Forty-Year Trends in Cardiac Implantable Electronic Device Infective Endocarditis
Background: Studies investigating cardiac implantable electronic device infective endocarditis (CIED-IE) epidemiological changes and prognosis over long periods of time are lacking. Methods: Retrospective single cardiovascular surgery center cohort study of definite CIED-IE episodes between 1981-202...
| Authors: | ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; |
|---|---|
| Format: | Article |
| Status: | Published version |
| Publication date: | 2022 |
| Country: | España |
| Institution: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repository: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/195064 |
| Online Access: | https://hdl.handle.net/2445/195064 |
| Access Level: | Open access |
| Keyword: | Pronòstic mèdic Epidemiologia Endocarditis Prognosis Epidemiology |
| _version_ | 1878731437485588480 |
|---|---|
| author | Hernández Meneses, Marta |
| author2 | Llopis Pérez, Jaime Sandoval, Elena Ninot, Salvador Almela, M. (Manel) Falces Salvador, Carles Pericàs, Juan M. Vidal, Bàrbara Perissinotti, Andrés Marco Reverté, Francesc Mestres, Carlos A. Pare i Bardera, J. Carles García de la Mària, Cristina Cuervo Requena, Guillermo Quintana, Eduard Tolosana, José M. (José María) Moreno Camacho, Ma. Asunción Miró Meda, José M. (José María), 1956- Hospital Clinic Infective Endocarditis Team Investigators |
| author2_role | author author author author author author author author author author author author author author author author author author |
| author_browse | Almela, M. (Manel) Cuervo Requena, Guillermo Falces Salvador, Carles García de la Mària, Cristina Hernández Meneses, Marta Hospital Clinic Infective Endocarditis Team Investigators Llopis Pérez, Jaime Marco Reverté, Francesc Mestres, Carlos A. Miró Meda, José M. (José María), 1956- Moreno Camacho, Ma. Asunción Ninot, Salvador Pare i Bardera, J. Carles Pericàs, Juan M. Perissinotti, Andrés Quintana, Eduard Sandoval, Elena Tolosana, José M. (José María) Vidal, Bàrbara |
| author_facet | Hernández Meneses, Marta Llopis Pérez, Jaime Sandoval, Elena Ninot, Salvador Almela, M. (Manel) Falces Salvador, Carles Pericàs, Juan M. Vidal, Bàrbara Perissinotti, Andrés Marco Reverté, Francesc Mestres, Carlos A. Pare i Bardera, J. Carles García de la Mària, Cristina Cuervo Requena, Guillermo Quintana, Eduard Tolosana, José M. (José María) Moreno Camacho, Ma. Asunción Miró Meda, José M. (José María), 1956- Hospital Clinic Infective Endocarditis Team Investigators |
| author_role | author |
| collection | Recercat. Dipósit de la Recerca de Catalunya |
| description | Background: Studies investigating cardiac implantable electronic device infective endocarditis (CIED-IE) epidemiological changes and prognosis over long periods of time are lacking. Methods: Retrospective single cardiovascular surgery center cohort study of definite CIED-IE episodes between 1981-2020. A comparative analysis of two periods (1981-2000 vs 2001-2020) was conducted to analyze changes in epidemiology and outcome over time. Results: One-hundred and thirty-eight CIED-IE episodes were diagnosed: 25 (18%) first period and 113 (82%) second. CIED-IE was 4.5 times more frequent in the second period, especially in implantable cardiac defibrillators. Age (63 [53-70] vs 71 [63-76] years, P < .01), comorbidities (CCI 3.0 [2-4] vs 4.5 [3-6], P > .01), nosocomial infections (4% vs 15.9%, P = .02) and transfers from other centers (8% vs 41.6%, P < .01) were significantly more frequent in the second period, as were methicillin-resistant coagulase-negative staphylococcal (MR-CoNS) (0% vs 13.3%, P < .01) and Enterococcus spp. (0% vs 5.3%, P = .01) infections, pulmonary embolism (0% vs 10.6%, P < .01) and heart failure (12% vs 28.3%, p < .01). Second period surgery rates were lower (96% vs 87.6%, P = .09), and there were no differences in in-hospital (20% vs 11.5%, P = .11) and one-year mortalities (24% vs 15%, P = .33), or relapses (8% vs 5.3%, P = 0.65). Multivariate analysis showed Charlson index (hazard ratios [95% confidence intervals]; 1.5 [1.16-1.94]) and septic shock (23.09 [4.57-116.67]) were associated with a worse prognosis, whereas device removal (0.11 [.02-.57]), transfers (0.13 [.02-0.95]), and second-period diagnosis (0.13 [.02-.71]) were associated with better one-year outcomes. Conclusions: CIED-IE episodes increased more than four-fold during last 40 years. Despite CIED-IE involved an older population with more comorbidities, antibiotic-resistant MR-CoNS, and complex devices, one-year survival improved. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_2f9c34bef2e420dfd65100f3fb38cbb9 |
| institution | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:recercat.cat:2445/195064 |
| publishDate | 2022 |
| publishDateSort | 2022 |
| publisher | Oxford University Press |
| publisherStr | Oxford University Press |
| reponame_str | Recercat. Dipósit de la Recerca de Catalunya |
| spelling | Forty-Year Trends in Cardiac Implantable Electronic Device Infective Endocarditis Hernández Meneses, Marta Llopis Pérez, Jaime Sandoval, Elena Ninot, Salvador Almela, M. (Manel) Falces Salvador, Carles Pericàs, Juan M. Vidal, Bàrbara Perissinotti, Andrés Marco Reverté, Francesc Mestres, Carlos A. Pare i Bardera, J. Carles García de la Mària, Cristina Cuervo Requena, Guillermo Quintana, Eduard Tolosana, José M. (José María) Moreno Camacho, Ma. Asunción Miró Meda, José M. (José María), 1956- Hospital Clinic Infective Endocarditis Team Investigators Pronòstic mèdic Epidemiologia Endocarditis Prognosis Epidemiology Background: Studies investigating cardiac implantable electronic device infective endocarditis (CIED-IE) epidemiological changes and prognosis over long periods of time are lacking. Methods: Retrospective single cardiovascular surgery center cohort study of definite CIED-IE episodes between 1981-2020. A comparative analysis of two periods (1981-2000 vs 2001-2020) was conducted to analyze changes in epidemiology and outcome over time. Results: One-hundred and thirty-eight CIED-IE episodes were diagnosed: 25 (18%) first period and 113 (82%) second. CIED-IE was 4.5 times more frequent in the second period, especially in implantable cardiac defibrillators. Age (63 [53-70] vs 71 [63-76] years, P < .01), comorbidities (CCI 3.0 [2-4] vs 4.5 [3-6], P > .01), nosocomial infections (4% vs 15.9%, P = .02) and transfers from other centers (8% vs 41.6%, P < .01) were significantly more frequent in the second period, as were methicillin-resistant coagulase-negative staphylococcal (MR-CoNS) (0% vs 13.3%, P < .01) and Enterococcus spp. (0% vs 5.3%, P = .01) infections, pulmonary embolism (0% vs 10.6%, P < .01) and heart failure (12% vs 28.3%, p < .01). Second period surgery rates were lower (96% vs 87.6%, P = .09), and there were no differences in in-hospital (20% vs 11.5%, P = .11) and one-year mortalities (24% vs 15%, P = .33), or relapses (8% vs 5.3%, P = 0.65). Multivariate analysis showed Charlson index (hazard ratios [95% confidence intervals]; 1.5 [1.16-1.94]) and septic shock (23.09 [4.57-116.67]) were associated with a worse prognosis, whereas device removal (0.11 [.02-.57]), transfers (0.13 [.02-0.95]), and second-period diagnosis (0.13 [.02-.71]) were associated with better one-year outcomes. Conclusions: CIED-IE episodes increased more than four-fold during last 40 years. Despite CIED-IE involved an older population with more comorbidities, antibiotic-resistant MR-CoNS, and complex devices, one-year survival improved. Oxford University Press https://hdl.handle.net/2445/195064 |
| spellingShingle | Forty-Year Trends in Cardiac Implantable Electronic Device Infective Endocarditis Hernández Meneses, Marta Pronòstic mèdic Epidemiologia Endocarditis Prognosis Epidemiology |
| status_str | publishedVersion |
| title | Forty-Year Trends in Cardiac Implantable Electronic Device Infective Endocarditis |
| title_full | Forty-Year Trends in Cardiac Implantable Electronic Device Infective Endocarditis |
| title_fullStr | Forty-Year Trends in Cardiac Implantable Electronic Device Infective Endocarditis |
| title_full_unstemmed | Forty-Year Trends in Cardiac Implantable Electronic Device Infective Endocarditis |
| title_short | Forty-Year Trends in Cardiac Implantable Electronic Device Infective Endocarditis |
| title_sort | Forty-Year Trends in Cardiac Implantable Electronic Device Infective Endocarditis |
| topic | Pronòstic mèdic Epidemiologia Endocarditis Prognosis Epidemiology |
| topic_facet | Pronòstic mèdic Epidemiologia Endocarditis Prognosis Epidemiology |
| url | https://hdl.handle.net/2445/195064 |