Dysphagia in Parkinson<acute accent>s disease. A 5-year follow-up study

Background and objective Dysphagia at time of diagnosis suggests atypical parkinsonism instead Parkinson<acute accent>s disease (PD). Our aim was to analyze the frequency of dysphagia in patients with early PD comparing with a control group and to identify related factors. Patients and methods Patie...

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Authors: Santos-García, D; Fonticoba, TD; Jesús, S; Cosgaya, M; Caldentey, JG; Caballol, N; Legarda, I; Vara, JH; Cabo, I; Manzanares, LL; Aramburu, IG; Rivera, MAA; Mayordomo, VG; Nogueira, V; García-Soto, JD; Borrué, C; Vila, BS; Sauco, MA; Vela, L; Escalante, S; Cubo, E; Mendoza, Z; Pareés, I; Alonso, PS; Losada, MGA; Ariztegui, NL; Gastón, I; Kulisevsky, J; Seijo, M; Valero, C; Redondo, RA; Ordás, C; Menendez-González, M; Mcafee, D; Martinez-Martin, P; Mir, P
Format: Article
Status:Published version
Publication date:2025
Country:España
Institution:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repository:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p19549
Online Access:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19549
Access Level:Open access
Keyword:Cohort
Early
Dysphagia
Impulse control disorder
Non-motor symptoms
Parkinson's disease
Summary:Background and objective Dysphagia at time of diagnosis suggests atypical parkinsonism instead Parkinson<acute accent>s disease (PD). Our aim was to analyze the frequency of dysphagia in patients with early PD comparing with a control group and to identify related factors. Patients and methods Patients with early PD (<= 2 years from symptoms onset) who were recruited from January/2016 to November/2017 (baseline visit; V0) and evaluated annually for 5 years from the Spanish cohort COPPADIS were included in this prospective study. Controls were assessed at baseline and at 2-, 4-, and 5-year follow-up. Dysphagia was defined as a score >= 1 in the item 20 of the Non-Motor Symptoms Scale (NMSS). Results Dysphagia was more frequent at baseline in PD patients (19.6% [36/184]; 62.3 +/- 8.3 years old; 56.8% males) than in controls (5.3% [11/206]; 60.9 +/- 8.3 years old; 50% males) (p < 0.0001) and in all visits as well (p < 0.0001). A worse quality of sleep (Parkinson<acute accent>s Disease Sleep Scale; OR = 0.974; p = 0.005), a greater impulse-control behavior (ICB) (Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale; OR = 1.066; p = 0.014), and non-motor symptoms burden (Non-Motor Symptoms Scale; OR = 1.016; p = 0.021) were independent factors associated with dysphagia at baseline. In those subjects with dysphagia, no differences were observed between patients and controls in the mean NMSS-item 20 overtime, and it didn<acute accent>t change throughout the follow-up. Conclusion Dysphagia was frequent in early PD patients compared to controls. However, it was minor and did not progress over time. Sleep, ICB, and non-motor symptoms burden were related to dysphagia.

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