Genetic predisposition to Alzheimer's disease is associated with enlargement of perivascular spaces in centrum semiovale region
This study investigated whether genetic factors involved in Alzheimer's disease (AD) are associated with enlargement of Perivascular Spaces (ePVS) in the brain. A total of 680 participants with T2-weighted MRI scans and genetic information were acquired from the ALFA study. ePVS in the basal ganglia...
| Authors: | ; ; ; ; ; ; ; ; ; ; ; |
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| Format: | Article |
| Status: | Published version |
| Publication date: | 2021 |
| Country: | España |
| Institution: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repository: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/189407 |
| Online Access: | https://hdl.handle.net/2445/189407 |
| Access Level: | Open access |
| Keyword: | Neurogenètica Malaltia d'Alzheimer Cervell Anàlisi multivariable Neurogenetics Alzheimer's disease Brain Multivariate analysis |
| _version_ | 1878730660254842880 |
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| author | Ciampa, Iacopo |
| author2 | Operto, Grégory Falcón, Carles Minguillón Gil, Carolina Castro de Moura, Manuel Piñeyro, David Esteller, Manel Molinuevo, José Luis Guigó Serra, Roderic Navarro, Arcadi Gispert, Juan Domingo Vilor Tejedor, Natalia |
| author2_role | author author author author author author author author author author author |
| author_browse | Castro de Moura, Manuel Ciampa, Iacopo Esteller, Manel Falcón, Carles Gispert, Juan Domingo Guigó Serra, Roderic Minguillón Gil, Carolina Molinuevo, José Luis Navarro, Arcadi Operto, Grégory Piñeyro, David Vilor Tejedor, Natalia |
| author_facet | Ciampa, Iacopo Operto, Grégory Falcón, Carles Minguillón Gil, Carolina Castro de Moura, Manuel Piñeyro, David Esteller, Manel Molinuevo, José Luis Guigó Serra, Roderic Navarro, Arcadi Gispert, Juan Domingo Vilor Tejedor, Natalia |
| author_role | author |
| collection | Recercat. Dipósit de la Recerca de Catalunya |
| description | This study investigated whether genetic factors involved in Alzheimer's disease (AD) are associated with enlargement of Perivascular Spaces (ePVS) in the brain. A total of 680 participants with T2-weighted MRI scans and genetic information were acquired from the ALFA study. ePVS in the basal ganglia (BG) and the centrum semiovale (CS) were assessed based on a validated visual rating scale. We used univariate and multivariate logistic regression models to investigate associations between ePVS in BG and CS with BIN1-rs744373, as well as APOE genotypes. We found a significant association of the BIN1-rs744373 polymorphism in the CS subscale (p value = 0.019; OR = 2.564), suggesting that G allele carriers have an increased risk of ePVS in comparison with A allele carriers. In stratified analysis by APOE-#4 status (carriers vs. non-carriers), these results remained significant only for '4 carriers (p value = 0.011; OR = 1.429). To our knowledge, the present study is the first suggesting that genetic predisposition for AD is associated with ePVS in CS. These findings provide evidence that underlying biological processes affecting AD may influence CS-ePVS. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_20cf63d5ba00a4bcf9e3d92a5e1cfd33 |
| institution | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:recercat.cat:2445/189407 |
| publishDate | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI |
| publisherStr | MDPI |
| reponame_str | Recercat. Dipósit de la Recerca de Catalunya |
| spelling | Genetic predisposition to Alzheimer's disease is associated with enlargement of perivascular spaces in centrum semiovale region Ciampa, Iacopo Operto, Grégory Falcón, Carles Minguillón Gil, Carolina Castro de Moura, Manuel Piñeyro, David Esteller, Manel Molinuevo, José Luis Guigó Serra, Roderic Navarro, Arcadi Gispert, Juan Domingo Vilor Tejedor, Natalia Neurogenètica Malaltia d'Alzheimer Cervell Anàlisi multivariable Neurogenetics Alzheimer's disease Brain Multivariate analysis This study investigated whether genetic factors involved in Alzheimer's disease (AD) are associated with enlargement of Perivascular Spaces (ePVS) in the brain. A total of 680 participants with T2-weighted MRI scans and genetic information were acquired from the ALFA study. ePVS in the basal ganglia (BG) and the centrum semiovale (CS) were assessed based on a validated visual rating scale. We used univariate and multivariate logistic regression models to investigate associations between ePVS in BG and CS with BIN1-rs744373, as well as APOE genotypes. We found a significant association of the BIN1-rs744373 polymorphism in the CS subscale (p value = 0.019; OR = 2.564), suggesting that G allele carriers have an increased risk of ePVS in comparison with A allele carriers. In stratified analysis by APOE-#4 status (carriers vs. non-carriers), these results remained significant only for '4 carriers (p value = 0.011; OR = 1.429). To our knowledge, the present study is the first suggesting that genetic predisposition for AD is associated with ePVS in CS. These findings provide evidence that underlying biological processes affecting AD may influence CS-ePVS. MDPI https://hdl.handle.net/2445/189407 |
| spellingShingle | Genetic predisposition to Alzheimer's disease is associated with enlargement of perivascular spaces in centrum semiovale region Ciampa, Iacopo Neurogenètica Malaltia d'Alzheimer Cervell Anàlisi multivariable Neurogenetics Alzheimer's disease Brain Multivariate analysis |
| status_str | publishedVersion |
| title | Genetic predisposition to Alzheimer's disease is associated with enlargement of perivascular spaces in centrum semiovale region |
| title_full | Genetic predisposition to Alzheimer's disease is associated with enlargement of perivascular spaces in centrum semiovale region |
| title_fullStr | Genetic predisposition to Alzheimer's disease is associated with enlargement of perivascular spaces in centrum semiovale region |
| title_full_unstemmed | Genetic predisposition to Alzheimer's disease is associated with enlargement of perivascular spaces in centrum semiovale region |
| title_short | Genetic predisposition to Alzheimer's disease is associated with enlargement of perivascular spaces in centrum semiovale region |
| title_sort | Genetic predisposition to Alzheimer's disease is associated with enlargement of perivascular spaces in centrum semiovale region |
| topic | Neurogenètica Malaltia d'Alzheimer Cervell Anàlisi multivariable Neurogenetics Alzheimer's disease Brain Multivariate analysis |
| topic_facet | Neurogenètica Malaltia d'Alzheimer Cervell Anàlisi multivariable Neurogenetics Alzheimer's disease Brain Multivariate analysis |
| url | https://hdl.handle.net/2445/189407 |