Paternal body mass index and offspring DNA methylation: findings from the PACE consortium
Background: Accumulating evidence links paternal adiposity in the periconceptional period to offspring health outcomes. DNA methylation has been proposed as a mediating mechanism, but very few studies have explored this possibility in humans. Methods: In the Pregnancy And Childhood Epigenetics (PACE...
| Authors: | ; ; ; ; ; ; ; ; ; ; |
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| Format: | Article |
| Status: | Published version |
| Publication date: | 2021 |
| Country: | España |
| Institution: | Universitat Pompeu Fabra |
| Repository: | Repositorio Digital de la UPF |
| OAI Identifier: | oai:repositori.upf.edu:10230/53214 |
| Online Access: | http://hdl.handle.net/10230/53214 http://dx.doi.org/10.1093/ije/dyaa267 |
| Access Level: | Open access |
| Keyword: | DNA methylation DOHaD Paternal Body mass index Epigenetics Fathers Pregnancy |
| _version_ | 1878731095797661696 |
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| author | Sharp, Gemma C. |
| author2 | Alfano, Rossella Ghantous, Akram Urquiza, José M. Rifas-Shiman, Sheryl L. Page, Christian M. Jin, Jianping Fernández-Barrés, Sílvia Santorelli, Gillian Tindula, Gwen Pregnancy and Childhood Epigenetics (PACE) consortium |
| author2_role | author author author author author author author author author author |
| author_browse | Alfano, Rossella Fernández-Barrés, Sílvia Ghantous, Akram Jin, Jianping Page, Christian M. Pregnancy and Childhood Epigenetics (PACE) consortium Rifas-Shiman, Sheryl L. Santorelli, Gillian Sharp, Gemma C. Tindula, Gwen Urquiza, José M. |
| author_facet | Sharp, Gemma C. Alfano, Rossella Ghantous, Akram Urquiza, José M. Rifas-Shiman, Sheryl L. Page, Christian M. Jin, Jianping Fernández-Barrés, Sílvia Santorelli, Gillian Tindula, Gwen Pregnancy and Childhood Epigenetics (PACE) consortium |
| author_role | author |
| collection | Repositorio Digital de la UPF |
| description | Background: Accumulating evidence links paternal adiposity in the periconceptional period to offspring health outcomes. DNA methylation has been proposed as a mediating mechanism, but very few studies have explored this possibility in humans. Methods: In the Pregnancy And Childhood Epigenetics (PACE) consortium, we conducted a meta-analysis of coordinated epigenome-wide association studies (EWAS) of paternal prenatal body mass index (BMI) (with and without adjustment for maternal BMI) in relation to DNA methylation in offspring blood at birth (13 data sets; total n = 4894) and in childhood (6 data sets; total n = 1982). Results: We found little evidence of an association at either time point: at all CpGs, the false-discovery-rate-adjusted P-values were >0.05. In secondary sex-stratified analyses, we found just four CpGs for which there was robust evidence of an association in female offspring. To compare our findings to those of other studies, we conducted a systematic review, which identified seven studies, including five candidate gene studies showing associations between paternal BMI/obesity and offspring or sperm DNA methylation at imprinted regions. However, in our own study, we found very little evidence of enrichment for imprinted genes. Conclusion: Our findings do not support the hypothesis that paternal BMI around the time of pregnancy is associated with offspring-blood DNA methylation, even at imprinted regions. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_28dd93fc204dca1faae0bfe8a6779be2 |
| institution | Universitat Pompeu Fabra |
| instname_str | Universitat Pompeu Fabra |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:repositori.upf.edu:10230/53214 |
| publishDate | 2021 |
| publishDateSort | 2021 |
| publisher | Oxford University Press |
| publisherStr | Oxford University Press |
| reponame_str | Repositorio Digital de la UPF |
| spelling | Paternal body mass index and offspring DNA methylation: findings from the PACE consortium Sharp, Gemma C. Alfano, Rossella Ghantous, Akram Urquiza, José M. Rifas-Shiman, Sheryl L. Page, Christian M. Jin, Jianping Fernández-Barrés, Sílvia Santorelli, Gillian Tindula, Gwen Pregnancy and Childhood Epigenetics (PACE) consortium DNA methylation DOHaD Paternal Body mass index Epigenetics Fathers Pregnancy Background: Accumulating evidence links paternal adiposity in the periconceptional period to offspring health outcomes. DNA methylation has been proposed as a mediating mechanism, but very few studies have explored this possibility in humans. Methods: In the Pregnancy And Childhood Epigenetics (PACE) consortium, we conducted a meta-analysis of coordinated epigenome-wide association studies (EWAS) of paternal prenatal body mass index (BMI) (with and without adjustment for maternal BMI) in relation to DNA methylation in offspring blood at birth (13 data sets; total n = 4894) and in childhood (6 data sets; total n = 1982). Results: We found little evidence of an association at either time point: at all CpGs, the false-discovery-rate-adjusted P-values were >0.05. In secondary sex-stratified analyses, we found just four CpGs for which there was robust evidence of an association in female offspring. To compare our findings to those of other studies, we conducted a systematic review, which identified seven studies, including five candidate gene studies showing associations between paternal BMI/obesity and offspring or sperm DNA methylation at imprinted regions. However, in our own study, we found very little evidence of enrichment for imprinted genes. Conclusion: Our findings do not support the hypothesis that paternal BMI around the time of pregnancy is associated with offspring-blood DNA methylation, even at imprinted regions. Oxford University Press http://hdl.handle.net/10230/53214 http://dx.doi.org/10.1093/ije/dyaa267 |
| spellingShingle | Paternal body mass index and offspring DNA methylation: findings from the PACE consortium Sharp, Gemma C. DNA methylation DOHaD Paternal Body mass index Epigenetics Fathers Pregnancy |
| status_str | publishedVersion |
| title | Paternal body mass index and offspring DNA methylation: findings from the PACE consortium |
| title_full | Paternal body mass index and offspring DNA methylation: findings from the PACE consortium |
| title_fullStr | Paternal body mass index and offspring DNA methylation: findings from the PACE consortium |
| title_full_unstemmed | Paternal body mass index and offspring DNA methylation: findings from the PACE consortium |
| title_short | Paternal body mass index and offspring DNA methylation: findings from the PACE consortium |
| title_sort | Paternal body mass index and offspring DNA methylation: findings from the PACE consortium |
| topic | DNA methylation DOHaD Paternal Body mass index Epigenetics Fathers Pregnancy |
| topic_facet | DNA methylation DOHaD Paternal Body mass index Epigenetics Fathers Pregnancy |
| url | http://hdl.handle.net/10230/53214 http://dx.doi.org/10.1093/ije/dyaa267 |