Structural Heart Alterations in Brugada Syndrome: Is it Really a Channelopathy? A Systematic Review
Brugada syndrome (BrS) is classified as an inherited cardiac channelopathy attributed to dysfunctional ion channels and/or associated proteins in cardiomyocytes rather than to structural heart alterations. However, hearts of some BrS patients exhibit slight histologic abnormalities, suggesting that...
| Autores: | ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; |
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| Tipo de documento: | Artículo |
| Estado: | Published version |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:10256/21569 |
| Acceso en línea: | http://hdl.handle.net/10256/21569 |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | Mort sobtada Sudden death Brugada, Síndrome de -- Diagnòstic Brugada syndrome -- Diagnosi Patologia forense Forensic pathology Cor -- Histopatologia Heart -- Histopathology |
| _version_ | 1878731554044248064 |
|---|---|
| author | Oliva, Antonio |
| author2 | Grassi, Simone Pinchi, Vilma Cazzato, Francesca Coll Vidal, Mònica Alcalde Masegu, Mireia Vallverdú-Prats, Marta Perez-Serra, Alexandra Martínez-Barrios, Estefanía Cesar, Sergi Iglesias, Anna Cruzalegui, José Hernández Cera, Clara Fiol, Victoria Arbelo, Elena Díez-Escuté, Nuria Arena, Vincenzo Brugada Terradellas, Josep Sarquella Brugada, Geòrgia Brugada, Ramon Campuzano Larrea, Oscar |
| author2_role | author author author author author author author author author author author author author author author author author author author author |
| author_browse | Alcalde Masegu, Mireia Arbelo, Elena Arena, Vincenzo Brugada Terradellas, Josep Brugada, Ramon Campuzano Larrea, Oscar Cazzato, Francesca Cesar, Sergi Coll Vidal, Mònica Cruzalegui, José Díez-Escuté, Nuria Fiol, Victoria Grassi, Simone Hernández Cera, Clara Iglesias, Anna Martínez-Barrios, Estefanía Oliva, Antonio Perez-Serra, Alexandra Pinchi, Vilma Sarquella Brugada, Geòrgia Vallverdú-Prats, Marta |
| author_facet | Oliva, Antonio Grassi, Simone Pinchi, Vilma Cazzato, Francesca Coll Vidal, Mònica Alcalde Masegu, Mireia Vallverdú-Prats, Marta Perez-Serra, Alexandra Martínez-Barrios, Estefanía Cesar, Sergi Iglesias, Anna Cruzalegui, José Hernández Cera, Clara Fiol, Victoria Arbelo, Elena Díez-Escuté, Nuria Arena, Vincenzo Brugada Terradellas, Josep Sarquella Brugada, Geòrgia Brugada, Ramon Campuzano Larrea, Oscar |
| author_role | author |
| collection | Recercat. Dipósit de la Recerca de Catalunya |
| description | Brugada syndrome (BrS) is classified as an inherited cardiac channelopathy attributed to dysfunctional ion channels and/or associated proteins in cardiomyocytes rather than to structural heart alterations. However, hearts of some BrS patients exhibit slight histologic abnormalities, suggesting that BrS could be a phenotypic variant of arrhythmogenic cardiomyopathy. We performed a systematic review of the literature following Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statement (PRISMA) criteria. Our comprehensive analysis of structural findings did not reveal enough definitive evidence for reclassification of BrS as a cardiomyopathy. The collection and comprehensive analysis of new cases with a definitive BrS diagnosis are needed to clarify whether some of these structural features may have key roles in the pathophysiological pathways associated with malignant arrhythmogenic episodes |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_31f1b328ac4d288d4dcb4d29d88560dd |
| institution | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:recercat.cat:10256/21569 |
| publishDate | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI (Multidisciplinary Digital Publishing Institute) |
| publisherStr | MDPI (Multidisciplinary Digital Publishing Institute) |
| reponame_str | Recercat. Dipósit de la Recerca de Catalunya |
| spelling | Structural Heart Alterations in Brugada Syndrome: Is it Really a Channelopathy? A Systematic Review Oliva, Antonio Grassi, Simone Pinchi, Vilma Cazzato, Francesca Coll Vidal, Mònica Alcalde Masegu, Mireia Vallverdú-Prats, Marta Perez-Serra, Alexandra Martínez-Barrios, Estefanía Cesar, Sergi Iglesias, Anna Cruzalegui, José Hernández Cera, Clara Fiol, Victoria Arbelo, Elena Díez-Escuté, Nuria Arena, Vincenzo Brugada Terradellas, Josep Sarquella Brugada, Geòrgia Brugada, Ramon Campuzano Larrea, Oscar Mort sobtada Sudden death Brugada, Síndrome de -- Diagnòstic Brugada syndrome -- Diagnosi Patologia forense Forensic pathology Cor -- Histopatologia Heart -- Histopathology Brugada syndrome (BrS) is classified as an inherited cardiac channelopathy attributed to dysfunctional ion channels and/or associated proteins in cardiomyocytes rather than to structural heart alterations. However, hearts of some BrS patients exhibit slight histologic abnormalities, suggesting that BrS could be a phenotypic variant of arrhythmogenic cardiomyopathy. We performed a systematic review of the literature following Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statement (PRISMA) criteria. Our comprehensive analysis of structural findings did not reveal enough definitive evidence for reclassification of BrS as a cardiomyopathy. The collection and comprehensive analysis of new cases with a definitive BrS diagnosis are needed to clarify whether some of these structural features may have key roles in the pathophysiological pathways associated with malignant arrhythmogenic episodes MDPI (Multidisciplinary Digital Publishing Institute) http://hdl.handle.net/10256/21569 |
| spellingShingle | Structural Heart Alterations in Brugada Syndrome: Is it Really a Channelopathy? A Systematic Review Oliva, Antonio Mort sobtada Sudden death Brugada, Síndrome de -- Diagnòstic Brugada syndrome -- Diagnosi Patologia forense Forensic pathology Cor -- Histopatologia Heart -- Histopathology |
| status_str | publishedVersion |
| title | Structural Heart Alterations in Brugada Syndrome: Is it Really a Channelopathy? A Systematic Review |
| title_full | Structural Heart Alterations in Brugada Syndrome: Is it Really a Channelopathy? A Systematic Review |
| title_fullStr | Structural Heart Alterations in Brugada Syndrome: Is it Really a Channelopathy? A Systematic Review |
| title_full_unstemmed | Structural Heart Alterations in Brugada Syndrome: Is it Really a Channelopathy? A Systematic Review |
| title_short | Structural Heart Alterations in Brugada Syndrome: Is it Really a Channelopathy? A Systematic Review |
| title_sort | Structural Heart Alterations in Brugada Syndrome: Is it Really a Channelopathy? A Systematic Review |
| topic | Mort sobtada Sudden death Brugada, Síndrome de -- Diagnòstic Brugada syndrome -- Diagnosi Patologia forense Forensic pathology Cor -- Histopatologia Heart -- Histopathology |
| topic_facet | Mort sobtada Sudden death Brugada, Síndrome de -- Diagnòstic Brugada syndrome -- Diagnosi Patologia forense Forensic pathology Cor -- Histopatologia Heart -- Histopathology |
| url | http://hdl.handle.net/10256/21569 |