Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study
Purpose: The objective of this study is to analyse the relative survival with breast cancer in women diagnosed after new treatments were generalised and to ascertain the current effect that tumour characteristics such as grade, stage or subtype have on survival as well as the new AJCC-pathological p...
| Authors: | ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; |
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| Format: | Article |
| Publication date: | 2020 |
| Country: | España |
| Institution: | Instituto de Salud Carlos III (ISCIII) |
| Repository: | Repisalud |
| Language: | English |
| OAI Identifier: | oai:repisalud.isciii.es:20.500.12105/14109 |
| Online Access: | http://hdl.handle.net/20.500.12105/14109 |
| Access Level: | Open access |
| Keyword: | Survivorship Adult Aged |
| _version_ | 1878730561930919936 |
|---|---|
| author | Gómez-Acebo, Inés |
| author2 | Dierssen-Sotos, Trinidad Palazuelos-Calderón, Camilo Perez-Gomez, Beatriz Amiano, Pilar Guevara, Marcela Molina, Antonio J Domingo, Laia Fernández-Ortiz, María Moreno, Victor Alguacil, Juan Fernández-Tardón, Guillermo Ibáñez, Josefa Marcos-Gragera, Rafael Diaz-Santos, Marian Alonso, María Henar Alonso-Molero, Jéssica Castaño-Vinyals, Gemma Palomo, Andrés García Ardanaz, Eva Molinuevo, Amaia Aragones, Nuria Kogevinas, Manolis Pollan-Santamaria, Marina Llorca, Javier |
| author2_role | author author author author author author author author author author author author author author author author author author author author author author author author |
| author_browse | Alguacil, Juan Alonso, María Henar Alonso-Molero, Jéssica Amiano, Pilar Aragones, Nuria Ardanaz, Eva Castaño-Vinyals, Gemma Diaz-Santos, Marian Dierssen-Sotos, Trinidad Domingo, Laia Fernández-Ortiz, María Fernández-Tardón, Guillermo Guevara, Marcela Gómez-Acebo, Inés Ibáñez, Josefa Kogevinas, Manolis Llorca, Javier Marcos-Gragera, Rafael Molina, Antonio J Molinuevo, Amaia Moreno, Victor Palazuelos-Calderón, Camilo Palomo, Andrés García Perez-Gomez, Beatriz Pollan-Santamaria, Marina |
| author_facet | Gómez-Acebo, Inés Dierssen-Sotos, Trinidad Palazuelos-Calderón, Camilo Perez-Gomez, Beatriz Amiano, Pilar Guevara, Marcela Molina, Antonio J Domingo, Laia Fernández-Ortiz, María Moreno, Victor Alguacil, Juan Fernández-Tardón, Guillermo Ibáñez, Josefa Marcos-Gragera, Rafael Diaz-Santos, Marian Alonso, María Henar Alonso-Molero, Jéssica Castaño-Vinyals, Gemma Palomo, Andrés García Ardanaz, Eva Molinuevo, Amaia Aragones, Nuria Kogevinas, Manolis Pollan-Santamaria, Marina Llorca, Javier |
| author_role | author |
| collection | Repisalud |
| description | Purpose: The objective of this study is to analyse the relative survival with breast cancer in women diagnosed after new treatments were generalised and to ascertain the current effect that tumour characteristics such as grade, stage or subtype have on survival as well as the new AJCC-pathological prognostic score. Methods: The breast cancer MCC-Spain follow-up study is a prospective cohort study of 1685 incident breast cancer cases. Women between 20 and 85 years old were recruited between the years 2008 and 2013 in 18 hospitals located in 10 Spanish provinces and they have been followed until 2017/2018. Relative survival was estimated after 3, 5 and 8 years of follow-up using Ederer II method. In addition, Weibull regression adjusted by age, hospital, grade and stage was used to investigate prognosis factors. Results: Among components of TNM staging system, tumour size greater than 50 mm (i.e. T3 or T4) more than doubled the risk of dying, while N3 nodal involvement and presence of metastasis had a huge effect on mortality. The AJCC pathological prognostic score strongly correlated with survival; thus, hazard ratios increased as the score rose, being 2.31, 4.00, 4.94, 7.92, 2.26, 14.9 and 58.9 for scores IB, IIA, IIB, IIIA, IIIB, IIIC and IV, respectively. Conclusion: Both TNM staging and histological/molecular biomarkers are associated with overall survival in Spanish women with breast cancer; when both are combined in the AJCC pathological prognosis score, the prognostic value improved with risk indices that increased rapidly as the pathological prognosis score increased. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_1ecdff7df44a2db97aacbf64ff1373be |
| institution | Instituto de Salud Carlos III (ISCIII) |
| instname_str | Instituto de Salud Carlos III (ISCIII) |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:repisalud.isciii.es:20.500.12105/14109 |
| publishDate | 2020 |
| publishDateSort | 2020 |
| publisher | Springer |
| publisherStr | Springer |
| reponame_str | Repisalud |
| spelling | Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study Gómez-Acebo, Inés Dierssen-Sotos, Trinidad Palazuelos-Calderón, Camilo Perez-Gomez, Beatriz Amiano, Pilar Guevara, Marcela Molina, Antonio J Domingo, Laia Fernández-Ortiz, María Moreno, Victor Alguacil, Juan Fernández-Tardón, Guillermo Ibáñez, Josefa Marcos-Gragera, Rafael Diaz-Santos, Marian Alonso, María Henar Alonso-Molero, Jéssica Castaño-Vinyals, Gemma Palomo, Andrés García Ardanaz, Eva Molinuevo, Amaia Aragones, Nuria Kogevinas, Manolis Pollan-Santamaria, Marina Llorca, Javier Survivorship Adult Aged Purpose: The objective of this study is to analyse the relative survival with breast cancer in women diagnosed after new treatments were generalised and to ascertain the current effect that tumour characteristics such as grade, stage or subtype have on survival as well as the new AJCC-pathological prognostic score. Methods: The breast cancer MCC-Spain follow-up study is a prospective cohort study of 1685 incident breast cancer cases. Women between 20 and 85 years old were recruited between the years 2008 and 2013 in 18 hospitals located in 10 Spanish provinces and they have been followed until 2017/2018. Relative survival was estimated after 3, 5 and 8 years of follow-up using Ederer II method. In addition, Weibull regression adjusted by age, hospital, grade and stage was used to investigate prognosis factors. Results: Among components of TNM staging system, tumour size greater than 50 mm (i.e. T3 or T4) more than doubled the risk of dying, while N3 nodal involvement and presence of metastasis had a huge effect on mortality. The AJCC pathological prognostic score strongly correlated with survival; thus, hazard ratios increased as the score rose, being 2.31, 4.00, 4.94, 7.92, 2.26, 14.9 and 58.9 for scores IB, IIA, IIB, IIIA, IIIB, IIIC and IV, respectively. Conclusion: Both TNM staging and histological/molecular biomarkers are associated with overall survival in Spanish women with breast cancer; when both are combined in the AJCC pathological prognosis score, the prognostic value improved with risk indices that increased rapidly as the pathological prognosis score increased. Springer http://hdl.handle.net/20.500.12105/14109 |
| spellingShingle | Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study Gómez-Acebo, Inés Survivorship Adult Aged |
| title | Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study |
| title_full | Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study |
| title_fullStr | Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study |
| title_full_unstemmed | Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study |
| title_short | Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study |
| title_sort | Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study |
| topic | Survivorship Adult Aged |
| topic_facet | Survivorship Adult Aged |
| url | http://hdl.handle.net/20.500.12105/14109 |