A Prospective, Multicenter, Real-World Registry of Coronary Lithotripsy in Calcified Coronary Arteries
Background: Intravascular lithotripsy (IVL) has demonstrated effectiveness in the treatment of calcified lesions in selected patients with stable coronary disease. Objectives: The authors sought to assess the performance of coronary IVL in calcified coronary lesions in a real-life, all comers, setti...
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| Tipo de documento: | Artículo |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Lenguaje: | Inglés |
| OAI Identifier: | oai:ddd.uab.cat:310578 |
| Acceso en línea: | https://ddd.uab.cat/record/310578 https://dx.doi.org/urn:doi:10.1016/j.jcin.2023.12.018 |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | Acute coronary syndrome Coronary artery calcification Intravascular lithotripsy |
| _version_ | 1878732251654520832 |
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| author | Rodriguez-Leor, Oriol|||0000-0003-2657-5657 |
| author2 | Cid-Alvarez, Ana Belen Lopez-Benito, Maria Gonzalo, Nieves|||0000-0003-3827-945X Vilalta, Victoria|||0000-0003-1767-5963 Diarte de Miguel, Jose Antonio Fernandez López, Leticia Jurado-Roman, Alfonso Diego, Alejandro Oteo, Juan F.|||0000-0002-2641-4135 Cuellas, Carlos Trillo, Ramiro Travieso, Alejandro|||0000-0003-3013-2592 Alfonso, Fernando|||0000-0002-7480-2511 Carrillo, Xavier|||0000-0001-6691-8859 Vegas-Valle, José Miguel Cortes-Villar, Carlos|||0000-0002-9332-4236 Pascual, Isaac|||0000-0001-5433-1364 Muñoz Camacho, Juan Francisco Flores, Xacobe Vera-Vera, Silvio|||0000-0002-3165-6948 Moreu, Jose Barreira de Sousa, Gilles Martí, David Jimenez-Mazuecos, Jesus Fuertes, Monica Ocaranza, Raymundo de la Torre Hernandez, Jose Maria|||0000-0003-4570-8902 Lozano, Fernando|||0000-0001-9513-0614 Solana Martinez, Santiago G. Gomez Lara, Josep|||0000-0001-9731-4767 Perez de Prado, Armando|||0000-0003-3283-0597 |
| author2_role | author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| author_browse | Alfonso, Fernando|||0000-0002-7480-2511 Barreira de Sousa, Gilles Carrillo, Xavier|||0000-0001-6691-8859 Cid-Alvarez, Ana Belen Cortes-Villar, Carlos|||0000-0002-9332-4236 Cuellas, Carlos Diarte de Miguel, Jose Antonio Diego, Alejandro Fernandez López, Leticia Flores, Xacobe Fuertes, Monica Gomez Lara, Josep|||0000-0001-9731-4767 Gonzalo, Nieves|||0000-0003-3827-945X Jimenez-Mazuecos, Jesus Jurado-Roman, Alfonso Lopez-Benito, Maria Lozano, Fernando|||0000-0001-9513-0614 Martí, David Moreu, Jose Muñoz Camacho, Juan Francisco Ocaranza, Raymundo Oteo, Juan F.|||0000-0002-2641-4135 Pascual, Isaac|||0000-0001-5433-1364 Perez de Prado, Armando|||0000-0003-3283-0597 Rodriguez-Leor, Oriol|||0000-0003-2657-5657 Solana Martinez, Santiago G. Travieso, Alejandro|||0000-0003-3013-2592 Trillo, Ramiro Vegas-Valle, José Miguel Vera-Vera, Silvio|||0000-0002-3165-6948 Vilalta, Victoria|||0000-0003-1767-5963 de la Torre Hernandez, Jose Maria|||0000-0003-4570-8902 |
| author_facet | Rodriguez-Leor, Oriol|||0000-0003-2657-5657 Cid-Alvarez, Ana Belen Lopez-Benito, Maria Gonzalo, Nieves|||0000-0003-3827-945X Vilalta, Victoria|||0000-0003-1767-5963 Diarte de Miguel, Jose Antonio Fernandez López, Leticia Jurado-Roman, Alfonso Diego, Alejandro Oteo, Juan F.|||0000-0002-2641-4135 Cuellas, Carlos Trillo, Ramiro Travieso, Alejandro|||0000-0003-3013-2592 Alfonso, Fernando|||0000-0002-7480-2511 Carrillo, Xavier|||0000-0001-6691-8859 Vegas-Valle, José Miguel Cortes-Villar, Carlos|||0000-0002-9332-4236 Pascual, Isaac|||0000-0001-5433-1364 Muñoz Camacho, Juan Francisco Flores, Xacobe Vera-Vera, Silvio|||0000-0002-3165-6948 Moreu, Jose Barreira de Sousa, Gilles Martí, David Jimenez-Mazuecos, Jesus Fuertes, Monica Ocaranza, Raymundo de la Torre Hernandez, Jose Maria|||0000-0003-4570-8902 Lozano, Fernando|||0000-0001-9513-0614 Solana Martinez, Santiago G. Gomez Lara, Josep|||0000-0001-9731-4767 Perez de Prado, Armando|||0000-0003-3283-0597 |
| author_role | author |
| collection | Dipòsit Digital de Documents de la UAB |
| description | Background: Intravascular lithotripsy (IVL) has demonstrated effectiveness in the treatment of calcified lesions in selected patients with stable coronary disease. Objectives: The authors sought to assess the performance of coronary IVL in calcified coronary lesions in a real-life, all comers, setting. Methods: The REPLICA-EPIC18 study prospectively enrolled consecutive patients treated with IVL in 26 centers in Spain. An independent core laboratory performed the angiographic analysis and event adjudication. The primary effectiveness endpoint assessed procedural success (successful IVL delivery, final diameter stenosis <20%, and absence of in-hospital major adverse cardiovascular events [MACE]). The primary safety endpoint measured freedom from MACE at 30 days. A predefined substudy compared outcomes between acute coronary syndrome (ACS) and chronic coronary syndrome (CCS) patients. Results: A total of 426 patients (456 lesions) were included, 63% of the patients presenting with ACS. IVL delivery was successful in 99% of cases. Before IVL, 49% of lesions were considered undilatable. The primary effectiveness endpoint was achieved in 66% of patients, with similar rates among CCS patients (68%) and ACS patients (65%). Likewise, there were no significant differences in angiographic success after IVL between CCS and ACS patients. The rate of MACE at 30 days (primary safety endpoint) was 3% (1% in CCS and 5% in ACS patients [P = 0.073]). Conclusions: Coronary IVL proved to be a feasible and safe procedure in a "real-life" setting, effectively facilitating stent implantation in severely calcified lesions. Patients with ACS on admission showed similar angiographic success rates but showed a trend toward higher 30-day MACE compared with patients with CCS. (REPLICA-EPIC18 study [Registry of Coronary Lithotripsy in Spain]; NCT04298307). |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_3f69d10e30c8261bda56c2aefa8d64e5 |
| institution | Universitat Autònoma de Barcelona |
| instname_str | Universitat Autònoma de Barcelona |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:ddd.uab.cat:310578 |
| publishDate | 2024 |
| publishDateSort | 2024 |
| reponame_str | Dipòsit Digital de Documents de la UAB |
| spelling | A Prospective, Multicenter, Real-World Registry of Coronary Lithotripsy in Calcified Coronary Arteries The REPLICA-EPIC18 Study Rodriguez-Leor, Oriol|||0000-0003-2657-5657 Cid-Alvarez, Ana Belen Lopez-Benito, Maria Gonzalo, Nieves|||0000-0003-3827-945X Vilalta, Victoria|||0000-0003-1767-5963 Diarte de Miguel, Jose Antonio Fernandez López, Leticia Jurado-Roman, Alfonso Diego, Alejandro Oteo, Juan F.|||0000-0002-2641-4135 Cuellas, Carlos Trillo, Ramiro Travieso, Alejandro|||0000-0003-3013-2592 Alfonso, Fernando|||0000-0002-7480-2511 Carrillo, Xavier|||0000-0001-6691-8859 Vegas-Valle, José Miguel Cortes-Villar, Carlos|||0000-0002-9332-4236 Pascual, Isaac|||0000-0001-5433-1364 Muñoz Camacho, Juan Francisco Flores, Xacobe Vera-Vera, Silvio|||0000-0002-3165-6948 Moreu, Jose Barreira de Sousa, Gilles Martí, David Jimenez-Mazuecos, Jesus Fuertes, Monica Ocaranza, Raymundo de la Torre Hernandez, Jose Maria|||0000-0003-4570-8902 Lozano, Fernando|||0000-0001-9513-0614 Solana Martinez, Santiago G. Gomez Lara, Josep|||0000-0001-9731-4767 Perez de Prado, Armando|||0000-0003-3283-0597 Acute coronary syndrome Coronary artery calcification Intravascular lithotripsy Background: Intravascular lithotripsy (IVL) has demonstrated effectiveness in the treatment of calcified lesions in selected patients with stable coronary disease. Objectives: The authors sought to assess the performance of coronary IVL in calcified coronary lesions in a real-life, all comers, setting. Methods: The REPLICA-EPIC18 study prospectively enrolled consecutive patients treated with IVL in 26 centers in Spain. An independent core laboratory performed the angiographic analysis and event adjudication. The primary effectiveness endpoint assessed procedural success (successful IVL delivery, final diameter stenosis <20%, and absence of in-hospital major adverse cardiovascular events [MACE]). The primary safety endpoint measured freedom from MACE at 30 days. A predefined substudy compared outcomes between acute coronary syndrome (ACS) and chronic coronary syndrome (CCS) patients. Results: A total of 426 patients (456 lesions) were included, 63% of the patients presenting with ACS. IVL delivery was successful in 99% of cases. Before IVL, 49% of lesions were considered undilatable. The primary effectiveness endpoint was achieved in 66% of patients, with similar rates among CCS patients (68%) and ACS patients (65%). Likewise, there were no significant differences in angiographic success after IVL between CCS and ACS patients. The rate of MACE at 30 days (primary safety endpoint) was 3% (1% in CCS and 5% in ACS patients [P = 0.073]). Conclusions: Coronary IVL proved to be a feasible and safe procedure in a "real-life" setting, effectively facilitating stent implantation in severely calcified lesions. Patients with ACS on admission showed similar angiographic success rates but showed a trend toward higher 30-day MACE compared with patients with CCS. (REPLICA-EPIC18 study [Registry of Coronary Lithotripsy in Spain]; NCT04298307). https://ddd.uab.cat/record/310578 https://dx.doi.org/urn:doi:10.1016/j.jcin.2023.12.018 |
| spellingShingle | A Prospective, Multicenter, Real-World Registry of Coronary Lithotripsy in Calcified Coronary Arteries Rodriguez-Leor, Oriol|||0000-0003-2657-5657 Acute coronary syndrome Coronary artery calcification Intravascular lithotripsy |
| title | A Prospective, Multicenter, Real-World Registry of Coronary Lithotripsy in Calcified Coronary Arteries |
| title_full | A Prospective, Multicenter, Real-World Registry of Coronary Lithotripsy in Calcified Coronary Arteries |
| title_fullStr | A Prospective, Multicenter, Real-World Registry of Coronary Lithotripsy in Calcified Coronary Arteries |
| title_full_unstemmed | A Prospective, Multicenter, Real-World Registry of Coronary Lithotripsy in Calcified Coronary Arteries |
| title_short | A Prospective, Multicenter, Real-World Registry of Coronary Lithotripsy in Calcified Coronary Arteries |
| title_sort | A Prospective, Multicenter, Real-World Registry of Coronary Lithotripsy in Calcified Coronary Arteries |
| topic | Acute coronary syndrome Coronary artery calcification Intravascular lithotripsy |
| topic_facet | Acute coronary syndrome Coronary artery calcification Intravascular lithotripsy |
| url | https://ddd.uab.cat/record/310578 https://dx.doi.org/urn:doi:10.1016/j.jcin.2023.12.018 |