Correlation of Bcl-2 expression with prognosis and survival in patients with head and neck cancer: A systematic review and meta-analysis
Head and neck cancer (HNC) is a growing disease, affecting more than 700.000 cases per year and ranking as the sixth most prevalent type of cancer worldwide. The impossibility of properly entering into apoptosis directly influences uncontrolled growth and consequently tumor development and progressi...
| Authors: | ; ; ; ; ; ; ; ; ; |
|---|---|
| Format: | Article |
| Publication date: | 2023 |
| Country: | España |
| Institution: | Servizo Galego de Saúde (SERGAS) |
| Repository: | RUNA. Repositorio da Consellería de Sanidade e Sergas |
| OAI Identifier: | oai:runa.sergas.gal:20.500.11940/21278 |
| Online Access: | https://portalcientifico.sergas.gal//documentos/64860188a219857f1d78b6e9 http://hdl.handle.net/20.500.11940/21278 |
| Access Level: | Open access |
| Keyword: | Humans Biomarkers, Tumor Prognosis Head and Neck Neoplasms AS Santiago IDIS AS Pontevedra AS Pontevedra AP AS A Coruña AS Coruña AP CHUS |
| _version_ | 1878731309242646528 |
|---|---|
| author | Silva, F.F.V.E. |
| author2 | Caponio, V.C.A. Camolesi, G.C.V. Padin Iruegas, Maria Elena Lorenzo Pouso, Alejandro Ismael Lima, K.C. Vieira, S.L.S. Chamorro Petronacci, Cintia Micaela Suárez Peñaranda, Jose Manuel Pérez Sayáns, Mario |
| author2_role | author author author author author author author author author |
| author_browse | Camolesi, G.C.V. Caponio, V.C.A. Chamorro Petronacci, Cintia Micaela Lima, K.C. Lorenzo Pouso, Alejandro Ismael Padin Iruegas, Maria Elena Pérez Sayáns, Mario Silva, F.F.V.E. Suárez Peñaranda, Jose Manuel Vieira, S.L.S. |
| author_facet | Silva, F.F.V.E. Caponio, V.C.A. Camolesi, G.C.V. Padin Iruegas, Maria Elena Lorenzo Pouso, Alejandro Ismael Lima, K.C. Vieira, S.L.S. Chamorro Petronacci, Cintia Micaela Suárez Peñaranda, Jose Manuel Pérez Sayáns, Mario |
| author_role | author |
| collection | RUNA. Repositorio da Consellería de Sanidade e Sergas |
| description | Head and neck cancer (HNC) is a growing disease, affecting more than 700.000 cases per year and ranking as the sixth most prevalent type of cancer worldwide. The impossibility of properly entering into apoptosis directly influences uncontrolled growth and consequently tumor development and progression. Bcl-2 emerged as a key regulator in the balance between cell apoptosis and proliferation in apoptosis machinery. This systematic review and meta-analysis aimed to review all published studies investigating changes in Bcl-2 protein expression assessed by immunohistochemistry (IHC) and related to prognostic and survival values of patients with HNC. After applying the inclusion and exclusion factors, we reached the number of 20 articles included in the meta-analysis. The random-effect pooled HR (CI95%) value of OS related to Bcl-2 IHC expression in tissues from HNC patients was 1.80 (CI95% 1.21-2.67) (p 0.0001) and DFS was 1.90 (CI95% 1.26-2.86 (p 0.0001). The OS value for the specific oral cavity tumors was 1.89 (1.34-2.67), while in the larynx it was 1.77 (0.62-5.06), and the DFS in the pharynx was 2.02 (1.46-2.79). The univariate and multivariate analyses of OS were respectively 1.43 (1.11-1.86) and 1.88 (1.12-3.16), while in DFS it was 1.70 (0.95-3.03) and 2.08 (1.55-2.80). The OS considering a low cut-off for Bcl-2 positivity was 1.19 (0.60-2.37) and DFS was 1.48 (0.91-2.41), while studies with a high cut-off demonstrated OS of 2.28 (1.47-3.52) and DFS of 2.77 (1.74-4.40). Our meta-analysis demonstrates that Bcl-2 protein overexpression can result in worse LNM, OS, and DFS in patients with HNC, however, it is not a reliable conclusion, due to the wide divergences between the original studies and the fact that many studies have a very high range of confidence and also a high risk of bias. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_2d03bc5ee2b0a0fbc1cf46c3e1f032a5 |
| institution | Servizo Galego de Saúde (SERGAS) |
| instname_str | Servizo Galego de Saúde (SERGAS) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:runa.sergas.gal:20.500.11940/21278 |
| publishDate | 2023 |
| publishDateSort | 2023 |
| reponame_str | RUNA. Repositorio da Consellería de Sanidade e Sergas |
| spelling | Correlation of Bcl-2 expression with prognosis and survival in patients with head and neck cancer: A systematic review and meta-analysis Silva, F.F.V.E. Caponio, V.C.A. Camolesi, G.C.V. Padin Iruegas, Maria Elena Lorenzo Pouso, Alejandro Ismael Lima, K.C. Vieira, S.L.S. Chamorro Petronacci, Cintia Micaela Suárez Peñaranda, Jose Manuel Pérez Sayáns, Mario Humans Biomarkers, Tumor Prognosis Head and Neck Neoplasms AS Santiago IDIS AS Pontevedra AS Pontevedra AP AS A Coruña AS Coruña AP CHUS Head and neck cancer (HNC) is a growing disease, affecting more than 700.000 cases per year and ranking as the sixth most prevalent type of cancer worldwide. The impossibility of properly entering into apoptosis directly influences uncontrolled growth and consequently tumor development and progression. Bcl-2 emerged as a key regulator in the balance between cell apoptosis and proliferation in apoptosis machinery. This systematic review and meta-analysis aimed to review all published studies investigating changes in Bcl-2 protein expression assessed by immunohistochemistry (IHC) and related to prognostic and survival values of patients with HNC. After applying the inclusion and exclusion factors, we reached the number of 20 articles included in the meta-analysis. The random-effect pooled HR (CI95%) value of OS related to Bcl-2 IHC expression in tissues from HNC patients was 1.80 (CI95% 1.21-2.67) (p 0.0001) and DFS was 1.90 (CI95% 1.26-2.86 (p 0.0001). The OS value for the specific oral cavity tumors was 1.89 (1.34-2.67), while in the larynx it was 1.77 (0.62-5.06), and the DFS in the pharynx was 2.02 (1.46-2.79). The univariate and multivariate analyses of OS were respectively 1.43 (1.11-1.86) and 1.88 (1.12-3.16), while in DFS it was 1.70 (0.95-3.03) and 2.08 (1.55-2.80). The OS considering a low cut-off for Bcl-2 positivity was 1.19 (0.60-2.37) and DFS was 1.48 (0.91-2.41), while studies with a high cut-off demonstrated OS of 2.28 (1.47-3.52) and DFS of 2.77 (1.74-4.40). Our meta-analysis demonstrates that Bcl-2 protein overexpression can result in worse LNM, OS, and DFS in patients with HNC, however, it is not a reliable conclusion, due to the wide divergences between the original studies and the fact that many studies have a very high range of confidence and also a high risk of bias. https://portalcientifico.sergas.gal//documentos/64860188a219857f1d78b6e9 http://hdl.handle.net/20.500.11940/21278 |
| spellingShingle | Correlation of Bcl-2 expression with prognosis and survival in patients with head and neck cancer: A systematic review and meta-analysis Silva, F.F.V.E. Humans Biomarkers, Tumor Prognosis Head and Neck Neoplasms AS Santiago IDIS AS Pontevedra AS Pontevedra AP AS A Coruña AS Coruña AP CHUS |
| title | Correlation of Bcl-2 expression with prognosis and survival in patients with head and neck cancer: A systematic review and meta-analysis |
| title_full | Correlation of Bcl-2 expression with prognosis and survival in patients with head and neck cancer: A systematic review and meta-analysis |
| title_fullStr | Correlation of Bcl-2 expression with prognosis and survival in patients with head and neck cancer: A systematic review and meta-analysis |
| title_full_unstemmed | Correlation of Bcl-2 expression with prognosis and survival in patients with head and neck cancer: A systematic review and meta-analysis |
| title_short | Correlation of Bcl-2 expression with prognosis and survival in patients with head and neck cancer: A systematic review and meta-analysis |
| title_sort | Correlation of Bcl-2 expression with prognosis and survival in patients with head and neck cancer: A systematic review and meta-analysis |
| topic | Humans Biomarkers, Tumor Prognosis Head and Neck Neoplasms AS Santiago IDIS AS Pontevedra AS Pontevedra AP AS A Coruña AS Coruña AP CHUS |
| topic_facet | Humans Biomarkers, Tumor Prognosis Head and Neck Neoplasms AS Santiago IDIS AS Pontevedra AS Pontevedra AP AS A Coruña AS Coruña AP CHUS |
| url | https://portalcientifico.sergas.gal//documentos/64860188a219857f1d78b6e9 http://hdl.handle.net/20.500.11940/21278 |