Butler enables rapid cloud-based analysis of thousands of human genomes

We present Butler, a computational tool that facilitates large-scale genomic analyses on public and academic clouds. Butler includes innovative anomaly detection and self-healing functions that improve the efficiency of data processing and analysis by 43% compared with current approaches. Butler ena...

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Bibliographic Details
Authors: PCAWG Technical Working Group; PCAWG Consortium; Gelpí Buchaca, Josep Lluís
Format: Article
Status:Published version
Publication date:2020
Country:España
Institution:Universidad de Barcelona
Repository:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/172342
Online Access:https://hdl.handle.net/2445/172342
Access Level:Open access
Keyword:Genoma humà
Biologia computacional
Human genome
Computational biology
Description
Summary:We present Butler, a computational tool that facilitates large-scale genomic analyses on public and academic clouds. Butler includes innovative anomaly detection and self-healing functions that improve the efficiency of data processing and analysis by 43% compared with current approaches. Butler enabled processing of a 725-terabyte cancer genome dataset from the Pan-Cancer Analysis of Whole Genomes (PCAWG) project in a time-efficient and uniform manner.