Cervical Electrical Neuromodulation Effectively Enhances Hand Motor Output in Healthy Subjects by Engaging a Use-Dependent Intervention
Electrical enabling motor control (eEmc) through transcutaneous spinal cord stimulation is a non-invasive method that can modify the functional state of the sensory-motor system. We hypothesize that eEmc delivery, together with hand training, improves hand function in healthy subjects more than eith...
| Authors: | ; ; ; ; ; ; ; ; ; |
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| Format: | Article |
| Publication date: | 2021 |
| Country: | España |
| Institution: | Universitat Autònoma de Barcelona |
| Repository: | Dipòsit Digital de Documents de la UAB |
| Language: | English |
| OAI Identifier: | oai:ddd.uab.cat:236226 |
| Online Access: | https://ddd.uab.cat/record/236226 https://dx.doi.org/urn:doi:10.3390/jcm10020195 |
| Access Level: | Open access |
| Keyword: | Transcutaneous spinal cord stimulation Hand training Combined intervention Neuromodulation Cervical spinal cord |
| _version_ | 1878730332185821185 |
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| author | Kumru, Hatice|||0000-0002-0501-1660 |
| author2 | Flores de los Heros, Africa|||0000-0003-0720-2409 Rodríguez-Cañón, María|||0000-0003-4093-5292 Edgerton, Victor|||0000-0001-6534-1875 García-Alén, Loreto|||0000-0001-9910-9476 Benito-Penalva, Jesús|||0000-0003-1232-1808 Navarro, X. (Xavier)|||0000-0001-9849-902X Gerasimenko, Yury P.|||0000-0002-9345-3791 García Alias, Guillermo|||0000-0003-0197-0503 Vidal, Joan|||0000-0002-3952-2442 |
| author2_role | author author author author author author author author author |
| author_browse | Benito-Penalva, Jesús|||0000-0003-1232-1808 Edgerton, Victor|||0000-0001-6534-1875 Flores de los Heros, Africa|||0000-0003-0720-2409 García Alias, Guillermo|||0000-0003-0197-0503 García-Alén, Loreto|||0000-0001-9910-9476 Gerasimenko, Yury P.|||0000-0002-9345-3791 Kumru, Hatice|||0000-0002-0501-1660 Navarro, X. (Xavier)|||0000-0001-9849-902X Rodríguez-Cañón, María|||0000-0003-4093-5292 Vidal, Joan|||0000-0002-3952-2442 |
| author_facet | Kumru, Hatice|||0000-0002-0501-1660 Flores de los Heros, Africa|||0000-0003-0720-2409 Rodríguez-Cañón, María|||0000-0003-4093-5292 Edgerton, Victor|||0000-0001-6534-1875 García-Alén, Loreto|||0000-0001-9910-9476 Benito-Penalva, Jesús|||0000-0003-1232-1808 Navarro, X. (Xavier)|||0000-0001-9849-902X Gerasimenko, Yury P.|||0000-0002-9345-3791 García Alias, Guillermo|||0000-0003-0197-0503 Vidal, Joan|||0000-0002-3952-2442 |
| author_role | author |
| collection | Dipòsit Digital de Documents de la UAB |
| description | Electrical enabling motor control (eEmc) through transcutaneous spinal cord stimulation is a non-invasive method that can modify the functional state of the sensory-motor system. We hypothesize that eEmc delivery, together with hand training, improves hand function in healthy subjects more than either intervention alone by inducing plastic changes at spinal and cortical levels. Ten voluntary participants were included in the following three interventions: (i) hand grip training, (ii) eEmc, and (iii) eEmc with hand training. Functional evaluation included the box and blocks test (BBT) and hand grip maximum voluntary contraction (MVC), spinal and cortical motor evoked potential (sMEP and cMEP), and resting motor thresholds (RMT), short interval intracortical inhibition (SICI), and F wave in the abductor pollicis brevis muscle. eEmc combined with hand training retained MVC and increased F wave amplitude and persistency, reduced cortical RMT and facilitated cMEP amplitude. In contrast, eEmc alone only increased F wave amplitude, whereas hand training alone reduced MVC and increased cortical RMT and SICI. In conclusion, eEmc combined with hand grip training enhanced hand motor output and induced plastic changes at spinal and cortical level in healthy subjects when compared to either intervention alone. These data suggest that electrical neuromodulation changes spinal and, perhaps, supraspinal networks to a more malleable state, while a concomitant use-dependent mechanism drives these networks to a higher functional state. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_1a277e4fa4eab3ef8db6d99bc9267202 |
| institution | Universitat Autònoma de Barcelona |
| instname_str | Universitat Autònoma de Barcelona |
| language | eng |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:ddd.uab.cat:236226 |
| publishDate | 2021 |
| publishDateSort | 2021 |
| reponame_str | Dipòsit Digital de Documents de la UAB |
| spelling | Cervical Electrical Neuromodulation Effectively Enhances Hand Motor Output in Healthy Subjects by Engaging a Use-Dependent Intervention Kumru, Hatice|||0000-0002-0501-1660 Flores de los Heros, Africa|||0000-0003-0720-2409 Rodríguez-Cañón, María|||0000-0003-4093-5292 Edgerton, Victor|||0000-0001-6534-1875 García-Alén, Loreto|||0000-0001-9910-9476 Benito-Penalva, Jesús|||0000-0003-1232-1808 Navarro, X. (Xavier)|||0000-0001-9849-902X Gerasimenko, Yury P.|||0000-0002-9345-3791 García Alias, Guillermo|||0000-0003-0197-0503 Vidal, Joan|||0000-0002-3952-2442 Transcutaneous spinal cord stimulation Hand training Combined intervention Neuromodulation Cervical spinal cord Electrical enabling motor control (eEmc) through transcutaneous spinal cord stimulation is a non-invasive method that can modify the functional state of the sensory-motor system. We hypothesize that eEmc delivery, together with hand training, improves hand function in healthy subjects more than either intervention alone by inducing plastic changes at spinal and cortical levels. Ten voluntary participants were included in the following three interventions: (i) hand grip training, (ii) eEmc, and (iii) eEmc with hand training. Functional evaluation included the box and blocks test (BBT) and hand grip maximum voluntary contraction (MVC), spinal and cortical motor evoked potential (sMEP and cMEP), and resting motor thresholds (RMT), short interval intracortical inhibition (SICI), and F wave in the abductor pollicis brevis muscle. eEmc combined with hand training retained MVC and increased F wave amplitude and persistency, reduced cortical RMT and facilitated cMEP amplitude. In contrast, eEmc alone only increased F wave amplitude, whereas hand training alone reduced MVC and increased cortical RMT and SICI. In conclusion, eEmc combined with hand grip training enhanced hand motor output and induced plastic changes at spinal and cortical level in healthy subjects when compared to either intervention alone. These data suggest that electrical neuromodulation changes spinal and, perhaps, supraspinal networks to a more malleable state, while a concomitant use-dependent mechanism drives these networks to a higher functional state. https://ddd.uab.cat/record/236226 https://dx.doi.org/urn:doi:10.3390/jcm10020195 |
| spellingShingle | Cervical Electrical Neuromodulation Effectively Enhances Hand Motor Output in Healthy Subjects by Engaging a Use-Dependent Intervention Kumru, Hatice|||0000-0002-0501-1660 Transcutaneous spinal cord stimulation Hand training Combined intervention Neuromodulation Cervical spinal cord |
| title | Cervical Electrical Neuromodulation Effectively Enhances Hand Motor Output in Healthy Subjects by Engaging a Use-Dependent Intervention |
| title_full | Cervical Electrical Neuromodulation Effectively Enhances Hand Motor Output in Healthy Subjects by Engaging a Use-Dependent Intervention |
| title_fullStr | Cervical Electrical Neuromodulation Effectively Enhances Hand Motor Output in Healthy Subjects by Engaging a Use-Dependent Intervention |
| title_full_unstemmed | Cervical Electrical Neuromodulation Effectively Enhances Hand Motor Output in Healthy Subjects by Engaging a Use-Dependent Intervention |
| title_short | Cervical Electrical Neuromodulation Effectively Enhances Hand Motor Output in Healthy Subjects by Engaging a Use-Dependent Intervention |
| title_sort | Cervical Electrical Neuromodulation Effectively Enhances Hand Motor Output in Healthy Subjects by Engaging a Use-Dependent Intervention |
| topic | Transcutaneous spinal cord stimulation Hand training Combined intervention Neuromodulation Cervical spinal cord |
| topic_facet | Transcutaneous spinal cord stimulation Hand training Combined intervention Neuromodulation Cervical spinal cord |
| url | https://ddd.uab.cat/record/236226 https://dx.doi.org/urn:doi:10.3390/jcm10020195 |