Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations
A polygenic score (PGS) for Alzheimer's disease (AD) was derived recently from data on genome-wide significant loci in European ancestry populations. We applied this PGS to populations in 17 European countries and observed a consistent association with the AD risk, age at onset and cerebrospinal flu...
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| Tipo de documento: | Artículo |
| Estado: | Published version |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
| Repositorio: | r-FISABIO. Repositorio Institucional de Producción Científica |
| OAI Identifier: | oai:dnet:r-fisabio___::28773980ce39cb259e439e00c4ac26b7 |
| Acceso en línea: | https://fisabio.portalinvestigacion.com/publicaciones/21026 |
| Nivel de acceso: | Acceso abierto |
| _version_ | 1878732710072025088 |
|---|---|
| author | Nicolas, A |
| author2 | Sherva, R Grenier-Boley, B Kim, Y Kikuchi, M Timsina, J de Rojas, I Dalmasso, MC Zhou, XP Le Guen, Y Arboleda-Bustos, CE Bicalho, MAC Guerchet, M van der Lee, S Goss, M Castillo, A Bellenguez, C Küçükali, F Satizabal, CL Fongang, B Yang, Q Peters, O Schneider, A Dichgans, M Rujescu, D Scherbaum, N Deckert, J Riedel-Heller, S Hausner, L Molina-Porcel, L Duezel, E Grimmer, T Wiltfang, J Heilmann-Heimbach, S Moebus, S Tegos, T Scarmeas, N Dols-Icardo, O Moreno, F Pérez-Tur, J Bullido, MJ Pastor, P Sánchez-Valle, R Alvarez, V Cao, H Ip, NY Fu, AKY Ip, FCF Olivar, N Muchnik, C Cuesta, C Campanelli, L Solis, P Politis, DG Kochen, S Brusco, LI Boada, M García-González, P Puerta, R Mir, P Real, LM Pinol-Ripoll, G García-Alberca, JM Royo, JL Rodriguez-Rodriguez, E Soininen, H Heikkinen, S de Mendonça, A Mehrabian, S Traykov, L Hort, J Vyhnalek, M Rasmussen, KL Thomassen, JQ Pijnenburg, YAL Holstege, H van Swieten, JC Seelaar, H Claassen, JAHR Jansen, WJ Ramakers, I Verhey, F van der Lugt, A Scheltens, P Ortega-Rojas, J Mera, AGC Mahecha, MF Pardo, R Arboleda, G Bahrami, S Fominykh, V Selbaek, G Graff, C Papenberg, G Giedraitis, V Boland, A Deleuze, JF de Marco, LA de Moraes, EN Viana, BD Cintra, MTG Juarez-Cedillo, T Griswold, AJ Forund, T Haines, J Farrer, L Destefano, A Wijsman, E Mayeux, R Pericak-Vance, M Kunkle, B Goate, A Schellenberg, GD Vardarajan, B Wang, LS Leung, YY Dalgard, CL Nicolas, G Wallon, D Dufouil, C Pasquier, F Hanon, O Debette, S Gruenblatt, E Popp, J Angel, B Gloger, S Chacon, MV Aranguiz, R Orellana, P Slachevsky, A Gonzalez-Billault, C Albala, C Fuentes, P Sachdev, P Mather, KA Hauger, RL Merritt, V Panizzon, M Zhang, R Gaziano, JM Ghidoni, R Galimberti, D Arosio, B Mecocci, P Solfrizzi, V Parnetti, L Squassina, A Tremolizzo, L Borroni, B Nacmias, B Caffarra, P Seripa, D Rainero, I Daniele, A Piras, F Leonard, HL Yokoyama, JS Nalls, MA Miyashita, A Hara, N Ozaki, K Niida, S Williams, J Masullo, C Amouyel, P Preux, PM Mbelesso, P Bandzouzi, B Saykin, A Jessen, F Kehoe, PG Van Duijn, C Ben Salem, N Frikke-Schmidt, R Cherni, L Greicius, MD Tsolaki, M Sánchez-Juan, P Silva, MAR Porter, T Laws, SM Sleegers, K Ingelsson, M Dartigues, JF Seshadri, S Rossi, G Morelli, L Hiltunen, M Sims, R van der Flier, W Andreassen, OA Arboleda, H Cruchaga, C Escott-Price, V Ruiz, A Lee, KH Ikeuchi, T Ramirez, A Gim, J Logue, M Lambert, JC |
| author2_role | author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| author_browse | Albala, C Alvarez, V Amouyel, P Andreassen, OA Angel, B Aranguiz, R Arboleda, G Arboleda, H Arboleda-Bustos, CE Arosio, B Bahrami, S Bandzouzi, B Bellenguez, C Ben Salem, N Bicalho, MAC Boada, M Boland, A Borroni, B Brusco, LI Bullido, MJ Caffarra, P Campanelli, L Cao, H Castillo, A Chacon, MV Cherni, L Cintra, MTG Claassen, JAHR Cruchaga, C Cuesta, C Dalgard, CL Dalmasso, MC Daniele, A Dartigues, JF Debette, S Deckert, J Deleuze, JF Destefano, A Dichgans, M Dols-Icardo, O Duezel, E Dufouil, C Escott-Price, V Farrer, L Fominykh, V Fongang, B Forund, T Frikke-Schmidt, R Fu, AKY Fuentes, P Galimberti, D García-Alberca, JM García-González, P Gaziano, JM Ghidoni, R Giedraitis, V Gim, J Gloger, S Goate, A Gonzalez-Billault, C Goss, M Graff, C Greicius, MD Grenier-Boley, B Grimmer, T Griswold, AJ Gruenblatt, E Guerchet, M Haines, J Hanon, O Hara, N Hauger, RL Hausner, L Heikkinen, S Heilmann-Heimbach, S Hiltunen, M Holstege, H Hort, J Ikeuchi, T Ingelsson, M Ip, FCF Ip, NY Jansen, WJ Jessen, F Juarez-Cedillo, T Kehoe, PG Kikuchi, M Kim, Y Kochen, S Kunkle, B Küçükali, F Lambert, JC Laws, SM Le Guen, Y Lee, KH Leonard, HL Leung, YY Logue, M Mahecha, MF Masullo, C Mather, KA Mayeux, R Mbelesso, P Mecocci, P Mehrabian, S Mera, AGC Merritt, V Mir, P Miyashita, A Moebus, S Molina-Porcel, L Morelli, L Moreno, F Muchnik, C Nacmias, B Nalls, MA Nicolas, A Nicolas, G Niida, S Olivar, N Orellana, P Ortega-Rojas, J Ozaki, K Panizzon, M Papenberg, G Pardo, R Parnetti, L Pasquier, F Pastor, P Pericak-Vance, M Peters, O Pijnenburg, YAL Pinol-Ripoll, G Piras, F Politis, DG Popp, J Porter, T Preux, PM Puerta, R Pérez-Tur, J Rainero, I Ramakers, I Ramirez, A Rasmussen, KL Real, LM Riedel-Heller, S Rodriguez-Rodriguez, E Rossi, G Royo, JL Ruiz, A Rujescu, D Sachdev, P Satizabal, CL Saykin, A Scarmeas, N Schellenberg, GD Scheltens, P Scherbaum, N Schneider, A Seelaar, H Selbaek, G Seripa, D Seshadri, S Sherva, R Silva, MAR Sims, R Slachevsky, A Sleegers, K Soininen, H Solfrizzi, V Solis, P Squassina, A Sánchez-Juan, P Sánchez-Valle, R Tegos, T Thomassen, JQ Timsina, J Traykov, L Tremolizzo, L Tsolaki, M Van Duijn, C Vardarajan, B Verhey, F Viana, BD Vyhnalek, M Wallon, D Wang, LS Wijsman, E Williams, J Wiltfang, J Yang, Q Yokoyama, JS Zhang, R Zhou, XP de Marco, LA de Mendonça, A de Moraes, EN de Rojas, I van Swieten, JC van der Flier, W van der Lee, S van der Lugt, A |
| author_facet | Nicolas, A Sherva, R Grenier-Boley, B Kim, Y Kikuchi, M Timsina, J de Rojas, I Dalmasso, MC Zhou, XP Le Guen, Y Arboleda-Bustos, CE Bicalho, MAC Guerchet, M van der Lee, S Goss, M Castillo, A Bellenguez, C Küçükali, F Satizabal, CL Fongang, B Yang, Q Peters, O Schneider, A Dichgans, M Rujescu, D Scherbaum, N Deckert, J Riedel-Heller, S Hausner, L Molina-Porcel, L Duezel, E Grimmer, T Wiltfang, J Heilmann-Heimbach, S Moebus, S Tegos, T Scarmeas, N Dols-Icardo, O Moreno, F Pérez-Tur, J Bullido, MJ Pastor, P Sánchez-Valle, R Alvarez, V Cao, H Ip, NY Fu, AKY Ip, FCF Olivar, N Muchnik, C Cuesta, C Campanelli, L Solis, P Politis, DG Kochen, S Brusco, LI Boada, M García-González, P Puerta, R Mir, P Real, LM Pinol-Ripoll, G García-Alberca, JM Royo, JL Rodriguez-Rodriguez, E Soininen, H Heikkinen, S de Mendonça, A Mehrabian, S Traykov, L Hort, J Vyhnalek, M Rasmussen, KL Thomassen, JQ Pijnenburg, YAL Holstege, H van Swieten, JC Seelaar, H Claassen, JAHR Jansen, WJ Ramakers, I Verhey, F van der Lugt, A Scheltens, P Ortega-Rojas, J Mera, AGC Mahecha, MF Pardo, R Arboleda, G Bahrami, S Fominykh, V Selbaek, G Graff, C Papenberg, G Giedraitis, V Boland, A Deleuze, JF de Marco, LA de Moraes, EN Viana, BD Cintra, MTG Juarez-Cedillo, T Griswold, AJ Forund, T Haines, J Farrer, L Destefano, A Wijsman, E Mayeux, R Pericak-Vance, M Kunkle, B Goate, A Schellenberg, GD Vardarajan, B Wang, LS Leung, YY Dalgard, CL Nicolas, G Wallon, D Dufouil, C Pasquier, F Hanon, O Debette, S Gruenblatt, E Popp, J Angel, B Gloger, S Chacon, MV Aranguiz, R Orellana, P Slachevsky, A Gonzalez-Billault, C Albala, C Fuentes, P Sachdev, P Mather, KA Hauger, RL Merritt, V Panizzon, M Zhang, R Gaziano, JM Ghidoni, R Galimberti, D Arosio, B Mecocci, P Solfrizzi, V Parnetti, L Squassina, A Tremolizzo, L Borroni, B Nacmias, B Caffarra, P Seripa, D Rainero, I Daniele, A Piras, F Leonard, HL Yokoyama, JS Nalls, MA Miyashita, A Hara, N Ozaki, K Niida, S Williams, J Masullo, C Amouyel, P Preux, PM Mbelesso, P Bandzouzi, B Saykin, A Jessen, F Kehoe, PG Van Duijn, C Ben Salem, N Frikke-Schmidt, R Cherni, L Greicius, MD Tsolaki, M Sánchez-Juan, P Silva, MAR Porter, T Laws, SM Sleegers, K Ingelsson, M Dartigues, JF Seshadri, S Rossi, G Morelli, L Hiltunen, M Sims, R van der Flier, W Andreassen, OA Arboleda, H Cruchaga, C Escott-Price, V Ruiz, A Lee, KH Ikeuchi, T Ramirez, A Gim, J Logue, M Lambert, JC |
| author_role | author |
| collection | r-FISABIO. Repositorio Institucional de Producción Científica |
| description | A polygenic score (PGS) for Alzheimer's disease (AD) was derived recently from data on genome-wide significant loci in European ancestry populations. We applied this PGS to populations in 17 European countries and observed a consistent association with the AD risk, age at onset and cerebrospinal fluid levels of AD biomarkers, independently of apolipoprotein E locus (APOE). This PGS was also associated with the AD risk in many other populations of diverse ancestries. A cross-ancestry polygenic risk score improved the association with the AD risk in most of the multiancestry populations tested when the APOE region was included. Finally, we found that the PGS/polygenic risk score captured AD-specific information because the association weakened as the diagnosis was broadened. In conclusion, a simple PGS captures the AD-specific genetic information that is common to populations of different ancestries, although studies of more diverse populations are still needed to better characterize the genetics of AD. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_483f7f7864664fec565fcbc3d19e92f1 |
| institution | Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
| instname_str | Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:dnet:r-fisabio___::28773980ce39cb259e439e00c4ac26b7 |
| publishDate | 2025 |
| publishDateSort | 2025 |
| publisher | NATURE PORTFOLIO |
| publisherStr | NATURE PORTFOLIO |
| reponame_str | r-FISABIO. Repositorio Institucional de Producción Científica |
| spelling | Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations Nicolas, A Sherva, R Grenier-Boley, B Kim, Y Kikuchi, M Timsina, J de Rojas, I Dalmasso, MC Zhou, XP Le Guen, Y Arboleda-Bustos, CE Bicalho, MAC Guerchet, M van der Lee, S Goss, M Castillo, A Bellenguez, C Küçükali, F Satizabal, CL Fongang, B Yang, Q Peters, O Schneider, A Dichgans, M Rujescu, D Scherbaum, N Deckert, J Riedel-Heller, S Hausner, L Molina-Porcel, L Duezel, E Grimmer, T Wiltfang, J Heilmann-Heimbach, S Moebus, S Tegos, T Scarmeas, N Dols-Icardo, O Moreno, F Pérez-Tur, J Bullido, MJ Pastor, P Sánchez-Valle, R Alvarez, V Cao, H Ip, NY Fu, AKY Ip, FCF Olivar, N Muchnik, C Cuesta, C Campanelli, L Solis, P Politis, DG Kochen, S Brusco, LI Boada, M García-González, P Puerta, R Mir, P Real, LM Pinol-Ripoll, G García-Alberca, JM Royo, JL Rodriguez-Rodriguez, E Soininen, H Heikkinen, S de Mendonça, A Mehrabian, S Traykov, L Hort, J Vyhnalek, M Rasmussen, KL Thomassen, JQ Pijnenburg, YAL Holstege, H van Swieten, JC Seelaar, H Claassen, JAHR Jansen, WJ Ramakers, I Verhey, F van der Lugt, A Scheltens, P Ortega-Rojas, J Mera, AGC Mahecha, MF Pardo, R Arboleda, G Bahrami, S Fominykh, V Selbaek, G Graff, C Papenberg, G Giedraitis, V Boland, A Deleuze, JF de Marco, LA de Moraes, EN Viana, BD Cintra, MTG Juarez-Cedillo, T Griswold, AJ Forund, T Haines, J Farrer, L Destefano, A Wijsman, E Mayeux, R Pericak-Vance, M Kunkle, B Goate, A Schellenberg, GD Vardarajan, B Wang, LS Leung, YY Dalgard, CL Nicolas, G Wallon, D Dufouil, C Pasquier, F Hanon, O Debette, S Gruenblatt, E Popp, J Angel, B Gloger, S Chacon, MV Aranguiz, R Orellana, P Slachevsky, A Gonzalez-Billault, C Albala, C Fuentes, P Sachdev, P Mather, KA Hauger, RL Merritt, V Panizzon, M Zhang, R Gaziano, JM Ghidoni, R Galimberti, D Arosio, B Mecocci, P Solfrizzi, V Parnetti, L Squassina, A Tremolizzo, L Borroni, B Nacmias, B Caffarra, P Seripa, D Rainero, I Daniele, A Piras, F Leonard, HL Yokoyama, JS Nalls, MA Miyashita, A Hara, N Ozaki, K Niida, S Williams, J Masullo, C Amouyel, P Preux, PM Mbelesso, P Bandzouzi, B Saykin, A Jessen, F Kehoe, PG Van Duijn, C Ben Salem, N Frikke-Schmidt, R Cherni, L Greicius, MD Tsolaki, M Sánchez-Juan, P Silva, MAR Porter, T Laws, SM Sleegers, K Ingelsson, M Dartigues, JF Seshadri, S Rossi, G Morelli, L Hiltunen, M Sims, R van der Flier, W Andreassen, OA Arboleda, H Cruchaga, C Escott-Price, V Ruiz, A Lee, KH Ikeuchi, T Ramirez, A Gim, J Logue, M Lambert, JC A polygenic score (PGS) for Alzheimer's disease (AD) was derived recently from data on genome-wide significant loci in European ancestry populations. We applied this PGS to populations in 17 European countries and observed a consistent association with the AD risk, age at onset and cerebrospinal fluid levels of AD biomarkers, independently of apolipoprotein E locus (APOE). This PGS was also associated with the AD risk in many other populations of diverse ancestries. A cross-ancestry polygenic risk score improved the association with the AD risk in most of the multiancestry populations tested when the APOE region was included. Finally, we found that the PGS/polygenic risk score captured AD-specific information because the association weakened as the diagnosis was broadened. In conclusion, a simple PGS captures the AD-specific genetic information that is common to populations of different ancestries, although studies of more diverse populations are still needed to better characterize the genetics of AD. NATURE PORTFOLIO https://fisabio.portalinvestigacion.com/publicaciones/21026 |
| spellingShingle | Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations Nicolas, A |
| status_str | publishedVersion |
| title | Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations |
| title_full | Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations |
| title_fullStr | Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations |
| title_full_unstemmed | Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations |
| title_short | Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations |
| title_sort | Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations |
| url | https://fisabio.portalinvestigacion.com/publicaciones/21026 |