Genetic contribution to the comorbidity between attention-deficit/hyperactivity disorder and substance use disorders
Attention-deficit hyperactivity disorder; Pleiotropy; Substance use disorders
| Autores: | ; ; ; ; ; ; ; ; ; |
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| Tipo de documento: | Artículo |
| Estado: | Published version |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Departament de Salut de la Generalitat de Catalunya (DS) |
| Repositorio: | Scientia. Dipòsit d'Informació Digital del Departament de Salut |
| OAI Identifier: | oai:scientiasalut.gencat.cat:11351/12211 |
| Acceso en línea: | https://hdl.handle.net/11351/12211 |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | Comorbiditat Trastorn per dèficit d'atenció amb hiperactivitat - Aspectes genètics Diagnòstic dual Abús de substàncies DISEASES::Chemically-Induced Disorders::Substance-Related Disorders Other subheadings::Other subheadings::Other subheadings::/genetics PSYCHIATRY AND PSYCHOLOGY::Mental Disorders::Neurodevelopmental Disorders::Attention Deficit and Disruptive Behavior Disorders::Attention Deficit Disorder with Hyperactivity PUBLIC HEALTH::Epidemiology and Biostatistics::Epidemiology::Health-Disease Process::Comorbidity ENFERMEDADES::trastornos inducidos químicamente::trastornos relacionados con sustancias Otros calificadores::Otros calificadores::Otros calificadores::/genética PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales::trastornos del desarrollo neurológico::trastornos conductuales disruptivos y déficit de atención::trastornos de déficit de atención con hiperactividad SALUD PÚBLICA::epidemiología y bioestadística::epidemiología::proceso salud-enfermedad::comorbilidad |
| _version_ | 1878732455362428928 |
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| author | Koller, Dora |
| author2 | Mitjans, Marina Kouakou, Manuela Friligkou, Eleni Cabrera-Mendoza, Brenda Deak, Joseph Soler Artigas, María Llonga, Natalia Ribases, Marta Ramos-Quiroga, Josep Antoni |
| author2_role | author author author author author author author author author |
| author_browse | Cabrera-Mendoza, Brenda Deak, Joseph Friligkou, Eleni Koller, Dora Kouakou, Manuela Llonga, Natalia Mitjans, Marina Ramos-Quiroga, Josep Antoni Ribases, Marta Soler Artigas, María |
| author_facet | Koller, Dora Mitjans, Marina Kouakou, Manuela Friligkou, Eleni Cabrera-Mendoza, Brenda Deak, Joseph Soler Artigas, María Llonga, Natalia Ribases, Marta Ramos-Quiroga, Josep Antoni |
| author_role | author |
| collection | Scientia. Dipòsit d'Informació Digital del Departament de Salut |
| description | Attention-deficit hyperactivity disorder; Pleiotropy; Substance use disorders |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_4358c8a2a5cbeb4eacf860b7c32b27b3 |
| institution | Departament de Salut de la Generalitat de Catalunya (DS) |
| instname_str | Departament de Salut de la Generalitat de Catalunya (DS) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:scientiasalut.gencat.cat:11351/12211 |
| publishDate | 2024 |
| publishDateSort | 2024 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| reponame_str | Scientia. Dipòsit d'Informació Digital del Departament de Salut |
| spelling | Genetic contribution to the comorbidity between attention-deficit/hyperactivity disorder and substance use disorders Koller, Dora Mitjans, Marina Kouakou, Manuela Friligkou, Eleni Cabrera-Mendoza, Brenda Deak, Joseph Soler Artigas, María Llonga, Natalia Ribases, Marta Ramos-Quiroga, Josep Antoni Comorbiditat Trastorn per dèficit d'atenció amb hiperactivitat - Aspectes genètics Diagnòstic dual Abús de substàncies DISEASES::Chemically-Induced Disorders::Substance-Related Disorders Other subheadings::Other subheadings::Other subheadings::/genetics PSYCHIATRY AND PSYCHOLOGY::Mental Disorders::Neurodevelopmental Disorders::Attention Deficit and Disruptive Behavior Disorders::Attention Deficit Disorder with Hyperactivity PUBLIC HEALTH::Epidemiology and Biostatistics::Epidemiology::Health-Disease Process::Comorbidity ENFERMEDADES::trastornos inducidos químicamente::trastornos relacionados con sustancias Otros calificadores::Otros calificadores::Otros calificadores::/genética PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales::trastornos del desarrollo neurológico::trastornos conductuales disruptivos y déficit de atención::trastornos de déficit de atención con hiperactividad SALUD PÚBLICA::epidemiología y bioestadística::epidemiología::proceso salud-enfermedad::comorbilidad Attention-deficit hyperactivity disorder; Pleiotropy; Substance use disorders Trastorn per dèficit d'atenció amb hiperactivitat; Pleiotropia; Trastorns per consum de substàncies Trastorno por déficit de atención con hiperactividad; Pleiotropía; Trastornos por consumo de sustancias We characterized the genetic architecture of the attention-deficit hyperactivity disorder-substance use disorder (ADHD-SUD) relationship by investigating genetic correlation, causality, pleiotropy, and common polygenic risk. Summary statistics from genome-wide association studies (GWAS) were used to investigate ADHD (Neff = 51,568), cannabis use disorder (CanUD, Neff = 161,053), opioid use disorder (OUD, Neff = 57,120), problematic alcohol use (PAU, Neff = 502,272), and problematic tobacco use (PTU, Neff = 97,836). ADHD, CanUD, and OUD GWAS meta-analyses included cohorts with case definitions based on different diagnostic criteria. PAU GWAS combined information related to alcohol use disorder, alcohol dependence, and the items related to alcohol problematic consequences assessed by the alcohol use disorders identification test. PTU GWAS was generated a multi-trait analysis including information regarding Fagerström Test for Nicotine Dependence and cigarettes per day. Linkage disequilibrium score regression analyses indicated positive genetic correlation with CanUD, OUD, PAU, and PTU. Genomic structural equation modeling showed that these genetic correlations were related to two latent factors: one including ADHD, CanUD, and PTU and the other with OUD and PAU. The evidence of a causal effect of PAU and PTU on ADHD was stronger than the reverse in the two-sample Mendelian randomization analysis. Conversely, similar strength of evidence was found between ADHD and CanUD. CADM2 rs62250713 was a pleiotropic SNP between ADHD and all SUDs. We found seven, one, and twenty-eight pleiotropic variants between ADHD and CanUD, PAU, and PTU, respectively. Finally, OUD, CanUD, and PAU PRS were associated with increased odds of ADHD. Our findings demonstrated the contribution of multiple pleiotropic mechanisms to the comorbidity between ADHD and SUDs. The authors acknowledge support from the Horizon 2020 Marie Sklodowska-Curie Individual Fellowship from the European Commission (101028810), the National Institutes of Health (R33 DA047527, R21 DC018098, RF1 MH132337, K99 AG078503, T32 MH014276, T32 AA02825, K01 DA051759), Veterans Affairs Office of Research & Development (5IK2BX005058 and CX001849-01), Alzheimer's Association Research Fellowship (AARF-22-967171), American Foundation for Suicide Prevention (PDF-1-022-21), the Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR, 2021-SGR-01093), grants RYC-2017-21636 and RYC2021-033573-I funded by MCIN/AEI/10.13039/501100011033 and by the European Union “NextGenerationEU”/PRTR” Ramón y Cajal contract (RYC-2017-21636) and One Mind. BC received financial support from the Spanish ‘Ministerio de Ciencia, Innovación y Universidades’ (PID2021-1277760B-I100), ‘Generalitat de Catalunya/AGAUR’ (2021-SGR-01093), ICREA Academia 2021, ‘Fundació La Marató de TV3’ (202218-31), and the European Union H2020 Program [H2020/2014-2020] under grant agreements n° 667302 (CoCA), 728018 (Eat2beNICE), and 841899 (GRASAD). We thank the participants and the investigators involved in the UK Biobank, Million Veteran Program, and the Psychiatric Genomics Consortium for making their data publicly available. This publication does not represent the views of the Department of Veterans Affairs or the United States Government. Elsevier https://hdl.handle.net/11351/12211 |
| spellingShingle | Genetic contribution to the comorbidity between attention-deficit/hyperactivity disorder and substance use disorders Koller, Dora Comorbiditat Trastorn per dèficit d'atenció amb hiperactivitat - Aspectes genètics Diagnòstic dual Abús de substàncies DISEASES::Chemically-Induced Disorders::Substance-Related Disorders Other subheadings::Other subheadings::Other subheadings::/genetics PSYCHIATRY AND PSYCHOLOGY::Mental Disorders::Neurodevelopmental Disorders::Attention Deficit and Disruptive Behavior Disorders::Attention Deficit Disorder with Hyperactivity PUBLIC HEALTH::Epidemiology and Biostatistics::Epidemiology::Health-Disease Process::Comorbidity ENFERMEDADES::trastornos inducidos químicamente::trastornos relacionados con sustancias Otros calificadores::Otros calificadores::Otros calificadores::/genética PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales::trastornos del desarrollo neurológico::trastornos conductuales disruptivos y déficit de atención::trastornos de déficit de atención con hiperactividad SALUD PÚBLICA::epidemiología y bioestadística::epidemiología::proceso salud-enfermedad::comorbilidad |
| status_str | publishedVersion |
| title | Genetic contribution to the comorbidity between attention-deficit/hyperactivity disorder and substance use disorders |
| title_full | Genetic contribution to the comorbidity between attention-deficit/hyperactivity disorder and substance use disorders |
| title_fullStr | Genetic contribution to the comorbidity between attention-deficit/hyperactivity disorder and substance use disorders |
| title_full_unstemmed | Genetic contribution to the comorbidity between attention-deficit/hyperactivity disorder and substance use disorders |
| title_short | Genetic contribution to the comorbidity between attention-deficit/hyperactivity disorder and substance use disorders |
| title_sort | Genetic contribution to the comorbidity between attention-deficit/hyperactivity disorder and substance use disorders |
| topic | Comorbiditat Trastorn per dèficit d'atenció amb hiperactivitat - Aspectes genètics Diagnòstic dual Abús de substàncies DISEASES::Chemically-Induced Disorders::Substance-Related Disorders Other subheadings::Other subheadings::Other subheadings::/genetics PSYCHIATRY AND PSYCHOLOGY::Mental Disorders::Neurodevelopmental Disorders::Attention Deficit and Disruptive Behavior Disorders::Attention Deficit Disorder with Hyperactivity PUBLIC HEALTH::Epidemiology and Biostatistics::Epidemiology::Health-Disease Process::Comorbidity ENFERMEDADES::trastornos inducidos químicamente::trastornos relacionados con sustancias Otros calificadores::Otros calificadores::Otros calificadores::/genética PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales::trastornos del desarrollo neurológico::trastornos conductuales disruptivos y déficit de atención::trastornos de déficit de atención con hiperactividad SALUD PÚBLICA::epidemiología y bioestadística::epidemiología::proceso salud-enfermedad::comorbilidad |
| topic_facet | Comorbiditat Trastorn per dèficit d'atenció amb hiperactivitat - Aspectes genètics Diagnòstic dual Abús de substàncies DISEASES::Chemically-Induced Disorders::Substance-Related Disorders Other subheadings::Other subheadings::Other subheadings::/genetics PSYCHIATRY AND PSYCHOLOGY::Mental Disorders::Neurodevelopmental Disorders::Attention Deficit and Disruptive Behavior Disorders::Attention Deficit Disorder with Hyperactivity PUBLIC HEALTH::Epidemiology and Biostatistics::Epidemiology::Health-Disease Process::Comorbidity ENFERMEDADES::trastornos inducidos químicamente::trastornos relacionados con sustancias Otros calificadores::Otros calificadores::Otros calificadores::/genética PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales::trastornos del desarrollo neurológico::trastornos conductuales disruptivos y déficit de atención::trastornos de déficit de atención con hiperactividad SALUD PÚBLICA::epidemiología y bioestadística::epidemiología::proceso salud-enfermedad::comorbilidad |
| url | https://hdl.handle.net/11351/12211 |