Effect of time of day of recreational and household physical activity on prostate and breast cancer risk (MCC-Spain study)
ABSTRACT: Experimental evidence indicates that exercise performed at different times of the day may affect circadian rhythms and circadian disruption has been linked to breast and prostate cancer. We examined in a population-based case-control study (MCC-Spain) if the time-of-day when physical activ...
| Authors: | ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; |
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| Format: | Article |
| Publication date: | 2021 |
| Country: | España |
| Institution: | Universidad de Cantabria (UC) |
| Repository: | UCrea Repositorio Abierto de la Universidad de Cantabria |
| Language: | English |
| OAI Identifier: | oai:repositorio.unican.es:10902/21176 |
| Online Access: | http://hdl.handle.net/10902/21176 |
| Access Level: | Open access |
| Keyword: | Breast Cancer Circadian disruption Physical activity Prostate |
| _version_ | 1878731418316570624 |
|---|---|
| author | Weitzer, Jakob |
| author2 | Castaño-Vinyals, Gemma Aragonés, Nuria Gómez Acebo, Inés|||0000-0001-8793-8314 Guevara, Marcela Amiano, Pilar Martín, Vicente Molina-Barceló, Ana Alguacil, Juan Moreno, Victor Suarez-Calleja, Claudia Jiménez-Moleón, José Juan Marcos-Gragera, Rafael Papantoniou, Kyriaki Pérez-Gómez, Beatriz Llorca Díaz, Francisco Javier|||0000-0001-8569-861X Ascunce, Nieves Gil, Leire Gracia-Lavedan, Esther Casabonne, Delphine Lope, Virginia Pollán, Marina Kogevinas, Manolis |
| author2_role | author author author author author author author author author author author author author author author author author author author author author author |
| author_browse | Alguacil, Juan Amiano, Pilar Aragonés, Nuria Ascunce, Nieves Casabonne, Delphine Castaño-Vinyals, Gemma Gil, Leire Gracia-Lavedan, Esther Guevara, Marcela Gómez Acebo, Inés|||0000-0001-8793-8314 Jiménez-Moleón, José Juan Kogevinas, Manolis Llorca Díaz, Francisco Javier|||0000-0001-8569-861X Lope, Virginia Marcos-Gragera, Rafael Martín, Vicente Molina-Barceló, Ana Moreno, Victor Papantoniou, Kyriaki Pollán, Marina Pérez-Gómez, Beatriz Suarez-Calleja, Claudia Weitzer, Jakob |
| author_facet | Weitzer, Jakob Castaño-Vinyals, Gemma Aragonés, Nuria Gómez Acebo, Inés|||0000-0001-8793-8314 Guevara, Marcela Amiano, Pilar Martín, Vicente Molina-Barceló, Ana Alguacil, Juan Moreno, Victor Suarez-Calleja, Claudia Jiménez-Moleón, José Juan Marcos-Gragera, Rafael Papantoniou, Kyriaki Pérez-Gómez, Beatriz Llorca Díaz, Francisco Javier|||0000-0001-8569-861X Ascunce, Nieves Gil, Leire Gracia-Lavedan, Esther Casabonne, Delphine Lope, Virginia Pollán, Marina Kogevinas, Manolis |
| author_role | author |
| collection | UCrea Repositorio Abierto de la Universidad de Cantabria |
| description | ABSTRACT: Experimental evidence indicates that exercise performed at different times of the day may affect circadian rhythms and circadian disruption has been linked to breast and prostate cancer. We examined in a population-based case-control study (MCC-Spain) if the time-of-day when physical activity is done affects prostate and breast cancer risk. Lifetime recreational and household physical activity was assessed by in-person interviews. Information on time-of-day of activity (assessed approximately 3-years after the assessment of lifetime physical activity and confounders) was available for 781 breast cancer cases, 865 population female controls, 504 prostate cases and 645 population male controls from 10 Spanish regions, 2008-2013. We estimated odds ratios (ORs) and 95% confidence intervals (95% CI) for different activity timings compared to inactive subjects using unconditional logistic regression adjusting for confounders. Early morning (8-10 am) activity was associated with a protective effect compared to no physical activity for both breast (OR = 0.74, 95% CI = 0.48-1.15) and prostate cancer (OR = 0.73, 95% CI = 0.44-1.20); meta-OR for the two cancers combined 0.74 (95%CI = 0.53-1.02). There was no effect observed for breast or prostate cancer for late morning to afternoon activity while a protective effect was also observed for evening activity only for prostate cancer (OR = 0.75, 95% CI = 0.45-1.24). Protective effects of early morning activity were more pronounced for intermediate/evening chronotypes for both cancers. This is the first population-based investigation identifying a differential effect of timing of physical activity on cancer risk with more pronounced effects for morning hour activity. Our results, if confirmed, may improve current physical activity recommendations for cancer preventio |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_2f2f855d72ea5c16df2a62bdbf43dcd6 |
| institution | Universidad de Cantabria (UC) |
| instname_str | Universidad de Cantabria (UC) |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:repositorio.unican.es:10902/21176 |
| publishDate | 2021 |
| publishDateSort | 2021 |
| publisher | Wiley-Liss |
| publisherStr | Wiley-Liss |
| reponame_str | UCrea Repositorio Abierto de la Universidad de Cantabria |
| spelling | Effect of time of day of recreational and household physical activity on prostate and breast cancer risk (MCC-Spain study) Weitzer, Jakob Castaño-Vinyals, Gemma Aragonés, Nuria Gómez Acebo, Inés|||0000-0001-8793-8314 Guevara, Marcela Amiano, Pilar Martín, Vicente Molina-Barceló, Ana Alguacil, Juan Moreno, Victor Suarez-Calleja, Claudia Jiménez-Moleón, José Juan Marcos-Gragera, Rafael Papantoniou, Kyriaki Pérez-Gómez, Beatriz Llorca Díaz, Francisco Javier|||0000-0001-8569-861X Ascunce, Nieves Gil, Leire Gracia-Lavedan, Esther Casabonne, Delphine Lope, Virginia Pollán, Marina Kogevinas, Manolis Breast Cancer Circadian disruption Physical activity Prostate ABSTRACT: Experimental evidence indicates that exercise performed at different times of the day may affect circadian rhythms and circadian disruption has been linked to breast and prostate cancer. We examined in a population-based case-control study (MCC-Spain) if the time-of-day when physical activity is done affects prostate and breast cancer risk. Lifetime recreational and household physical activity was assessed by in-person interviews. Information on time-of-day of activity (assessed approximately 3-years after the assessment of lifetime physical activity and confounders) was available for 781 breast cancer cases, 865 population female controls, 504 prostate cases and 645 population male controls from 10 Spanish regions, 2008-2013. We estimated odds ratios (ORs) and 95% confidence intervals (95% CI) for different activity timings compared to inactive subjects using unconditional logistic regression adjusting for confounders. Early morning (8-10 am) activity was associated with a protective effect compared to no physical activity for both breast (OR = 0.74, 95% CI = 0.48-1.15) and prostate cancer (OR = 0.73, 95% CI = 0.44-1.20); meta-OR for the two cancers combined 0.74 (95%CI = 0.53-1.02). There was no effect observed for breast or prostate cancer for late morning to afternoon activity while a protective effect was also observed for evening activity only for prostate cancer (OR = 0.75, 95% CI = 0.45-1.24). Protective effects of early morning activity were more pronounced for intermediate/evening chronotypes for both cancers. This is the first population-based investigation identifying a differential effect of timing of physical activity on cancer risk with more pronounced effects for morning hour activity. Our results, if confirmed, may improve current physical activity recommendations for cancer preventio Instituto de Salud Carlos III, Grant/Award Numbers: PI11/01889, PI08/1770, PI08/0533, PI08/1359, PS09/00773, PS09/01286, PS09/01903, PS09/02078, PS09/01662, PI11/02213, PI12/00488, PI12/01270Fundación Marqués de Valdecilla, Grant/Award Number: API 10/09ICGC International Cancer Genome Consortium CLL (The ICGC CLL-Genome Project is funded by Spanish Ministerio de Economía y Competitividad (MINECO) through the Instituto de Salud Carlos III (ISCIII) and Red Temática de Investigación del Cáncer (RTICC) del ISCIII), Grant/Award Number: RD12/0036/0036Junta de Castilla y León, Grant/Award Number: LE22A10-2Consejería de Salud of the Junta de Andalucía, Grant/ Award Numbers: PI-0571-2009, PI-0306-2011, salud201200057018traConselleria de Sanitat of the Generalitat Valenciana, Grant/Award Number: AP_061/10Recercaixa, Grant/Award Number: 2010ACUP 00310Regional Government of the Basque CountryConsejería de Sanidad de la Región de MurciaEuropean Commission, Grant/Award Number: FOOD-CT2006-036224-HIWATESpanish Association Against Cancer (AECC) Scientific FoundationCatalan Government-Agency for Management of University and Research Grants (AGAUR), Grant/Award Numbers: 2017SGR723, 2014SGR850Fundación Caja de Ahorros de Asturias and by the University of OviedoSpanish Ministry of Science and Innovation through the “Centro de Excelencia Severo Ochoa 2019-2023” Program, Grant/Award Number: CEX2018-000806-SGeneralitat de Catalunya through the CERCA Program. Wiley-Liss http://hdl.handle.net/10902/21176 |
| spellingShingle | Effect of time of day of recreational and household physical activity on prostate and breast cancer risk (MCC-Spain study) Weitzer, Jakob Breast Cancer Circadian disruption Physical activity Prostate |
| title | Effect of time of day of recreational and household physical activity on prostate and breast cancer risk (MCC-Spain study) |
| title_full | Effect of time of day of recreational and household physical activity on prostate and breast cancer risk (MCC-Spain study) |
| title_fullStr | Effect of time of day of recreational and household physical activity on prostate and breast cancer risk (MCC-Spain study) |
| title_full_unstemmed | Effect of time of day of recreational and household physical activity on prostate and breast cancer risk (MCC-Spain study) |
| title_short | Effect of time of day of recreational and household physical activity on prostate and breast cancer risk (MCC-Spain study) |
| title_sort | Effect of time of day of recreational and household physical activity on prostate and breast cancer risk (MCC-Spain study) |
| topic | Breast Cancer Circadian disruption Physical activity Prostate |
| topic_facet | Breast Cancer Circadian disruption Physical activity Prostate |
| url | http://hdl.handle.net/10902/21176 |