TUP1-mediated filamentation in Candida albicans leads to inability to colonize the mouse gut.
AIM To investigate the role of Candida albicans TUP1-mediated filamentation in the colonization of the mice gut. MATERIALS & METHODS We used molecular genetics to generate a strain where filamentation is regulated by altering the expression of the TUP1 gene with tetracyclines. RESULTS The colonizati...
| Autores: | ; ; ; ; |
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| Tipo de documento: | Artículo |
| Fecha de publicación: | 2018 |
| País: | España |
| Institución: | Universidad Complutense de Madrid (UCM) |
| Repositorio: | Docta Complutense |
| Lenguaje: | Inglés |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/13365 |
| Acceso en línea: | https://hdl.handle.net/20.500.14352/13365 |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | 579 Candida albicans Commensalism Filamentous growth TUP1 Microbiología (Farmacia) 3302.03 Microbiología Industrial |
| _version_ | 1878732795252047872 |
|---|---|
| author | Román González, Elvira |
| author2 | Huertas, Blanca Prieto, Daniel Díez Orejas, Rosalía María Pla Alonso, Jesús |
| author2_role | author author author author |
| author_browse | Díez Orejas, Rosalía María Huertas, Blanca Pla Alonso, Jesús Prieto, Daniel Román González, Elvira |
| author_facet | Román González, Elvira Huertas, Blanca Prieto, Daniel Díez Orejas, Rosalía María Pla Alonso, Jesús |
| author_role | author |
| collection | Docta Complutense |
| description | AIM To investigate the role of Candida albicans TUP1-mediated filamentation in the colonization of the mice gut. MATERIALS & METHODS We used molecular genetics to generate a strain where filamentation is regulated by altering the expression of the TUP1 gene with tetracyclines. RESULTS The colonization rates reached with the TUP1-RFP strain were lower compared with wild-type strain and completely absent after induction of filamentation. No differences in the susceptibility to bile salts nor in the adhesion to the mouse intestine epithelium were observed. CONCLUSION Blockage of C. albicans in a filamentous form impedes gut cell colonization in the mouse. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_49f3b12e4d6501ba5b6b6ed1a232cfce |
| institution | Universidad Complutense de Madrid (UCM) |
| instname_str | Universidad Complutense de Madrid (UCM) |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:docta.ucm.es:20.500.14352/13365 |
| publishDate | 2018 |
| publishDateSort | 2018 |
| publisher | Future Medicine |
| publisherStr | Future Medicine |
| reponame_str | Docta Complutense |
| spelling | TUP1-mediated filamentation in Candida albicans leads to inability to colonize the mouse gut. Román González, Elvira Huertas, Blanca Prieto, Daniel Díez Orejas, Rosalía María Pla Alonso, Jesús 579 Candida albicans Commensalism Filamentous growth TUP1 Microbiología (Farmacia) 3302.03 Microbiología Industrial AIM To investigate the role of Candida albicans TUP1-mediated filamentation in the colonization of the mice gut. MATERIALS & METHODS We used molecular genetics to generate a strain where filamentation is regulated by altering the expression of the TUP1 gene with tetracyclines. RESULTS The colonization rates reached with the TUP1-RFP strain were lower compared with wild-type strain and completely absent after induction of filamentation. No differences in the susceptibility to bile salts nor in the adhesion to the mouse intestine epithelium were observed. CONCLUSION Blockage of C. albicans in a filamentous form impedes gut cell colonization in the mouse. Future Medicine https://hdl.handle.net/20.500.14352/13365 |
| spellingShingle | TUP1-mediated filamentation in Candida albicans leads to inability to colonize the mouse gut. Román González, Elvira 579 Candida albicans Commensalism Filamentous growth TUP1 Microbiología (Farmacia) 3302.03 Microbiología Industrial |
| title | TUP1-mediated filamentation in Candida albicans leads to inability to colonize the mouse gut. |
| title_full | TUP1-mediated filamentation in Candida albicans leads to inability to colonize the mouse gut. |
| title_fullStr | TUP1-mediated filamentation in Candida albicans leads to inability to colonize the mouse gut. |
| title_full_unstemmed | TUP1-mediated filamentation in Candida albicans leads to inability to colonize the mouse gut. |
| title_short | TUP1-mediated filamentation in Candida albicans leads to inability to colonize the mouse gut. |
| title_sort | TUP1-mediated filamentation in Candida albicans leads to inability to colonize the mouse gut. |
| topic | 579 Candida albicans Commensalism Filamentous growth TUP1 Microbiología (Farmacia) 3302.03 Microbiología Industrial |
| topic_facet | 579 Candida albicans Commensalism Filamentous growth TUP1 Microbiología (Farmacia) 3302.03 Microbiología Industrial |
| url | https://hdl.handle.net/20.500.14352/13365 |