Combination of Fenugreek and Quinoa Husk as Sources of Steroidal and Triterpenoid Saponins: Bioactivity of Their Co-Extracts and Hydrolysates
Saponins, both steroidal and triterpenoid, exhibit distinct bioactivities. However, they are not commonly found together in natural sources; instead, sources tend to be rich in one type or another and mainly in the form of saponins rather than the sapogenin aglycones. Developing co-extracts containi...
| Authors: | ; ; ; ; ; |
|---|---|
| Format: | Article |
| Publication date: | 2024 |
| Country: | España |
| Institution: | Universidad Complutense de Madrid (UCM) |
| Repository: | Docta Complutense |
| Language: | English |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/103393 |
| Online Access: | https://hdl.handle.net/20.500.14352/103393 |
| Access Level: | Open access |
| Keyword: | 612.39 Ultrasound-assisted extraction Co-extraction Diosgenin Oleanolic acid Hypocholesterolemic Anti-inflammatory Tecnología de los alimentos 3309 Tecnología de Los Alimentos |
| _version_ | 1878731437436305408 |
|---|---|
| author | Cantero-Bahillo, Emma |
| author2 | Navarro Del Hierro, Joaquín Siles-Sánchez, María de las Nieves Jaime, Laura Santoyo, Susana Martín, Diana |
| author2_role | author author author author author |
| author_browse | Cantero-Bahillo, Emma Jaime, Laura Martín, Diana Navarro Del Hierro, Joaquín Santoyo, Susana Siles-Sánchez, María de las Nieves |
| author_facet | Cantero-Bahillo, Emma Navarro Del Hierro, Joaquín Siles-Sánchez, María de las Nieves Jaime, Laura Santoyo, Susana Martín, Diana |
| author_role | author |
| collection | Docta Complutense |
| description | Saponins, both steroidal and triterpenoid, exhibit distinct bioactivities. However, they are not commonly found together in natural sources; instead, sources tend to be rich in one type or another and mainly in the form of saponins rather than the sapogenin aglycones. Developing co-extracts containing both saponin or sapogenin types would be a strategy to harness their respective bioactivities, yielding multibioactive extracts. Therefore, this study evaluates the bioactivity (hypolipidemic, antioxidant, and anti-inflammatory activities) of co-extracts from fenugreek seeds (steroidal-rich saponins) and quinoa husk (triterpenoid-rich saponins), co-extracted at varying proportions, alongside their respective sapogenin-rich hydrolysates. Pancreatic lipase inhibition increased with fenugreek content in co-extracts, especially in sapogenin-rich variants. The latter substantially interfered with cholesterol bioaccessibility (90% vs. 15% in sapogenin-rich extracts). Saponin-rich co-extracts exhibited reduced cytokine release with increased fenugreek content, while sapogenin-rich counterparts showed greater reductions with higher quinoa husk content. Limited cellular antioxidant activities were observed in all extracts, with improved post-hydrolysis bioactivity. Therefore, simultaneous co-extraction of steroidal and triterpenoid sources, such as fenugreek and quinoa husk, as well as their subsequent hydrolysis, are innovative strategies for obtaining multibioactive natural extracts. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_2f9b239d1a7c9bf10ccd6ca2dcfb854d |
| institution | Universidad Complutense de Madrid (UCM) |
| instname_str | Universidad Complutense de Madrid (UCM) |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:docta.ucm.es:20.500.14352/103393 |
| publishDate | 2024 |
| publishDateSort | 2024 |
| publisher | MDPI |
| publisherStr | MDPI |
| reponame_str | Docta Complutense |
| spelling | Combination of Fenugreek and Quinoa Husk as Sources of Steroidal and Triterpenoid Saponins: Bioactivity of Their Co-Extracts and Hydrolysates Cantero-Bahillo, Emma Navarro Del Hierro, Joaquín Siles-Sánchez, María de las Nieves Jaime, Laura Santoyo, Susana Martín, Diana 612.39 Ultrasound-assisted extraction Co-extraction Diosgenin Oleanolic acid Hypocholesterolemic Anti-inflammatory Tecnología de los alimentos 3309 Tecnología de Los Alimentos Saponins, both steroidal and triterpenoid, exhibit distinct bioactivities. However, they are not commonly found together in natural sources; instead, sources tend to be rich in one type or another and mainly in the form of saponins rather than the sapogenin aglycones. Developing co-extracts containing both saponin or sapogenin types would be a strategy to harness their respective bioactivities, yielding multibioactive extracts. Therefore, this study evaluates the bioactivity (hypolipidemic, antioxidant, and anti-inflammatory activities) of co-extracts from fenugreek seeds (steroidal-rich saponins) and quinoa husk (triterpenoid-rich saponins), co-extracted at varying proportions, alongside their respective sapogenin-rich hydrolysates. Pancreatic lipase inhibition increased with fenugreek content in co-extracts, especially in sapogenin-rich variants. The latter substantially interfered with cholesterol bioaccessibility (90% vs. 15% in sapogenin-rich extracts). Saponin-rich co-extracts exhibited reduced cytokine release with increased fenugreek content, while sapogenin-rich counterparts showed greater reductions with higher quinoa husk content. Limited cellular antioxidant activities were observed in all extracts, with improved post-hydrolysis bioactivity. Therefore, simultaneous co-extraction of steroidal and triterpenoid sources, such as fenugreek and quinoa husk, as well as their subsequent hydrolysis, are innovative strategies for obtaining multibioactive natural extracts. MDPI https://hdl.handle.net/20.500.14352/103393 |
| spellingShingle | Combination of Fenugreek and Quinoa Husk as Sources of Steroidal and Triterpenoid Saponins: Bioactivity of Their Co-Extracts and Hydrolysates Cantero-Bahillo, Emma 612.39 Ultrasound-assisted extraction Co-extraction Diosgenin Oleanolic acid Hypocholesterolemic Anti-inflammatory Tecnología de los alimentos 3309 Tecnología de Los Alimentos |
| title | Combination of Fenugreek and Quinoa Husk as Sources of Steroidal and Triterpenoid Saponins: Bioactivity of Their Co-Extracts and Hydrolysates |
| title_full | Combination of Fenugreek and Quinoa Husk as Sources of Steroidal and Triterpenoid Saponins: Bioactivity of Their Co-Extracts and Hydrolysates |
| title_fullStr | Combination of Fenugreek and Quinoa Husk as Sources of Steroidal and Triterpenoid Saponins: Bioactivity of Their Co-Extracts and Hydrolysates |
| title_full_unstemmed | Combination of Fenugreek and Quinoa Husk as Sources of Steroidal and Triterpenoid Saponins: Bioactivity of Their Co-Extracts and Hydrolysates |
| title_short | Combination of Fenugreek and Quinoa Husk as Sources of Steroidal and Triterpenoid Saponins: Bioactivity of Their Co-Extracts and Hydrolysates |
| title_sort | Combination of Fenugreek and Quinoa Husk as Sources of Steroidal and Triterpenoid Saponins: Bioactivity of Their Co-Extracts and Hydrolysates |
| topic | 612.39 Ultrasound-assisted extraction Co-extraction Diosgenin Oleanolic acid Hypocholesterolemic Anti-inflammatory Tecnología de los alimentos 3309 Tecnología de Los Alimentos |
| topic_facet | 612.39 Ultrasound-assisted extraction Co-extraction Diosgenin Oleanolic acid Hypocholesterolemic Anti-inflammatory Tecnología de los alimentos 3309 Tecnología de Los Alimentos |
| url | https://hdl.handle.net/20.500.14352/103393 |