Severe acute hepatitis and cold agglutinin-related hemolytic anemia secondary to prime infection with Epstein-Barr virus
Epstein-Barr virus, a member of the Herpesviridae family, is responsible for the infectious mononucleosis clinical syndrome, which mainly includes the pharyngitis, fever, and lymphadenopathy triad after incubation for 30-50 days. The liver is involved in 80-90% of patients in a self-limiting transie...
| Authors: | ; ; ; ; |
|---|---|
| Format: | Article |
| Status: | Published version |
| Publication date: | 2017 |
| Country: | España |
| Institution: | Universidad de Sevilla (US) |
| Repository: | idUS. Depósito de Investigación de la Universidad de Sevilla |
| OAI Identifier: | oai:idus.us.es:11441/158771 |
| Online Access: | https://hdl.handle.net/11441/158771 https://doi.org/10.17235/reed.2017.4072/2015 |
| Access Level: | Open access |
| Keyword: | Epstein-Barr virus Acute hepatitis Hemolytic anemia |
| _version_ | 1878732261758599168 |
|---|---|
| author | Ontanilla-Clavijo, Guillermo |
| author2 | Praena Segovia, Julia Giráldez Gallego, Álvaro Cordero Matia, María Elisa Sousa Martín, José Manuel |
| author2_role | author author author author |
| author_browse | Cordero Matia, María Elisa Giráldez Gallego, Álvaro Ontanilla-Clavijo, Guillermo Praena Segovia, Julia Sousa Martín, José Manuel |
| author_facet | Ontanilla-Clavijo, Guillermo Praena Segovia, Julia Giráldez Gallego, Álvaro Cordero Matia, María Elisa Sousa Martín, José Manuel |
| author_role | author |
| collection | idUS. Depósito de Investigación de la Universidad de Sevilla |
| description | Epstein-Barr virus, a member of the Herpesviridae family, is responsible for the infectious mononucleosis clinical syndrome, which mainly includes the pharyngitis, fever, and lymphadenopathy triad after incubation for 30-50 days. The liver is involved in 80-90% of patients in a self-limiting transient manner, with jaundice being much more uncommon (5%). From a hematological standpoint it may manifest aplastic anemia, neutropenia, and thrombocytopenia. We report a case of infectious mononucleosis that included severe acute hepatitis and was associated with severe hemolytic anemia secondary to cold agglutinins. After exclusion of other etiologies, and given the clinical suspicion of the above association, which was later confirmed by lab tests, empiric therapy was initiated with antiviral agents (aciclovir + valganciclovir) and corticoids, which resulted in a progressive clinical improvement until complete remission. Therefore, we believe that this case report will reinforce the clinical evidence in support of the above combined therapy for serious infectious mononucleosis as a step prior to liver transplantation. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_3f9fd1ddbc44ff2e56fbc1bcb28e861d |
| institution | Universidad de Sevilla (US) |
| instname_str | Universidad de Sevilla (US) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:idus.us.es:11441/158771 |
| publishDate | 2017 |
| publishDateSort | 2017 |
| publisher | Aran Ediciones S.A. |
| publisherStr | Aran Ediciones S.A. |
| reponame_str | idUS. Depósito de Investigación de la Universidad de Sevilla |
| spelling | Severe acute hepatitis and cold agglutinin-related hemolytic anemia secondary to prime infection with Epstein-Barr virus Ontanilla-Clavijo, Guillermo Praena Segovia, Julia Giráldez Gallego, Álvaro Cordero Matia, María Elisa Sousa Martín, José Manuel Epstein-Barr virus Acute hepatitis Hemolytic anemia Epstein-Barr virus, a member of the Herpesviridae family, is responsible for the infectious mononucleosis clinical syndrome, which mainly includes the pharyngitis, fever, and lymphadenopathy triad after incubation for 30-50 days. The liver is involved in 80-90% of patients in a self-limiting transient manner, with jaundice being much more uncommon (5%). From a hematological standpoint it may manifest aplastic anemia, neutropenia, and thrombocytopenia. We report a case of infectious mononucleosis that included severe acute hepatitis and was associated with severe hemolytic anemia secondary to cold agglutinins. After exclusion of other etiologies, and given the clinical suspicion of the above association, which was later confirmed by lab tests, empiric therapy was initiated with antiviral agents (aciclovir + valganciclovir) and corticoids, which resulted in a progressive clinical improvement until complete remission. Therefore, we believe that this case report will reinforce the clinical evidence in support of the above combined therapy for serious infectious mononucleosis as a step prior to liver transplantation. Aran Ediciones S.A. https://hdl.handle.net/11441/158771 https://doi.org/10.17235/reed.2017.4072/2015 |
| spellingShingle | Severe acute hepatitis and cold agglutinin-related hemolytic anemia secondary to prime infection with Epstein-Barr virus Ontanilla-Clavijo, Guillermo Epstein-Barr virus Acute hepatitis Hemolytic anemia |
| status_str | publishedVersion |
| title | Severe acute hepatitis and cold agglutinin-related hemolytic anemia secondary to prime infection with Epstein-Barr virus |
| title_full | Severe acute hepatitis and cold agglutinin-related hemolytic anemia secondary to prime infection with Epstein-Barr virus |
| title_fullStr | Severe acute hepatitis and cold agglutinin-related hemolytic anemia secondary to prime infection with Epstein-Barr virus |
| title_full_unstemmed | Severe acute hepatitis and cold agglutinin-related hemolytic anemia secondary to prime infection with Epstein-Barr virus |
| title_short | Severe acute hepatitis and cold agglutinin-related hemolytic anemia secondary to prime infection with Epstein-Barr virus |
| title_sort | Severe acute hepatitis and cold agglutinin-related hemolytic anemia secondary to prime infection with Epstein-Barr virus |
| topic | Epstein-Barr virus Acute hepatitis Hemolytic anemia |
| topic_facet | Epstein-Barr virus Acute hepatitis Hemolytic anemia |
| url | https://hdl.handle.net/11441/158771 https://doi.org/10.17235/reed.2017.4072/2015 |