Association between chronic immune-mediated inflammatory diseases and cardiovascular risk
Objective: To examine the association between chronic immune-mediated diseases (rheumatoid arthritis, systemic lupus erythematosus or the following chronic immune-mediated inflammatory diagnoses groups: inflammatory bowel diseases, inflammatory polyarthropathies, systemic connective tissue disorders...
| Authors: | ; ; ; ; ; ; ; ; ; |
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| Format: | Article |
| Status: | Accepted version |
| Publication date: | 2018 |
| Country: | España |
| Institution: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repository: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/178169 |
| Online Access: | https://hdl.handle.net/2445/178169 |
| Access Level: | Open access |
| Keyword: | Malalties cardiovasculars Inflamació Cardiovascular diseases Inflammation |
| _version_ | 1878732736850558976 |
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| author | Baena Díez, José Miguel |
| author2 | García Gil, Maria Comas Cufí, Marc Ramos, Rafel Prieto Alhambra, Daniel Salvador González, Betlem Elosua, Roberto Degano, Irene R. Peñafiel, Judith Grau, Maria |
| author2_role | author author author author author author author author author |
| author_browse | Baena Díez, José Miguel Comas Cufí, Marc Degano, Irene R. Elosua, Roberto García Gil, Maria Grau, Maria Peñafiel, Judith Prieto Alhambra, Daniel Ramos, Rafel Salvador González, Betlem |
| author_facet | Baena Díez, José Miguel García Gil, Maria Comas Cufí, Marc Ramos, Rafel Prieto Alhambra, Daniel Salvador González, Betlem Elosua, Roberto Degano, Irene R. Peñafiel, Judith Grau, Maria |
| author_role | author |
| collection | Recercat. Dipósit de la Recerca de Catalunya |
| description | Objective: To examine the association between chronic immune-mediated diseases (rheumatoid arthritis, systemic lupus erythematosus or the following chronic immune-mediated inflammatory diagnoses groups: inflammatory bowel diseases, inflammatory polyarthropathies, systemic connective tissue disorders and spondylopathies) and the 6-year coronary artery disease, stroke, cardiovascular disease incidence and overall mortality; and to estimate the population attributable fractions for all four end-points for each chronic immune-mediated inflammatory disease. Methods: Cohort study of individuals aged 35-85 years, with no history of cardiovascular disease from Catalonia (Spain). The coded diagnoses of chronic immune-mediated diseases and cardiovascular diseases were ascertained and registered using validated codes, and date of death was obtained from administrative data. Cox regression models for each outcome according to exposure were fitted to estimate HRs in two models 1 : after adjustment for sex, age, cardiovascular risk factors and 2 further adjusted for drug use. Population attributable fractions were estimated for each exposure. Results: Data were collected from 991 546 participants. The risk of cardiovascular disease was increased in systemic connective tissue disorders (model 1: HR=1.38 (95% CI 1.21 to 1.57) and model 2: HR=1.31 (95% CI 1.15 to 1.49)), rheumatoid arthritis (HR=1.43 (95% CI 1.26 to 1.62) and HR=1.31 (95% CI 1.15 to 1.49)) and inflammatory bowel diseases (HR=1.18 (95% CI 1.06 to 1.32) and HR=1.12 (95% CI 1.01 to 1.25)). The effect of anti-inflammatory treatment was significant in all instances (HR=1.50 (95% CI 1.24 to 1.81); HR=1.47 (95% CI 1.23 to 1.75); HR=1.43 (95% CI 1.19 to 1.73), respectively). The population attributable fractions for all three disorders were 13.4%, 15.7% and 10.7%, respectively. Conclusion: Systemic connective tissue disorders and rheumatoid arthritis conferred the highest cardiovascular risk and population impact, followed by inflammatory bowel diseases. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_48c84416a6d7b8f5c833e44add8d7607 |
| institution | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:recercat.cat:2445/178169 |
| publishDate | 2018 |
| publishDateSort | 2018 |
| publisher | BMJ Publishing Group & British Cardiovascular Society |
| publisherStr | BMJ Publishing Group & British Cardiovascular Society |
| reponame_str | Recercat. Dipósit de la Recerca de Catalunya |
| spelling | Association between chronic immune-mediated inflammatory diseases and cardiovascular risk Baena Díez, José Miguel García Gil, Maria Comas Cufí, Marc Ramos, Rafel Prieto Alhambra, Daniel Salvador González, Betlem Elosua, Roberto Degano, Irene R. Peñafiel, Judith Grau, Maria Malalties cardiovasculars Inflamació Cardiovascular diseases Inflammation Objective: To examine the association between chronic immune-mediated diseases (rheumatoid arthritis, systemic lupus erythematosus or the following chronic immune-mediated inflammatory diagnoses groups: inflammatory bowel diseases, inflammatory polyarthropathies, systemic connective tissue disorders and spondylopathies) and the 6-year coronary artery disease, stroke, cardiovascular disease incidence and overall mortality; and to estimate the population attributable fractions for all four end-points for each chronic immune-mediated inflammatory disease. Methods: Cohort study of individuals aged 35-85 years, with no history of cardiovascular disease from Catalonia (Spain). The coded diagnoses of chronic immune-mediated diseases and cardiovascular diseases were ascertained and registered using validated codes, and date of death was obtained from administrative data. Cox regression models for each outcome according to exposure were fitted to estimate HRs in two models 1 : after adjustment for sex, age, cardiovascular risk factors and 2 further adjusted for drug use. Population attributable fractions were estimated for each exposure. Results: Data were collected from 991 546 participants. The risk of cardiovascular disease was increased in systemic connective tissue disorders (model 1: HR=1.38 (95% CI 1.21 to 1.57) and model 2: HR=1.31 (95% CI 1.15 to 1.49)), rheumatoid arthritis (HR=1.43 (95% CI 1.26 to 1.62) and HR=1.31 (95% CI 1.15 to 1.49)) and inflammatory bowel diseases (HR=1.18 (95% CI 1.06 to 1.32) and HR=1.12 (95% CI 1.01 to 1.25)). The effect of anti-inflammatory treatment was significant in all instances (HR=1.50 (95% CI 1.24 to 1.81); HR=1.47 (95% CI 1.23 to 1.75); HR=1.43 (95% CI 1.19 to 1.73), respectively). The population attributable fractions for all three disorders were 13.4%, 15.7% and 10.7%, respectively. Conclusion: Systemic connective tissue disorders and rheumatoid arthritis conferred the highest cardiovascular risk and population impact, followed by inflammatory bowel diseases. BMJ Publishing Group & British Cardiovascular Society https://hdl.handle.net/2445/178169 |
| spellingShingle | Association between chronic immune-mediated inflammatory diseases and cardiovascular risk Baena Díez, José Miguel Malalties cardiovasculars Inflamació Cardiovascular diseases Inflammation |
| status_str | acceptedVersion |
| title | Association between chronic immune-mediated inflammatory diseases and cardiovascular risk |
| title_full | Association between chronic immune-mediated inflammatory diseases and cardiovascular risk |
| title_fullStr | Association between chronic immune-mediated inflammatory diseases and cardiovascular risk |
| title_full_unstemmed | Association between chronic immune-mediated inflammatory diseases and cardiovascular risk |
| title_short | Association between chronic immune-mediated inflammatory diseases and cardiovascular risk |
| title_sort | Association between chronic immune-mediated inflammatory diseases and cardiovascular risk |
| topic | Malalties cardiovasculars Inflamació Cardiovascular diseases Inflammation |
| topic_facet | Malalties cardiovasculars Inflamació Cardiovascular diseases Inflammation |
| url | https://hdl.handle.net/2445/178169 |