NcRNAs in Therapeutics: Challenges and Limitations in Nucleic Acid-Based Drug Delivery
Non-coding RNAs (ncRNAs) are emerging therapeutic tools but there are barriers to their translation to clinical practice. Key issues concern the specificity of the targets, the delivery of the molecules, and their stability, while avoiding "on-target" and "off-target" side effects. In this "ncRNA in...
| Authors: | ; ; ; ; ; |
|---|---|
| Format: | Article |
| Status: | Published version |
| Publication date: | 2021 |
| Country: | España |
| Institution: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repository: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/181697 |
| Online Access: | https://hdl.handle.net/2445/181697 |
| Access Level: | Open access |
| Keyword: | Nanomedicina Àcids nucleics Nanomedicine Nucleic acids |
| _version_ | 1878731779846701056 |
|---|---|
| author | Hueso Val, Miguel |
| author2 | Mallén, Adrián Suñé Pou, Marc Aran Perramon, Josep M. Suñé i Negre, Josep M. (Josep Maria) Navarro, Estanis |
| author2_role | author author author author author |
| author_browse | Aran Perramon, Josep M. Hueso Val, Miguel Mallén, Adrián Navarro, Estanis Suñé Pou, Marc Suñé i Negre, Josep M. (Josep Maria) |
| author_facet | Hueso Val, Miguel Mallén, Adrián Suñé Pou, Marc Aran Perramon, Josep M. Suñé i Negre, Josep M. (Josep Maria) Navarro, Estanis |
| author_role | author |
| collection | Recercat. Dipósit de la Recerca de Catalunya |
| description | Non-coding RNAs (ncRNAs) are emerging therapeutic tools but there are barriers to their translation to clinical practice. Key issues concern the specificity of the targets, the delivery of the molecules, and their stability, while avoiding "on-target" and "off-target" side effects. In this "ncRNA in therapeutics" issue, we collect several studies of the differential expression of ncRNAs in cardiovascular diseases, bone metabolism-related disorders, neurology, and oncology, and their potential to be used as biomarkers or therapeutic targets. Moreover, we review recent advances in the use of antisense ncRNAs in targeted therapies with a particular emphasis on their basic biological mechanisms, their translational potential, and future trends. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_366e8b0bd1df6f92d8545f9cdc41aae9 |
| institution | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:recercat.cat:2445/181697 |
| publishDate | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI AG |
| publisherStr | MDPI AG |
| reponame_str | Recercat. Dipósit de la Recerca de Catalunya |
| spelling | NcRNAs in Therapeutics: Challenges and Limitations in Nucleic Acid-Based Drug Delivery Hueso Val, Miguel Mallén, Adrián Suñé Pou, Marc Aran Perramon, Josep M. Suñé i Negre, Josep M. (Josep Maria) Navarro, Estanis Nanomedicina Àcids nucleics Nanomedicine Nucleic acids Non-coding RNAs (ncRNAs) are emerging therapeutic tools but there are barriers to their translation to clinical practice. Key issues concern the specificity of the targets, the delivery of the molecules, and their stability, while avoiding "on-target" and "off-target" side effects. In this "ncRNA in therapeutics" issue, we collect several studies of the differential expression of ncRNAs in cardiovascular diseases, bone metabolism-related disorders, neurology, and oncology, and their potential to be used as biomarkers or therapeutic targets. Moreover, we review recent advances in the use of antisense ncRNAs in targeted therapies with a particular emphasis on their basic biological mechanisms, their translational potential, and future trends. MDPI AG https://hdl.handle.net/2445/181697 |
| spellingShingle | NcRNAs in Therapeutics: Challenges and Limitations in Nucleic Acid-Based Drug Delivery Hueso Val, Miguel Nanomedicina Àcids nucleics Nanomedicine Nucleic acids |
| status_str | publishedVersion |
| title | NcRNAs in Therapeutics: Challenges and Limitations in Nucleic Acid-Based Drug Delivery |
| title_full | NcRNAs in Therapeutics: Challenges and Limitations in Nucleic Acid-Based Drug Delivery |
| title_fullStr | NcRNAs in Therapeutics: Challenges and Limitations in Nucleic Acid-Based Drug Delivery |
| title_full_unstemmed | NcRNAs in Therapeutics: Challenges and Limitations in Nucleic Acid-Based Drug Delivery |
| title_short | NcRNAs in Therapeutics: Challenges and Limitations in Nucleic Acid-Based Drug Delivery |
| title_sort | NcRNAs in Therapeutics: Challenges and Limitations in Nucleic Acid-Based Drug Delivery |
| topic | Nanomedicina Àcids nucleics Nanomedicine Nucleic acids |
| topic_facet | Nanomedicina Àcids nucleics Nanomedicine Nucleic acids |
| url | https://hdl.handle.net/2445/181697 |