Cortical microstructure in primary progressive aphasia
Background: Cortical mean diffusivity is a novel imaging metric sensitive to early changes in neurodegenerative syndromes. Higher cortical mean diffusivity values reflect microstructural disorganization and have been proposed as a sensitive biomarker that might antedate macroscopic cortical changes....
| Autores: | ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; |
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| Tipo de documento: | Artículo |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Lenguaje: | Inglés |
| OAI Identifier: | oai:ddd.uab.cat:282270 |
| Acceso en línea: | https://ddd.uab.cat/record/282270 https://dx.doi.org/urn:doi:10.1186/s13195-022-00974-0 |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | Difusion Magnetic resonance Primary progressive aphasia Alzheimer's disease Frontotemporal lobar degeneration |
| _version_ | 1878732210817728512 |
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| author | Illán-Gala, Ignacio|||0000-0002-5418-2052 |
| author2 | Montal, Victor|||0000-0002-5714-9282 Borrego-Écija, Sergi|||0000-0003-2557-0010 Mandelli, Maria Luisa|||0000-0002-2518-2520 Falgàs, Neus|||0000-0002-3404-2765 Welch, Ariane E. Pegueroles, Jordi|||0000-0002-3554-2446 Santos Santos, Miguel Ángel|||0000-0003-1567-617X Bejanin, Alexandre|||0000-0002-9958-0951 Alcolea, Daniel|||0000-0002-3819-3245 Dols Icardo, Oriol|||0000-0003-2656-8748 Belbin, Olivia|||0000-0002-6109-6371 Sánchez-Saudinós, María Belén|||0000-0003-1795-1833 Bargalló, Núria|||0000-0001-6284-5402 González-Ortiz, Sofía|||0000-0003-2578-6671 Llado Plarrumani, Albert|||0000-0002-5066-4150 Blesa, Rafael|||0000-0003-4026-2884 Dickerson, Bradford C. Rosen, Howard J.|||0000-0001-9281-7402 Miller, Bruce L.|||0000-0002-2152-4220 Lleó, Alberto|||0000-0002-2568-5478 Gorno-Tempini, Maria Luisa Sanchez-Valle, Raquel|||0000-0001-7750-896X Fortea, Juan|||0000-0002-1340-638X |
| author2_role | author author author author author author author author author author author author author author author author author author author author author author author |
| author_browse | Alcolea, Daniel|||0000-0002-3819-3245 Bargalló, Núria|||0000-0001-6284-5402 Bejanin, Alexandre|||0000-0002-9958-0951 Belbin, Olivia|||0000-0002-6109-6371 Blesa, Rafael|||0000-0003-4026-2884 Borrego-Écija, Sergi|||0000-0003-2557-0010 Dickerson, Bradford C. Dols Icardo, Oriol|||0000-0003-2656-8748 Falgàs, Neus|||0000-0002-3404-2765 Fortea, Juan|||0000-0002-1340-638X González-Ortiz, Sofía|||0000-0003-2578-6671 Gorno-Tempini, Maria Luisa Illán-Gala, Ignacio|||0000-0002-5418-2052 Llado Plarrumani, Albert|||0000-0002-5066-4150 Lleó, Alberto|||0000-0002-2568-5478 Mandelli, Maria Luisa|||0000-0002-2518-2520 Miller, Bruce L.|||0000-0002-2152-4220 Montal, Victor|||0000-0002-5714-9282 Pegueroles, Jordi|||0000-0002-3554-2446 Rosen, Howard J.|||0000-0001-9281-7402 Sanchez-Valle, Raquel|||0000-0001-7750-896X Santos Santos, Miguel Ángel|||0000-0003-1567-617X Sánchez-Saudinós, María Belén|||0000-0003-1795-1833 Welch, Ariane E. |
| author_facet | Illán-Gala, Ignacio|||0000-0002-5418-2052 Montal, Victor|||0000-0002-5714-9282 Borrego-Écija, Sergi|||0000-0003-2557-0010 Mandelli, Maria Luisa|||0000-0002-2518-2520 Falgàs, Neus|||0000-0002-3404-2765 Welch, Ariane E. Pegueroles, Jordi|||0000-0002-3554-2446 Santos Santos, Miguel Ángel|||0000-0003-1567-617X Bejanin, Alexandre|||0000-0002-9958-0951 Alcolea, Daniel|||0000-0002-3819-3245 Dols Icardo, Oriol|||0000-0003-2656-8748 Belbin, Olivia|||0000-0002-6109-6371 Sánchez-Saudinós, María Belén|||0000-0003-1795-1833 Bargalló, Núria|||0000-0001-6284-5402 González-Ortiz, Sofía|||0000-0003-2578-6671 Llado Plarrumani, Albert|||0000-0002-5066-4150 Blesa, Rafael|||0000-0003-4026-2884 Dickerson, Bradford C. Rosen, Howard J.|||0000-0001-9281-7402 Miller, Bruce L.|||0000-0002-2152-4220 Lleó, Alberto|||0000-0002-2568-5478 Gorno-Tempini, Maria Luisa Sanchez-Valle, Raquel|||0000-0001-7750-896X Fortea, Juan|||0000-0002-1340-638X |
| author_role | author |
| collection | Dipòsit Digital de Documents de la UAB |
| description | Background: Cortical mean diffusivity is a novel imaging metric sensitive to early changes in neurodegenerative syndromes. Higher cortical mean diffusivity values reflect microstructural disorganization and have been proposed as a sensitive biomarker that might antedate macroscopic cortical changes. We aimed to test the hypothesis that cortical mean diffusivity is more sensitive than cortical thickness to detect cortical changes in primary progressive aphasia (PPA). Methods: In this multicenter, case-control study, we recruited 120 patients with PPA (52 non-fluent, 31 semantic, and 32 logopenic variants; and 5 GRN-related PPA) as well as 89 controls from three centers. The 3-Tesla MRI protocol included structural and diffusion-weighted sequences. Disease severity was assessed with the Clinical Dementia Rating scale. Cortical thickness and cortical mean diffusivity were computed using a surface-based approach. Results: The comparison between each PPA variant and controls revealed cortical mean diffusivity increases and cortical thinning in overlapping regions, reflecting the canonical loci of neurodegeneration of each variant. Importantly, cortical mean diffusivity increases also expanded to other PPA-related areas and correlated with disease severity in all PPA groups. Cortical mean diffusivity was also increased in patients with very mild PPA when only minimal cortical thinning was observed and showed a good correlation with measures of disease severity. Conclusions: Cortical mean diffusivity shows promise as a sensitive biomarker for the study of the neurodegeneration-related microstructural changes in PPA. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_3ea837d6dbdf9c7b0ff1bb75e07fd9fa |
| institution | Universitat Autònoma de Barcelona |
| instname_str | Universitat Autònoma de Barcelona |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:ddd.uab.cat:282270 |
| publishDate | 2022 |
| publishDateSort | 2022 |
| reponame_str | Dipòsit Digital de Documents de la UAB |
| spelling | Cortical microstructure in primary progressive aphasia a multicenter study Illán-Gala, Ignacio|||0000-0002-5418-2052 Montal, Victor|||0000-0002-5714-9282 Borrego-Écija, Sergi|||0000-0003-2557-0010 Mandelli, Maria Luisa|||0000-0002-2518-2520 Falgàs, Neus|||0000-0002-3404-2765 Welch, Ariane E. Pegueroles, Jordi|||0000-0002-3554-2446 Santos Santos, Miguel Ángel|||0000-0003-1567-617X Bejanin, Alexandre|||0000-0002-9958-0951 Alcolea, Daniel|||0000-0002-3819-3245 Dols Icardo, Oriol|||0000-0003-2656-8748 Belbin, Olivia|||0000-0002-6109-6371 Sánchez-Saudinós, María Belén|||0000-0003-1795-1833 Bargalló, Núria|||0000-0001-6284-5402 González-Ortiz, Sofía|||0000-0003-2578-6671 Llado Plarrumani, Albert|||0000-0002-5066-4150 Blesa, Rafael|||0000-0003-4026-2884 Dickerson, Bradford C. Rosen, Howard J.|||0000-0001-9281-7402 Miller, Bruce L.|||0000-0002-2152-4220 Lleó, Alberto|||0000-0002-2568-5478 Gorno-Tempini, Maria Luisa Sanchez-Valle, Raquel|||0000-0001-7750-896X Fortea, Juan|||0000-0002-1340-638X Difusion Magnetic resonance Primary progressive aphasia Alzheimer's disease Frontotemporal lobar degeneration Background: Cortical mean diffusivity is a novel imaging metric sensitive to early changes in neurodegenerative syndromes. Higher cortical mean diffusivity values reflect microstructural disorganization and have been proposed as a sensitive biomarker that might antedate macroscopic cortical changes. We aimed to test the hypothesis that cortical mean diffusivity is more sensitive than cortical thickness to detect cortical changes in primary progressive aphasia (PPA). Methods: In this multicenter, case-control study, we recruited 120 patients with PPA (52 non-fluent, 31 semantic, and 32 logopenic variants; and 5 GRN-related PPA) as well as 89 controls from three centers. The 3-Tesla MRI protocol included structural and diffusion-weighted sequences. Disease severity was assessed with the Clinical Dementia Rating scale. Cortical thickness and cortical mean diffusivity were computed using a surface-based approach. Results: The comparison between each PPA variant and controls revealed cortical mean diffusivity increases and cortical thinning in overlapping regions, reflecting the canonical loci of neurodegeneration of each variant. Importantly, cortical mean diffusivity increases also expanded to other PPA-related areas and correlated with disease severity in all PPA groups. Cortical mean diffusivity was also increased in patients with very mild PPA when only minimal cortical thinning was observed and showed a good correlation with measures of disease severity. Conclusions: Cortical mean diffusivity shows promise as a sensitive biomarker for the study of the neurodegeneration-related microstructural changes in PPA. https://ddd.uab.cat/record/282270 https://dx.doi.org/urn:doi:10.1186/s13195-022-00974-0 |
| spellingShingle | Cortical microstructure in primary progressive aphasia Illán-Gala, Ignacio|||0000-0002-5418-2052 Difusion Magnetic resonance Primary progressive aphasia Alzheimer's disease Frontotemporal lobar degeneration |
| title | Cortical microstructure in primary progressive aphasia |
| title_full | Cortical microstructure in primary progressive aphasia |
| title_fullStr | Cortical microstructure in primary progressive aphasia |
| title_full_unstemmed | Cortical microstructure in primary progressive aphasia |
| title_short | Cortical microstructure in primary progressive aphasia |
| title_sort | Cortical microstructure in primary progressive aphasia |
| topic | Difusion Magnetic resonance Primary progressive aphasia Alzheimer's disease Frontotemporal lobar degeneration |
| topic_facet | Difusion Magnetic resonance Primary progressive aphasia Alzheimer's disease Frontotemporal lobar degeneration |
| url | https://ddd.uab.cat/record/282270 https://dx.doi.org/urn:doi:10.1186/s13195-022-00974-0 |