A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 st...
| Authors: | ; ; ; ; |
|---|---|
| Format: | Article |
| Status: | Accepted version |
| Publication date: | 2010 |
| Country: | España |
| Institution: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repository: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:10230/36598 |
| Online Access: | http://hdl.handle.net/10230/36598 http://dx.doi.org/10.1038/ng.687 |
| Access Level: | Open access |
| Keyword: | Bladder cancer Genome-wide association studies Psychology |
| _version_ | 1878731192319082496 |
|---|---|
| author | Rothman, Nathaniel |
| author2 | Real, Francisco X. Serra, Consol Lloreta, Josep, 1958- Chanock, Stephen J. |
| author2_role | author author author author |
| author_browse | Chanock, Stephen J. Lloreta, Josep, 1958- Real, Francisco X. Rothman, Nathaniel Serra, Consol |
| author_facet | Rothman, Nathaniel Real, Francisco X. Serra, Consol Lloreta, Josep, 1958- Chanock, Stephen J. |
| author_role | author |
| collection | Recercat. Dipósit de la Recerca de Catalunya |
| description | We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 × 10⁻¹²) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 × 10⁻¹¹) on 19q12 maps to CCNE1 and rs11892031 (P = 1 × 10⁻⁷) maps to the UGT1A cluster on 2q37.1. We confirmed four previously identified genome-wide associations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate associations for the GSTM1 deletion (P = 4 × 10⁻¹¹) and a tag SNP for NAT2 acetylation status (P = 4 × 10⁻¹¹), and found interactions with smoking in both regions. Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_2aba3dc99291cc883ccfa77d4e8f97fb |
| institution | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:recercat.cat:10230/36598 |
| publishDate | 2010 |
| publishDateSort | 2010 |
| publisher | Nature Research |
| publisherStr | Nature Research |
| reponame_str | Recercat. Dipósit de la Recerca de Catalunya |
| spelling | A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci Rothman, Nathaniel Real, Francisco X. Serra, Consol Lloreta, Josep, 1958- Chanock, Stephen J. Bladder cancer Genome-wide association studies Psychology We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 × 10⁻¹²) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 × 10⁻¹¹) on 19q12 maps to CCNE1 and rs11892031 (P = 1 × 10⁻⁷) maps to the UGT1A cluster on 2q37.1. We confirmed four previously identified genome-wide associations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate associations for the GSTM1 deletion (P = 4 × 10⁻¹¹) and a tag SNP for NAT2 acetylation status (P = 4 × 10⁻¹¹), and found interactions with smoking in both regions. Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis. Nature Research http://hdl.handle.net/10230/36598 http://dx.doi.org/10.1038/ng.687 |
| spellingShingle | A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci Rothman, Nathaniel Bladder cancer Genome-wide association studies Psychology |
| status_str | acceptedVersion |
| title | A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci |
| title_full | A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci |
| title_fullStr | A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci |
| title_full_unstemmed | A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci |
| title_short | A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci |
| title_sort | A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci |
| topic | Bladder cancer Genome-wide association studies Psychology |
| topic_facet | Bladder cancer Genome-wide association studies Psychology |
| url | http://hdl.handle.net/10230/36598 http://dx.doi.org/10.1038/ng.687 |