Plasma lipid profiles discriminate bacterial from viral infection in febrile children

Fever is the most common reason that children present to Emergency Departments. Clinical signs and symptoms suggestive of bacterial infection are often non-specific, and there is no definitive test for the accurate diagnosis of infection. The 'omics' approaches to identifying biomarkers from the hos...

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Authors: Wang, XZ; Nijman, R; Camuzeaux, S; Sands, C; Jackson, H; Kaforou, M; Emonts, M; Herberg, JA; Maconochie, I; Carrol, ED; Paulus, SC; Zenz, W; Van der Flier, M; de Groot, R; Schlapbach, LJ; Pollard, AJ; Fink, C; Kuijpers, TT; Anderson, S; Lewis, MR; Levin, M; McClure, M; Gormley, S; Hamilton, S; Hourmat, B; Hoggart, C; Sancho-Shimizu, V; Wright, V; Abdulla, A; Agapow, P; Bartlett, M; Bellos, E; Eleftherohorinou, H; Galassini, R; Inwald, D; Mashbat, M; Menikou, S; Mustafa, S; Nadel, S; Rahman, R; Thakker, C; Coin, LMJ; Bokhand, S; Power, S; Barham, H; Pathan, N; Ridout, J; White, D; Thurston, S; Faust, S; Patel, S; McCorkell, J; Davies, P; Crate, L; Navarra, H; Carter, S; Ramaiah, R; Patel, R; Tuffrey, C; Gribbin, A; McCready, S; Peters, M; Hardy, K; Standing, F; O'Neill, L; Abelake, E; Deep, A; Nsirim, E; Willis, L; Young, Z; Royad, C; White, S; Fortune, PM; Hudnott, P; Gonzalez, FA; Barral-Arca, R; Cebey-Lopez, M; Curras-Tuala, MJ; Garcia, N; Vicente, LG; Gomez-Carballa, A; Rial, JG; Beiroa, AG; Grande, AJ; Iglesias, PL; Santos, AEM; Martinon-Torres, F; MartinonTorres, N; Sanchez, JMM; Gutierrez, BM; Perez, BM; Pacheco, PO; Pardo-Seco, J; Pischedda, S; RiveroCalle, I; Rodriguez-Tenreiro, C; Redondo-Collazo, L; Ellacuriagal, AS; Fernandez, SS; Silva, MDSP; Vega, A; Trillo, LV; Salas, A; Reyes, SB; Leon, MCL; Mingorance, AN; Barrios, XG; Vergara, EO; Torre, AC; Vivanco, A; Fernandez, R; Sanchez, FG; Forte, MS; Rojo, P; Contreras, JR; Palacios, A; Ibarrondo, CE; Cooke, EF; Navarro, M; Alvarez, CA; Lozano, MJ; Carreras, E; Sanagustin, SB; Neth, O; Padilla, MDCM; Tato, LMP; Guillen, S; Silveira, LF; Moreno, D; van Furth, AMT; Boeddha, NP; Driessen, GJA; Hazelzet, JA; Pajkrt, D; Sanders, EAM; Van De Beek, D; van der Ende, A; Philipsen, HLA; Adeel, AOA; Breukels, MA; Brinkman, DMC; de Korte, CCMM; de Vries, E; de Waal, WJ; Dekkers, R; Dings-Lammertink, A; Doedens, RA; Donker, AE; Dousma, M; Faber, TE; Gerrits, GPJM; Gerver, JAM; Heidema, J; Homan-van der Veen, J; Jacobs, MAM; Jansen, NJG; Kawczynski, P; Klucovska, K; Kneyber, MCJ; Koopman-Keemink, Y; Langenhorst, VJ; Leusink, J; Loza, BF; Merth, IT; Miedema, CJ; Neeleman, C; Noordzij, JG; Obihara, CC; van Overbeek-van Gils, ALT; Poortman, GH; Potgieter, ST; Potjewijd, J; Rosias, PPR; Sprong, T; ten Tussher, GW; Thio, BJ; Tramper-Stranders, GA; van Deuren, M; van der Meer, H; van Kuppevelt, AJM; van Wermeskerken, AM; Verwijs, WA; Wolfs, TFW; Agyeman, P; Aebi, C; Giannoni, E; Stocker, M; Posfay-Barbe, KM; Heininger, U; Bernhard-Stirnemann, S; Niederer-Loher, A; Kahlert, C; Hasters, P; Relly, C; Baer, W; Berger, C; Frederick, H; Jennings, R; Johnston, J; Kenwright, R; Pinnock, E; Agbeko, R; Secka, F; Bojang, K; Sarr, I; Kebbeh, N; Sey, G; Momodou, SK; Cole, F; Thomas, G; Antonio, M; Klobassa, DS; Binder, A; Schweintzger, NA; Sagmeister, M; Baumgart, H; Baumgartner, M; Behrends, U; Biebl, A; Birnbacher, R; Blanke, JG; Boelke, C; Breuling, K; Brunner, J; Buller, M; Dahlem, P; Dietrich, B; Eber, E; Elias, J; Emhofer, J; Etschmaier, R; Farr, S; Girtler, Y; Grigorow, I; Heimann, K; Ihm, U; Jaros, Z; Kalhoff, H; Kaulfersch, W; Kemen, C; Klocker, N; Koster, B; Kohlmaier, B; Komini, E; Kramer, L; Neubert, A; Ortner, D; Pescollderungg, L; Pfurtscheller, K; Reiter, K; Ristic, G; Rodl, S; Sellner, A; Sonnleitner, A; Sperl, M; Stelzl, W; Till, H; Trobisch, A; Vierzig, A; Vogel, U; Weingarten, C; Welke, S; Wimmer, A; Wintergerst, U; Wuller, D; Zaunschirm, A; Ziuraite, I; Zukovskaja, V
Format: Article
Status:Published version
Publication date:2019
Country:España
Institution:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repository:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p2238
Online Access:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=2238
Access Level:Open access
Description
Summary:Fever is the most common reason that children present to Emergency Departments. Clinical signs and symptoms suggestive of bacterial infection are often non-specific, and there is no definitive test for the accurate diagnosis of infection. The 'omics' approaches to identifying biomarkers from the host-response to bacterial infection are promising. In this study, lipidomic analysis was carried out with plasma samples obtained from febrile children with confirmed bacterial infection (n = 20) and confirmed viral infection (n = 20). We show for the first time that bacterial and viral infection produces distinct profile in the host lipidome. Some species of glycerophosphoinositol, sphingomyelin, lysophosphatidylcholine and cholesterol sulfate were higher in the confirmed virus infected group, while some species of fatty acids, glycerophosphocholine, glycerophosphoserine, lactosylceramide and bilirubin were lower in the confirmed virus infected group when compared with confirmed bacterial infected group. A combination of three lipids achieved an area under the receiver operating characteristic (ROC) curve of 0.911 (95% CI 0.81 to 0.98). This pilot study demonstrates the potential of metabolic biomarkers to assist clinicians in distinguishing bacterial from viral infection in febrile children, to facilitate effective clinical management and to the limit inappropriate use of antibiotics.