Structural brain changes and cognition in relation to markers of vascular dysfunction
The aim was to investigate the relationship between blood markers of vascular dysfunction with brain microstructural changes and cognition. Eighty-six participants from the Barcelona-Asymptomatic Intracranial Atherosclerosis (AsIA) neuropsychology study were included. Subjects were 50–65 years old,...
| Autores: | ; ; ; ; ; ; ; ; ; ; ; ; ; ; |
|---|---|
| Tipo de documento: | Artigo |
| Estado: | Accepted version |
| Data de publicação: | 2012 |
| País: | España |
| Recursos: | Universidad de Barcelona |
| Repositório: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/226410 |
| Acesso em linha: | https://hdl.handle.net/2445/226410 |
| Nível de acesso: | Acesso aberto |
| Palavra-chave: | Malalties cerebrovasculars Cervell Cerebrovascular disease Brain |
| _version_ | 1878730494889164800 |
|---|---|
| author | Miralbell Blanch, Júlia |
| author2 | Soriano Raya, Juan José Spulber, Gabriela López Cancio, Elena Arenillas, Juan Francisco Bargalló Alabart, Núria Galán, Amparo Barrios Cerrejón, M. Teresa Cáceres, Cynthia Alzamora, María Teresa Pera, Guillem Kivipelto, Miia Wahlund, Lars-Olof Dávalos, Antoni Mataró Serrat, Maria |
| author2_role | author author author author author author author author author author author author author author |
| author_browse | Alzamora, María Teresa Arenillas, Juan Francisco Bargalló Alabart, Núria Barrios Cerrejón, M. Teresa Cáceres, Cynthia Dávalos, Antoni Galán, Amparo Kivipelto, Miia López Cancio, Elena Mataró Serrat, Maria Miralbell Blanch, Júlia Pera, Guillem Soriano Raya, Juan José Spulber, Gabriela Wahlund, Lars-Olof |
| author_facet | Miralbell Blanch, Júlia Soriano Raya, Juan José Spulber, Gabriela López Cancio, Elena Arenillas, Juan Francisco Bargalló Alabart, Núria Galán, Amparo Barrios Cerrejón, M. Teresa Cáceres, Cynthia Alzamora, María Teresa Pera, Guillem Kivipelto, Miia Wahlund, Lars-Olof Dávalos, Antoni Mataró Serrat, Maria |
| author_role | author |
| collection | Dipòsit Digital de la UB |
| description | The aim was to investigate the relationship between blood markers of vascular dysfunction with brain microstructural changes and cognition. Eighty-six participants from the Barcelona-Asymptomatic Intracranial Atherosclerosis (AsIA) neuropsychology study were included. Subjects were 50–65 years old, free from dementia and without history of vascular disease. We assessed correlations of blood levels of inflammatory biomarkers (C-reactive protein [CRP] and resistin) and fibrinolysis inhibitors (plasminogen activator inhibitor-1 [PAI-1] and A-lipoprotein (Lp (a)) with fractional anisotropy (FA) measurements of diffusion tensor images (DTI), regional gray matter (GM) volumes and performance in several cognitive domains. Increasing levels of C-reactive protein and PAI-1 levels were associated with white matter (WM) integrity loss in corticosubcortical pathways and association fibers of frontal and temporal lobes, independently of age, sex and vascular risk factors. PAI-1 was also related to lower speed and visuomotor/coordination. None of the biomarkers were related to gray matter volume changes. Our findings suggest that inflammation and dysregulation of the fibrynolitic system may be involved in the pathological mechanisms underlying the WM damage seen in cerebrovascular disease and subsequent cognitive impairment. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_1d760f280260312dfd2cb841eca4b771 |
| institution | Universidad de Barcelona |
| instname_str | Universidad de Barcelona |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:diposit.ub.edu:2445/226410 |
| publishDate | 2012 |
| publishDateSort | 2012 |
| publisher | Elsevier B.V. |
| publisherStr | Elsevier B.V. |
| reponame_str | Dipòsit Digital de la UB |
| spelling | Structural brain changes and cognition in relation to markers of vascular dysfunction Miralbell Blanch, Júlia Soriano Raya, Juan José Spulber, Gabriela López Cancio, Elena Arenillas, Juan Francisco Bargalló Alabart, Núria Galán, Amparo Barrios Cerrejón, M. Teresa Cáceres, Cynthia Alzamora, María Teresa Pera, Guillem Kivipelto, Miia Wahlund, Lars-Olof Dávalos, Antoni Mataró Serrat, Maria Malalties cerebrovasculars Cervell Cerebrovascular disease Brain The aim was to investigate the relationship between blood markers of vascular dysfunction with brain microstructural changes and cognition. Eighty-six participants from the Barcelona-Asymptomatic Intracranial Atherosclerosis (AsIA) neuropsychology study were included. Subjects were 50–65 years old, free from dementia and without history of vascular disease. We assessed correlations of blood levels of inflammatory biomarkers (C-reactive protein [CRP] and resistin) and fibrinolysis inhibitors (plasminogen activator inhibitor-1 [PAI-1] and A-lipoprotein (Lp (a)) with fractional anisotropy (FA) measurements of diffusion tensor images (DTI), regional gray matter (GM) volumes and performance in several cognitive domains. Increasing levels of C-reactive protein and PAI-1 levels were associated with white matter (WM) integrity loss in corticosubcortical pathways and association fibers of frontal and temporal lobes, independently of age, sex and vascular risk factors. PAI-1 was also related to lower speed and visuomotor/coordination. None of the biomarkers were related to gray matter volume changes. Our findings suggest that inflammation and dysregulation of the fibrynolitic system may be involved in the pathological mechanisms underlying the WM damage seen in cerebrovascular disease and subsequent cognitive impairment. Elsevier B.V. https://hdl.handle.net/2445/226410 |
| spellingShingle | Structural brain changes and cognition in relation to markers of vascular dysfunction Miralbell Blanch, Júlia Malalties cerebrovasculars Cervell Cerebrovascular disease Brain |
| status_str | acceptedVersion |
| title | Structural brain changes and cognition in relation to markers of vascular dysfunction |
| title_full | Structural brain changes and cognition in relation to markers of vascular dysfunction |
| title_fullStr | Structural brain changes and cognition in relation to markers of vascular dysfunction |
| title_full_unstemmed | Structural brain changes and cognition in relation to markers of vascular dysfunction |
| title_short | Structural brain changes and cognition in relation to markers of vascular dysfunction |
| title_sort | Structural brain changes and cognition in relation to markers of vascular dysfunction |
| topic | Malalties cerebrovasculars Cervell Cerebrovascular disease Brain |
| topic_facet | Malalties cerebrovasculars Cervell Cerebrovascular disease Brain |
| url | https://hdl.handle.net/2445/226410 |