Cannabis use in male and female first episode of non-affective psychosis patients: long-term clinical, neuropsychological and functional differences
BACKGROUND: Numerous studies show the existence of a high prevalence of cannabis use among patients with psychosis. However, the differences between men and women who debut with a first episode of psychosis (FEP) regarding cannabis use have not been largely explored. The aim of this study was to ide...
| Autores: | ; ; ; ; ; ; |
|---|---|
| Tipo de documento: | Artículo |
| Estado: | Published version |
| Fecha de publicación: | 2017 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/130958 |
| Acceso en línea: | https://hdl.handle.net/2445/130958 |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | Cànnabis Psicosi Factors sexuals en les malalties Cannabis Psychoses Sex factors in disease |
| _version_ | 1878732495795519488 |
|---|---|
| author | Setien Suero, Esther |
| author2 | Neergaard, Karl Ramirez Bonilla, Mariluz Correa Ghisays, Patricia Fañanás Saura, Lourdes Crepo Facorro, Benedicto Ayesa Arriola, Rosa |
| author2_role | author author author author author author |
| author_browse | Ayesa Arriola, Rosa Correa Ghisays, Patricia Crepo Facorro, Benedicto Fañanás Saura, Lourdes Neergaard, Karl Ramirez Bonilla, Mariluz Setien Suero, Esther |
| author_facet | Setien Suero, Esther Neergaard, Karl Ramirez Bonilla, Mariluz Correa Ghisays, Patricia Fañanás Saura, Lourdes Crepo Facorro, Benedicto Ayesa Arriola, Rosa |
| author_role | author |
| collection | Recercat. Dipósit de la Recerca de Catalunya |
| description | BACKGROUND: Numerous studies show the existence of a high prevalence of cannabis use among patients with psychosis. However, the differences between men and women who debut with a first episode of psychosis (FEP) regarding cannabis use have not been largely explored. The aim of this study was to identify the specific sex factors and differences in clinical evolution associated with cannabis use. METHOD: Sociodemographic characteristics at baseline were considered in our sample of FEP patients to find differences depending on sex and the use of cannabis. Clinical, functional and neurocognitive variables at baseline, 1-year, and 3-years follow-up were also explored. RESULTS: A total of 549 patients, of whom 43% (N = 236) were cannabis users, 79% (N = 186) male and 21% (N = 50) female, were included in the study. There was a clear relationship between being male and being a user of cannabis (OR = 5.6). Cannabis users were younger at illness onset. Longitudinal analysis showed that women significantly improved in all three dimensions of psychotic symptoms, both in the subgroup of cannabis users and in the non-users subgroup. Conversely, subgroups of men did not show improvement in the negative dimension. In cognitive function, only men presented a significant time by group interaction in processing speed, showing a greater improvement in the subgroup of cannabis users. CONCLUSION: Despite knowing that there is a relationship between cannabis use and psychosis, due to the high prevalence of cannabis use among male FEP patients, the results showed that there were very few differences in clinical and neurocognitive outcomes between men and women who used cannabis at the start of treatment compared to those who did not. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_441e0fc90d8dac321e61c4e526799697 |
| institution | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:recercat.cat:2445/130958 |
| publishDate | 2017 |
| publishDateSort | 2017 |
| publisher | Public Library of Science (PLoS) |
| publisherStr | Public Library of Science (PLoS) |
| reponame_str | Recercat. Dipósit de la Recerca de Catalunya |
| spelling | Cannabis use in male and female first episode of non-affective psychosis patients: long-term clinical, neuropsychological and functional differences Setien Suero, Esther Neergaard, Karl Ramirez Bonilla, Mariluz Correa Ghisays, Patricia Fañanás Saura, Lourdes Crepo Facorro, Benedicto Ayesa Arriola, Rosa Cànnabis Psicosi Factors sexuals en les malalties Cannabis Psychoses Sex factors in disease BACKGROUND: Numerous studies show the existence of a high prevalence of cannabis use among patients with psychosis. However, the differences between men and women who debut with a first episode of psychosis (FEP) regarding cannabis use have not been largely explored. The aim of this study was to identify the specific sex factors and differences in clinical evolution associated with cannabis use. METHOD: Sociodemographic characteristics at baseline were considered in our sample of FEP patients to find differences depending on sex and the use of cannabis. Clinical, functional and neurocognitive variables at baseline, 1-year, and 3-years follow-up were also explored. RESULTS: A total of 549 patients, of whom 43% (N = 236) were cannabis users, 79% (N = 186) male and 21% (N = 50) female, were included in the study. There was a clear relationship between being male and being a user of cannabis (OR = 5.6). Cannabis users were younger at illness onset. Longitudinal analysis showed that women significantly improved in all three dimensions of psychotic symptoms, both in the subgroup of cannabis users and in the non-users subgroup. Conversely, subgroups of men did not show improvement in the negative dimension. In cognitive function, only men presented a significant time by group interaction in processing speed, showing a greater improvement in the subgroup of cannabis users. CONCLUSION: Despite knowing that there is a relationship between cannabis use and psychosis, due to the high prevalence of cannabis use among male FEP patients, the results showed that there were very few differences in clinical and neurocognitive outcomes between men and women who used cannabis at the start of treatment compared to those who did not. Public Library of Science (PLoS) https://hdl.handle.net/2445/130958 |
| spellingShingle | Cannabis use in male and female first episode of non-affective psychosis patients: long-term clinical, neuropsychological and functional differences Setien Suero, Esther Cànnabis Psicosi Factors sexuals en les malalties Cannabis Psychoses Sex factors in disease |
| status_str | publishedVersion |
| title | Cannabis use in male and female first episode of non-affective psychosis patients: long-term clinical, neuropsychological and functional differences |
| title_full | Cannabis use in male and female first episode of non-affective psychosis patients: long-term clinical, neuropsychological and functional differences |
| title_fullStr | Cannabis use in male and female first episode of non-affective psychosis patients: long-term clinical, neuropsychological and functional differences |
| title_full_unstemmed | Cannabis use in male and female first episode of non-affective psychosis patients: long-term clinical, neuropsychological and functional differences |
| title_short | Cannabis use in male and female first episode of non-affective psychosis patients: long-term clinical, neuropsychological and functional differences |
| title_sort | Cannabis use in male and female first episode of non-affective psychosis patients: long-term clinical, neuropsychological and functional differences |
| topic | Cànnabis Psicosi Factors sexuals en les malalties Cannabis Psychoses Sex factors in disease |
| topic_facet | Cànnabis Psicosi Factors sexuals en les malalties Cannabis Psychoses Sex factors in disease |
| url | https://hdl.handle.net/2445/130958 |