Gut Microbiota Profile and Its Association with Clinical Variables and Dietary Intake in Overweight/Obese and Lean Subjects: A Cross-Sectional Study
We aimed to differentiate gut microbiota composition of overweight/obese and lean subjects and to determine its association with clinical variables and dietary intake. A cross-sectional study was performed with 96 overweight/obese subjects and 32 lean subjects. Anthropometric parameters were positiv...
| Autores: | ; ; ; ; ; ; ; ; ; ; ; ; |
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| Tipo de documento: | Artículo |
| Estado: | Published version |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
| Repositorio: | r-FISABIO. Repositorio Institucional de Producción Científica |
| OAI Identifier: | oai:fisabio.fundanetsuite.com:p11960 |
| Acceso en línea: | https://fisabio.portalinvestigacion.com/publicaciones/11960 |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | obesity gut microbiota dietary intake saturated fatty acids |
| _version_ | 1878730864819437568 |
|---|---|
| author | Companys, J |
| author2 | Gosalbes, MJ Pla-Paga, L Calderon-Perez, L Llaurado, E Pedret, A Valls, RM Jimenez-Hernandez, N Sandoval-Ramirez, BA del Bas, JM Caimari, A Rubio, L Sola, R |
| author2_role | author author author author author author author author author author author author |
| author_browse | Caimari, A Calderon-Perez, L Companys, J Gosalbes, MJ Jimenez-Hernandez, N Llaurado, E Pedret, A Pla-Paga, L Rubio, L Sandoval-Ramirez, BA Sola, R Valls, RM del Bas, JM |
| author_facet | Companys, J Gosalbes, MJ Pla-Paga, L Calderon-Perez, L Llaurado, E Pedret, A Valls, RM Jimenez-Hernandez, N Sandoval-Ramirez, BA del Bas, JM Caimari, A Rubio, L Sola, R |
| author_role | author |
| collection | r-FISABIO. Repositorio Institucional de Producción Científica |
| description | We aimed to differentiate gut microbiota composition of overweight/obese and lean subjects and to determine its association with clinical variables and dietary intake. A cross-sectional study was performed with 96 overweight/obese subjects and 32 lean subjects. Anthropometric parameters were positively associated with Collinsella aerofaciens, Dorea formicigenerans and Dorea longicatena, which had higher abundance the overweight/obese subjects. Moreover, different genera of Lachnospiraceae were negatively associated with body fat, LDL and total cholesterol. Saturated fatty acids (SFAs) were negatively associated with the genus Intestinimonas, a biomarker of the overweight/obese group, whereas SFAs were positively associated with Roseburia, a biomarker for the lean group. In conclusion, Dorea formicigenerans, Dorea longicatena and Collinsella aerofaciens could be considered obesity biomarkers, Lachnospiraceae is associated with lipid cardiovascular risk factors. SFAs exhibited opposite association profiles with butyrate-producing bacteria depending on the BMI. Thus, the relationship between diet and microbiota opens new tools for the management of obesity. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_24cc4e9814d763dd048d4d4e04f9ecb6 |
| institution | Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
| instname_str | Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:fisabio.fundanetsuite.com:p11960 |
| publishDate | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI |
| publisherStr | MDPI |
| reponame_str | r-FISABIO. Repositorio Institucional de Producción Científica |
| spelling | Gut Microbiota Profile and Its Association with Clinical Variables and Dietary Intake in Overweight/Obese and Lean Subjects: A Cross-Sectional Study Companys, J Gosalbes, MJ Pla-Paga, L Calderon-Perez, L Llaurado, E Pedret, A Valls, RM Jimenez-Hernandez, N Sandoval-Ramirez, BA del Bas, JM Caimari, A Rubio, L Sola, R obesity gut microbiota dietary intake saturated fatty acids We aimed to differentiate gut microbiota composition of overweight/obese and lean subjects and to determine its association with clinical variables and dietary intake. A cross-sectional study was performed with 96 overweight/obese subjects and 32 lean subjects. Anthropometric parameters were positively associated with Collinsella aerofaciens, Dorea formicigenerans and Dorea longicatena, which had higher abundance the overweight/obese subjects. Moreover, different genera of Lachnospiraceae were negatively associated with body fat, LDL and total cholesterol. Saturated fatty acids (SFAs) were negatively associated with the genus Intestinimonas, a biomarker of the overweight/obese group, whereas SFAs were positively associated with Roseburia, a biomarker for the lean group. In conclusion, Dorea formicigenerans, Dorea longicatena and Collinsella aerofaciens could be considered obesity biomarkers, Lachnospiraceae is associated with lipid cardiovascular risk factors. SFAs exhibited opposite association profiles with butyrate-producing bacteria depending on the BMI. Thus, the relationship between diet and microbiota opens new tools for the management of obesity. MDPI https://fisabio.portalinvestigacion.com/publicaciones/11960 |
| spellingShingle | Gut Microbiota Profile and Its Association with Clinical Variables and Dietary Intake in Overweight/Obese and Lean Subjects: A Cross-Sectional Study Companys, J obesity gut microbiota dietary intake saturated fatty acids |
| status_str | publishedVersion |
| title | Gut Microbiota Profile and Its Association with Clinical Variables and Dietary Intake in Overweight/Obese and Lean Subjects: A Cross-Sectional Study |
| title_full | Gut Microbiota Profile and Its Association with Clinical Variables and Dietary Intake in Overweight/Obese and Lean Subjects: A Cross-Sectional Study |
| title_fullStr | Gut Microbiota Profile and Its Association with Clinical Variables and Dietary Intake in Overweight/Obese and Lean Subjects: A Cross-Sectional Study |
| title_full_unstemmed | Gut Microbiota Profile and Its Association with Clinical Variables and Dietary Intake in Overweight/Obese and Lean Subjects: A Cross-Sectional Study |
| title_short | Gut Microbiota Profile and Its Association with Clinical Variables and Dietary Intake in Overweight/Obese and Lean Subjects: A Cross-Sectional Study |
| title_sort | Gut Microbiota Profile and Its Association with Clinical Variables and Dietary Intake in Overweight/Obese and Lean Subjects: A Cross-Sectional Study |
| topic | obesity gut microbiota dietary intake saturated fatty acids |
| topic_facet | obesity gut microbiota dietary intake saturated fatty acids |
| url | https://fisabio.portalinvestigacion.com/publicaciones/11960 |