Rev1 wbdR tagged vaccines against Brucella ovis
Sheep brucellosis is a worldwide extended disease caused by B. melitensis and B. ovis, two species respectively carrying smooth or rough lipopolysaccharide. Vaccine B. melitensis Rev1 is used against B. melitensis and B. ovis but induces an anti-smooth-lipopolysaccharide response interfering with B....
| Authors: | ; ; ; ; ; ; ; ; |
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| Format: | Article |
| Status: | Published version |
| Publication date: | 2019 |
| Country: | España |
| Institution: | Universidad de Zaragoza |
| Repository: | Zaguán. Repositorio Digital de la Universidad de Zaragoza |
| OAI Identifier: | oai:zaguan.unizar.es:87634 |
| Online Access: | http://zaguan.unizar.es/record/87634 |
| Access Level: | Open access |
| _version_ | 1878732268203147264 |
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| author | Aragón-Aranda, Beatriz |
| author2 | De Miguel, María Jesús Martínez-Gómez, Estrella Zúñiga-Ripa, Amaia Salvador-Bescós, Miriam Moriyón, Ignacio Iriarte, Maite Muñoz, Pilar M. Conde-Álvarez, Raquel |
| author2_role | author author author author author author author author |
| author_browse | Aragón-Aranda, Beatriz Conde-Álvarez, Raquel De Miguel, María Jesús Iriarte, Maite Martínez-Gómez, Estrella Moriyón, Ignacio Muñoz, Pilar M. Salvador-Bescós, Miriam Zúñiga-Ripa, Amaia |
| author_facet | Aragón-Aranda, Beatriz De Miguel, María Jesús Martínez-Gómez, Estrella Zúñiga-Ripa, Amaia Salvador-Bescós, Miriam Moriyón, Ignacio Iriarte, Maite Muñoz, Pilar M. Conde-Álvarez, Raquel |
| author_role | author |
| collection | Zaguán. Repositorio Digital de la Universidad de Zaragoza |
| description | Sheep brucellosis is a worldwide extended disease caused by B. melitensis and B. ovis, two species respectively carrying smooth or rough lipopolysaccharide. Vaccine B. melitensis Rev1 is used against B. melitensis and B. ovis but induces an anti-smooth-lipopolysaccharide response interfering with B. melitensis serodiagnosis, which precludes its use against B. ovis where B. melitensis is absent. In mice, Rev1 deleted in wbkC (Brucella lipopolysaccharide formyl-transferase) and carrying wbdR (E. coli acetyl-transferase) triggered antibodies that could be differentiated from those evoked by wild-type strains, was comparatively attenuated and protected against B. ovis, suggesting its potential as a B. ovis vaccine. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_3fbc141ee7e91fcb2d9bfdb7e143cd44 |
| institution | Universidad de Zaragoza |
| instname_str | Universidad de Zaragoza |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:zaguan.unizar.es:87634 |
| publishDate | 2019 |
| publishDateSort | 2019 |
| reponame_str | Zaguán. Repositorio Digital de la Universidad de Zaragoza |
| spelling | Rev1 wbdR tagged vaccines against Brucella ovis Aragón-Aranda, Beatriz De Miguel, María Jesús Martínez-Gómez, Estrella Zúñiga-Ripa, Amaia Salvador-Bescós, Miriam Moriyón, Ignacio Iriarte, Maite Muñoz, Pilar M. Conde-Álvarez, Raquel Sheep brucellosis is a worldwide extended disease caused by B. melitensis and B. ovis, two species respectively carrying smooth or rough lipopolysaccharide. Vaccine B. melitensis Rev1 is used against B. melitensis and B. ovis but induces an anti-smooth-lipopolysaccharide response interfering with B. melitensis serodiagnosis, which precludes its use against B. ovis where B. melitensis is absent. In mice, Rev1 deleted in wbkC (Brucella lipopolysaccharide formyl-transferase) and carrying wbdR (E. coli acetyl-transferase) triggered antibodies that could be differentiated from those evoked by wild-type strains, was comparatively attenuated and protected against B. ovis, suggesting its potential as a B. ovis vaccine. http://zaguan.unizar.es/record/87634 |
| spellingShingle | Rev1 wbdR tagged vaccines against Brucella ovis Aragón-Aranda, Beatriz |
| status_str | publishedVersion |
| title | Rev1 wbdR tagged vaccines against Brucella ovis |
| title_full | Rev1 wbdR tagged vaccines against Brucella ovis |
| title_fullStr | Rev1 wbdR tagged vaccines against Brucella ovis |
| title_full_unstemmed | Rev1 wbdR tagged vaccines against Brucella ovis |
| title_short | Rev1 wbdR tagged vaccines against Brucella ovis |
| title_sort | Rev1 wbdR tagged vaccines against Brucella ovis |
| url | http://zaguan.unizar.es/record/87634 |