New Insights of Oral Colonic Drug Delivery Systems for Inflammatory Bowel Disease Therapy
[EN] Colonic Drug Delivery Systems (CDDS) are especially advantageous for local treatment of inflammatory bowel diseases (IBD). Site-targeted drug release allows to obtain a high drug concentration in injured tissues and less systemic adverse effects, as consequence of less/null drug absorption in s...
| Authors: | ; ; ; ; ; ; ; |
|---|---|
| Format: | Article |
| Publication date: | 2020 |
| Country: | España |
| Institution: | Universitat Politècnica de València (UPV) |
| Repository: | RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia |
| Language: | English |
| OAI Identifier: | oai:riunet.upv.es:10251/169426 |
| Online Access: | https://riunet.upv.es/handle/10251/169426 |
| Access Level: | Open access |
| Keyword: | Intestinal permeability Colon Drug delivery Inflammatory bowel diseases QUIMICA INORGANICA QUIMICA ORGANICA QUIMICA ANALITICA |
| _version_ | 1878730666307223552 |
|---|---|
| author | Hernández Teruel, Adrián |
| author2 | Gonzalez-Alvarez, Isabel Bermejo, Marival Merino Sanjuán, Virginia Gonzalez-Alvarez, Marta Marcos Martínez, María Dolores|||0000-0001-7079-8589 Sancenón Galarza, Félix|||0000-0002-5205-7135 Martínez-Máñez, Ramón|||0000-0001-5873-9674 |
| author2_role | author author author author author author author |
| author_browse | Bermejo, Marival Gonzalez-Alvarez, Isabel Gonzalez-Alvarez, Marta Hernández Teruel, Adrián Marcos Martínez, María Dolores|||0000-0001-7079-8589 Martínez-Máñez, Ramón|||0000-0001-5873-9674 Merino Sanjuán, Virginia Sancenón Galarza, Félix|||0000-0002-5205-7135 |
| author_facet | Hernández Teruel, Adrián Gonzalez-Alvarez, Isabel Bermejo, Marival Merino Sanjuán, Virginia Gonzalez-Alvarez, Marta Marcos Martínez, María Dolores|||0000-0001-7079-8589 Sancenón Galarza, Félix|||0000-0002-5205-7135 Martínez-Máñez, Ramón|||0000-0001-5873-9674 |
| author_role | author |
| collection | RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia |
| description | [EN] Colonic Drug Delivery Systems (CDDS) are especially advantageous for local treatment of inflammatory bowel diseases (IBD). Site-targeted drug release allows to obtain a high drug concentration in injured tissues and less systemic adverse effects, as consequence of less/null drug absorption in small intestine. This review focused on the reported contributions in the last four years to improve the effectiveness of treatments of inflammatory bowel diseases. The work concludes that there has been an increase in the development of CDDS in which pH, specific enzymes, reactive oxygen species (ROS), or a combination of all of these triggers the release. These delivery systems demonstrated a therapeutic improvement with fewer adverse effects. Future perspectives to the treatment of this disease include the elucidation of molecular basis of IBD diseases in order to design more specific treatments, and the performance of more in vivo assays to validate the specificity and stability of the obtained systems. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_20ebd3e54e89cd4e1d50d5beab8bfc76 |
| institution | Universitat Politècnica de València (UPV) |
| instname_str | Universitat Politècnica de València (UPV) |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:riunet.upv.es:10251/169426 |
| publishDate | 2020 |
| publishDateSort | 2020 |
| publisher | MDPI AG |
| publisherStr | MDPI AG |
| reponame_str | RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia |
| spelling | New Insights of Oral Colonic Drug Delivery Systems for Inflammatory Bowel Disease Therapy Hernández Teruel, Adrián Gonzalez-Alvarez, Isabel Bermejo, Marival Merino Sanjuán, Virginia Gonzalez-Alvarez, Marta Marcos Martínez, María Dolores|||0000-0001-7079-8589 Sancenón Galarza, Félix|||0000-0002-5205-7135 Martínez-Máñez, Ramón|||0000-0001-5873-9674 Intestinal permeability Colon Drug delivery Inflammatory bowel diseases QUIMICA INORGANICA QUIMICA ORGANICA QUIMICA ANALITICA [EN] Colonic Drug Delivery Systems (CDDS) are especially advantageous for local treatment of inflammatory bowel diseases (IBD). Site-targeted drug release allows to obtain a high drug concentration in injured tissues and less systemic adverse effects, as consequence of less/null drug absorption in small intestine. This review focused on the reported contributions in the last four years to improve the effectiveness of treatments of inflammatory bowel diseases. The work concludes that there has been an increase in the development of CDDS in which pH, specific enzymes, reactive oxygen species (ROS), or a combination of all of these triggers the release. These delivery systems demonstrated a therapeutic improvement with fewer adverse effects. Future perspectives to the treatment of this disease include the elucidation of molecular basis of IBD diseases in order to design more specific treatments, and the performance of more in vivo assays to validate the specificity and stability of the obtained systems. The authors want to thank the Spanish Government (project RTI2018-100910-B-C41 (MCUI/AEI/FEDER, UE)) and the Generalitat Valenciana (project PROMETEO/2018/024) for support. This work was also supported by the project "MODELOS IN VITRO DE EVALUACION BIOFARMACEUTICA" SAF2016-78756(AEI/FEDER, EU) funded by Agencia Estatal Investigacion and European Union, through FEDER (Fondo Europeo de Desarrollo Regional). MDPI AG https://riunet.upv.es/handle/10251/169426 |
| spellingShingle | New Insights of Oral Colonic Drug Delivery Systems for Inflammatory Bowel Disease Therapy Hernández Teruel, Adrián Intestinal permeability Colon Drug delivery Inflammatory bowel diseases QUIMICA INORGANICA QUIMICA ORGANICA QUIMICA ANALITICA |
| title | New Insights of Oral Colonic Drug Delivery Systems for Inflammatory Bowel Disease Therapy |
| title_full | New Insights of Oral Colonic Drug Delivery Systems for Inflammatory Bowel Disease Therapy |
| title_fullStr | New Insights of Oral Colonic Drug Delivery Systems for Inflammatory Bowel Disease Therapy |
| title_full_unstemmed | New Insights of Oral Colonic Drug Delivery Systems for Inflammatory Bowel Disease Therapy |
| title_short | New Insights of Oral Colonic Drug Delivery Systems for Inflammatory Bowel Disease Therapy |
| title_sort | New Insights of Oral Colonic Drug Delivery Systems for Inflammatory Bowel Disease Therapy |
| topic | Intestinal permeability Colon Drug delivery Inflammatory bowel diseases QUIMICA INORGANICA QUIMICA ORGANICA QUIMICA ANALITICA |
| topic_facet | Intestinal permeability Colon Drug delivery Inflammatory bowel diseases QUIMICA INORGANICA QUIMICA ORGANICA QUIMICA ANALITICA |
| url | https://riunet.upv.es/handle/10251/169426 |