A versatile multilevel converter platform for cancer treatment using irreversible electroporation
Electroporation is an effective technique based on applying an electric field to cells, commonly used to increase the effectivity of drug and gene delivery. When the applied electric field is strong enough, it can be used for selective cell death with promising results in cancer treatment. This pape...
| Autores: | ; ; ; ; ; |
|---|---|
| Tipo de documento: | Artigo |
| Estado: | Accepted version |
| Data de publicação: | 2016 |
| País: | España |
| Recursos: | Universitat Pompeu Fabra |
| Repositório: | Repositorio Digital de la UPF |
| OAI Identifier: | oai:repositori.upf.edu:10230/26153 |
| Acesso em linha: | http://hdl.handle.net/10230/26153 http://dx.doi.org/10.1109/JESTPE.2015.2512324 |
| Nível de acesso: | Acesso aberto |
| Palavra-chave: | Electroporation Multilevel converter Power electronics |
| _version_ | 1878730443390451712 |
|---|---|
| author | Sarnago, Héctor |
| author2 | Lucía, Óscar Naval, Alejandro Burdío, José M. Castellví Fernández, Quim Ivorra Cano, Antoni, 1974- |
| author2_role | author author author author author |
| author_browse | Burdío, José M. Castellví Fernández, Quim Ivorra Cano, Antoni, 1974- Lucía, Óscar Naval, Alejandro Sarnago, Héctor |
| author_facet | Sarnago, Héctor Lucía, Óscar Naval, Alejandro Burdío, José M. Castellví Fernández, Quim Ivorra Cano, Antoni, 1974- |
| author_role | author |
| collection | Repositorio Digital de la UPF |
| description | Electroporation is an effective technique based on applying an electric field to cells, commonly used to increase the effectivity of drug and gene delivery. When the applied electric field is strong enough, it can be used for selective cell death with promising results in cancer treatment. This paper proposes the development of a modular multilevel topology in order to provide a high-performance tool for research in electroporation. The proposed converter based on a scalable multicell approach is detailed and analyzed in this paper, and an experimental prototype has been designed and built. The experimental results prove the feasibility of this proposal to enable advanced electroporation techniques. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_1c6a61f84f2d64e4c0b96fe337edba02 |
| institution | Universitat Pompeu Fabra |
| instname_str | Universitat Pompeu Fabra |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:repositori.upf.edu:10230/26153 |
| publishDate | 2016 |
| publishDateSort | 2016 |
| publisher | Institute of Electrical and Electronics Engineers (IEEE) |
| publisherStr | Institute of Electrical and Electronics Engineers (IEEE) |
| reponame_str | Repositorio Digital de la UPF |
| spelling | A versatile multilevel converter platform for cancer treatment using irreversible electroporation Sarnago, Héctor Lucía, Óscar Naval, Alejandro Burdío, José M. Castellví Fernández, Quim Ivorra Cano, Antoni, 1974- Electroporation Multilevel converter Power electronics Electroporation is an effective technique based on applying an electric field to cells, commonly used to increase the effectivity of drug and gene delivery. When the applied electric field is strong enough, it can be used for selective cell death with promising results in cancer treatment. This paper proposes the development of a modular multilevel topology in order to provide a high-performance tool for research in electroporation. The proposed converter based on a scalable multicell approach is detailed and analyzed in this paper, and an experimental prototype has been designed and built. The experimental results prove the feasibility of this proposal to enable advanced electroporation techniques. This work was supported in part by Diputación General de Aragón-Fondo Social Europeo, in part by the University of Zaragoza/nunder Grant JIUZ-2014-TEC-08, and in part by the Spanish Ministerio de Economía y Competitividad under Grant CSD2009-00046, Grant TEC2013-42937-R, and Grant Project RTC-2014-1847-6. Institute of Electrical and Electronics Engineers (IEEE) http://hdl.handle.net/10230/26153 http://dx.doi.org/10.1109/JESTPE.2015.2512324 |
| spellingShingle | A versatile multilevel converter platform for cancer treatment using irreversible electroporation Sarnago, Héctor Electroporation Multilevel converter Power electronics |
| status_str | acceptedVersion |
| title | A versatile multilevel converter platform for cancer treatment using irreversible electroporation |
| title_full | A versatile multilevel converter platform for cancer treatment using irreversible electroporation |
| title_fullStr | A versatile multilevel converter platform for cancer treatment using irreversible electroporation |
| title_full_unstemmed | A versatile multilevel converter platform for cancer treatment using irreversible electroporation |
| title_short | A versatile multilevel converter platform for cancer treatment using irreversible electroporation |
| title_sort | A versatile multilevel converter platform for cancer treatment using irreversible electroporation |
| topic | Electroporation Multilevel converter Power electronics |
| topic_facet | Electroporation Multilevel converter Power electronics |
| url | http://hdl.handle.net/10230/26153 http://dx.doi.org/10.1109/JESTPE.2015.2512324 |