Identification of atrial-enriched lncRNA Walras linked to cardiomyocyte cytoarchitecture and atrial fibrillation

Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia in humans. Genetic and genomic analyses have recently demonstrated that the homeobox transcription factor Pitx2 plays a fundamental role regulating expression of distinct growth factors, microRNAs and ion channels leading to morpholog...

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Authors: García-Padilla, Carlos; Domínguez, Jorge N.; Lodde, Valeria; Munk, Rachel; Abdelmohsen, Kotb; Gorospe, Myriam; Jiménez-Sábado, Verónica|||0000-0001-7720-988X; Ginel, Antonino|||0000-0002-8820-7545; Madsen, Leif Hove|||0000-0001-5493-3998; Aránega, Amelia|||0000-0002-0046-9410; Franco, Diego|||0000-0002-5669-7164
Format: Article
Publication date:2022
Country:España
Institution:Universitat Autònoma de Barcelona
Repository:Dipòsit Digital de Documents de la UAB
Language:English
OAI Identifier:oai:ddd.uab.cat:280902
Online Access:https://ddd.uab.cat/record/280902
https://dx.doi.org/urn:doi:10.1096/fj.202100844RR
Access Level:Open access
Keyword:Animals
Atrial Fibrillation
Cytoskeleton
Heart Atria
Humans
Lncrna
Mice
Mice, Knockout
Myocytes, Cardiac
Post-transcriptional regulation
RNA, Long Noncoding
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author García-Padilla, Carlos
author2 Domínguez, Jorge N.
Lodde, Valeria
Munk, Rachel
Abdelmohsen, Kotb
Gorospe, Myriam
Jiménez-Sábado, Verónica|||0000-0001-7720-988X
Ginel, Antonino|||0000-0002-8820-7545
Madsen, Leif Hove|||0000-0001-5493-3998
Aránega, Amelia|||0000-0002-0046-9410
Franco, Diego|||0000-0002-5669-7164
author2_role author
author
author
author
author
author
author
author
author
author
author_browse Abdelmohsen, Kotb
Aránega, Amelia|||0000-0002-0046-9410
Domínguez, Jorge N.
Franco, Diego|||0000-0002-5669-7164
García-Padilla, Carlos
Ginel, Antonino|||0000-0002-8820-7545
Gorospe, Myriam
Jiménez-Sábado, Verónica|||0000-0001-7720-988X
Lodde, Valeria
Madsen, Leif Hove|||0000-0001-5493-3998
Munk, Rachel
author_facet García-Padilla, Carlos
Domínguez, Jorge N.
Lodde, Valeria
Munk, Rachel
Abdelmohsen, Kotb
Gorospe, Myriam
Jiménez-Sábado, Verónica|||0000-0001-7720-988X
Ginel, Antonino|||0000-0002-8820-7545
Madsen, Leif Hove|||0000-0001-5493-3998
Aránega, Amelia|||0000-0002-0046-9410
Franco, Diego|||0000-0002-5669-7164
author_role author
collection Dipòsit Digital de Documents de la UAB
description Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia in humans. Genetic and genomic analyses have recently demonstrated that the homeobox transcription factor Pitx2 plays a fundamental role regulating expression of distinct growth factors, microRNAs and ion channels leading to morphological and molecular alterations that promote the onset of AF. Here we address the plausible contribution of long non-coding (lnc)RNAs within the Pitx2.
eu_rights_str_mv openAccess
format article
id ES_2d9a89cc821ef26f5efeeaba02c97ffd
institution Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
language eng
network_acronym_str ES
network_name_str España
oai_identifier_str oai:ddd.uab.cat:280902
publishDate 2022
publishDateSort 2022
reponame_str Dipòsit Digital de Documents de la UAB
spelling Identification of atrial-enriched lncRNA Walras linked to cardiomyocyte cytoarchitecture and atrial fibrillation García-Padilla, Carlos Domínguez, Jorge N. Lodde, Valeria Munk, Rachel Abdelmohsen, Kotb Gorospe, Myriam Jiménez-Sábado, Verónica|||0000-0001-7720-988X Ginel, Antonino|||0000-0002-8820-7545 Madsen, Leif Hove|||0000-0001-5493-3998 Aránega, Amelia|||0000-0002-0046-9410 Franco, Diego|||0000-0002-5669-7164 Animals Atrial Fibrillation Cytoskeleton Heart Atria Humans Lncrna Mice Mice, Knockout Myocytes, Cardiac Post-transcriptional regulation RNA, Long Noncoding Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia in humans. Genetic and genomic analyses have recently demonstrated that the homeobox transcription factor Pitx2 plays a fundamental role regulating expression of distinct growth factors, microRNAs and ion channels leading to morphological and molecular alterations that promote the onset of AF. Here we address the plausible contribution of long non-coding (lnc)RNAs within the Pitx2. https://ddd.uab.cat/record/280902 https://dx.doi.org/urn:doi:10.1096/fj.202100844RR
spellingShingle Identification of atrial-enriched lncRNA Walras linked to cardiomyocyte cytoarchitecture and atrial fibrillation
García-Padilla, Carlos
Animals
Atrial Fibrillation
Cytoskeleton
Heart Atria
Humans
Lncrna
Mice
Mice, Knockout
Myocytes, Cardiac
Post-transcriptional regulation
RNA, Long Noncoding
title Identification of atrial-enriched lncRNA Walras linked to cardiomyocyte cytoarchitecture and atrial fibrillation
title_full Identification of atrial-enriched lncRNA Walras linked to cardiomyocyte cytoarchitecture and atrial fibrillation
title_fullStr Identification of atrial-enriched lncRNA Walras linked to cardiomyocyte cytoarchitecture and atrial fibrillation
title_full_unstemmed Identification of atrial-enriched lncRNA Walras linked to cardiomyocyte cytoarchitecture and atrial fibrillation
title_short Identification of atrial-enriched lncRNA Walras linked to cardiomyocyte cytoarchitecture and atrial fibrillation
title_sort Identification of atrial-enriched lncRNA Walras linked to cardiomyocyte cytoarchitecture and atrial fibrillation
topic Animals
Atrial Fibrillation
Cytoskeleton
Heart Atria
Humans
Lncrna
Mice
Mice, Knockout
Myocytes, Cardiac
Post-transcriptional regulation
RNA, Long Noncoding
topic_facet Animals
Atrial Fibrillation
Cytoskeleton
Heart Atria
Humans
Lncrna
Mice
Mice, Knockout
Myocytes, Cardiac
Post-transcriptional regulation
RNA, Long Noncoding
url https://ddd.uab.cat/record/280902
https://dx.doi.org/urn:doi:10.1096/fj.202100844RR