoglobulin G (IgG) responses to vaccines, but it is unknown whether this effect involves IgA, which coats intestinal microbes. That IgA may amplify postimmune IgG production is suggested by the impaired IgG response to pneumococcal vaccines in some IgA-deficient patients. Here, we found that antipneumococcal but not total IgG production was impaired in mice with IgA deficiency. The positive effect of gut IgA on antipneumococcal IgG responses started very early in life and could implicate gut bacteria, as these responses were attenuated in germ-free mice recolonized with gut microbes from IgA-deficient donors. IgA could exert this effect by constraining the systemic translocation of gut antigens, which was associated with chronic immune activation, including T cell overexpression of programmed cell death protein 1 (PD-1). This inhibitory receptor may attenuate antipneumococcal IgG production by causing B cell hyporesponsiveness, which improved upon anti-PD-1 treatment. Thus, gut IgA functionally interacts with systemic IgG to enhance antipneumococcal vaccine responses |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_4c7790260e4e4b2f0c5bd2aa72729db6 |
| institution | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:recercat.cat:2445/219500 |
| publishDate | 2025 |
| publishDateSort | 2025 |
| publisher | American Association for the Advancement of Science |
| publisherStr | American Association for the Advancement of Science |
| reponame_str | Recercat. Dipósit de la Recerca de Catalunya |
| spelling | Gut IgA functionally interacts with systemic IgG to enhance antipneumococcal vaccine responses Gutzeit, Cindy Grasset, Emilie K. Matthews, Dean B. Maglione, Paul J. Britton, Graham J. Miller, Halley Magri, Giuliana Tomalin, Lewis Stapylton, Matthew Canales Herrerias, Pablo Sominskaia, Musia Guzman, Mauricio Pybus, Marc Tejedor Vaquero, Sonia Radigan, Lin Tachó Piñot, Roser Martín Nalda, Andrea García Prat, Marina Martínez Gallo, Mónica Dieli Crimi, Romina Clemente, José C. Mehandru, Saurabh Suárez Farinas, Mayte Faith, Jeremiah J. Cunningham-Rundles, Charlotte Cerutti, Andrea Immunoglobulina G Microbiota intestinal Immunoglobulina A Vacuna antipneumocòccica Immunoglobulin G Gastrointestinal microbiome Immunoglobulin A Pneumococcal vaccine The gut microbiota enhances systemic immunoglobulin G (IgG) responses to vaccines, but it is unknown whether this effect involves IgA, which coats intestinal microbes. That IgA may amplify postimmune IgG production is suggested by the impaired IgG response to pneumococcal vaccines in some IgA-deficient patients. Here, we found that antipneumococcal but not total IgG production was impaired in mice with IgA deficiency. The positive effect of gut IgA on antipneumococcal IgG responses started very early in life and could implicate gut bacteria, as these responses were attenuated in germ-free mice recolonized with gut microbes from IgA-deficient donors. IgA could exert this effect by constraining the systemic translocation of gut antigens, which was associated with chronic immune activation, including T cell overexpression of programmed cell death protein 1 (PD-1). This inhibitory receptor may attenuate antipneumococcal IgG production by causing B cell hyporesponsiveness, which improved upon anti-PD-1 treatment. Thus, gut IgA functionally interacts with systemic IgG to enhance antipneumococcal vaccine responses American Association for the Advancement of Science https://hdl.handle.net/2445/219500 |
| spellingShingle | Gut IgA functionally interacts with systemic IgG to enhance antipneumococcal vaccine responses Gutzeit, Cindy Immunoglobulina G Microbiota intestinal Immunoglobulina A Vacuna antipneumocòccica Immunoglobulin G Gastrointestinal microbiome Immunoglobulin A Pneumococcal vaccine |
| status_str | publishedVersion |
| title | Gut IgA functionally interacts with systemic IgG to enhance antipneumococcal vaccine responses |
| title_full | Gut IgA functionally interacts with systemic IgG to enhance antipneumococcal vaccine responses |
| title_fullStr | Gut IgA functionally interacts with systemic IgG to enhance antipneumococcal vaccine responses |
| title_full_unstemmed | Gut IgA functionally interacts with systemic IgG to enhance antipneumococcal vaccine responses |
| title_short | Gut IgA functionally interacts with systemic IgG to enhance antipneumococcal vaccine responses |
| title_sort | Gut IgA functionally interacts with systemic IgG to enhance antipneumococcal vaccine responses |
| topic | Immunoglobulina G Microbiota intestinal Immunoglobulina A Vacuna antipneumocòccica Immunoglobulin G Gastrointestinal microbiome Immunoglobulin A Pneumococcal vaccine |
| topic_facet | Immunoglobulina G Microbiota intestinal Immunoglobulina A Vacuna antipneumocòccica Immunoglobulin G Gastrointestinal microbiome Immunoglobulin A Pneumococcal vaccine |
| url | https://hdl.handle.net/2445/219500 |