t(10
Recently, it was shown that t(10;16)(q22;p13) fuses the MORF and CREBBP genes in a case of childhood acute myeloid leukemia (AML) M5a, with a complex karyotype containing other rearrangements. Here, we report a new case with the MORF-CREBBP fusion in an 84-year-old patient diagnosed with AML M5b, in...
| Autores: | ; ; ; ; ; ; ; |
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| Tipo de documento: | Artigo |
| Data de publicação: | 2003 |
| País: | España |
| Recursos: | Universidad de Navarra |
| Repositório: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | Inglês |
| OAI Identifier: | oai:dadun.unav.edu:10171/19610 |
| Acesso em linha: | https://hdl.handle.net/10171/19610 |
| Nível de acesso: | Acesso aberto |
| Palavra-chave: | Chromosomes, Human, Pair 10/genetics Chromosomes, Human, Pair 16/genetics Leukemia, Monocytic, Acute/genetics Nuclear Proteins/genetics Oncogene Proteins, Fusion/genetics Saccharomyces cerevisiae Proteins/genetics Trans-Activators/genetics |
| Resumo: | Recently, it was shown that t(10;16)(q22;p13) fuses the MORF and CREBBP genes in a case of childhood acute myeloid leukemia (AML) M5a, with a complex karyotype containing other rearrangements. Here, we report a new case with the MORF-CREBBP fusion in an 84-year-old patient diagnosed with AML M5b, in which the t(10;16)(q22;p13) was the only cytogenetic aberration. This supports that this is a recurrent pathogenic translocation in AML. |
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