Mixed strain pathogen populations accelerate the evolution of antibiotic resistance in patients
Antibiotic resistance poses a global health threat, but the within-host drivers of resistance remain poorly understood. Pathogen populations are often assumed to be clonal within hosts, and resistance is thought to emerge due to selection for de novo variants. Here we show that mixed strain populati...
| Authors: | ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; |
|---|---|
| Format: | Article |
| Publication date: | 2023 |
| Country: | España |
| Institution: | Conselleria de Salut i Consum del Govern de les Illes Balears |
| Repository: | Docusalut |
| Language: | English |
| OAI Identifier: | oai:docusalut.com:20.500.13003/19376 |
| Online Access: | https://hdl.handle.net/20.500.13003/19376 |
| Access Level: | Open access |
| Keyword: | Humans Patients Drug Resistance, Microbial Humanos Pacientes Farmacorresistencia Microbiana |
| _version_ | 1878731219190939648 |
|---|---|
| author | Diaz Caballero, Julio |
| author2 | Wheatley, Rachel M Kapel, Natalia López-Causapé, Carla Van der Schalk, Thomas Quinn, Angus Shaw, Liam P Ogunlana, Lois Recanatini, Claudia Xavier, Basil Britto Timbermont, Leen Kluytmans, Jan Ruzin, Alexey Esser, Mark Malhotra-Kumar, Surbhi Oliver, Antonio MacLean, R Craig |
| author2_role | author author author author author author author author author author author author author author author author |
| author_browse | Diaz Caballero, Julio Esser, Mark Kapel, Natalia Kluytmans, Jan López-Causapé, Carla MacLean, R Craig Malhotra-Kumar, Surbhi Ogunlana, Lois Oliver, Antonio Quinn, Angus Recanatini, Claudia Ruzin, Alexey Shaw, Liam P Timbermont, Leen Van der Schalk, Thomas Wheatley, Rachel M Xavier, Basil Britto |
| author_facet | Diaz Caballero, Julio Wheatley, Rachel M Kapel, Natalia López-Causapé, Carla Van der Schalk, Thomas Quinn, Angus Shaw, Liam P Ogunlana, Lois Recanatini, Claudia Xavier, Basil Britto Timbermont, Leen Kluytmans, Jan Ruzin, Alexey Esser, Mark Malhotra-Kumar, Surbhi Oliver, Antonio MacLean, R Craig |
| author_role | author |
| collection | Docusalut |
| description | Antibiotic resistance poses a global health threat, but the within-host drivers of resistance remain poorly understood. Pathogen populations are often assumed to be clonal within hosts, and resistance is thought to emerge due to selection for de novo variants. Here we show that mixed strain populations are common in the opportunistic pathogen P. aeruginosa. Crucially, resistance evolves rapidly in patients colonized by multiple strains through selection for pre-existing resistant strains. In contrast, resistance evolves sporadically in patients colonized by single strains due to selection for novel resistance mutations. However, strong trade-offs between resistance and growth rate occur in mixed strain populations, suggesting that within-host diversity can also drive the loss of resistance in the absence of antibiotic treatment. In summary, we show that the within-host diversity of pathogen populations plays a key role in shaping the emergence of resistance in response to treatment. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_2b3a1bb843a03ace64c75e3d4e665094 |
| institution | Conselleria de Salut i Consum del Govern de les Illes Balears |
| instname_str | Conselleria de Salut i Consum del Govern de les Illes Balears |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:docusalut.com:20.500.13003/19376 |
| publishDate | 2023 |
| publishDateSort | 2023 |
| publisher | Nature |
| publisherStr | Nature |
| reponame_str | Docusalut |
| spelling | Mixed strain pathogen populations accelerate the evolution of antibiotic resistance in patients Diaz Caballero, Julio Wheatley, Rachel M Kapel, Natalia López-Causapé, Carla Van der Schalk, Thomas Quinn, Angus Shaw, Liam P Ogunlana, Lois Recanatini, Claudia Xavier, Basil Britto Timbermont, Leen Kluytmans, Jan Ruzin, Alexey Esser, Mark Malhotra-Kumar, Surbhi Oliver, Antonio MacLean, R Craig Humans Patients Drug Resistance, Microbial Humanos Pacientes Farmacorresistencia Microbiana Antibiotic resistance poses a global health threat, but the within-host drivers of resistance remain poorly understood. Pathogen populations are often assumed to be clonal within hosts, and resistance is thought to emerge due to selection for de novo variants. Here we show that mixed strain populations are common in the opportunistic pathogen P. aeruginosa. Crucially, resistance evolves rapidly in patients colonized by multiple strains through selection for pre-existing resistant strains. In contrast, resistance evolves sporadically in patients colonized by single strains due to selection for novel resistance mutations. However, strong trade-offs between resistance and growth rate occur in mixed strain populations, suggesting that within-host diversity can also drive the loss of resistance in the absence of antibiotic treatment. In summary, we show that the within-host diversity of pathogen populations plays a key role in shaping the emergence of resistance in response to treatment. Nature https://hdl.handle.net/20.500.13003/19376 |
| spellingShingle | Mixed strain pathogen populations accelerate the evolution of antibiotic resistance in patients Diaz Caballero, Julio Humans Patients Drug Resistance, Microbial Humanos Pacientes Farmacorresistencia Microbiana |
| title | Mixed strain pathogen populations accelerate the evolution of antibiotic resistance in patients |
| title_full | Mixed strain pathogen populations accelerate the evolution of antibiotic resistance in patients |
| title_fullStr | Mixed strain pathogen populations accelerate the evolution of antibiotic resistance in patients |
| title_full_unstemmed | Mixed strain pathogen populations accelerate the evolution of antibiotic resistance in patients |
| title_short | Mixed strain pathogen populations accelerate the evolution of antibiotic resistance in patients |
| title_sort | Mixed strain pathogen populations accelerate the evolution of antibiotic resistance in patients |
| topic | Humans Patients Drug Resistance, Microbial Humanos Pacientes Farmacorresistencia Microbiana |
| topic_facet | Humans Patients Drug Resistance, Microbial Humanos Pacientes Farmacorresistencia Microbiana |
| url | https://hdl.handle.net/20.500.13003/19376 |