Neurotoxicity induced by microcystins and cylindrospermopsin: A review
Microcystins (MCs) and cylindrospermopsin (CYN) are among the most frequent toxins produced by cyanobacteria. These toxic secondary metabolites are classified as hepatotoxins and cytotoxin, respectively. Furthermore, both may present the ability to induce damage to the nervous system. In this sense,...
| Authors: | ; ; ; ; ; |
|---|---|
| Format: | Article |
| Status: | Accepted version |
| Publication date: | 2019 |
| Country: | España |
| Institution: | Universidad de Sevilla (US) |
| Repository: | idUS. Depósito de Investigación de la Universidad de Sevilla |
| OAI Identifier: | oai:idus.us.es:11441/128525 |
| Online Access: | https://hdl.handle.net/11441/128525 https://doi.org/10.1016/j.scitotenv.2019.02.426 |
| Access Level: | Open access |
| Keyword: | Cyanotoxins MCs CYN Nervous system Ecotoxicology Environmental risk |
| _version_ | 1878730975376048129 |
|---|---|
| author | Hinojosa Hidalgo, María Gracia |
| author2 | Gutiérrez-Praena, Daniel Prieto Ortega, Ana Isabel Guzmán Guillén, Remedios Jos Gallego, Ángeles Mencía Cameán Fernández, Ana María |
| author2_role | author author author author author |
| author_browse | Cameán Fernández, Ana María Gutiérrez-Praena, Daniel Guzmán Guillén, Remedios Hinojosa Hidalgo, María Gracia Jos Gallego, Ángeles Mencía Prieto Ortega, Ana Isabel |
| author_facet | Hinojosa Hidalgo, María Gracia Gutiérrez-Praena, Daniel Prieto Ortega, Ana Isabel Guzmán Guillén, Remedios Jos Gallego, Ángeles Mencía Cameán Fernández, Ana María |
| author_role | author |
| collection | idUS. Depósito de Investigación de la Universidad de Sevilla |
| description | Microcystins (MCs) and cylindrospermopsin (CYN) are among the most frequent toxins produced by cyanobacteria. These toxic secondary metabolites are classified as hepatotoxins and cytotoxin, respectively. Furthermore, both may present the ability to induce damage to the nervous system. In this sense, there are many studies manifesting the potential of MCs to cause neurotoxicity both in vitro and in vivo, due to their probable capacity to cross the blood-brain-barrier through organic anion transporting polypeptides. Moreover, the presence of MCs has been detected in brain of several experimental models. Among the neurological effects, histopathological brain changes, deregulation of biochemical parameters in brain (production of oxidative stress and inhibition of protein phosphatases) and behavioral alterations have been described. It is noteworthy that minority variants such as MC-LF and -LW have demonstrated to exert higher neurotoxic effects compared to the most studied congener, MC-LR. By contrast, the available studies concerning CYN-neurotoxic effects are very scarce, mostly showing inflammation and apoptosis in neural murine cell lines, oxidative stress, and alteration of the acetylcholinesterase activity in vivo. However, more studies are required in order to clarify the neurotoxic potential of both toxins, as well as their possible contribution to neurodegenerative diseases. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_26a20e27770a734de9dc6430f67fea4e |
| institution | Universidad de Sevilla (US) |
| instname_str | Universidad de Sevilla (US) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:idus.us.es:11441/128525 |
| publishDate | 2019 |
| publishDateSort | 2019 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| reponame_str | idUS. Depósito de Investigación de la Universidad de Sevilla |
| spelling | Neurotoxicity induced by microcystins and cylindrospermopsin: A review Hinojosa Hidalgo, María Gracia Gutiérrez-Praena, Daniel Prieto Ortega, Ana Isabel Guzmán Guillén, Remedios Jos Gallego, Ángeles Mencía Cameán Fernández, Ana María Cyanotoxins MCs CYN Nervous system Ecotoxicology Environmental risk Microcystins (MCs) and cylindrospermopsin (CYN) are among the most frequent toxins produced by cyanobacteria. These toxic secondary metabolites are classified as hepatotoxins and cytotoxin, respectively. Furthermore, both may present the ability to induce damage to the nervous system. In this sense, there are many studies manifesting the potential of MCs to cause neurotoxicity both in vitro and in vivo, due to their probable capacity to cross the blood-brain-barrier through organic anion transporting polypeptides. Moreover, the presence of MCs has been detected in brain of several experimental models. Among the neurological effects, histopathological brain changes, deregulation of biochemical parameters in brain (production of oxidative stress and inhibition of protein phosphatases) and behavioral alterations have been described. It is noteworthy that minority variants such as MC-LF and -LW have demonstrated to exert higher neurotoxic effects compared to the most studied congener, MC-LR. By contrast, the available studies concerning CYN-neurotoxic effects are very scarce, mostly showing inflammation and apoptosis in neural murine cell lines, oxidative stress, and alteration of the acetylcholinesterase activity in vivo. However, more studies are required in order to clarify the neurotoxic potential of both toxins, as well as their possible contribution to neurodegenerative diseases. Ministerio de Economía y Competitividad (AGL2015-64558-R, MINECO/FEDER, UE) Elsevier https://hdl.handle.net/11441/128525 https://doi.org/10.1016/j.scitotenv.2019.02.426 |
| spellingShingle | Neurotoxicity induced by microcystins and cylindrospermopsin: A review Hinojosa Hidalgo, María Gracia Cyanotoxins MCs CYN Nervous system Ecotoxicology Environmental risk |
| status_str | acceptedVersion |
| title | Neurotoxicity induced by microcystins and cylindrospermopsin: A review |
| title_full | Neurotoxicity induced by microcystins and cylindrospermopsin: A review |
| title_fullStr | Neurotoxicity induced by microcystins and cylindrospermopsin: A review |
| title_full_unstemmed | Neurotoxicity induced by microcystins and cylindrospermopsin: A review |
| title_short | Neurotoxicity induced by microcystins and cylindrospermopsin: A review |
| title_sort | Neurotoxicity induced by microcystins and cylindrospermopsin: A review |
| topic | Cyanotoxins MCs CYN Nervous system Ecotoxicology Environmental risk |
| topic_facet | Cyanotoxins MCs CYN Nervous system Ecotoxicology Environmental risk |
| url | https://hdl.handle.net/11441/128525 https://doi.org/10.1016/j.scitotenv.2019.02.426 |