Plasma Arginine/Asymmetric Dimethylarginine Ratio and Incidence of Cardiovascular Events: A Case-Cohort Study
CONTEXT: Arginine, its methylated metabolites, and other metabolites related to the urea cycle have been independently associated with cardiovascular risk, but the potential causal meaning of these associations (positive for some metabolites and negative for others) remains elusive due to a lack of...
| Autores: | ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; |
|---|---|
| Tipo de documento: | Artículo |
| Estado: | Accepted version |
| Fecha de publicación: | 2017 |
| País: | España |
| Institución: | Universitat Pompeu Fabra |
| Repositorio: | Repositorio Digital de la UPF |
| OAI Identifier: | oai:repositori.upf.edu:10230/34875 |
| Acceso en línea: | http://hdl.handle.net/10230/34875 http://dx.doi.org/10.1210/jc.2016-3569 |
| Nivel de acceso: | Acceso abierto |
| Palabra clave: | Sistema cardiovascular -- Malalties Dieta -- Mediterrània, Regió de la |
| _version_ | 1878729741620477952 |
|---|---|
| author | Yu, Edward |
| author2 | Ruiz-Canela, Miguel Hu, Frank B. Clish, Clary B. Corella, Dolores Salas-Salvadó, Jordi Hruby, Adela Fitó Colomer, Montserrat Liang, Liming Toledo, Estefania Ros, Emilio Estruch, Ramón Gómez-Gracia, Enrique Lapetra, José Arós, Fernando Romaguera Bosch, Dora Serra-Majem, Luis Guasch Ferré, Marta Wang, Dong D. Martínez-González, Miguel Ángel, 1957- |
| author2_role | author author author author author author author author author author author author author author author author author author author |
| author_browse | Arós, Fernando Clish, Clary B. Corella, Dolores Estruch, Ramón Fitó Colomer, Montserrat Guasch Ferré, Marta Gómez-Gracia, Enrique Hruby, Adela Hu, Frank B. Lapetra, José Liang, Liming Martínez-González, Miguel Ángel, 1957- Romaguera Bosch, Dora Ros, Emilio Ruiz-Canela, Miguel Salas-Salvadó, Jordi Serra-Majem, Luis Toledo, Estefania Wang, Dong D. Yu, Edward |
| author_facet | Yu, Edward Ruiz-Canela, Miguel Hu, Frank B. Clish, Clary B. Corella, Dolores Salas-Salvadó, Jordi Hruby, Adela Fitó Colomer, Montserrat Liang, Liming Toledo, Estefania Ros, Emilio Estruch, Ramón Gómez-Gracia, Enrique Lapetra, José Arós, Fernando Romaguera Bosch, Dora Serra-Majem, Luis Guasch Ferré, Marta Wang, Dong D. Martínez-González, Miguel Ángel, 1957- |
| author_role | author |
| collection | Repositorio Digital de la UPF |
| description | CONTEXT: Arginine, its methylated metabolites, and other metabolites related to the urea cycle have been independently associated with cardiovascular risk, but the potential causal meaning of these associations (positive for some metabolites and negative for others) remains elusive due to a lack of studies measuring metabolite changes over time. OBJECTIVE: To examine the association between baseline and 1-year concentrations of urea cycle metabolites and cardiovascular disease (CVD) in a case-cohort setting. DESIGN: A case-cohort study was nested within the Prevención con Dieta Mediterránea trial. We used liquid chromatography-tandem mass spectrometry to assess metabolite levels at baseline and after 1-year follow-up. The primary CVD outcome was a composite of myocardial infarction, stroke and cardiovascular death. We used weighted Cox regression models (Barlow weights) to estimate multivariable-adjusted hazard ratios (HRs) and their 95% confidence intervals (CIs). SETTING: Multicenter randomized trial in Spain. PARTICIPANTS: Participants were 984 participants accruing 231 events over 4.7 years' median follow-up. MAIN OUTCOME MEASURE: Incident CVD. RESULTS: Baseline arginine/asymmetric dimethylarginine ratio [HR per standard deviation (SD) = 0.80; 95% CI, 0.67 to 0.96] and global arginine availability [arginine / (ornithine + citrulline)] (HR per SD = 0.83; 95% CI, 0.69 to 1.00) were significantly associated with lower risk of CVD. We observed no significant association for 1-year changes in these ratios or any effect modification by the Mediterranean diet (MD) intervention. CONCLUSIONS: A higher baseline arginine/asymmetric dimethylarginine ratio was associated with lower CVD incidence in a high cardiovascular risk population. The intervention with the MD did not change 1-year levels of these metabolites. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ES_0e169003fc8de0bf808f7c54845f87cd |
| institution | Universitat Pompeu Fabra |
| instname_str | Universitat Pompeu Fabra |
| network_acronym_str | ES |
| network_name_str | España |
| oai_identifier_str | oai:repositori.upf.edu:10230/34875 |
| publishDate | 2017 |
| publishDateSort | 2017 |
| publisher | Oxford University Press |
| publisherStr | Oxford University Press |
| reponame_str | Repositorio Digital de la UPF |
| spelling | Plasma Arginine/Asymmetric Dimethylarginine Ratio and Incidence of Cardiovascular Events: A Case-Cohort Study Yu, Edward Ruiz-Canela, Miguel Hu, Frank B. Clish, Clary B. Corella, Dolores Salas-Salvadó, Jordi Hruby, Adela Fitó Colomer, Montserrat Liang, Liming Toledo, Estefania Ros, Emilio Estruch, Ramón Gómez-Gracia, Enrique Lapetra, José Arós, Fernando Romaguera Bosch, Dora Serra-Majem, Luis Guasch Ferré, Marta Wang, Dong D. Martínez-González, Miguel Ángel, 1957- Sistema cardiovascular -- Malalties Dieta -- Mediterrània, Regió de la CONTEXT: Arginine, its methylated metabolites, and other metabolites related to the urea cycle have been independently associated with cardiovascular risk, but the potential causal meaning of these associations (positive for some metabolites and negative for others) remains elusive due to a lack of studies measuring metabolite changes over time. OBJECTIVE: To examine the association between baseline and 1-year concentrations of urea cycle metabolites and cardiovascular disease (CVD) in a case-cohort setting. DESIGN: A case-cohort study was nested within the Prevención con Dieta Mediterránea trial. We used liquid chromatography-tandem mass spectrometry to assess metabolite levels at baseline and after 1-year follow-up. The primary CVD outcome was a composite of myocardial infarction, stroke and cardiovascular death. We used weighted Cox regression models (Barlow weights) to estimate multivariable-adjusted hazard ratios (HRs) and their 95% confidence intervals (CIs). SETTING: Multicenter randomized trial in Spain. PARTICIPANTS: Participants were 984 participants accruing 231 events over 4.7 years' median follow-up. MAIN OUTCOME MEASURE: Incident CVD. RESULTS: Baseline arginine/asymmetric dimethylarginine ratio [HR per standard deviation (SD) = 0.80; 95% CI, 0.67 to 0.96] and global arginine availability [arginine / (ornithine + citrulline)] (HR per SD = 0.83; 95% CI, 0.69 to 1.00) were significantly associated with lower risk of CVD. We observed no significant association for 1-year changes in these ratios or any effect modification by the Mediterranean diet (MD) intervention. CONCLUSIONS: A higher baseline arginine/asymmetric dimethylarginine ratio was associated with lower CVD incidence in a high cardiovascular risk population. The intervention with the MD did not change 1-year levels of these metabolites. Oxford University Press http://hdl.handle.net/10230/34875 http://dx.doi.org/10.1210/jc.2016-3569 |
| spellingShingle | Plasma Arginine/Asymmetric Dimethylarginine Ratio and Incidence of Cardiovascular Events: A Case-Cohort Study Yu, Edward Sistema cardiovascular -- Malalties Dieta -- Mediterrània, Regió de la |
| status_str | acceptedVersion |
| title | Plasma Arginine/Asymmetric Dimethylarginine Ratio and Incidence of Cardiovascular Events: A Case-Cohort Study |
| title_full | Plasma Arginine/Asymmetric Dimethylarginine Ratio and Incidence of Cardiovascular Events: A Case-Cohort Study |
| title_fullStr | Plasma Arginine/Asymmetric Dimethylarginine Ratio and Incidence of Cardiovascular Events: A Case-Cohort Study |
| title_full_unstemmed | Plasma Arginine/Asymmetric Dimethylarginine Ratio and Incidence of Cardiovascular Events: A Case-Cohort Study |
| title_short | Plasma Arginine/Asymmetric Dimethylarginine Ratio and Incidence of Cardiovascular Events: A Case-Cohort Study |
| title_sort | Plasma Arginine/Asymmetric Dimethylarginine Ratio and Incidence of Cardiovascular Events: A Case-Cohort Study |
| topic | Sistema cardiovascular -- Malalties Dieta -- Mediterrània, Regió de la |
| topic_facet | Sistema cardiovascular -- Malalties Dieta -- Mediterrània, Regió de la |
| url | http://hdl.handle.net/10230/34875 http://dx.doi.org/10.1210/jc.2016-3569 |