Reduction of Spasticity With Repetitive Transcranial Magnetic Stimulation in Patients With Spinal Cord Injury
Objective. Spasticity with increased tone and spasms is frequent in patients after spinal cord injury (SCI). Damage to descending corticospinal pathways that normally exert spinal segmental control is thought to play an important causal role in spasticity. The authors examined whether the modulation...
| Authors: | ; ; ; ; ; ; ; ; |
|---|---|
| Format: | Article |
| Publication date: | 2010 |
| Country: | España |
| Institution: | Universidad Católica de Valencia San Vicente Mártir |
| Repository: | RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir |
| Language: | English |
| OAI Identifier: | oai:riucv.ucv.es:20.500.12466/3320 |
| Online Access: | http://hdl.handle.net/20.500.12466/3320 |
| Access Level: | Open access |
| Keyword: | Spasticity Repetitive TMS Spinal cord injury Neurophysiological examination 2411.11 Neurofisiología 2490 Neurociencias |
| _version_ | 1878731863864901632 |
|---|---|
| author | Kumru, Hatice |
| author2 | Murillo, Narda Vidal Sanso, Joan Valls Sole, Josep Edwards, Dylan Pelayo, Raúl Valero Cabre, Antoni Tormos Muñoz, José María Pascual Leone, Álvaro |
| author2_role | author author author author author author author author |
| author_browse | Edwards, Dylan Kumru, Hatice Murillo, Narda Pascual Leone, Álvaro Pelayo, Raúl Tormos Muñoz, José María Valero Cabre, Antoni Valls Sole, Josep Vidal Sanso, Joan |
| author_facet | Kumru, Hatice Murillo, Narda Vidal Sanso, Joan Valls Sole, Josep Edwards, Dylan Pelayo, Raúl Valero Cabre, Antoni Tormos Muñoz, José María Pascual Leone, Álvaro |
| author_role | author |
| collection | RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir |
| description | Objective. Spasticity with increased tone and spasms is frequent in patients after spinal cord injury (SCI). Damage to descending corticospinal pathways that normally exert spinal segmental control is thought to play an important causal role in spasticity. The authors examined whether the modulation of excitability of the primary motor cortex with highfrequency repetitive transcranial magnetic stimulation (rTMS) could modify lower limb spasticity in patients with incomplete SCI. Methods. Patients were assessed by the Modified Ashworth Scale, Visual Analogue Scale, and the Spinal Cord Injury Spasticity Evaluation Tool (SCI-SET) and neurophysiologically with measures of corticospinal and segmental excitability by the Hmax/Mmax, T reflex, and withdrawal reflex. Fifteen patients received 5 days of daily sessions of active (n = 14) or sham (n = 7) rTMS to the leg motor area (20 trains of 40 pulses at 20 Hz and an intensity of 90% of resting motor threshold for the biceps brachii muscle). Result. A significant clinical improvement in lower limb spasticity was observed in patients following active rTMS but not after sham stimulation. This improvement lasted for at least 1 week following the intervention. Neurophysiological studies did not change. Conclusions. High-frequency rTMS over the leg motor area can improve aspects of spasticity in patients with incomplete SCI. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_382581663c3b649e89f8c8ef0ae1479e |
| institution | Universidad Católica de Valencia San Vicente Mártir |
| instname_str | Universidad Católica de Valencia San Vicente Mártir |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:riucv.ucv.es:20.500.12466/3320 |
| publishDate | 2010 |
| publishDateSort | 2010 |
| reponame_str | RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir |
| spelling | Reduction of Spasticity With Repetitive Transcranial Magnetic Stimulation in Patients With Spinal Cord Injury Kumru, Hatice Murillo, Narda Vidal Sanso, Joan Valls Sole, Josep Edwards, Dylan Pelayo, Raúl Valero Cabre, Antoni Tormos Muñoz, José María Pascual Leone, Álvaro Spasticity Repetitive TMS Spinal cord injury Neurophysiological examination 2411.11 Neurofisiología 2490 Neurociencias Objective. Spasticity with increased tone and spasms is frequent in patients after spinal cord injury (SCI). Damage to descending corticospinal pathways that normally exert spinal segmental control is thought to play an important causal role in spasticity. The authors examined whether the modulation of excitability of the primary motor cortex with highfrequency repetitive transcranial magnetic stimulation (rTMS) could modify lower limb spasticity in patients with incomplete SCI. Methods. Patients were assessed by the Modified Ashworth Scale, Visual Analogue Scale, and the Spinal Cord Injury Spasticity Evaluation Tool (SCI-SET) and neurophysiologically with measures of corticospinal and segmental excitability by the Hmax/Mmax, T reflex, and withdrawal reflex. Fifteen patients received 5 days of daily sessions of active (n = 14) or sham (n = 7) rTMS to the leg motor area (20 trains of 40 pulses at 20 Hz and an intensity of 90% of resting motor threshold for the biceps brachii muscle). Result. A significant clinical improvement in lower limb spasticity was observed in patients following active rTMS but not after sham stimulation. This improvement lasted for at least 1 week following the intervention. Neurophysiological studies did not change. Conclusions. High-frequency rTMS over the leg motor area can improve aspects of spasticity in patients with incomplete SCI. http://hdl.handle.net/20.500.12466/3320 |
| spellingShingle | Reduction of Spasticity With Repetitive Transcranial Magnetic Stimulation in Patients With Spinal Cord Injury Kumru, Hatice Spasticity Repetitive TMS Spinal cord injury Neurophysiological examination 2411.11 Neurofisiología 2490 Neurociencias |
| title | Reduction of Spasticity With Repetitive Transcranial Magnetic Stimulation in Patients With Spinal Cord Injury |
| title_full | Reduction of Spasticity With Repetitive Transcranial Magnetic Stimulation in Patients With Spinal Cord Injury |
| title_fullStr | Reduction of Spasticity With Repetitive Transcranial Magnetic Stimulation in Patients With Spinal Cord Injury |
| title_full_unstemmed | Reduction of Spasticity With Repetitive Transcranial Magnetic Stimulation in Patients With Spinal Cord Injury |
| title_short | Reduction of Spasticity With Repetitive Transcranial Magnetic Stimulation in Patients With Spinal Cord Injury |
| title_sort | Reduction of Spasticity With Repetitive Transcranial Magnetic Stimulation in Patients With Spinal Cord Injury |
| topic | Spasticity Repetitive TMS Spinal cord injury Neurophysiological examination 2411.11 Neurofisiología 2490 Neurociencias |
| topic_facet | Spasticity Repetitive TMS Spinal cord injury Neurophysiological examination 2411.11 Neurofisiología 2490 Neurociencias |
| url | http://hdl.handle.net/20.500.12466/3320 |