Reduced Dose Intravesical Bacillus Calmette-Guerin: Why It Might Not Matter

When it comes to the treatment of patients with non-muscle-invasive bladder cancer (NMIBC) with intravesical bacillus Calmette-Guerin (BCG), two questions must be considered: 1) what dose to give, and 2) for how long? The issue of optimal dose and duration has been the subject of several randomized...

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Detalles Bibliográficos
Autores: Kamat, AM; Lobo, N; Lerner, SP; Li, R; Matulay, JT; Palou, J; Witjes, JA; Roupret, M; Smith, AB; Chang, SS; Shore, ND; Steinberg, GD; Dinney, CP; Svatek, RS; Lamm, DL
Tipo de documento: Artículo
Estado:Published version
Fecha de publicación:2022
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p11269
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=11269
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85131789813&doi=10.3233%2fBLC-211648&partnerID=40&md5=f5c0502c5f5f3bb4948d7389c466f5d1
Nivel de acceso:Acceso abierto
Palabra clave:Non-muscle-invasive bladder cancer
bacillus Calmette-Guerin
reduced dose
immunotherapy
Descripción
Sumario:When it comes to the treatment of patients with non-muscle-invasive bladder cancer (NMIBC) with intravesical bacillus Calmette-Guerin (BCG), two questions must be considered: 1) what dose to give, and 2) for how long? The issue of optimal dose and duration has been the subject of several randomized trials and is especially pertinent in the context of a global BCG shortage. Despite this, there appears to be uncertainty as to whether BCG dose or duration may be compromised in the event of shortage. As such, we wish to summarize the available evidence as an aid to the practicing urologist.