Health-related quality of life in men with prostate cancer undergoing active surveillance versus radical prostatectomy, external-beam radiotherapy, prostate brachytherapy and reference population: a cross-sectional study
BACKGROUND: The purpose of this study is to describe Health-Related Quality of Life (HRQoL) of localized prostate cancer patients in an Active Surveillance (AS) program, and to compare them with those undergoing radical prostatectomy (RP), external-beam radiotherapy (XRT) and brachytherapy (BT). MET...
| Authors: | ; ; ; ; ; ; ; ; ; |
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| Format: | Article |
| Status: | Published version |
| Publication date: | 2019 |
| Country: | España |
| Institution: | Universitat Pompeu Fabra |
| Repository: | Repositorio Digital de la UPF |
| OAI Identifier: | oai:repositori.upf.edu:10230/37243 |
| Online Access: | http://hdl.handle.net/10230/37243 http://dx.doi.org/10.1186/s12955-019-1082-4 |
| Access Level: | Open access |
| Keyword: | Prostatectomia Pròstata -- Càncer Active surveillance Brachytherapy External-beam radiotherapy Health-related quality of life Radical prostatectomy |
| _version_ | 1878732852002029568 |
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| author | Sureda Gomila, Antoni |
| author2 | Fumadó Ciutat, Lluis Ferrer Forés, Maria Montserrat Garin Boronat, Olatz, 1979- Bonet, X. Mir, M.C. Abascal-Junquera, José María Vigués, F. Cecchini Rosell, Lluís Suárez Novo, José Francisco |
| author2_role | author author author author author author author author author |
| author_browse | Abascal-Junquera, José María Bonet, X. Cecchini Rosell, Lluís Ferrer Forés, Maria Montserrat Fumadó Ciutat, Lluis Garin Boronat, Olatz, 1979- Mir, M.C. Sureda Gomila, Antoni Suárez Novo, José Francisco Vigués, F. |
| author_facet | Sureda Gomila, Antoni Fumadó Ciutat, Lluis Ferrer Forés, Maria Montserrat Garin Boronat, Olatz, 1979- Bonet, X. Mir, M.C. Abascal-Junquera, José María Vigués, F. Cecchini Rosell, Lluís Suárez Novo, José Francisco |
| author_role | author |
| collection | Repositorio Digital de la UPF |
| description | BACKGROUND: The purpose of this study is to describe Health-Related Quality of Life (HRQoL) of localized prostate cancer patients in an Active Surveillance (AS) program, and to compare them with those undergoing radical prostatectomy (RP), external-beam radiotherapy (XRT) and brachytherapy (BT). METHODS: Multi-institutional pooled cross-sectional analysis on patients in an AS protocol: < 75 years old; pathologically confirmed LPC (maximum of three positive cylinders); Gleason score < 3 + 4; clinical stage T1a-T2b; and PSA < 15 ng/ml. Exclusion criteria for this study were: less than 6 months in AS, termination of AS protocol, or incomplete data. Patients in AS were matched with those treated with RP, XRT or BT from the 'Spanish Multicentric Study of Clinically Localized Prostate Cancer' cohort according to risk group, time from treatment selection to HRQoL survey, and age. Prostate-specific (EPIC) and generic (SF-36) HRQoL instruments were completed. Analysis was stratified by HRQoL survey moment (>or < 2.5 years from treatment selection), and age (>or < 70 years old). RESULTS: Median of time from treatment selection to HRQoL survey in the total 396 patients (99 per treatment group) was 2.4 years (range 0.5-8.3). Patients in AS presented higher (better) urinary incontinence scores than RP ones in both stratus of time from treatment selection to HRQoL survey (92.6 vs 67.0 and 81.4 vs 64.4, p < 0.01). Patients in AS for < 2.5 years presented greater sexual scores than any active treatment (p < 0.01), but only statistically higher than RP for those in AS for longer than 2.5 years. The magnitude of the differences between AS and RP groups in both EPIC domains ranged from moderate (0.7 SD) to large (1.0 SD). Regardless of treatment applied, patients presented similar and slightly increased SF-36 scores than US general population reference norms. Nonetheless, patients in AS for < 2.5 years reported worse outcomes than other treatment groups on physical health domains, especially in bodily pain (0.5-0.6 SD), and vitality (0.6-0.8 SD). CONCLUSIONS: Considering patients' well-being, AS can be a good therapeutic option due to the low impact caused on urinary continence and sexual function. However, longitudinal studies are required to take into account HRQoL evolution over time. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_4b159c8fa26d65bbf3068d4e2aa3f75f |
| institution | Universitat Pompeu Fabra |
| instname_str | Universitat Pompeu Fabra |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:repositori.upf.edu:10230/37243 |
| publishDate | 2019 |
| publishDateSort | 2019 |
| publisher | BioMed Central |
| publisherStr | BioMed Central |
| reponame_str | Repositorio Digital de la UPF |
| spelling | Health-related quality of life in men with prostate cancer undergoing active surveillance versus radical prostatectomy, external-beam radiotherapy, prostate brachytherapy and reference population: a cross-sectional study Sureda Gomila, Antoni Fumadó Ciutat, Lluis Ferrer Forés, Maria Montserrat Garin Boronat, Olatz, 1979- Bonet, X. Mir, M.C. Abascal-Junquera, José María Vigués, F. Cecchini Rosell, Lluís Suárez Novo, José Francisco Prostatectomia Pròstata -- Càncer Active surveillance Brachytherapy External-beam radiotherapy Health-related quality of life Radical prostatectomy BACKGROUND: The purpose of this study is to describe Health-Related Quality of Life (HRQoL) of localized prostate cancer patients in an Active Surveillance (AS) program, and to compare them with those undergoing radical prostatectomy (RP), external-beam radiotherapy (XRT) and brachytherapy (BT). METHODS: Multi-institutional pooled cross-sectional analysis on patients in an AS protocol: < 75 years old; pathologically confirmed LPC (maximum of three positive cylinders); Gleason score < 3 + 4; clinical stage T1a-T2b; and PSA < 15 ng/ml. Exclusion criteria for this study were: less than 6 months in AS, termination of AS protocol, or incomplete data. Patients in AS were matched with those treated with RP, XRT or BT from the 'Spanish Multicentric Study of Clinically Localized Prostate Cancer' cohort according to risk group, time from treatment selection to HRQoL survey, and age. Prostate-specific (EPIC) and generic (SF-36) HRQoL instruments were completed. Analysis was stratified by HRQoL survey moment (>or < 2.5 years from treatment selection), and age (>or < 70 years old). RESULTS: Median of time from treatment selection to HRQoL survey in the total 396 patients (99 per treatment group) was 2.4 years (range 0.5-8.3). Patients in AS presented higher (better) urinary incontinence scores than RP ones in both stratus of time from treatment selection to HRQoL survey (92.6 vs 67.0 and 81.4 vs 64.4, p < 0.01). Patients in AS for < 2.5 years presented greater sexual scores than any active treatment (p < 0.01), but only statistically higher than RP for those in AS for longer than 2.5 years. The magnitude of the differences between AS and RP groups in both EPIC domains ranged from moderate (0.7 SD) to large (1.0 SD). Regardless of treatment applied, patients presented similar and slightly increased SF-36 scores than US general population reference norms. Nonetheless, patients in AS for < 2.5 years reported worse outcomes than other treatment groups on physical health domains, especially in bodily pain (0.5-0.6 SD), and vitality (0.6-0.8 SD). CONCLUSIONS: Considering patients' well-being, AS can be a good therapeutic option due to the low impact caused on urinary continence and sexual function. However, longitudinal studies are required to take into account HRQoL evolution over time. BioMed Central http://hdl.handle.net/10230/37243 http://dx.doi.org/10.1186/s12955-019-1082-4 |
| spellingShingle | Health-related quality of life in men with prostate cancer undergoing active surveillance versus radical prostatectomy, external-beam radiotherapy, prostate brachytherapy and reference population: a cross-sectional study Sureda Gomila, Antoni Prostatectomia Pròstata -- Càncer Active surveillance Brachytherapy External-beam radiotherapy Health-related quality of life Radical prostatectomy |
| status_str | publishedVersion |
| title | Health-related quality of life in men with prostate cancer undergoing active surveillance versus radical prostatectomy, external-beam radiotherapy, prostate brachytherapy and reference population: a cross-sectional study |
| title_full | Health-related quality of life in men with prostate cancer undergoing active surveillance versus radical prostatectomy, external-beam radiotherapy, prostate brachytherapy and reference population: a cross-sectional study |
| title_fullStr | Health-related quality of life in men with prostate cancer undergoing active surveillance versus radical prostatectomy, external-beam radiotherapy, prostate brachytherapy and reference population: a cross-sectional study |
| title_full_unstemmed | Health-related quality of life in men with prostate cancer undergoing active surveillance versus radical prostatectomy, external-beam radiotherapy, prostate brachytherapy and reference population: a cross-sectional study |
| title_short | Health-related quality of life in men with prostate cancer undergoing active surveillance versus radical prostatectomy, external-beam radiotherapy, prostate brachytherapy and reference population: a cross-sectional study |
| title_sort | Health-related quality of life in men with prostate cancer undergoing active surveillance versus radical prostatectomy, external-beam radiotherapy, prostate brachytherapy and reference population: a cross-sectional study |
| topic | Prostatectomia Pròstata -- Càncer Active surveillance Brachytherapy External-beam radiotherapy Health-related quality of life Radical prostatectomy |
| topic_facet | Prostatectomia Pròstata -- Càncer Active surveillance Brachytherapy External-beam radiotherapy Health-related quality of life Radical prostatectomy |
| url | http://hdl.handle.net/10230/37243 http://dx.doi.org/10.1186/s12955-019-1082-4 |