Risk-reducing gynecological surgery in Lynch syndrome: results of an international survey from the prospective Lynch syndrome database
Purpose: To survey risk-reducing hysterectomy and bilateral salpingo-oophorectomy (BSO) practice and advice regarding hormone replacement therapy (HRT) in women with Lynch syndrome. Methods: We conducted a survey in 31 contributing centers from the Prospective Lynch Syndrome Database (PLSD), which i...
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| Tipo de documento: | Artículo |
| Estado: | Published version |
| Fecha de publicación: | 2020 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/173632 |
| Acceso en línea: | https://hdl.handle.net/2445/173632 |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | Malalties hereditàries Càncer d'endometri Càncer d'ovari Genetic disorders Endometrial cancer Ovarian cancer |
| _version_ | 1878730507495145472 |
|---|---|
| author | Dominguez Valentin, Mev |
| author2 | Seppälä, Toni T. Engel, Christoph Aretz, Stefan Macrae, Finlay Winship, Ingrid Capellá, G. (Gabriel) Thomas, Huw Hovig, Eivind Nielsen, Maartje Sijmons, Rolf H. Bertario, Lucio Bonanni, Bernardo Tibiletti, Maria Grazia Cavestro, Giulia Martina Mints, Miriam Gluck, Nathan Katz, Lior Heinimann, Karl Vaccaro, Carlos A. Green, Kate Lalloo, Fiona Hill, James Schmiegel, Wolff Vangala, Deepak Perne, Claudia Strauß, Hans-Georg Tecklenburg, Johanna Holinski-Feder, Elke Steinke-Lange, Verena Mecklin, Jukka-Pekka Plazzer, John-Paul Pineda Riu, Marta Navarro, Matilde Brunet, Joan Kariv, Revital Rosner, Guy Piñero, Tamara Alejandra Gonzalez, María Laura Kalfayan, Pablo Sampson, Julian R. Ryan, Neil A. J. Evans, D. Gareth Møller, Pål Crosbie, Emma J. |
| author2_role | author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| author_browse | Aretz, Stefan Bertario, Lucio Bonanni, Bernardo Brunet, Joan Capellá, G. (Gabriel) Cavestro, Giulia Martina Crosbie, Emma J. Dominguez Valentin, Mev Engel, Christoph Evans, D. Gareth Gluck, Nathan Gonzalez, María Laura Green, Kate Heinimann, Karl Hill, James Holinski-Feder, Elke Hovig, Eivind Kalfayan, Pablo Kariv, Revital Katz, Lior Lalloo, Fiona Macrae, Finlay Mecklin, Jukka-Pekka Mints, Miriam Møller, Pål Navarro, Matilde Nielsen, Maartje Perne, Claudia Pineda Riu, Marta Piñero, Tamara Alejandra Plazzer, John-Paul Rosner, Guy Ryan, Neil A. J. Sampson, Julian R. Schmiegel, Wolff Seppälä, Toni T. Sijmons, Rolf H. Steinke-Lange, Verena Strauß, Hans-Georg Tecklenburg, Johanna Thomas, Huw Tibiletti, Maria Grazia Vaccaro, Carlos A. Vangala, Deepak Winship, Ingrid |
| author_facet | Dominguez Valentin, Mev Seppälä, Toni T. Engel, Christoph Aretz, Stefan Macrae, Finlay Winship, Ingrid Capellá, G. (Gabriel) Thomas, Huw Hovig, Eivind Nielsen, Maartje Sijmons, Rolf H. Bertario, Lucio Bonanni, Bernardo Tibiletti, Maria Grazia Cavestro, Giulia Martina Mints, Miriam Gluck, Nathan Katz, Lior Heinimann, Karl Vaccaro, Carlos A. Green, Kate Lalloo, Fiona Hill, James Schmiegel, Wolff Vangala, Deepak Perne, Claudia Strauß, Hans-Georg Tecklenburg, Johanna Holinski-Feder, Elke Steinke-Lange, Verena Mecklin, Jukka-Pekka Plazzer, John-Paul Pineda Riu, Marta Navarro, Matilde Brunet, Joan Kariv, Revital Rosner, Guy Piñero, Tamara Alejandra Gonzalez, María Laura Kalfayan, Pablo Sampson, Julian R. Ryan, Neil A. J. Evans, D. Gareth Møller, Pål Crosbie, Emma J. |
| author_role | author |
| collection | Recercat. Dipósit de la Recerca de Catalunya |
| description | Purpose: To survey risk-reducing hysterectomy and bilateral salpingo-oophorectomy (BSO) practice and advice regarding hormone replacement therapy (HRT) in women with Lynch syndrome. Methods: We conducted a survey in 31 contributing centers from the Prospective Lynch Syndrome Database (PLSD), which incorporates 18 countries worldwide. The survey covered local policies for risk-reducing hysterectomy and BSO in Lynch syndrome, the timing when these measures are offered, the involvement of stakeholders and advice regarding HRT. Results: Risk-reducing hysterectomy and BSO are offered to path_MLH1 and path_MSH2 carriers in 20/21 (95%) contributing centers, to path_MSH6 carriers in 19/21 (91%) and to path_PMS2 carriers in 14/21 (67%). Regarding the involvement of stakeholders, there is global agreement (similar to 90%) that risk-reducing surgery should be offered to women, and that this discussion may involve gynecologists, genetic counselors and/or medical geneticists. Prescription of estrogen-only HRT is offered by 15/21 (71%) centers to women of variable age range (35-55 years). Conclusions: Most centers offer risk-reducing gynecological surgery to carriers of path_MLH1, path_MSH2 and path_MSH6 variants but less so for path_PMS2 carriers. There is wide variation in how, when and to whom this is offered. The Manchester International Consensus Group developed recommendations to harmonize clinical practice across centers, but there is a clear need for more research. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_1db2c86b57ecde0eab427085a42e3e61 |
| institution | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| instname_str | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:recercat.cat:2445/173632 |
| publishDate | 2020 |
| publishDateSort | 2020 |
| publisher | MDPI |
| publisherStr | MDPI |
| reponame_str | Recercat. Dipósit de la Recerca de Catalunya |
| spelling | Risk-reducing gynecological surgery in Lynch syndrome: results of an international survey from the prospective Lynch syndrome database Dominguez Valentin, Mev Seppälä, Toni T. Engel, Christoph Aretz, Stefan Macrae, Finlay Winship, Ingrid Capellá, G. (Gabriel) Thomas, Huw Hovig, Eivind Nielsen, Maartje Sijmons, Rolf H. Bertario, Lucio Bonanni, Bernardo Tibiletti, Maria Grazia Cavestro, Giulia Martina Mints, Miriam Gluck, Nathan Katz, Lior Heinimann, Karl Vaccaro, Carlos A. Green, Kate Lalloo, Fiona Hill, James Schmiegel, Wolff Vangala, Deepak Perne, Claudia Strauß, Hans-Georg Tecklenburg, Johanna Holinski-Feder, Elke Steinke-Lange, Verena Mecklin, Jukka-Pekka Plazzer, John-Paul Pineda Riu, Marta Navarro, Matilde Brunet, Joan Kariv, Revital Rosner, Guy Piñero, Tamara Alejandra Gonzalez, María Laura Kalfayan, Pablo Sampson, Julian R. Ryan, Neil A. J. Evans, D. Gareth Møller, Pål Crosbie, Emma J. Malalties hereditàries Càncer d'endometri Càncer d'ovari Genetic disorders Endometrial cancer Ovarian cancer Purpose: To survey risk-reducing hysterectomy and bilateral salpingo-oophorectomy (BSO) practice and advice regarding hormone replacement therapy (HRT) in women with Lynch syndrome. Methods: We conducted a survey in 31 contributing centers from the Prospective Lynch Syndrome Database (PLSD), which incorporates 18 countries worldwide. The survey covered local policies for risk-reducing hysterectomy and BSO in Lynch syndrome, the timing when these measures are offered, the involvement of stakeholders and advice regarding HRT. Results: Risk-reducing hysterectomy and BSO are offered to path_MLH1 and path_MSH2 carriers in 20/21 (95%) contributing centers, to path_MSH6 carriers in 19/21 (91%) and to path_PMS2 carriers in 14/21 (67%). Regarding the involvement of stakeholders, there is global agreement (similar to 90%) that risk-reducing surgery should be offered to women, and that this discussion may involve gynecologists, genetic counselors and/or medical geneticists. Prescription of estrogen-only HRT is offered by 15/21 (71%) centers to women of variable age range (35-55 years). Conclusions: Most centers offer risk-reducing gynecological surgery to carriers of path_MLH1, path_MSH2 and path_MSH6 variants but less so for path_PMS2 carriers. There is wide variation in how, when and to whom this is offered. The Manchester International Consensus Group developed recommendations to harmonize clinical practice across centers, but there is a clear need for more research. MDPI https://hdl.handle.net/2445/173632 |
| spellingShingle | Risk-reducing gynecological surgery in Lynch syndrome: results of an international survey from the prospective Lynch syndrome database Dominguez Valentin, Mev Malalties hereditàries Càncer d'endometri Càncer d'ovari Genetic disorders Endometrial cancer Ovarian cancer |
| status_str | publishedVersion |
| title | Risk-reducing gynecological surgery in Lynch syndrome: results of an international survey from the prospective Lynch syndrome database |
| title_full | Risk-reducing gynecological surgery in Lynch syndrome: results of an international survey from the prospective Lynch syndrome database |
| title_fullStr | Risk-reducing gynecological surgery in Lynch syndrome: results of an international survey from the prospective Lynch syndrome database |
| title_full_unstemmed | Risk-reducing gynecological surgery in Lynch syndrome: results of an international survey from the prospective Lynch syndrome database |
| title_short | Risk-reducing gynecological surgery in Lynch syndrome: results of an international survey from the prospective Lynch syndrome database |
| title_sort | Risk-reducing gynecological surgery in Lynch syndrome: results of an international survey from the prospective Lynch syndrome database |
| topic | Malalties hereditàries Càncer d'endometri Càncer d'ovari Genetic disorders Endometrial cancer Ovarian cancer |
| topic_facet | Malalties hereditàries Càncer d'endometri Càncer d'ovari Genetic disorders Endometrial cancer Ovarian cancer |
| url | https://hdl.handle.net/2445/173632 |